| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Annesofie Faurscho. Role of tumor necrosis factor-α in the regulation of keratinocyte cell cycle and DNA repair after ultraviolet-B radiation. Danish medical bulletin. vol 57. issue 10. 2011-06-22. PMID:21040686. |
cells treated with infliximab had significantly increased levels of dna damage despite enhanced g2/m checkpoint arrest, increased apoptosis and inhibition of akt. |
2011-06-22 |
2023-08-12 |
Not clear |
| Ahmed Malki, Stephen C Bergmeie. Novel quinuclidinone derivative 8a induced apoptosis in human MCF-7 breast cancer cell lines. Anticancer research. vol 31. issue 3. 2011-06-21. PMID:21498708. |
8a induced g(1) phase arrest, presumably sensitizing the breast cancer cells to apoptosis by increasing expression level of p21 and cyclin e. moreover, 8a increased expression level of erk1, p53 and bax, and it reduced expression level of akt and bcl-2. |
2011-06-21 |
2023-08-12 |
human |
| Dinender K Singla, Reetu D Singla, Stephanie Lamm, Carley Glas. TGF-β2 treatment enhances cytoprotective factors released from embryonic stem cells and inhibits apoptosis in infarcted myocardium. American journal of physiology. Heart and circulatory physiology. vol 300. issue 4. 2011-06-20. PMID:21297031. |
next, we confirmed that apoptosis is mediated through a prosurvival akt pathway. |
2011-06-20 |
2023-08-12 |
mouse |
| Sanja Mijatovic, Danijela Maksimovic-Ivanic, Marija Mojic, Gordana Timotijevic, Djordje Miljkovic, Katia Mangano, Marco Donia, Antonio Di Cataldo, Yousef Al-Abed, Kai Fan Cheng, Stanislava Stosic-Grujicic, Ferdinando Nicolett. Cytotoxic and immune-sensitizing properties of nitric oxide-modified Saquinavir in iNOS-positive human melanoma cells. Journal of cellular physiology. vol 226. issue 7. 2011-06-17. PMID:21506111. |
saq-no-triggered apoptosis was dependent on transient akt up-regulation and reduced perk and inos expression that were observed within the first 12 h of exposure to the drug. |
2011-06-17 |
2023-08-12 |
mouse |
| Jing Xu, Jun-Ying Zhou, Wei-Zen Wei, Gen Sheng W. Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells. PloS one. vol 5. issue 4. 2011-06-16. PMID:20419107. |
taken together, our data indicate that inactivation of functional pten and the consequent activation of the akt pathway prevents trail-induced apoptosis, leading to trail resistance. |
2011-06-16 |
2023-08-12 |
mouse |
| Ashfaque A Memon, Mathias Munk, Ebba Nexo, Boe S Sorense. Calcium-induced apoptosis is delayed by HER1 receptor signalling through the Akt and PLCγ pathways in bladder cancer cells. Scandinavian journal of clinical and laboratory investigation. vol 71. issue 1. 2011-06-10. PMID:21087080. |
calcium-induced apoptosis is delayed by her1 receptor signalling through the akt and plcγ pathways in bladder cancer cells. |
2011-06-10 |
2023-08-12 |
Not clear |
| Ashfaque A Memon, Mathias Munk, Ebba Nexo, Boe S Sorense. Calcium-induced apoptosis is delayed by HER1 receptor signalling through the Akt and PLCγ pathways in bladder cancer cells. Scandinavian journal of clinical and laboratory investigation. vol 71. issue 1. 2011-06-10. PMID:21087080. |
inhibition of her1 with gefitinib (5 μm) or tyrphostin (ag1478) (20 μm) augmented the calcium-induced apoptosis, and with her1 inhibition apoptosis was detectable after 6 h. analysis of downstream signalling molecules showed an increased activation of akt, plcγ and mapk in response to calcium treatment. |
2011-06-10 |
2023-08-12 |
Not clear |
| Ashfaque A Memon, Mathias Munk, Ebba Nexo, Boe S Sorense. Calcium-induced apoptosis is delayed by HER1 receptor signalling through the Akt and PLCγ pathways in bladder cancer cells. Scandinavian journal of clinical and laboratory investigation. vol 71. issue 1. 2011-06-10. PMID:21087080. |
in addition, incubation with inhibitors of akt and plcγ significantly augmented calcium-induced apoptosis, whereas this was not seen with mapk inhibition. |
2011-06-10 |
2023-08-12 |
Not clear |
| Ashfaque A Memon, Mathias Munk, Ebba Nexo, Boe S Sorense. Calcium-induced apoptosis is delayed by HER1 receptor signalling through the Akt and PLCγ pathways in bladder cancer cells. Scandinavian journal of clinical and laboratory investigation. vol 71. issue 1. 2011-06-10. PMID:21087080. |
in conclusion we show that calcium-induced apoptosis in bladder cancer cells is delayed by her1 receptor activation involving the akt and plcγ signalling pathways. |
2011-06-10 |
2023-08-12 |
Not clear |
| G C Mitchell, J L Fillinger, S Sittadjody, J L Avila, R Burd, K H Limesan. IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter. Cell death & disease. vol 1. 2011-06-10. PMID:21480565. |
it has been previously shown in mice expressing a constitutively active form of akt (myr-akt1), or in mice pretreated with igf1, apoptosis is suppressed, which correlates with maintained salivary gland function measured by stimulated salivary flow. |
2011-06-10 |
2023-08-12 |
mouse |
| I Cristóbal, L Garcia-Orti, C Cirauqui, M M Alonso, M J Calasanz, M D Oder. PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect. Leukemia. vol 25. issue 4. 2011-06-09. PMID:21233840. |
