| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aftab Taiyab, Ch Mohan Ra. HSP90 modulates actin dynamics: inhibition of HSP90 leads to decreased cell motility and impairs invasion. Biochimica et biophysica acta. vol 1813. issue 1. 2011-03-22. PMID:20883729. |
inhibition of hsp90 by inhibitors such as 17-allylamino-demethoxy-geldanamycin (17aag) is known to induce apoptosis in various cancer cells by decreasing the activation or expression of pro-survival molecules such as protein kinase b (akt). |
2011-03-22 |
2023-08-12 |
human |
| Han Zhong, Hong Xin, Li-Xin Wu, Yi-Zhun Zh. Salidroside attenuates apoptosis in ischemic cardiomyocytes: a mechanism through a mitochondria-dependent pathway. Journal of pharmacological sciences. vol 114. issue 4. 2011-03-22. PMID:21160132. |
salidroside administration also inhibited myocardial apoptosis in ami rats by increasing phosphorylation of akt and decreasing activation of caspase-3. |
2011-03-22 |
2023-08-12 |
rat |
| N Berndt, H Yang, B Trinczek, S Betzi, Z Zhang, B Wu, N J Lawrence, M Pellecchia, E Schönbrunn, J Q Cheng, S M Sebt. The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane. Cell death and differentiation. vol 17. issue 11. 2011-03-21. PMID:20489726. |
finally, constitutively active akt mutants, akt1-t308d/s473d and myr-akt1, but not the transforming mutant akt1-e17k, are resistant to tcn and rescue from its inhibition of proliferation and induction of apoptosis. |
2011-03-21 |
2023-08-12 |
human |
| Xia Lei, Bo Liu, Weinong Han, Mei Ming, Yu-Ying H. UVB-Induced p21 degradation promotes apoptosis of human keratinocytes. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. vol 9. issue 12. 2011-03-21. PMID:20931139. |
although at the molecular level increasing p21 expression has no effect on the protein levels of the bcl-2 family members, it enhances the activation of akt, a critical survival pathway to protect cells from apoptosis. |
2011-03-21 |
2023-08-12 |
mouse |
| Shyamali Basuroy, Dilyara Tcheranova, Sujoy Bhattacharya, Charles W Leffler, Helena Parfenov. Nox4 NADPH oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF-α-induced apoptosis. American journal of physiology. Cell physiology. vol 300. issue 2. 2011-03-21. PMID:21123734. |
in akt sirna-transfected cmvec and in cells with pharmacologically inhibited akt, erk1/2, and p38 mitogen-activated protein kinase (mapk) activities, corm-a1 was no longer capable of blocking nox4 activation and apoptosis caused by tnf-α. |
2011-03-21 |
2023-08-12 |
Not clear |
| Anna Krześla. [Akt kinase: a key regulator of metabolism and progression of tumors]. Postepy higieny i medycyny doswiadczalnej (Online). vol 64. 2011-03-17. PMID:20966507. |
although activation of akt alone is believed to be insufficient for tumorigenesis, it contributes to cancer progression by inhibiting apoptosis, promoting changes in metabolism and proliferation of cells and regulating their migration and invasion capabilities. |
2011-03-17 |
2023-08-12 |
human |
| Tiewei Lu, Sampath Parthasarathy, Hong Hao, Min Luo, Shabnam Ahmed, Jing Zhu, Suxin Luo, Periannan Kuppusamy, Chandan K Sen, Catherine M Verfaillie, Jie Tian, Zhenguo Li. Reactive oxygen species mediate oxidized low-density lipoprotein-induced inhibition of oct-4 expression and endothelial differentiation of bone marrow stem cells. Antioxidants & redox signaling. vol 13. issue 12. 2011-03-15. PMID:20836655. |
however, other mechanism(s) like akt signaling and apoptosis might also play a critical role in mediating the effect of ox-ldl on these cells. |
