| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fenggen Yan, Mei Wang, Hui Chen, Jingjing Su, Xiaoshan Wang, Fei Wang, Lunzhu Xia, Qinglin L. Gambogenic acid mediated apoptosis through the mitochondrial oxidative stress and inactivation of Akt signaling pathway in human nasopharyngeal carcinoma CNE-1 cells. European journal of pharmacology. vol 652. issue 1-3. 2011-04-18. PMID:21118682. |
gambogenic acid mediated apoptosis through the mitochondrial oxidative stress and inactivation of akt signaling pathway in human nasopharyngeal carcinoma cne-1 cells. |
2011-04-18 |
2023-08-12 |
human |
| Fenggen Yan, Mei Wang, Hui Chen, Jingjing Su, Xiaoshan Wang, Fei Wang, Lunzhu Xia, Qinglin L. Gambogenic acid mediated apoptosis through the mitochondrial oxidative stress and inactivation of Akt signaling pathway in human nasopharyngeal carcinoma CNE-1 cells. European journal of pharmacology. vol 652. issue 1-3. 2011-04-18. PMID:21118682. |
overall, our results indicated that gambogenic acid mediated apoptosis through inactivation of akt, accompanied with mitochondrial oxidative stress and cross-talk with bcl-2 family in the process of apoptosis. |
2011-04-18 |
2023-08-12 |
human |
| Hong-jye HONG, Ju-chi LIU, Tzu-hurng CHENG, Paul CHA. Tanshinone IIA attenuates angiotensin II-induced apoptosis via Akt pathway in neonatal rat cardiomyocytes. Acta pharmacologica Sinica. vol 31. issue 12. 2011-04-15. PMID:21102479. |
tanshinone iia attenuates angiotensin ii-induced apoptosis via akt pathway in neonatal rat cardiomyocytes. |
2011-04-15 |
2023-08-12 |
rat |
| Oneel Patel, Kathryn M Marshall, Gianni Bramante, Graham S Baldwin, Arthur Shulke. The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway. Regulatory peptides. vol 165. issue 2-3. 2011-04-14. PMID:20727916. |
using the human gastric carcinoma cell line ags we show that ctfp attenuates apoptosis through a pi3-kinase pathway by stimulating the phosphorylation of akt leading to sustained increases in the concentrations of bcl-xl and phosphorylated bad protein and by reducing caspase 3 activity. |
2011-04-14 |
2023-08-12 |
human |
| Dezheng Zhao, Kyriaki Bakirtzi, Yanai Zhan, Huiyan Zeng, Hon Wai Koon, Charalabos Pothoulaki. Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells. The Journal of biological chemistry. vol 286. issue 8. 2011-04-14. PMID:21212273. |
pretreatment with ag1024 also inhibits akt activation and apoptosis induced by nt. |
2011-04-14 |
2023-08-12 |
human |
| Kristina Janjetovic, Ljubica Vucicevic, Maja Misirkic, Urosh Vilimanovich, Gordana Tovilovic, Nevena Zogovic, Zoran Nikolic, Svetlana Jovanovic, Vladimir Bumbasirevic, Vladimir Trajkovic, Ljubica Harhaji-Trajkovi. Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt. European journal of pharmacology. vol 651. issue 1-3. 2011-04-11. PMID:21114978. |
cell viability was determined by mtt and ldh release assay, oxidative stress and apoptosis (caspase activation, dna fragmentation, and phosphatidylserine exposure) were assessed by flow cytometry, while activation of ampk and akt was analyzed by immunoblotting. |
2011-04-11 |
2023-08-12 |
mouse |
| Jonathan L Coloff, Emily F Mason, Brian J Altman, Valerie A Gerriets, Tingyu Liu, Amanda N Nichols, Yuxing Zhao, Jessica A Wofford, Sarah R Jacobs, Olga Ilkayeva, Sean P Garrison, Gerard P Zambetti, Jeffrey C Rathmel. Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. The Journal of biological chemistry. vol 286. issue 7. 2011-04-11. PMID:21159778. |
akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic t cells. |
2011-04-11 |
2023-08-12 |
Not clear |
| Jonathan L Coloff, Emily F Mason, Brian J Altman, Valerie A Gerriets, Tingyu Liu, Amanda N Nichols, Yuxing Zhao, Jessica A Wofford, Sarah R Jacobs, Olga Ilkayeva, Sean P Garrison, Gerard P Zambetti, Jeffrey C Rathmel. Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. The Journal of biological chemistry. vol 286. issue 7. 2011-04-11. PMID:21159778. |
in particular, unlike anti-apoptotic bcl-2 family proteins that prevent apoptosis independent of glucose, akt requires glucose metabolism to inhibit cell death. |
2011-04-11 |
2023-08-12 |
Not clear |
| Jonathan L Coloff, Emily F Mason, Brian J Altman, Valerie A Gerriets, Tingyu Liu, Amanda N Nichols, Yuxing Zhao, Jessica A Wofford, Sarah R Jacobs, Olga Ilkayeva, Sean P Garrison, Gerard P Zambetti, Jeffrey C Rathmel. Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. The Journal of biological chemistry. vol 286. issue 7. 2011-04-11. PMID:21159778. |
importantly, preventing puma expression was critical for akt-mediated cell survival, as puma deficiency protected cells from glucose deprivation and akt could not readily block puma-mediated apoptosis. |
2011-04-11 |
2023-08-12 |
Not clear |
| M Salhab, L Tosca, C Cabau, P Papillier, C Perreau, J Dupont, P Mermillod, S Uzbekov. Kinetics of gene expression and signaling in bovine cumulus cells throughout IVM in different mediums in relation to oocyte developmental competence, cumulus apoptosis and progesterone secretion. Theriogenology. vol 75. issue 1. 2011-04-08. PMID:20961603. |
higher phosphorylation levels of smad2, akt and map kinase jnk1, but not of map kinases erk1/erk2 or p38, was positively correlated with oocyte developmental competence and progesterone secretion and negatively correlated with cumulus apoptosis rate. |
2011-04-08 |
2023-08-12 |
cattle |
| Wei Han, Hongya Pan, Linlin Jiang, Kuijie Wei, Duohong Zou, Zhiyuan Zhan. A novel approach to rescue immune escape in oral squamous cell carcinoma: Combined use of interferon-γ and LY294002. Oncology reports. vol 25. issue 1. 2011-04-06. PMID:21109975. |
with the combined application of ly294002 (specific inhibitor of akt signaling) and ifn-γ, tumor cell apoptosis was induced and the expression of tap-1 and tapasin was still up-regulated. |
2011-04-06 |
2023-08-12 |
Not clear |
| Hyunho Yoon, Jeong-Ki Min, Jung Whoi Lee, Dae-Ghon Kim, Hyo Jeong Hon. Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2. Biochemical and biophysical research communications. vol 405. issue 3. 2011-04-06. PMID:21130731. |
inhibition of akt activation by phosphoinocitide 3-kinase (pi3k) inhibitor ly294002 resulted in reduced bcl-2 expression and enhanced bax expression and thus induced apoptosis in the resistant cells, whereas inhibition of erk1/2 activation by mitogen-activated protein kinase (mek) inhibitor u0126 did not induce apoptosis without affecting the expression of bcl-2 and bax but decreased cell growth. |
2011-04-06 |
2023-08-12 |
Not clear |
| Hyunho Yoon, Jeong-Ki Min, Jung Whoi Lee, Dae-Ghon Kim, Hyo Jeong Hon. Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2. Biochemical and biophysical research communications. vol 405. issue 3. 2011-04-06. PMID:21130731. |
moreover, the inhibition of akt or erk1/2 sensitized the resistant cells to cisplatin and therefore resulted in greatly enhanced cisplatin-induced apoptosis and growth inhibition in the cells. |
