| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nha T P Vo, Sibylle Madlener, Zsuzsanna Bago-Horvath, Irene Herbacek, Nicole Stark, Manuela Gridling, Paul Probst, Benedikt Giessrigl, Sabine Bauer, Caroline Vonach, Philipp Saiko, Michael Grusch, Thomas Szekeres, Monika Fritzer-Szekeres, Walter Jäger, Georg Krupitza, Afschin Soleima. Pro- and anticarcinogenic mechanisms of piceatannol are activated dose dependently in MCF-7 breast cancer cells. Carcinogenesis. vol 31. issue 12. 2011-01-06. PMID:19696164. |
apoptosis was most probably inhibited due to activation of akt; however, high pic concentrations (>100 μm) permitted apoptosis-like cell death in consequence to disruption of orchestrated mitotic signaling. |
2011-01-06 |
2023-08-12 |
Not clear |
| Shenglei Li, Yu Xi, Hongyan Zhang, Yange Wang, Xin Wang, Hongtao Liu, Kuisheng Che. A pivotal role for Pim-1 kinase in esophageal squamous cell carcinoma involving cell apoptosis induced by reducing Akt phosphorylation. Oncology reports. vol 24. issue 4. 2011-01-06. PMID:20811681. |
a pivotal role for pim-1 kinase in esophageal squamous cell carcinoma involving cell apoptosis induced by reducing akt phosphorylation. |
2011-01-06 |
2023-08-12 |
Not clear |
| Shenglei Li, Yu Xi, Hongyan Zhang, Yange Wang, Xin Wang, Hongtao Liu, Kuisheng Che. A pivotal role for Pim-1 kinase in esophageal squamous cell carcinoma involving cell apoptosis induced by reducing Akt phosphorylation. Oncology reports. vol 24. issue 4. 2011-01-06. PMID:20811681. |
these data suggest that pim-1 sirna-mediated apoptosis is closely related to the decrease in akt and bad phosphorylation and increase in cleaved caspase-3/-9 activities, and thus manipulation of pim-1 is a potential target for molecular therapy in the clinical treatment of patients with escc. |
2011-01-06 |
2023-08-12 |
Not clear |
| Simona Dedoni, Maria C Olianas, Pierluigi Onal. Interferon-β induces apoptosis in human SH-SY5Y neuroblastoma cells through activation of JAK-STAT signaling and down-regulation of PI3K/Akt pathway. Journal of neurochemistry. vol 115. issue 6. 2011-01-04. PMID:21044071. |
moreover, long-term ifn-β treatment led to down-regulation of phosphatidylinositol 3-kinase/akt signaling and ifn-β-induced apoptosis was attenuated in cells expressing constitutively active akt. |
2011-01-04 |
2023-08-12 |
mouse |
| Fei Zhong, Shineng Zhang, Chunkui Shao, Jing Yang, Xiangyuan W. Arsenic trioxide inhibits cholangiocarcinoma cell growth and induces apoptosis. Pathology oncology research : POR. vol 16. issue 3. 2011-01-03. PMID:20012722. |
as(2)o(3) inhibition of akt phosphorylation may contribute to as(2)o(3)-mediated cholangiocarcinoma cell growth inhibition and apoptosis induction. |
2011-01-03 |
2023-08-12 |
human |
| Hye-Ryung Choi, Jung-Won Shin, Hyun-Kyoung Lee, Jin-Young Kim, Chang-Hun Huh, Sang-Woong Youn, Kyoung Chan Par. Potential redox-sensitive Akt activation by dopamine activates Bad and promotes cell death in melanocytes. Oxidative medicine and cellular longevity. vol 3. issue 3. 2010-12-30. PMID:20716947. |
in addition, akt has been reported to deliver a survival signal that inhibits apoptosis. |
2010-12-30 |
2023-08-12 |
Not clear |
| Hye-Ryung Choi, Jung-Won Shin, Hyun-Kyoung Lee, Jin-Young Kim, Chang-Hun Huh, Sang-Woong Youn, Kyoung Chan Par. Potential redox-sensitive Akt activation by dopamine activates Bad and promotes cell death in melanocytes. Oxidative medicine and cellular longevity. vol 3. issue 3. 2010-12-30. PMID:20716947. |
