| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jordi Martínez-Serra, Elena Maffiotte, Javier Martín, Teresa Bex, María Navarro-Palou, Teresa Ros, Joana M Plazas, Oliver Vögler, Antonio Gutiérrez, Juan Carlos Amat, Rafael Ramos, Carlos Saus, Jordi Ginés, Regina Alemany, Matias Diaz, Joan Besalduc. Yondelis® (ET-743, Trabectedin) sensitizes cancer cell lines to CD95-mediated cell death: new molecular insight into the mechanism of action. European journal of pharmacology. vol 658. issue 2-3. 2011-07-25. PMID:21371453. |
in addition we show that the facilitated apoptosis activated through the fas death receptor, is associated with a significant increase of membrane fas/fasl, as well as the modulation of accessory proteins regulating this route, such as flip (l) or akt. |
2011-07-25 |
2023-08-12 |
Not clear |
| Jian-Lin Shao, Xiao-Hong Wan, Yan Chen, Chun Bi, Hong-Mei Chen, Ying Zhong, Xin-Hua Heng, Jin-Qiao Qia. H2S protects hippocampal neurons from anoxia-reoxygenation through cAMP-mediated PI3K/Akt/p70S6K cell-survival signaling pathways. Journal of molecular neuroscience : MN. vol 43. issue 3. 2011-07-21. PMID:20967511. |
neuronal purity and cell viability were assessed in each group, as well as apoptosis and expression of cyclic adenosine 3', 5'-monophosphate (camp), pi3k, akt, and p70s6k. |
2011-07-21 |
2023-08-12 |
rat |
| Zhiwei Wang, Yiwei Li, Aamir Ahmad, Sanjeev Banerjee, Asfar S Azmi, Dejuan Kong, Christine Wojewoda, Lucio Miele, Fazlul H Sarka. Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells. Journal of cellular biochemistry. vol 112. issue 1. 2011-07-19. PMID:20658545. |
down-regulation of notch-1 is associated with akt and foxm1 in inducing cell growth inhibition and apoptosis in prostate cancer cells. |
2011-07-19 |
2023-08-12 |
human |
| Zhiwei Wang, Yiwei Li, Aamir Ahmad, Sanjeev Banerjee, Asfar S Azmi, Dejuan Kong, Christine Wojewoda, Lucio Miele, Fazlul H Sarka. Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells. Journal of cellular biochemistry. vol 112. issue 1. 2011-07-19. PMID:20658545. |
we found that the down-regulation of notch-1 led to the inhibition of cell growth and induction of apoptosis, which was mechanistically linked with down-regulation of akt and foxm1, suggesting for the first time that akt and foxm1 are downstream targets of notch-1 signaling. |
2011-07-19 |
2023-08-12 |
human |
| Zhiwei Wang, Yiwei Li, Aamir Ahmad, Sanjeev Banerjee, Asfar S Azmi, Dejuan Kong, Christine Wojewoda, Lucio Miele, Fazlul H Sarka. Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells. Journal of cellular biochemistry. vol 112. issue 1. 2011-07-19. PMID:20658545. |
moreover, we found that a "natural agent" (genistein) originally discovered from soybean could cause significant reduction in cell viability and induced apoptosis of pca cells, which was consistent with down-regulation of notch-1, akt, and foxm1. |
2011-07-19 |
2023-08-12 |
human |
| Virginie Carmignac, Ronan Quéré, Madeleine Durbee. Proteasome inhibition improves the muscle of laminin α2 chain-deficient mice. Human molecular genetics. vol 20. issue 3. 2011-07-19. PMID:21084425. |
specifically, treatment with mg-132 increases lifespan, enhances locomotive activity, enlarges muscle fiber diameter, reduces fibrosis, restores akt phosphorylation and decreases apoptosis. |
2011-07-19 |
2023-08-12 |
mouse |
| Claudia Tubaro, Cataldo Arcuri, Ileana Giambanco, Rosario Donat. S100B in myoblasts regulates the transition from activation to quiescence and from quiescence to activation and reduces apoptosis. Biochimica et biophysica acta. vol 1813. issue 5. 2011-07-18. PMID:21130124. |
