| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhaoyang Li, Chen-Feng Qi, Dong-Mi Shin, Adriana Zingone, Helen J Newbery, Alexander L Kovalchuk, Catherine M Abbott, Herbert C Mors. Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomas. PloS one. vol 5. issue 5. 2010-09-07. PMID:20505761. |
eef1a2 promotes cell growth, inhibits apoptosis and activates jak/stat and akt signaling in mouse plasmacytomas. |
2010-09-07 |
2023-08-12 |
mouse |
| Hiroto Ueba, Michael Brines, Michael Yamin, Tomio Umemoto, Junya Ako, Shin-ichi Momomura, Anthony Cerami, Masanobu Kawakam. Cardioprotection by a nonerythropoietic, tissue-protective peptide mimicking the 3D structure of erythropoietin. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 32. 2010-09-07. PMID:20660739. |
in cultured neonatal rat cardiomyocytes, hbsp clearly inhibited apoptosis (approximately 80%) induced by tnf-alpha, which was comparable with the effect of epo, and activated critical signaling pathways of cell survival, including akt, erk1/2, and stat3. |
2010-09-07 |
2023-08-12 |
rat |
| Hiroto Ueba, Michael Brines, Michael Yamin, Tomio Umemoto, Junya Ako, Shin-ichi Momomura, Anthony Cerami, Masanobu Kawakam. Cardioprotection by a nonerythropoietic, tissue-protective peptide mimicking the 3D structure of erythropoietin. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 32. 2010-09-07. PMID:20660739. |
among these pathways, akt was shown to play an essential role in hbsp-induced prevention of apoptosis, as assessed by using a small interfering rna approach. |
2010-09-07 |
2023-08-12 |
rat |
| Hiroto Ueba, Michael Brines, Michael Yamin, Tomio Umemoto, Junya Ako, Shin-ichi Momomura, Anthony Cerami, Masanobu Kawakam. Cardioprotection by a nonerythropoietic, tissue-protective peptide mimicking the 3D structure of erythropoietin. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 32. 2010-09-07. PMID:20660739. |
in the dilated cardiomyopathic hamster (j2n-k), whose cardiac tissues diffusely expressed tnf-alpha, hbsp also inhibited apoptosis (approximately 70%) and activated akt in cardiomyocytes. |
2010-09-07 |
2023-08-12 |
rat |
| Stephen L Abrams, Linda S Steelman, John G Shelton, Ellis W T Wong, William H Chappell, Jörg Bäsecke, Franca Stivala, Marco Donia, Ferdinando Nicoletti, Massimo Libra, Alberto M Martelli, James A McCubre. The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy. Cell cycle (Georgetown, Tex.). vol 9. issue 9. 2010-09-03. PMID:20436278. |
the effects of the raf/mek/erk and pi3k/pten/akt/mtor signaling pathways on proliferation, drug resistance, prevention of apoptosis and sensitivity to signal transduction inhibitors were examined in fl/deltaakt-1:er*(myr(+)) + deltaraf-1:ar cells which are conditionally-transformed to grow in response to raf and akt activation. |
2010-09-03 |
2023-08-12 |
Not clear |
| X X Xu, H R Jiang, H B Li, T N Zhang, Q Zhou, N Li. Apoptosis of stomach cancer cell SGC-7901 and regulation of Akt signaling way induced by bovine lactoferrin. Journal of dairy science. vol 93. issue 6. 2010-09-03. PMID:20494139. |
apoptosis of stomach cancer cell sgc-7901 and regulation of akt signaling way induced by bovine lactoferrin. |
2010-09-03 |
2023-08-12 |
human |
| X X Xu, H R Jiang, H B Li, T N Zhang, Q Zhou, N Li. Apoptosis of stomach cancer cell SGC-7901 and regulation of Akt signaling way induced by bovine lactoferrin. Journal of dairy science. vol 93. issue 6. 2010-09-03. PMID:20494139. |
these results suggest that lactoferrin inhibits akt activation and modulates its downstream proteins phosphorylation in apoptosis of sgc-7901 human stomach cancer cells. |
2010-09-03 |
2023-08-12 |
human |