here, we show that pp2a inactivation is a recurrent event in acute myeloid leukemia (aml), and that restoration of pp2a phosphatase activity by treatment with forskolin in aml cells blocks proliferation, induces caspase-dependent apoptosis and affects akt and erk1/2 activity. |
2011-06-09 |
2023-08-12 |
human |
| Abaineh Dagne, Tamene Melkamu, Melissa M Schutten, Xuemin Qian, Pramod Upadhyaya, Xianghua Luo, Fekadu Kassi. Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice. Carcinogenesis. vol 32. issue 4. 2011-06-09. PMID:21273642. |
in in vitro assays with a549 and h460 lung cancer cells, exposure of the cells to a mixture of low concentrations of i3c (50 μm) plus silibinin (50 μm) for 72 h caused inhibition of cell growth and extracellular signal-regulated kinase (erk) and akt activation and induction of apoptosis, whereas the individual agents did not have any effect. |
2011-06-09 |
2023-08-12 |
mouse |
| Krishnendu Pal, SubrataKumar Pore, Sutapa Sinha, Rajiv Janardhanan, Debabrata Mukhopadhyay, Rajkumar Banerje. Structure-activity study to develop cationic lipid-conjugated haloperidol derivatives as a new class of anticancer therapeutics. Journal of medicinal chemistry. vol 54. issue 7. 2011-06-06. PMID:21391684. |
in conclusion, we developed σ receptor-targeting cationic lipid-modified hp derivatives as a promising class of anticancer therapeutic that concurrently affects cancer and tumor environment associated angiogenic vascular cells through induction of apoptosis and akt protein down-regulation. |
2011-06-06 |
2023-08-12 |
mouse |
| Hongxia Wang, Fengchun Zhang, Fei Ye, Yuan Ma, David Y Zhan. The effect of coptis chinensis on the signaling network in the squamous carcinoma cells. Frontiers in bioscience (Elite edition). vol 3. 2011-06-03. PMID:21196313. |
coptis chinensis has a wide effect on cell signaling, including cell cycle regulation (cdk6, cdk4, cyclin b1, cyclin e, cyclin d1, p27), cell adhesion (e-cadherin, osteopontin), differentiation, apoptosis(p-stat3, p53, brca1), cytoskeleton (p-pkc α/β ii, vimentin, p-pkcα), mapk signaling (raf-1, erk1/2, p-p38, p-erk), and the phosphatidylinositol 3-kinase signaling pathway (p-akt, akt, p-pten). |
2011-06-03 |
2023-08-12 |
mouse |
| Ponnuraj Nagendraprabhu, Ganapasam Sudhandira. Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2. Investigational new drugs. vol 29. issue 2. 2011-05-27. PMID:19876598. |
in conclusion, astaxanthin exhibits anti-inflammatory and anti-cancer effects by inducing apoptosis in dmh-induced rat colon carcinogenesis by modulating the expressions of nfkb, cox-2, mmps-2/9, akt and erk-2. |
2011-05-27 |
2023-08-12 |
rat |
| Yerra Koteswara Rao, Alexander T H Wu, Madamanchi Geethangili, Ming-Te Huang, Wan-Ju Chao, Chih-Hsiung Wu, Win-Ping Deng, Chi-Tai Yeh, Yew-Min Tzen. Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells. Chemical research in toxicology. vol 24. issue 2. 2011-05-26. PMID:21158420. |
furthermore, down-regulation of akt by small interfering rna prior to antrocin treatment resulted in enhanced cell growth inhibition and apoptosis. |
2011-05-26 |
2023-08-12 |
Not clear |
| Maki Kayama, Toru Nakazawa, Aristomenis Thanos, Yuki Morizane, Yusuke Murakami, Sofia Theodoropoulou, Toshiaki Abe, Demetrios Vavvas, Joan W Mille. Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase. The American journal of pathology. vol 178. issue 3. 2011-05-25. PMID:21356360. |
administration of quercetin, which inhibits hsp70 and suppresses akt phosphorylation significantly increased photoreceptor apoptosis. |
2011-05-25 |
2023-08-12 |
mouse |
| Maki Kayama, Toru Nakazawa, Aristomenis Thanos, Yuki Morizane, Yusuke Murakami, Sofia Theodoropoulou, Toshiaki Abe, Demetrios Vavvas, Joan W Mille. Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase. The American journal of pathology. vol 178. issue 3. 2011-05-25. PMID:21356360. |
on the other hand, administration of geranylgeranylacetone, which induces an increase in hsp70 significantly decreased photoreceptor apoptosis after rd through prolonged activation of akt pathway. |
2011-05-25 |
2023-08-12 |
mouse |
| Bo K Sun, Joo-Hang Kim, Hoan N Nguyen, So Y Kim, Seeun Oh, Yong J Lee, Jae J Son. TRAIL-induced caspase/p38 activation is responsible for the increased catalytic and invasive activities of Akt. International journal of oncology. vol 38. issue 1. 2011-05-24. PMID:21109947. |
this suggests that akt catalytic activation during trail-induced apoptosis is likely to play a compensatory role in the maintenance of cell homeostasis. |
2011-05-24 |
2023-08-12 |
Not clear |
| Eun Sun Yang, Min Jung Choi, Jin Hee Kim, Kyeong Sook Choi, Taeg Kyu Kwo. Withaferin A enhances radiation-induced apoptosis in Caki cells through induction of reactive oxygen species, Bcl-2 downregulation and Akt inhibition. Chemico-biological interactions. vol 190. issue 1. 2011-05-23. PMID:21256832. |
withaferin a enhances radiation-induced apoptosis in caki cells through induction of reactive oxygen species, bcl-2 downregulation and akt inhibition. |
2011-05-23 |
2023-08-12 |
human |