moreover, s100b reduces myoblast apoptosis in an mek-erk1/2, akt, jnk, and nf-κb-dependent manner. |
2011-07-18 |
2023-08-12 |
Not clear |
| María Ines Díaz Bessone, Damian E Berardi, Paola B Campodónico, Laura B Todaro, Leonard Lothstein, Elisa D Bal de Kier Joffé, Alejandro J Urtrege. Involvement of PKC delta (PKCδ) in the resistance against different doxorubicin analogs. Breast cancer research and treatment. vol 126. issue 3. 2011-07-15. PMID:20512658. |
altogether, our results indicate that pkcδ increases cell death resistance against different apoptosis inductors, independently of their mechanism of action, through a differential modulation of akt and nf-κb pathways. |
2011-07-15 |
2023-08-12 |
Not clear |
| Valentina Caldera, Marta Mellai, Laura Annovazzi, Guido Valente, Luciana Tessitore, Davide Schiffe. Stat3 expression and its correlation with proliferation and apoptosis/autophagy in gliomas. Journal of oncology. vol 2008. 2011-07-14. PMID:19421400. |
stat3 and akt did not show any correlation with apoptosis, whereas they showed an inverse correlation with beclin 1, a stimulator of autophagy, which was rarely positive in glioblastomas. |
2011-07-14 |
2023-08-12 |
Not clear |
| Ming-Chieh Shun, Weiping Yu, Sook-Kyung Park, Bob G Sanders, Kimberly Klin. Downregulation of Epidermal Growth Factor Receptor Expression Contributes to alpha-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines. Journal of oncology. vol 2010. 2011-07-14. PMID:20224651. |
in this study, we investigated the effects of alpha-tea on the expression of epidermal growth factor receptor (egfr) family members, erbb1, 2 and 3, and the role of erbb 2 and 3 in alpha-tea-induced apoptosis and suppression of akt, flip and survivin in the cisplatin-sensitive (a2780s) and -resistant (a2780/cp70r) human ovarian cancer cell lines. |
2011-07-14 |
2023-08-12 |
human |
| Ming-Chieh Shun, Weiping Yu, Sook-Kyung Park, Bob G Sanders, Kimberly Klin. Downregulation of Epidermal Growth Factor Receptor Expression Contributes to alpha-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines. Journal of oncology. vol 2010. 2011-07-14. PMID:20224651. |
data show that alpha-tea's ability to induced apoptosis was associated with reduced expression of erbb1 (cisplatin-resistant cells), 2 and 3 (both cell types) and reduced levels of the phosphorylated (active) form of akt; as well as, reduced levels of flip and survivin proteins in both cell types. |
2011-07-14 |
2023-08-12 |
human |
| Ming-Chieh Shun, Weiping Yu, Sook-Kyung Park, Bob G Sanders, Kimberly Klin. Downregulation of Epidermal Growth Factor Receptor Expression Contributes to alpha-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines. Journal of oncology. vol 2010. 2011-07-14. PMID:20224651. |
ectopic overexpression and sirna knockdown studies showed that erbb2, erbb3, akt, flip and survivin are involved in alpha-tea-induce apoptosis and that alpha-tea downregulates flip and survivin via suppression of pakt, which is mediated by erbb2 and erb3. |
2011-07-14 |
2023-08-12 |
human |
| Mu-Jang Lee, Han-Min Chen, Bor-Show Tzang, Chiu-Wen Lin, Chau-Jong Wang, Jer-Yuh Liu, Shao-Hsuan Ka. Ocimum gratissimum Aqueous Extract Protects H9c2 Myocardiac Cells from H(2)O(2)-Induced Cell Apoptosis through Akt Signalling. Evidence-based complementary and alternative medicine : eCAM. vol 2011. 2011-07-14. PMID:20953436. |
ocimum gratissimum aqueous extract protects h9c2 myocardiac cells from h(2)o(2)-induced cell apoptosis through akt signalling. |
2011-07-14 |
2023-08-12 |
Not clear |
| Jing Li, Weiping Yu, Richa Tiwary, Sook-Kyung Park, Ailian Xiong, Bob G Sanders, Kimberly Klin. α-TEA-induced death receptor dependent apoptosis involves activation of acid sphingomyelinase and elevated ceramide-enriched cell surface membranes. Cancer cell international. vol 10. 2011-07-14. PMID:20974006. |