| b' Bal\\xc3\\xa1zs Cs\\xc3\\xb3ka, Zolt\\xc3\\xa1n H N\\xc3\\xa9meth, Peter Rosenberger, Holger K Eltzschig, Zolt\\xc3\\xa1n Spolarics, P\\xc3\\xa1l Pacher, Zsolt Selmeczy, Bal\\xc3\\xa1zs Koscs\\xc3\\xb3, Leon\\xc3\\xb3ra Himer, E Sylvester Vizi, Michael R Blackburn, Edwin A Deitch, Gy\\xc3\\xb6rgy Hask\\xc3\\xb. A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation. Journal of immunology (Baltimore, Md. : 1950). vol 185. issue 1. 2010-09-01. PMID:20505145.' |
in addition, a(2b) receptor knockout mice showed increased splenic apoptosis and phosphatase and tensin homolog activation and decreased akt activation. |
2010-09-01 |
2023-08-12 |
mouse |
| Geetha M Habi. Arsenite causes down-regulation of Akt and c-Fos, cell cycle dysfunction and apoptosis in glutathione-deficient cells. Journal of cellular biochemistry. vol 110. issue 2. 2010-08-27. PMID:20336670. |
arsenite causes down-regulation of akt and c-fos, cell cycle dysfunction and apoptosis in glutathione-deficient cells. |
2010-08-27 |
2023-08-12 |
Not clear |
| Geetha M Habi. Arsenite causes down-regulation of Akt and c-Fos, cell cycle dysfunction and apoptosis in glutathione-deficient cells. Journal of cellular biochemistry. vol 110. issue 2. 2010-08-27. PMID:20336670. |
taken together, our results suggest that a possible mechanism of arsenite-induced toxicity under low/no gsh conditions, is to negatively regulate gcs-2 cell proliferation by attenuating akt and ap-1 by ubiquitination and causing cell cycle dysfunction and apoptosis. |
2010-08-27 |
2023-08-12 |
Not clear |
| Danish Sayed, Minzhen He, Chull Hong, Shumin Gao, Shweta Rane, Zhi Yang, Maha Abdellati. MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand. The Journal of biological chemistry. vol 285. issue 26. 2010-08-24. PMID:20404348. |
thus, we have identified a unique aspect of the function of akt by which it inhibits apoptosis through mir-21-dependent suppression of fasl. |
2010-08-24 |
2023-08-12 |
mouse |
| Ling Wang, Yang Jin, Yke Jildouw Arnoldussen, Ida Jonson, Su Qu, Gunhild M Maelandsmo, Alexandr Kristian, Bjørn Risberg, Håkon Waehre, Håvard E Danielsen, Fahri Saatciogl. STAMP1 is both a proliferative and an antiapoptotic factor in prostate cancer. Cancer research. vol 70. issue 14. 2010-08-24. PMID:20587517. |
knockdown of stamp1 expression in lncap cells also induced significant apoptosis under basal conditions as well as in response to tumor necrosis factor-related apoptosis-inducing ligand (trail) alone, or trail + akt inhibitor ly294002, previously established apoptotic agents in lncap cells. |
2010-08-24 |
2023-08-12 |
mouse |
| Shuangni Yu, Zhaohui Lu, Changzheng Liu, Yunxiao Meng, Yihui Ma, Wugan Zhao, Jianping Liu, Jia Yu, Jie Che. miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer. Cancer research. vol 70. issue 14. 2010-08-24. PMID:20610624. |
ectopic expression of mir-96 through a synthetic mirna precursor inhibited kras, dampened akt signaling, and triggered apoptosis in cells. |
2010-08-24 |
2023-08-12 |
human |
| Ying Qu, Jinhua Wang, Myung-Shin Sim, Bingya Liu, Armando Giuliano, James Barsoum, Xiaojiang Cu. Elesclomol, counteracted by Akt survival signaling, enhances the apoptotic effect of chemotherapy drugs in breast cancer cells. Breast cancer research and treatment. vol 121. issue 2. 2010-08-20. PMID:19609669. |
blockade of akt activation using a small-molecule inhibitor enhanced elesclomol-elicited apoptosis, while expression of a hyperactive akt abolished the elesclomol effect. |
2010-08-20 |
2023-08-12 |
human |
