| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eun Sun Yang, Min Jung Choi, Jin Hee Kim, Kyeong Sook Choi, Taeg Kyu Kwo. Withaferin A enhances radiation-induced apoptosis in Caki cells through induction of reactive oxygen species, Bcl-2 downregulation and Akt inhibition. Chemico-biological interactions. vol 190. issue 1. 2011-05-23. PMID:21256832. |
taken together, these results indicate that wit a enhanced radiation-induced apoptosis in caki cells through ros generation, down-regulation of bcl-2 and akt dephosphorylation. |
2011-05-23 |
2023-08-12 |
human |
| Kuen-Feng Chen, Hui-Ling Chen, Wei-Tien Tai, Wen-Chi Feng, Chih-Hung Hsu, Pei-Jer Chen, Ann-Lii Chen. Activation of phosphatidylinositol 3-kinase/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells. The Journal of pharmacology and experimental therapeutics. vol 337. issue 1. 2011-05-19. PMID:21205925. |
furthermore, the combination of 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2h)-one dihydrochloride (mk-2206), a novel allosteric akt inhibitor, and sorafenib restored the sensitivity of resistant cells to sorafenib-induced apoptosis. |
2011-05-19 |
2023-08-12 |
human |
| Hyoung-Oh Jun, Dong-hun Kim, Sae-Won Lee, Hye Shin Lee, Ji Hae Seo, Jeong Hun Kim, Jin Hyoung Kim, Young Suk Yu, Bon Hong Min, Kyu-Won Ki. Clusterin protects H9c2 cardiomyocytes from oxidative stress-induced apoptosis via Akt/GSK-3β signaling pathway. Experimental & molecular medicine. vol 43. issue 1. 2011-05-19. PMID:21270507. |
here, we report that clusterin protects h9c2 cardiomyocytes from h2o2-induced apoptosis by triggering the activation of akt and gsk-3β. |
2011-05-19 |
2023-08-12 |
Not clear |
| Hyoung-Oh Jun, Dong-hun Kim, Sae-Won Lee, Hye Shin Lee, Ji Hae Seo, Jeong Hun Kim, Jin Hyoung Kim, Young Suk Yu, Bon Hong Min, Kyu-Won Ki. Clusterin protects H9c2 cardiomyocytes from oxidative stress-induced apoptosis via Akt/GSK-3β signaling pathway. Experimental & molecular medicine. vol 43. issue 1. 2011-05-19. PMID:21270507. |
the protective effect of clusterin on h2o2-induced apoptosis is impaired by pi3k inhibitor ly294002, which effectively suppresses clusterin-induced activation of akt and gsk-3β. |
2011-05-19 |
2023-08-12 |
Not clear |
| Smitha V Bava, Chanickal N Sreekanth, Arun Kumar T Thulasidasan, Nikhil P Anto, Vino T Cheriyan, Vineshkumar T Puliyappadamba, Sajna G Menon, Santhosh D Ravichandran, Ruby John Ant. Akt is upstream and MAPKs are downstream of NF-κB in paclitaxel-induced survival signaling events, which are down-regulated by curcumin contributing to their synergism. The international journal of biochemistry & cell biology. vol 43. issue 3. 2011-05-18. PMID:20883815. |
our earlier report has shown that cervical cancer cells can be sensitized by curcumin to paclitaxel-induced apoptosis through down-regulation of nf-κb and akt. |
2011-05-18 |
2023-08-12 |
Not clear |
| Yongjie Ma, Bingbing Wang, Wenliang Li, Guoguang Ying, Li Fu, Ruifang Niu, Feng G. Reduction of intersectin1-s induced apoptosis of human glioblastoma cells. Brain research. vol 1351. 2011-05-17. PMID:20493827. |
our data demonstrate that several key proteins, including fak, akt, bcl-2, bad which are critical for cells apoptosis were probably involved in itsn1-s signaling pathways. |
2011-05-17 |
2023-08-12 |
human |
| Stefan Zahler, Johanna Liebl, Robert Fürst, Angelika M Vollma. Anti-angiogenic potential of small molecular inhibitors of cyclin dependent kinases in vitro. Angiogenesis. vol 13. issue 3. 2011-05-16. PMID:20706783. |
we have compared 6 reported structurally different inhibitors of cyclin-dependent kinases (cdks) regarding their functional effects on endothelial cells (proliferation, cell cycle, apoptosis, migration, tube formation), as well as their actions on some kinases (akt, p38, erk1/2, c-src, gsk3β). |