2011-04-06 |
2023-08-12 |
Not clear |
| Ming-Yue Li, Jackie Leung, Angel W Y Kong, Nian Ci Liang, Kefeng Wu, Michael K Y Hsin, Yi Feng Deng, Xianling Gong, Yingnian Lv, Tony S K Mok, Malcolm J Underwood, George G Che. Anticancer efficacy of 5F in NNK-induced lung cancer development of A/J mice and human lung cancer cells. Journal of molecular medicine (Berlin, Germany). vol 88. issue 12. 2011-04-04. PMID:20830463. |
the inhibition of akt further facilitated the apoptosis induced, suggesting that akt activation was anti-apoptotic rather than pro-apoptotic. |
2011-04-04 |
2023-08-12 |
mouse |
| Ajanta Chakraborty, Pramod Kumar, Kaushik Ghosh, Partha Ro. Evaluation of a Schiff base copper complex compound as potent anticancer molecule with multiple targets of action. European journal of pharmacology. vol 647. issue 1-3. 2011-04-01. PMID:20797395. |
it caused apoptosis within the tumor by the up regulation of caspase pathway and inhibition of the akt, matrix metalloproteinase 9 and α-methyl acyl coa racemase. |
2011-04-01 |
2023-08-12 |
rat |
| Eun-Ra Jang, Chung Soo Le. 7-ketocholesterol induces apoptosis in differentiated PC12 cells via reactive oxygen species-dependent activation of NF-κB and Akt pathways. Neurochemistry international. vol 58. issue 1. 2011-03-31. PMID:21035514. |
7-ketocholesterol induces apoptosis in differentiated pc12 cells via reactive oxygen species-dependent activation of nf-κb and akt pathways. |
2011-03-31 |
2023-08-12 |
Not clear |
| Eun-Ra Jang, Chung Soo Le. 7-ketocholesterol induces apoptosis in differentiated PC12 cells via reactive oxygen species-dependent activation of NF-κB and Akt pathways. Neurochemistry international. vol 58. issue 1. 2011-03-31. PMID:21035514. |
however, it is still unknown whether oxysterol-induced apoptosis in neuronal cells is mediated by akt and nf-κb pathways. |
2011-03-31 |
2023-08-12 |
Not clear |
| Anutosh Chakraborty, J Kent Werner, Michael A Koldobskiy, Asif K Mustafa, Krishna R Juluri, Joseph Pietropaoli, Adele M Snowman, Solomon H Snyde. Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 6. 2011-03-30. PMID:21262846. |
the inositol pyrophosphate, diphosphoinositol pentakisphosphate, regulates p53 and protein kinase akt signaling, and its aberrant increase in cells has been implicated in apoptosis and insulin resistance. |
2011-03-30 |
2023-08-12 |
Not clear |
| Xiajing Tang, Ke Yao, Li Zhang, Yunmei Yang, Hangping Ya. Honokiol inhibits H(2)O(2)-induced apoptosis in human lens epithelial cells via inhibition of the mitogen-activated protein kinase and Akt pathways. European journal of pharmacology. vol 650. issue 1. 2011-03-24. PMID:20965163. |
honokiol inhibits h(2)o(2)-induced apoptosis in human lens epithelial cells via inhibition of the mitogen-activated protein kinase and akt pathways. |
2011-03-24 |
2023-08-12 |
human |
| Xiajing Tang, Ke Yao, Li Zhang, Yunmei Yang, Hangping Ya. Honokiol inhibits H(2)O(2)-induced apoptosis in human lens epithelial cells via inhibition of the mitogen-activated protein kinase and Akt pathways. European journal of pharmacology. vol 650. issue 1. 2011-03-24. PMID:20965163. |
these results demonstrate that honokiol suppresses h(2)o(2)-induced hle cell apoptosis via interference with the mapks, akt and nf-κb signaling, suggesting that honokiol might have a potential effect against cataract formation. |
2011-03-24 |
2023-08-12 |
human |