| Wataru Okamoto, Isamu Okamoto, Takeshi Yoshida, Kunio Okamoto, Ken Takezawa, Erina Hatashita, Yuki Yamada, Kiyoko Kuwata, Tokuzo Arao, Kazuyoshi Yanagihara, Masahiro Fukuoka, Kazuto Nishio, Kazuhiko Nakagaw. Identification of c-Src as a potential therapeutic target for gastric cancer and of MET activation as a cause of resistance to c-Src inhibition. Molecular cancer therapeutics. vol 9. issue 5. 2010-08-20. PMID:20406949. |
in other responsive cell lines, dasatinib inhibited both erk and akt phosphorylation and induced apoptosis, as revealed by an increase in caspase-3 activity and cleavage of poly(adp-ribose) polymerase. |
2010-08-20 |
2023-08-12 |
human |
| Wataru Okamoto, Isamu Okamoto, Takeshi Yoshida, Kunio Okamoto, Ken Takezawa, Erina Hatashita, Yuki Yamada, Kiyoko Kuwata, Tokuzo Arao, Kazuyoshi Yanagihara, Masahiro Fukuoka, Kazuto Nishio, Kazuhiko Nakagaw. Identification of c-Src as a potential therapeutic target for gastric cancer and of MET activation as a cause of resistance to c-Src inhibition. Molecular cancer therapeutics. vol 9. issue 5. 2010-08-20. PMID:20406949. |
dasatinib had no effect on erk or akt signaling, whereas the met inhibitor pha-665752 induced apoptosis in these cells. |
2010-08-20 |
2023-08-12 |
human |
| Maria Serova, Lucile Astorgues-Xerri, Ivan Bieche, Sebastien Albert, Michel Vidaud, Karim A Benhadji, Shahin Emami, Dominique Vidaud, Pascal Hammel, Nathalie Theou-Anton, Christian Gespach, Sandrine Faivre, Eric Raymon. Epithelial-to-mesenchymal transition and oncogenic Ras expression in resistance to the protein kinase Cbeta inhibitor enzastaurin in colon cancer cells. Molecular cancer therapeutics. vol 9. issue 5. 2010-08-20. PMID:20406951. |
in colo205-s cells, inhibition of phosphorylated pkcbeta led to the inactivation of akt and glycogen synthase kinase 3beta and was associated with apoptosis without significant effect on cell cycle progression. |
2010-08-20 |
2023-08-12 |
human |
| Kyla M Grimshaw, Lisa-Jane K Hunter, Timothy A Yap, Simon P Heaton, Mike I Walton, Steven J Woodhead, Lynsey Fazal, Matthias Reule, Thomas G Davies, Lisa C Seavers, Victoria Lock, John F Lyons, Neil T Thompson, Paul Workman, Michelle D Garret. AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth. Molecular cancer therapeutics. vol 9. issue 5. 2010-08-20. PMID:20423992. |
to athymic mice implanted with the pten-deficient u87mg human glioblastoma xenograft model caused inhibition of phosphorylation of downstream substrates of both akt and p70s6k and induction of apoptosis, confirming the observations made in vitro. |
2010-08-20 |
2023-08-12 |
mouse |
| Nathalie Gaspar, Swee Y Sharp, Suzanne A Eccles, Sharon Gowan, Sergey Popov, Chris Jones, Andrew Pearson, Gilles Vassal, Paul Workma. Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma. Molecular cancer therapeutics. vol 9. issue 5. 2010-08-20. PMID:20457619. |
in vitro combination studies with inhibitors of phosphoinositide 3-kinase/mammalian target of rapamycin (pi-103) or mitogen-activated protein/extracellular signal-regulated kinase (erk) kinase (pd-0325901) supported the hypothesis that sustained inhibition of erk up to 72 hours and at least temporary inhibition of akt were necessary to induce apoptosis in gb lines. |
2010-08-20 |
2023-08-12 |
mouse |
| Nathalie Gaspar, Swee Y Sharp, Suzanne A Eccles, Sharon Gowan, Sergey Popov, Chris Jones, Andrew Pearson, Gilles Vassal, Paul Workma. Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma. Molecular cancer therapeutics. vol 9. issue 5. 2010-08-20. PMID:20457619. |
in athymic mice bearing established s.c u87mg gb xenografts, nvp-auy922 (50 mg/kg i.p x 3 days) caused the inhibition of erk1/2 and akt phosphorylation and induced apoptosis, whereas 17-aag used at maximum tolerated dose was less effective. |
2010-08-20 |
2023-08-12 |
mouse |