2011-05-16 |
2023-08-12 |
Not clear |
| Mouad Edderkaoui, Claudia Nitsche, Ling Zheng, Stephen J Pandol, Ilya Gukovsky, Anna S Gukovskay. NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox. The Journal of biological chemistry. vol 286. issue 10. 2011-05-11. PMID:21118808. |
up-regulation of p22(phox) represents a novel pro-survival mechanism through which growth factors and akt inhibit apoptosis in paca cells. |
2011-05-11 |
2023-08-12 |
Not clear |
| Zhengshun Xu, Hongtao Liu, Xinquan Lv, Yuqiong Liu, Shenglei Li, Huixiang L. Knockdown of the Bmi-1 oncogene inhibits cell proliferation and induces cell apoptosis and is involved in the decrease of Akt phosphorylation in the human breast carcinoma cell line MCF-7. Oncology reports. vol 25. issue 2. 2011-05-09. PMID:21152871. |
knockdown of the bmi-1 oncogene inhibits cell proliferation and induces cell apoptosis and is involved in the decrease of akt phosphorylation in the human breast carcinoma cell line mcf-7. |
2011-05-09 |
2023-08-12 |
human |
| Zhengshun Xu, Hongtao Liu, Xinquan Lv, Yuqiong Liu, Shenglei Li, Huixiang L. Knockdown of the Bmi-1 oncogene inhibits cell proliferation and induces cell apoptosis and is involved in the decrease of Akt phosphorylation in the human breast carcinoma cell line MCF-7. Oncology reports. vol 25. issue 2. 2011-05-09. PMID:21152871. |
our results demonstrated that bmi-1 sirna effectively down-regulated the expression of bmi-1, inhibited cell proliferation in vitro and in vivo, evoked cell cycle arrest in the g0/g1 phase and induced cell apoptosis in mcf-7 cells, coupled with decrease in cyclin d1, cyclin e, cdk2, bcl-2 and ki-67 expression and akt phosphorylation levels and an increase of p21 and bax expression and activities of caspase-3/-9. |
2011-05-09 |
2023-08-12 |
human |
| Long Chen, Baoshan Xu, Lei Liu, Yan Luo, Hongyu Zhou, Wenxing Chen, Tao Shen, Xiuzhen Han, Christopher D Kontos, Shile Huan. Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. Free radical biology & medicine. vol 50. issue 5. 2011-05-06. PMID:21195169. |
wortmannin, a phosphoinositide 3'-kinase (pi3k) inhibitor, partially attenuated cd-induced phosphorylation of akt, p70 s6 kinase 1, and eukaryotic initiation factor 4e-binding protein 1, as well as apoptosis of the neuronal cells. |
2011-05-06 |
2023-08-12 |
Not clear |
| Vidyarani Mohankumar, Nisha R Dhanushkodi, Ramaswamy Raj. Sindbis virus replication, is insensitive to rapamycin and torin1, and suppresses Akt/mTOR pathway late during infection in HEK cells. Biochemical and biophysical research communications. vol 406. issue 2. 2011-05-05. PMID:21316343. |
here, using hek293t cells as host, we report the following key findings: (a) robust sin replication occurs in the presence of mtor specific inhibitors, rapamycin and torin1 or ly294002--a pi3k inhibitor, suggesting a lack of requirement for pi3k/akt/mtor signaling; (b) suppression of phosphorylation of akt, mtor and its effectors s6, and 4e-bp1 occurs late during sin infection: a viral function that may be beneficial in counteracting cellular drug resistance to kinase inhibitors; (c) ly294002 and sin act additively to suppress pi3k/akt/mtor pathway with little effect on virus release; and (d) sin replication induces host translational shut off, phosphorylation of eif2α and apoptosis. |
2011-05-05 |
2023-08-12 |
human |
| Sofie Claerhout, Lien Verschooten, Sofie Van Kelst, Rita De Vos, Charlotte Proby, Patrizia Agostinis, Marjan Garmy. Concomitant inhibition of AKT and autophagy is required for efficient cisplatin-induced apoptosis of metastatic skin carcinoma. International journal of cancer. vol 127. issue 12. 2011-05-03. PMID:21351258. |
concomitant inhibition of akt and autophagy is required for efficient cisplatin-induced apoptosis of metastatic skin carcinoma. |
