| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nadeeja Wijesekara, Mansa Krishnamurthy, Alpana Bhattacharjee, Aamir Suhail, Gary Sweeney, Michael B Wheele. Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. The Journal of biological chemistry. vol 285. issue 44. 2010-11-16. PMID:20709750. |
24-h stimulation with adiponectin significantly increased cell viability by decreasing cellular apoptosis, and this was prevented by dominant negative akt, wortmannin (pi3k inhibitor), and u0126 (mek inhibitor). |
2010-11-16 |
2023-08-12 |
mouse |
| Nadeeja Wijesekara, Mansa Krishnamurthy, Alpana Bhattacharjee, Aamir Suhail, Gary Sweeney, Michael B Wheele. Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. The Journal of biological chemistry. vol 285. issue 44. 2010-11-16. PMID:20709750. |
this study demonstrates a lack of ampk involvement and implicates akt and erk in adiponectin signaling, leading to protection against apoptosis and stimulation of insulin gene expression and secretion in pancreatic beta cells. |
2010-11-16 |
2023-08-12 |
mouse |
| Natalie McGregor, Lalit Patel, Matthew Craig, Savannah Weidner, Shaomeng Wang, Kenneth J Pient. AT-101 (R-(-)-gossypol acetic acid) enhances the effectiveness of androgen deprivation therapy in the VCaP prostate cancer model. Journal of cellular biochemistry. vol 110. issue 5. 2010-11-15. PMID:20589722. |
akt and x inhibitor of apoptosis (xiap) are downregulated in the presence of at-101, and ar stimulation rescues protein expression. |
2010-11-15 |
2023-08-12 |
mouse |
| Xiaoyun Cheng, Weiya Xia, Jer-Yen Yang, Jennifer L Hsu, Jing-Yu Lang, Chao-Kai Chou, Yi Du, Hui-Lung Sun, Shannon L Wyszomierski, Gordon B Mills, William J Muller, Dihua Yu, Mien-Chie Hun. Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis. Cancer research. vol 70. issue 19. 2010-11-15. PMID:20841468. |
phosphorylation of mdm2 on ser(166) and ser(186) by the survival kinase akt inhibits p53-mediated apoptosis. |
2010-11-15 |
2023-08-12 |
mouse |
| Yong Zhang, Wenyong Wang, Zhijian Sun, Dongyun Feng, Yanchun Deng, Yonghong Liu, Gang Zhao, Huaning Wang, Yuangui Huan. Granulocyte colony-stimulating factor treatment prevents cognitive impairment following status epilepticus in rats. Biological & pharmaceutical bulletin. vol 33. issue 4. 2010-11-12. PMID:20410588. |
moreover, the phosphorylation of akt was evaluated with western blot at the 6th, 24th and 48th hours after the treatment to explore apoptosis and detect the protective effects of g-csf. |
2010-11-12 |
2023-08-12 |
human |
| D Deeb, X Gao, H Jiang, A S Arbab, S A Dulchavsky, S C Gauta. Growth inhibitory and apoptosis-inducing effects of xanthohumol, a prenylated chalone present in hops, in human prostate cancer cells. Anticancer research. vol 30. issue 9. 2010-11-10. PMID:20944105. |
induction of apoptosis by xn was associated with the inhibition of prosurvival akt, nf-κb and mtor signaling proteins and nf-κb-regulated anti-apoptotic bcl-2 and survivin. |
2010-11-10 |
2023-08-12 |
human |
| Kanokkarn Phromnoi, Simone Reuter, Bokyung Sung, Pornngarm Limtrakul, Bharat B Aggarwa. A Dihydroxy-pentamethoxyflavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways. Anticancer research. vol 30. issue 9. 2010-11-10. PMID:20944143. |
furthermore, dh-pmf inhibited akt and glycogen synthase kinase 3 beta (gsk3β) activation, reduced cell survival proteins, and induced apoptosis, as indicated by annexin v staining, tunel assay, and activation of caspase-8, -9 and -3. |
2010-11-10 |
2023-08-12 |
Not clear |
| Emma Sierecki, William Sinko, J Andrew McCammon, Alexandra C Newto. Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening. Journal of medicinal chemistry. vol 53. issue 19. 2010-11-09. PMID:20836557. |
biochemical and cellular assays resulted in the identification of two structurally diverse compounds that selectively inhibit phlpp in vitro, increase akt signaling in cells, and prevent apoptosis. |
2010-11-09 |
2023-08-12 |
Not clear |
| Guodong Tie, Jinglian Yan, Yagai Yang, Brian D Park, Julia A Messina, Robert L Raffai, Philip T Nowicki, Louis M Messin. Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway. Journal of vascular research. vol 47. issue 6. 2010-11-08. PMID:20431300. |
we tested the hypothesis that oxidized low-density lipoprotein (oxldl)-induced inactivation of akt within endothelial progenitor cells (epcs) is mediated at the level of phosphoinositide 3-kinase (pi3k), specifically by nitrosylation of the p85 subunit of pi3k, and that this action is critical in provoking oxldl-induced epc apoptosis. |
2010-11-08 |
2023-08-12 |
mouse |
| Guodong Tie, Jinglian Yan, Yagai Yang, Brian D Park, Julia A Messina, Robert L Raffai, Philip T Nowicki, Louis M Messin. Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway. Journal of vascular research. vol 47. issue 6. 2010-11-08. PMID:20431300. |
hypercholesterolemic apoe null mice had a significant reduction of the phosphorylated akt (p-akt)/akt ratio in epcs, as well as a greater percentage of apoptosis in these cells than epcs isolated from wild-type (wt) c57bl/6 mice. |
2010-11-08 |
