| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brian J Lannutti, Sarah A Meadows, Sarah E M Herman, Adam Kashishian, Bart Steiner, Amy J Johnson, John C Byrd, Jeffrey W Tyner, Marc M Loriaux, Mike Deininger, Brian J Druker, Kamal D Puri, Roger G Ulrich, Neill A Gies. CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood. vol 117. issue 2. 2011-02-23. PMID:20959606. |
cal-101 blocked constitutive phosphatidylinositol-3-kinase signaling, resulting in decreased phosphorylation of akt and other downstream effectors, an increase in poly(adp-ribose) polymerase and caspase cleavage and an induction of apoptosis. |
2011-02-23 |
2023-08-12 |
Not clear |
| Prem P Tripathi, Giulia Santorufo, Elisa Brilli, Emiliana Borrelli, Yuri Bozz. Kainic acid-induced seizures activate GSK-3β in the hippocampus of D2R-/- mice. Neuroreport. vol 21. issue 12. 2011-02-22. PMID:20625330. |
our results suggest that gsk-3beta activation participates, independently of akt, in the ka-induced apoptosis in the d2r-/- hippocampus. |
2011-02-22 |
2023-08-12 |
mouse |
| Qi-Wen Fan, Christine Cheng, Chris Hackett, Morri Feldman, Benjamin T Houseman, Theodore Nicolaides, Daphne Haas-Kogan, C David James, Scott A Oakes, Jayanta Debnath, Kevan M Shokat, William A Weis. Akt and autophagy cooperate to promote survival of drug-resistant glioma. Science signaling. vol 3. issue 147. 2011-02-22. PMID:21062993. |
we show that combined inhibition of pi3k and mtor, which activates autophagy without activating akt, cooperated with inhibition of autophagy to cause glioma cells to undergo apoptosis. |
2011-02-22 |
2023-08-12 |
Not clear |
| Yong Liu, Ming-zhi Lu, Si-si Fan, Sheng Yua. [Influence of AKT on survival and apoptosis of gastric adenocarcinoma cells]. Zhonghua bing li xue za zhi = Chinese journal of pathology. vol 38. issue 5. 2011-02-14. PMID:19575879. |
[influence of akt on survival and apoptosis of gastric adenocarcinoma cells]. |
2011-02-14 |
2023-08-12 |
Not clear |
| Tongsen Zheng, Xianzhi Meng, Jiabei Wang, Xi Chen, Dalong Yin, Yingjian Liang, Xuan Song, Shangha Pan, Hongchi Jiang, Lianxin Li. PTEN- and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice. Journal of cellular biochemistry. vol 111. issue 1. 2011-02-14. PMID:20506484. |
suppression of pten expression with sirna significantly reduced the p53 and p21 levels and activated akt, resulting in decreased apoptosis and increased cell survival. |
2011-02-14 |
2023-08-12 |
mouse |
| Stéphanie Bonnaud, Colin Niaudet, François Legoux, Isabelle Corre, Gregory Delpon, Xavier Saulquin, Zvi Fuks, Marie-Hélène Gaugler, Richard Kolesnick, François Pari. Sphingosine-1-phosphate activates the AKT pathway to protect small intestines from radiation-induced endothelial apoptosis. Cancer research. vol 70. issue 23. 2011-02-10. PMID:21118968. |
sphingosine-1-phosphate activates the akt pathway to protect small intestines from radiation-induced endothelial apoptosis. |
2011-02-10 |
2023-08-12 |
mouse |
| Xi Ma, Xia Ren, Pengfei Han, Shengdi Hu, Junjun Wang, Jingdong Yi. SiRNA against Fabp5 induces 3T3-L1 cells apoptosis during adipocytic induction. Molecular biology reports. vol 37. issue 8. 2011-02-07. PMID:20238174. |
in conclusion, our data suggests that fabp5 is crucial in maintaining the viability of preadipocytes during adipogenesis via the activation of akt cascade, and decreased fabp5 expression induce differentiating preadipocytes apoptosis via caspase-3 activation. |
2011-02-07 |
2023-08-12 |
Not clear |
| Masoumeh Ghayouri, David Boulware, Aejaz Nasir, Jonathan Strosberg, Larry Kvols, Domenico Coppol. Activation of the serine/theronine protein kinase Akt in enteropancreatic neuroendocrine tumors. Anticancer research. vol 30. issue 12. 2011-02-04. PMID:21187491. |
akt is a regulator of cell proliferation, tumorigenesis and apoptosis. |
2011-02-04 |
2023-08-12 |
Not clear |
| Shinsaku Togo, Hisa Sugiura, Amy Nelson, Tetsu Kobayashi, Xingqi Wang, Koh Kamio, Shin Kawasaki, Peter Bitterman, Stephen I Rennard, Xiangde Li. Hepatic growth factor (HGF) inhibits cigarette smoke extract induced apoptosis in human bronchial epithelial cells. Experimental cell research. vol 316. issue 20. 2011-01-26. PMID:20850432. |
this protective effect of hgf on cse-induced apoptosis was abolished by pi3k inhibitors, wortmannin and ly294002, and by introduction of the dominant negative akt into the cells. |
2011-01-26 |
2023-08-12 |
human |
| Min Jung Kim, Tae Hwa Lee, Sung Han Kim, Yeon-Joo Choi, Jeonghoon Heo, Young-Ho Ki. Triptolide inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway. International journal of oncology. vol 37. issue 5. 2011-01-25. PMID:20878065. |
triptolide-induced apoptosis was associated with a marked reduction in akt phosphorylation and was exacerbated by ly294002 (phosphatidylinositol-3'-kinase inhibitor). |
2011-01-25 |
2023-08-12 |
human |