2011-03-15 |
2023-08-12 |
rat |
| Rajesh S Alphonse, Arul Vadivel, Lavinia Coltan, Farah Eaton, Amy J Barr, Jason R B Dyck, Bernard Thébau. Activation of Akt protects alveoli from neonatal oxygen-induced lung injury. American journal of respiratory cell and molecular biology. vol 44. issue 2. 2011-03-14. PMID:20348209. |
in vitro studies with rat lung epithelial (rle) cells cultured in hyperoxia (95% o(2)) showed decreased apoptosis and improved cell survival after the forced expression of active akt by adenovirus-mediated gene transfer. |
2011-03-14 |
2023-08-12 |
rat |
| Miaoxian Su, Hau Yin Chung, Yaolan L. 6-O-Angeloylenolin induced cell-cycle arrest and apoptosis in human nasopharyngeal cancer cells. Chemico-biological interactions. vol 189. issue 3. 2011-03-14. PMID:21192922. |
while 6-o-angeloylenolin also triggered the activation of akt, erk and jnk, only the jnk inhibitor significantly decreased the extent of cell death and apoptosis in cne cells. |
2011-03-14 |
2023-08-12 |
human |
| Maria J Redlak, Thomas A Mille. Targeting PI3K/Akt/HSP90 signaling sensitizes gastric cancer cells to deoxycholate-induced apoptosis. Digestive diseases and sciences. vol 56. issue 2. 2011-03-11. PMID:20585984. |
in this paper, we investigated whether targeting both akt and hsp90 would inhibit the survival pathway in ags cells (human gastric mucosal cells), and how akt/hsp90 inhibition modulates the deoxycholate (dc)-induced apoptosis. |
2011-03-11 |
2023-08-12 |
human |
| Ning Zhou, Qiu-Jun Yu, Rui Si, Hao-Kao Gao, Ting Wang, Feng Gao, Hai-Chang Wang, Jie-Fang Bia. Postprocedure administration of insulin in canine autologous vein grafting: a potential strategy to attenuate intimal hyperplasia. Journal of cardiovascular pharmacology. vol 56. issue 4. 2011-03-10. PMID:20625311. |
then vein grafts were harvested for caspase-3 activation, cell apoptosis, phosphorylated akt, and endothelial nitric oxide synthase level assays. |
2011-03-10 |
2023-08-12 |
rat |
| Ning Zhou, Qiu-Jun Yu, Rui Si, Hao-Kao Gao, Ting Wang, Feng Gao, Hai-Chang Wang, Jie-Fang Bia. Postprocedure administration of insulin in canine autologous vein grafting: a potential strategy to attenuate intimal hyperplasia. Journal of cardiovascular pharmacology. vol 56. issue 4. 2011-03-10. PMID:20625311. |
glucose-potassium aggravated apoptosis and caspase-3 activation and decreased akt and endothelial nitric oxide synthase phosphorylation; however, glucose-insulin-potassium significantly inhibited cell apoptosis and caspase-3 activation and increased phosphorylated akt and pendothelial nitric oxide synthase levels in canine vein grafts. |
2011-03-10 |
2023-08-12 |
rat |
| Kalimuthu Senthilkumar, Perumal Elumalai, Ramachandran Arunkumar, Sivanantham Banudevi, Nandagopal Dharmalingam Gunadharini, Govindaraj Sharmila, Kandaswamy Selvakumar, Jagadeesan Arunakara. Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Molecular and cellular biochemistry. vol 344. issue 1-2. 2011-03-10. PMID:20658310. |
to investigate the effect of quercetin on insulin-like growth factor signaling and apoptosis in androgen independent prostate cancer cells (pc-3), igf-ir, pi-3k, p-akt, akt, cyclin d1, bad, cytochrome c, parp, caspases-9 and 10 protein levels were assessed by western blot analysis. |
2011-03-10 |
2023-08-12 |
Not clear |
| Johannes Werzowa, Stefan Koehrer, Sabine Strommer, Daniel Cejka, Thorsten Fuereder, Eva Zebedin, Volker Wachec. Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo. The Journal of investigative dermatology. vol 131. issue 2. 2011-03-10. PMID:21048785. |