2023-08-12 |
mouse |
| Guodong Tie, Jinglian Yan, Yagai Yang, Brian D Park, Julia A Messina, Robert L Raffai, Philip T Nowicki, Louis M Messin. Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway. Journal of vascular research. vol 47. issue 6. 2010-11-08. PMID:20431300. |
epc transfection with a constitutively active akt isoform (ad-myrakt) significantly reduced oxldl-induced apoptosis of wt epcs. |
2010-11-08 |
2023-08-12 |
mouse |
| Babak Oskouian, Julie D Sab. Cancer treatment strategies targeting sphingolipid metabolism. Advances in experimental medicine and biology. vol 688. 2010-11-05. PMID:20919655. |
this may be explained in part by the finding that both lipids impinge upon the pi3k/ akt pathway, which represses apoptosis and autophagy. |
2010-11-05 |
2023-08-12 |
Not clear |
| Sang Woo Kim, Hae Jong Kim, Young Jin Chun, Mie Young Ki. Ceramide produces apoptosis through induction of p27(kip1) by protein phosphatase 2A-dependent Akt dephosphorylation in PC-3 prostate cancer cells. Journal of toxicology and environmental health. Part A. vol 73. issue 21-22. 2010-11-05. PMID:20954073. |
ceramide produces apoptosis through induction of p27(kip1) by protein phosphatase 2a-dependent akt dephosphorylation in pc-3 prostate cancer cells. |
2010-11-05 |
2023-08-12 |
Not clear |
| Fusanori Yotsumoto, Eiji Oki, Eriko Tokunaga, Yoshihiko Maehara, Masahide Kuroki, Shingo Miyamot. HB-EGF orchestrates the complex signals involved in triple-negative and trastuzumab-resistant breast cancer. International journal of cancer. vol 127. issue 11. 2010-11-04. PMID:20499311. |
here, we found that heparin-binding epidermal growth factor-like growth factor (hb-egf), a member of the egfr ligands, was predominantly expressed in breast cancer and that treatment with crossreacting material 197 (crm197), a specific inhibitor of hb-egf, blocked erk as well as akt activation via complexes of egfr and unknown growth factor receptors in tnbc or through complexes of egfr and human epidermal growth factor receptor-2 in trastuzumab-resistant breast cancer, caused significant cell apoptosis and inhibited tumor growth. |
2010-11-04 |
2023-08-12 |
human |
| Hiroshi Hirai, Hiroshi Sootome, Yoko Nakatsuru, Katsuyoshi Miyama, Shunsuke Taguchi, Kyoko Tsujioka, Yoko Ueno, Harold Hatch, Pradip K Majumder, Bo-Sheng Pan, Hidehito Kotan. MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Molecular cancer therapeutics. vol 9. issue 7. 2010-11-04. PMID:20571069. |
the serine/threonine kinase akt lies at a critical signaling node downstream of phosphatidylinositol-3-kinase and is important in promoting cell survival and inhibiting apoptosis. |
2010-11-04 |
2023-08-12 |
human |
| Eun Jung Choi, Yun Kyeong Ryu, So Yeon Kim, Hong Gyun Wu, Jae Sung Kim, Il Han Kim, In Ah Ki. Targeting epidermal growth factor receptor-associated signaling pathways in non-small cell lung cancer cells: implication in radiation response. Molecular cancer research : MCR. vol 8. issue 7. 2010-11-01. PMID:20587532. |
although apoptosis was the primary mode of cell death when cells were pretreated with ly294002 or akt inhibitor viii, cells pretreated with rapamycin or pi-103 showed mixed modes of cell death, including apoptosis and autophagy. |
2010-11-01 |
2023-08-12 |
Not clear |
| b' N Goncharenko-Khaider, D Lane, I Matte, C Rancourt, A Pich\\xc3\\xa. The inhibition of Bid expression by Akt leads to resistance to TRAIL-induced apoptosis in ovarian cancer cells. Oncogene. vol 29. issue 40. 2010-11-01. PMID:20661217.' |
the inhibition of bid expression by akt leads to resistance to trail-induced apoptosis in ovarian cancer cells. |
2010-11-01 |
2023-08-12 |
Not clear |
| b' N Goncharenko-Khaider, D Lane, I Matte, C Rancourt, A Pich\\xc3\\xa. The inhibition of Bid expression by Akt leads to resistance to TRAIL-induced apoptosis in ovarian cancer cells. Oncogene. vol 29. issue 40. 2010-11-01. PMID:20661217.' |
in addition, we have previously shown that eoc ascites induce akt activation in the tumor necrosis factor-related apoptosis-inducing ligand (trail)-sensitive eoc cell line, caov3, leading to trail-mediated apoptosis inhibition. |
2010-11-01 |
2023-08-12 |
Not clear |
| b' N Goncharenko-Khaider, D Lane, I Matte, C Rancourt, A Pich\\xc3\\xa. The inhibition of Bid expression by Akt leads to resistance to TRAIL-induced apoptosis in ovarian cancer cells. Oncogene. vol 29. issue 40. 2010-11-01. PMID:20661217.' |
trail-resistant skov3ip1 and cov2 cells were sensitized to trail-induced apoptosis by pi3k or akt inhibitors although inhibition of pi3k/akt signaling pathway did not interfere with the recruitment and processing of caspase-8 to the death-inducing signaling complex. |
2010-11-01 |
2023-08-12 |
Not clear |
| b' N Goncharenko-Khaider, D Lane, I Matte, C Rancourt, A Pich\\xc3\\xa. The inhibition of Bid expression by Akt leads to resistance to TRAIL-induced apoptosis in ovarian cancer cells. Oncogene. vol 29. issue 40. 2010-11-01. PMID:20661217.' |
simultaneous blockade of akt pathway further increased trail-induced apoptosis. |
2010-11-01 |
2023-08-12 |
Not clear |