2011-05-03 |
2023-08-12 |
Not clear |
| Sofie Claerhout, Lien Verschooten, Sofie Van Kelst, Rita De Vos, Charlotte Proby, Patrizia Agostinis, Marjan Garmy. Concomitant inhibition of AKT and autophagy is required for efficient cisplatin-induced apoptosis of metastatic skin carcinoma. International journal of cancer. vol 127. issue 12. 2011-05-03. PMID:21351258. |
we show that skin tumor progression parallels enhanced akt activation and increased resistance to cisplatin-induced apoptosis. |
2011-05-03 |
2023-08-12 |
Not clear |
| Anju Preet, Zahida Qamri, Mohd W Nasser, Anil Prasad, Konstantin Shilo, Xianghong Zou, Jerome E Groopman, Ramesh K Ganj. Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 1. 2011-04-28. PMID:21097714. |
upon further elucidation into the molecular mechanism, we observed that both cb1 and cb2 agonists inhibited phosphorylation of akt, a key signaling molecule controlling cell survival, migration, and apoptosis, and reduced matrix metalloproteinase 9 expression and activity. |
2011-04-28 |
2023-08-12 |
Not clear |
| Liang Fang, HuiMng Wang, Lin Zhou, Da Y. Akt-FOXO3a signaling axis dysregulation in human oral squamous cell carcinoma and potent efficacy of FOXO3a-targeted gene therapy. Oral oncology. vol 47. issue 1. 2011-04-27. PMID:21109483. |
activation of akt suppresses foxo transcription factor-mediated growth arrest and apoptosis in various cancers. |
2011-04-27 |
2023-08-12 |
human |
| Satoshi Inoue, Hui Ding, Jose Portilla-Arias, Jinwei Hu, Bindu Konda, Manabu Fujita, Andres Espinoza, Sonal Suhane, Marisa Riley, Marcus Gates, Rameshwar Patil, Manuel L Penichet, Alexander V Ljubimov, Keith L Black, Eggehard Holler, Julia Y Ljubimov. Polymalic acid-based nanobiopolymer provides efficient systemic breast cancer treatment by inhibiting both HER2/neu receptor synthesis and activity. Cancer research. vol 71. issue 4. 2011-04-27. PMID:21303974. |
the results of the study showed that the lead drug tested significantly inhibited the growth of her2/neu-positive breast cancer cells in vitro and in vivo by enhanced apoptosis and inhibition of her2/neu receptor signaling with suppression of akt phosphorylation. |
2011-04-27 |
2023-08-12 |
mouse |
| S Lépine, J C Allegood, M Park, P Dent, S Milstien, S Spiege. Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy. Cell death and differentiation. vol 18. issue 2. 2011-04-25. PMID:20798685. |
autophagy triggered by downregulation of spp1 did not lead to apoptosis but rather stimulated, in a perk dependent manner, the survival signal akt, whose inhibition then sensitized cells to apoptosis. |
2011-04-25 |
2023-08-12 |
Not clear |
| Jürgen Knobloch, David Jungck, Andrea Koc. Apoptosis induction by thalidomide: critical for limb teratogenicity but therapeutic potential in idiopathic pulmonary fibrosis? Current molecular pharmacology. vol 4. issue 1. 2011-04-22. PMID:20958261. |
finally, we discuss the paradox that the embryonic molecular pathology induced by thalidomide suggests this drug as a candidate for therapeutic application in idiopathic pulmonary fibrosis (ipf), a chronic and fatal lung disease characterized by downregulation of bmp signaling, increased wnt and akt activity, and apoptosis resistance. |
2011-04-22 |
2023-08-12 |
Not clear |
| Jing-Ru Weng, Li-Yuan Bai, Hany A Omar, Aaron M Sargeant, Ching-Tung Yeh, Yuan-Yin Chen, Ming-Hsui Tsai, Chang-Fang Chi. A novel indole-3-carbinol derivative inhibits the growth of human oral squamous cell carcinoma in vitro. Oral oncology. vol 46. issue 10. 2011-04-20. PMID:20843730. |
osu-a9 down regulates akt and nf-κb signaling pathways, leading to changes in many downstream effectors involved in regulating cell cycle and apoptosis. |
2011-04-20 |
2023-08-12 |
human |