combined treatment with pi-103 and the prototypic mtorc1 inhibitor rapamycin led to the synergistic suppression of akt and ribosomal s6 protein phosphorylation and to the induction of apoptosis. |
2011-03-10 |
2023-08-12 |
mouse |
| El-Shaimaa A Arafa, Qianzheng Zhu, Zubair I Shah, Gulzar Wani, Bassant M Barakat, Ira Racoma, Mohamed A El-Mahdy, Altaf A Wan. Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells. Mutation research. vol 706. issue 1-2. 2011-03-03. PMID:21040738. |
our results reveal that up-regulation of the key upstream signaling factor, pten, in mcf-7/dox cells inhibited akt phosphorylation, which ultimately causes increase in their regulatory p53 levels affecting the induction of g2/m cell cycle arrest and apoptosis. |
2011-03-03 |
2023-08-12 |
human |
| Ze J Lu, Yan Zhou, Qi Song, Zhao Qin, Hong Zhang, Yong J Zhou, Lan T Gou, Jin L Yang, Feng Lu. Periplocin inhibits growth of lung cancer in vitro and in vivo by blocking AKT/ERK signaling pathways. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 26. issue 4-5. 2011-03-02. PMID:21063098. |
these findings suggested that periplocin could inhibit the growth of lung cancer both in vitro and in vivo, which could be attributed to the inhibition of proliferation and the induction of apoptosis signaling pathway, such as akt and erk. |
2011-03-02 |
2023-08-12 |
mouse |
| Bojiang Chen, Weimin L. [Current status of Akt in non-small cell lung cancer]. Zhongguo fei ai za zhi = Chinese journal of lung cancer. vol 13. issue 11. 2011-03-01. PMID:21081049. |
as an important protein in several signaling pathways, akt has been identified to play a major role in the growth, proliferation, apoptosis and invasion of tumor cells. |
2011-03-01 |
2023-08-12 |
Not clear |
| Tatsuki Kunoh, Takanori Noda, Koichi Koseki, Masayuki Sekigawa, Motoki Takagi, Kazuo Shin-ya, Naoki Goshima, Shun-ichiro Iemura, Tohru Natsume, Shu-ichi Wada, Yukio Mukai, Shinji Ohta, Ryuzo Sasaki, Tamio Mizukam. A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells. Molecular cancer therapeutics. vol 9. issue 11. 2011-02-28. PMID:20978158. |
a novel human dynactin-associated protein, dynap, promotes activation of akt, and ergosterol-related compounds induce dynap-dependent apoptosis of human cancer cells. |
2011-02-28 |
2023-08-12 |
human |
| Tatsuki Kunoh, Takanori Noda, Koichi Koseki, Masayuki Sekigawa, Motoki Takagi, Kazuo Shin-ya, Naoki Goshima, Shun-ichiro Iemura, Tohru Natsume, Shu-ichi Wada, Yukio Mukai, Shinji Ohta, Ryuzo Sasaki, Tamio Mizukam. A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells. Molecular cancer therapeutics. vol 9. issue 11. 2011-02-28. PMID:20978158. |
the ergosterol-related compounds identified by the yeast cell-based high-throughput screen abrogated activation of akt and induced apoptosis in a dynap-dependent manner. |
2011-02-28 |
2023-08-12 |
human |
| Liang Fang, Huiming Wang, Lin Zhou, Da Y. FOXO3a reactivation mediates the synergistic cytotoxic effects of rapamycin and cisplatin in oral squamous cell carcinoma cells. Toxicology and applied pharmacology. vol 251. issue 1. 2011-02-24. PMID:21092744. |
rapamycin combined with cisplatin as its feedback akt activation inhibitor revealed the most dramatic foxo3a nuclear localization and reactivation with the prevention of its feedback loop and exposed significant synergistic effects of decreased cell proliferation and increased apoptosis in vitro and decreased tumor size in vivo. |
2011-02-24 |
2023-08-12 |
Not clear |