however, it has also been reported that chronic akt activation leads to apoptosis in response to oxidative stress. |
2010-12-30 |
2023-08-12 |
Not clear |
| Yan Ding, Jin Kuk Kim, Sung Il Kim, Hee-Jun Na, Soo Young Jun, Seon Jin Lee, Mary E Cho. TGF-{beta}1 protects against mesangial cell apoptosis via induction of autophagy. The Journal of biological chemistry. vol 285. issue 48. 2010-12-30. PMID:20876581. |
taken together, our data indicate that tgf-β1 rescues mmc from serum deprivation-induced apoptosis via induction of autophagy through activation of the akt pathway. |
2010-12-30 |
2023-08-12 |
mouse |
| K-F Chen, C-Y Liu, Y-C Lin, H-C Yu, T-H Liu, D-R Hou, P-J Chen, A-L Chen. CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells. Oncogene. vol 29. issue 47. 2010-12-28. PMID:20729919. |
in conclusion, inhibition of cip2a determines the effects of bortezomib on apoptosis and pp2a-dependent akt inactivation in hcc. |
2010-12-28 |
2023-08-12 |
Not clear |
| Larysa Yuzefovych, Glenn Wilson, Lyudmila Rache. Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. American journal of physiology. Endocrinology and metabolism. vol 299. issue 6. 2010-12-28. PMID:20876761. |
oleate alone did not cause mtros generation and mtdna damage, and its addition to palmitate prevented palmitate-induced mtdna damage, increased total atp levels and cell viability, and prevented palmitate-induced apoptosis and inhibition of insulin-stimulated akt (ser(473)) phosphorylation. |
2010-12-28 |
2023-08-12 |
Not clear |
| Mariko Soumura, Shinji Kume, Keiji Isshiki, Naoko Takeda, Shin-ichi Araki, Yuki Tanaka, Toshiro Sugimoto, Masami Chin-Kanasaki, Yoshihiko Nishio, Masakazu Haneda, Daisuke Koya, Atsunori Kashiwagi, Hiroshi Maegawa, Takashi Uz. Oleate and eicosapentaenoic acid attenuate palmitate-induced inflammation and apoptosis in renal proximal tubular cell. Biochemical and biophysical research communications. vol 402. issue 2. 2010-12-28. PMID:20937260. |
furthermore, palmitate enhanced pkcθ-dependent mitochondrial apoptosis, which was also prevented by co-incubation with oleate or epa through restoration of pro-survival akt pathway. |
2010-12-28 |
2023-08-12 |
Not clear |
| Janet M Pavese, Rebecca L Farmer, Raymond C Berga. Inhibition of cancer cell invasion and metastasis by genistein. Cancer metastasis reviews. vol 29. issue 3. 2010-12-21. PMID:20730632. |
reports have demonstrated that, at high concentrations, genistein can inhibit several proteins involved with primary tumor growth and apoptosis, including the cyclin class of cell cycle regulators and the akt family of proteins. |
2010-12-21 |
2023-08-12 |
human |
| Ching-Ming Chien, Shang-Yu Chang, Kuei-Li Lin, Chien-Chih Chiu, Long-Sen Chang, Shinne-Ren Li. Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells. Toxicon : official journal of the International Society on Toxinology. vol 56. issue 4. 2010-12-13. PMID:20493203. |
taken together, these results indicate that ctx iii induces apoptosis and s-phase arrest in ca9-22 cells via concomitant inactivation of the src, egfr, stat3, stat5, pi3 k(p110), and akt signaling pathways. |
2010-12-13 |
2023-08-12 |
Not clear |