| Min Jung Kim, Tae Hwa Lee, Sung Han Kim, Yeon-Joo Choi, Jeonghoon Heo, Young-Ho Ki. Triptolide inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway. International journal of oncology. vol 37. issue 5. 2011-01-25. PMID:20878065. |
these findings show that triptolide induces caspase-dependent, mitochondria-mediated apoptosis in cervical cancer cells, in part, by negatively regulating akt and mcl-1. |
2011-01-25 |
2023-08-12 |
human |
| Xiao-Chun Zhao, Li Tian, Jian-Guo Cao, Fei Li. Induction of apoptosis by 5,7-dihydroxy-8-nitrochrysin in breast cancer cells: the role of reactive oxygen species and Akt. International journal of oncology. vol 37. issue 5. 2011-01-25. PMID:20878083. |
induction of apoptosis by 5,7-dihydroxy-8-nitrochrysin in breast cancer cells: the role of reactive oxygen species and akt. |
2011-01-25 |
2023-08-12 |
human |
| Xiao-Chun Zhao, Li Tian, Jian-Guo Cao, Fei Li. Induction of apoptosis by 5,7-dihydroxy-8-nitrochrysin in breast cancer cells: the role of reactive oxygen species and Akt. International journal of oncology. vol 37. issue 5. 2011-01-25. PMID:20878083. |
moreover, the results of our studies, for the first time, provide mechanistic evidence that noc induces apoptosis by the generation of reactive oxygen species and akt dephosphorylation. |
2011-01-25 |
2023-08-12 |
human |
| Carla R Bromati, Camilo Lellis-Santos, Tatiana S Yamanaka, Tatiane C A Nogueira, Mauro Leonelli, Luciana C Caperuto, Renata Gorjão, Adriana R Leite, Gabriel F Anhê, Silvana Bordi. UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression. American journal of physiology. Regulatory, integrative and comparative physiology. vol 300. issue 1. 2011-01-20. PMID:21068199. |
upr induces transient burst of apoptosis in islets of early lactating rats through reduced akt phosphorylation via atf4/chop stimulation of trb3 expression. |
2011-01-20 |
2023-08-12 |
rat |
| H Kilter, M Werner, C Roggia, J-C Reil, H-J Schäfers, U Kintscher, M Böh. The PPAR-gamma agonist rosiglitazone facilitates Akt rephosphorylation and inhibits apoptosis in cardiomyocytes during hypoxia/reoxygenation. Diabetes, obesity & metabolism. vol 11. issue 11. 2011-01-18. PMID:19732122. |
the ppar-gamma agonist rosiglitazone facilitates akt rephosphorylation and inhibits apoptosis in cardiomyocytes during hypoxia/reoxygenation. |
2011-01-18 |
2023-08-12 |
Not clear |
| Mervi E Hyvönen, Pauliina Saurus, Anita Wasik, Eija Heikkilä, Marika Havana, Ras Trokovic, Moin Saleem, Harry Holthöfer, Sanna Lehtone. Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes. Molecular and cellular endocrinology. vol 328. issue 1-2. 2011-01-18. PMID:20654688. |
overexpression of ship2 in cultured podocytes reduces akt activation in response to insulin, and promotes apoptosis. |
2011-01-18 |
2023-08-12 |
rat |
| Paul A J Krijnen, Jessica A Sipkens, Johan W Molling, Jan A Rauwerda, Coen D A Stehouwer, Alice Muller, Walter J Paulus, Geerten P van Nieuw Amerongen, C Erik Hack, Arthur J Verhoeven, Victor W M van Hinsbergh, Hans W M Niesse. Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase. Journal of molecular and cellular cardiology. vol 49. issue 5. 2011-01-18. PMID:20691698. |
however, only tcdb and c3, but not rock- or akt inhibition led to caspase 3 activation and thus apoptosis. |
2011-01-18 |
2023-08-12 |
rat |
| Yu Zhang, Hai Li, Zhengxing Lian, Ning L. Myofibroblasts protect myoblasts from intrinsic apoptosis associated with differentiation via β1 integrin-PI3K/Akt pathway. Development, growth & differentiation. vol 52. issue 8. 2011-01-13. PMID:20874716. |
using a membrane insert co-culture system, we studied it and found that the mitochondrial pathway played a crucial role in myoblast apoptosis during differentiation, and fibroblasts promoted not only cell cycle withdrawal but also myoblast survival in a paracrine fashion, which was coupled with upregulations of β1 integrin, phosphorylated akt and anti-apoptotic protein bcl2. |
2011-01-13 |
2023-08-12 |
Not clear |
| R Ehsanian, M Brown, H Lu, X P Yang, A Pattatheyil, B Yan, P Duggal, R Chuang, J Doondeea, S Feller, M Sudol, Z Chen, C Van Wae. YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets. Oncogene. vol 29. issue 46. 2011-01-11. PMID:20729916. |
akt and/or Δnp63 are potential targets for enhancing yap-mediated apoptosis and chemosensitivity in hnsccs. |
2011-01-11 |
2023-08-12 |
Not clear |
| Cristiana Perrotta, Laura Bizzozero, Denise Cazzato, Sara Morlacchi, Emma Assi, Fabio Simbari, Yang Zhang, Erich Gulbins, Maria Teresa Bassi, Patrizia Rosa, Emilio Clement. Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function. The Journal of biological chemistry. vol 285. issue 51. 2011-01-11. PMID:20956541. |
this leads to inhibition of the cd95-triggered signaling events, including caspase 3 and 9 activation and apoptosis, activation of the survival pathway involving the protein kinase akt, and important changes in cell cycle and proliferation. |
2011-01-11 |
2023-08-12 |
Not clear |