α-tea induces apoptosis via activation of extrinsic death receptors fas (cd95) and dr5, jnk/p73/noxa pathways, and suppression of anti-apoptotic mediators akt, erk, c-flip and survivin in breast, ovarian and prostate cancer cells. |
2011-07-14 |
2023-08-12 |
human |
| Prajna Mishra, Suresh K Paramasivam, Ramesh P Thylur, Ajay Rana, Basabi Ran. Peroxisome proliferator-activated receptor gamma ligand-mediated apoptosis of hepatocellular carcinoma cells depends upon modulation of PI3Kinase pathway independent of Akt. Journal of molecular signaling. vol 5. 2011-07-14. PMID:21144036. |
peroxisome proliferator-activated receptor gamma ligand-mediated apoptosis of hepatocellular carcinoma cells depends upon modulation of pi3kinase pathway independent of akt. |
2011-07-14 |
2023-08-12 |
Not clear |
| Szu-Erh Chan, Hung-Wen Lai, Chin-Cheng Su, Shou-Jen Kuo, Su-Yu Chien, Hui-Yi Lin, Dar-Ren Che. Effect of Supplementation of Tanshinone IIA and Sodium Tanshinone IIA Sulfonate on the Anticancer Effect of Epirubicin: An In Vitro Study. Evidence-based complementary and alternative medicine : eCAM. vol 2011. 2011-07-14. PMID:21716682. |
to evaluate the effect of tan iia or sts on the anticancer of epirubicin, the cell viability, apoptosis, akt expression, and uptake of epirubicin after supplementation of tan iia or sts in the epirubicin-treated bt-20 cells were measured and compared. |
2011-07-14 |
2023-08-12 |
Not clear |
| Szu-Erh Chan, Hung-Wen Lai, Chin-Cheng Su, Shou-Jen Kuo, Su-Yu Chien, Hui-Yi Lin, Dar-Ren Che. Effect of Supplementation of Tanshinone IIA and Sodium Tanshinone IIA Sulfonate on the Anticancer Effect of Epirubicin: An In Vitro Study. Evidence-based complementary and alternative medicine : eCAM. vol 2011. 2011-07-14. PMID:21716682. |
when tan iia was used with epirubicin, an increase of bt-20 cells apoptosis was accompanied by the decreasing phosphorylation of akt. |
2011-07-14 |
2023-08-12 |
Not clear |
| Szu-Erh Chan, Hung-Wen Lai, Chin-Cheng Su, Shou-Jen Kuo, Su-Yu Chien, Hui-Yi Lin, Dar-Ren Che. Effect of Supplementation of Tanshinone IIA and Sodium Tanshinone IIA Sulfonate on the Anticancer Effect of Epirubicin: An In Vitro Study. Evidence-based complementary and alternative medicine : eCAM. vol 2011. 2011-07-14. PMID:21716682. |
sts decreased the uptake of epirubicin in bt-20 cells and blocked epirubicin-induced apoptosis through activation of akt. |
2011-07-14 |
2023-08-12 |
Not clear |
| M Leyendecker, P Korsten, R Reinehr, B Speckmann, D Schmoll, W A Scherbaum, S R Bornstein, A Barthel, L-O Klot. Ceruloplasmin expression in rat liver cells is attenuated by insulin: role of FoxO transcription factors. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 43. issue 4. 2011-07-12. PMID:21332026. |
foxo (forkhead box, class o) transcription factors, substrates of the ser/thr kinase akt, control the expression of several target genes that are crucial to the defense against oxidative stress, the regulation of cell cycle, and apoptosis in mammalian cells. |
2011-07-12 |
2023-08-12 |
rat |
| Dhong Hyun Lee, Nils H Thoennissen, Catherine Goff, Gabriela B Iwanski, Charles Forscher, Ngan B Doan, Jonathan W Said, H Phillip Koeffle. Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma. Cancer letters. vol 306. issue 2. 2011-07-12. PMID:21440986. |
cucurbitacin b showed antiproliferative activity against seven human os cell lines in vitro accompanying g2/m cell cycle arrest, apoptosis, and inhibition of erk, akt, and mtor proteins. |
2011-07-12 |
2023-08-12 |
mouse |