| Bo Shen, Lin Gao, Yi-Te Hsu, Grant Bledsoe, Makato Hagiwara, Lee Chao, Julie Cha. Kallistatin attenuates endothelial apoptosis through inhibition of oxidative stress and activation of Akt-eNOS signaling. American journal of physiology. Heart and circulatory physiology. vol 299. issue 5. 2010-11-29. PMID:20729399. |
the transduction of endothelial cells with adenovirus expressing dominant-negative akt abolished the protective effect of kallistatin on endothelial apoptosis and caspase activity. |
2010-11-29 |
2023-08-12 |
rat |
| Luan Wen, Yong Yang, Yu Wang, Aimin Xu, Donghai Wu, Yonglong Che. Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells. Developmental dynamics : an official publication of the American Association of Anatomists. vol 239. issue 8. 2010-11-23. PMID:20568240. |
specific knockdown of appl1 in endoderm or inhibition of akt activity did not affect the formation of endodermal organ primordia at tail bud stages of development, but led to a gut-coiling defect, strong apoptosis in endodermal organs, and pancreas and sd hypoplasia or even aplasia at tadpole stages of development. |
2010-11-23 |
2023-08-12 |
xenopus_laevis |
| Medhat Shehata, Susanne Schnabl, Dita Demirtas, Martin Hilgarth, Rainer Hubmann, Elena Ponath, Sigrun Badrnya, Claudia Lehner, Andrea Hoelbl, Markus Duechler, Alexander Gaiger, Christoph Zielinski, Josef D Schwarzmeier, Ulrich Jaege. Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia. Blood. vol 116. issue 14. 2010-11-23. PMID:20576813. |
ck2 inhibitors (4,5,6,7-tetrabromo-1h-benzotriazole, apigenin, and 5,6-dichloro-1-β-d-ribofuranosylbenzimidazol) decreased phosphorylation of pten and akt, induced apoptosis in cll cells, and enhanced the response to fludarabine. |
2010-11-23 |
2023-08-12 |
human |
| S Grotegut, R Kappler, S Tarimoradi, F Lehembre, G Christofori, D Von Schweinit. Hepatocyte growth factor protects hepatoblastoma cells from chemotherapy-induced apoptosis by AKT activation. International journal of oncology. vol 36. issue 5. 2010-11-22. PMID:20372801. |
hepatocyte growth factor protects hepatoblastoma cells from chemotherapy-induced apoptosis by akt activation. |
2010-11-22 |
2023-08-12 |
Not clear |
| Eriko Suzuki, Tracy R Daniels, Gustavo Helguera, Manuel L Penichet, Kazuo Umezawa, Benjamin Bonavid. Inhibition of NF-kappaB and Akt pathways by an antibody-avidin fusion protein sensitizes malignant B-cells to cisplatin-induced apoptosis. International journal of oncology. vol 36. issue 5. 2010-11-22. PMID:20372806. |
inhibition of nf-kappab and akt pathways by an antibody-avidin fusion protein sensitizes malignant b-cells to cisplatin-induced apoptosis. |
2010-11-22 |
2023-08-12 |
human |
| S Ripka, A Neesse, J Riedel, E Bug, A Aigner, R Poulsom, S Fulda, J Neoptolemos, W Greenhalf, P Barth, T M Gress, P Mich. CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer. Gut. vol 59. issue 8. 2010-11-22. PMID:20442202. |
cux1: target of akt signalling and mediator of resistance to apoptosis in pancreatic cancer. |
2010-11-22 |
2023-08-12 |
Not clear |
| Nadeeja Wijesekara, Mansa Krishnamurthy, Alpana Bhattacharjee, Aamir Suhail, Gary Sweeney, Michael B Wheele. Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. The Journal of biological chemistry. vol 285. issue 44. 2010-11-16. PMID:20709750. |
adiponectin-induced erk and akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. |
2010-11-16 |
2023-08-12 |
mouse |