| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Yuan, Zhenjian He, Jueheng Wu, Yongcheng Lin, Xun Zh. A novel adriamycin analogue derived from marine microbes induces apoptosis by blocking Akt activation in human breast cancer cells. Molecular medicine reports. vol 4. issue 2. 2011-07-12. PMID:21468561. |
a novel adriamycin analogue derived from marine microbes induces apoptosis by blocking akt activation in human breast cancer cells. |
2011-07-12 |
2023-08-12 |
human |
| Jie Yuan, Zhenjian He, Jueheng Wu, Yongcheng Lin, Xun Zh. A novel adriamycin analogue derived from marine microbes induces apoptosis by blocking Akt activation in human breast cancer cells. Molecular medicine reports. vol 4. issue 2. 2011-07-12. PMID:21468561. |
taken together, our data demonstrated that 1403p-3 induced breast cancer cell apoptosis by blocking akt activation, suggesting that 1403p-3 may be a promising candidate compound for anti-tumor drug development. |
2011-07-12 |
2023-08-12 |
human |
| J-J Lee, B C Kim, M-J Park, Y-S Lee, Y-N Kim, B L Lee, J-S Le. PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation. Cell death and differentiation. vol 18. issue 4. 2011-07-11. PMID:21072054. |
we further observed that pten-deficient u87 cells with high levels of both akt activation and intracellular reactive oxygen species (ros) underwent senescence, whereas pten-proficient ln18 cells entered apoptosis. |
2011-07-11 |
2023-08-12 |
human |
| J-J Lee, B C Kim, M-J Park, Y-S Lee, Y-N Kim, B L Lee, J-S Le. PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation. Cell death and differentiation. vol 18. issue 4. 2011-07-11. PMID:21072054. |
furthermore, transfection with wild-type (wt) pten or akt small interfering rna induced a change from premature senescence to apoptosis and depletion of p53 or p21 prevented ir-induced premature senescence in u87 cells. |
2011-07-11 |
2023-08-12 |
human |
| Yan Cheng, Xingcong Ren, Yi Zhang, Rajesh Patel, Arati Sharma, Hao Wu, Gavin P Robertson, Li Yan, Eric Rubin, Jin-Ming Yan. eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206. Cancer research. vol 71. issue 7. 2011-07-11. PMID:21307130. |
eef-2 kinase dictates cross-talk between autophagy and apoptosis induced by akt inhibition, thereby modulating cytotoxicity of novel akt inhibitor mk-2206. |
2011-07-11 |
2023-08-12 |
human |
| Yan Cheng, Xingcong Ren, Yi Zhang, Rajesh Patel, Arati Sharma, Hao Wu, Gavin P Robertson, Li Yan, Eric Rubin, Jin-Ming Yan. eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206. Cancer research. vol 71. issue 7. 2011-07-11. PMID:21307130. |
inhibition of the survival kinase akt can trigger apoptosis, and also has been found to activate autophagy, which may confound tumor attack. |
2011-07-11 |
2023-08-12 |
human |
| Yan Cheng, Xingcong Ren, Yi Zhang, Rajesh Patel, Arati Sharma, Hao Wu, Gavin P Robertson, Li Yan, Eric Rubin, Jin-Ming Yan. eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206. Cancer research. vol 71. issue 7. 2011-07-11. PMID:21307130. |
in this study, we investigated regulatory mechanisms through which apoptosis and autophagy were modulated in tumor cells subjected to akt inhibition by mk-2206, the first allosteric small molecule inhibitor of akt to enter clinical development. |
2011-07-11 |
2023-08-12 |
human |
| Yan Cheng, Xingcong Ren, Yi Zhang, Rajesh Patel, Arati Sharma, Hao Wu, Gavin P Robertson, Li Yan, Eric Rubin, Jin-Ming Yan. eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206. Cancer research. vol 71. issue 7. 2011-07-11. PMID:21307130. |
together, these results showed that blunting autophagy and augmenting apoptosis by inhibition of eef-2 kinase could modulate the sensitivity of glioma cells to akt inhibition. |
2011-07-11 |
2023-08-12 |
human |
| Hae Mi Joo, Ji Young Kim, Jae Boon Jeong, Ki Moon Seong, Seon Young Nam, Kwang Hee Yang, Cha Soon Kim, Hee Sun Kim, Meeseon Jeong, Sungkwan An, Young Woo Ji. Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2. European journal of cell biology. vol 90. issue 5. 2011-07-11. PMID:21333377. |
ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of akt and mdm2. |
2011-07-11 |
2023-08-12 |
Not clear |
| Hae Mi Joo, Ji Young Kim, Jae Boon Jeong, Ki Moon Seong, Seon Young Nam, Kwang Hee Yang, Cha Soon Kim, Hee Sun Kim, Meeseon Jeong, Sungkwan An, Young Woo Ji. Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2. European journal of cell biology. vol 90. issue 5. 2011-07-11. PMID:21333377. |
here, we demonstrate that overexpression of rfp2 in cells induced apoptosis through proteasomal degradation of mdm2 and akt. |
2011-07-11 |
2023-08-12 |
Not clear |
| Hae Mi Joo, Ji Young Kim, Jae Boon Jeong, Ki Moon Seong, Seon Young Nam, Kwang Hee Yang, Cha Soon Kim, Hee Sun Kim, Meeseon Jeong, Sungkwan An, Young Woo Ji. Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2. European journal of cell biology. vol 90. issue 5. 2011-07-11. PMID:21333377. |
we observed that rfp2 formed a complex with mdm2, a negative regulator of the p53 tumor suppressor, and akt, a regulator of apoptosis inhibition at the cellular level. |
2011-07-11 |
2023-08-12 |
Not clear |
| Hae Mi Joo, Ji Young Kim, Jae Boon Jeong, Ki Moon Seong, Seon Young Nam, Kwang Hee Yang, Cha Soon Kim, Hee Sun Kim, Meeseon Jeong, Sungkwan An, Young Woo Ji. Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2. European journal of cell biology. vol 90. issue 5. 2011-07-11. PMID:21333377. |
thus, these data suggest that irradiation causes rfp2 overexpression, which enhances ionizing radiation-induced apoptosis by increasing p53 stability and decreasing akt kinase activity through mdm2 and akt degradation. |
2011-07-11 |
2023-08-12 |
Not clear |
| Lang Bai, Shanling Xu, Wenshu Chen, Zi Li, Xia Wang, Hong Tang, Yong Li. Blocking NF-κB and Akt by Hsp90 inhibition sensitizes Smac mimetic compound 3-induced extrinsic apoptosis pathway and results in synergistic cancer cell death. Apoptosis : an international journal on programmed cell death. vol 16. issue 1. 2011-07-05. PMID:20862547. |
blocking nf-κb and akt by hsp90 inhibition sensitizes smac mimetic compound 3-induced extrinsic apoptosis pathway and results in synergistic cancer cell death. |
2011-07-05 |
2023-08-12 |
Not clear |
| Ali Md Ahad, Song Zuohe, Lei Du-Cuny, Sylvestor A Moses, Li Li Zhou, Shuxing Zhang, Garth Powis, Emmanuelle J Meuillet, Eugene A Mas. Development of sulfonamide AKT PH domain inhibitors. Bioorganic & medicinal chemistry. vol 19. issue 6. 2011-07-04. PMID:21353784. |
previously we identified a lead sulfonamide that selectively bound to the pleckstrin homology (ph) domain of akt and induced apoptosis when present at low micromolar concentrations. |
2011-07-04 |
2023-08-12 |
Not clear |
| Jessica Silva, David A Cavazos, Elissa Donzis, William E Friedrichs, Robert Marciniak, Linda A deGraffenrie. Akt-induced tamoxifen resistance is associated with altered FKHR regulation. Cancer investigation. vol 25. issue 7. 2011-07-01. PMID:17952739. |
in addition, tunel analysis demonstrated higher levels of apoptosis in the control xenografts in response to tamoxifen treatment compared to the akt xenografts. |
2011-07-01 |
2023-08-12 |
Not clear |
| Maria De Salvo, Giovanna Maresca, Igea D'agnano, Rodolfo Marchese, Antonio Stigliano, Raffaella Gagliassi, Ercole Brunetti, Giorgio H Raza, Ugo De Paula, Barbara Bucc. Temozolomide induced c-Myc-mediated apoptosis via Akt signalling in MGMT expressing glioblastoma cells. International journal of radiation biology. vol 87. issue 5. 2011-07-01. PMID:21405945. |
temozolomide induced c-myc-mediated apoptosis via akt signalling in mgmt expressing glioblastoma cells. |
2011-07-01 |
2023-08-12 |
Not clear |
| K M E Chu, S Minogue, J J Hsuan, M G Waug. Differential effects of the phosphatidylinositol 4-kinases, PI4KIIα and PI4KIIIβ, on Akt activation and apoptosis. Cell death & disease. vol 1. 2011-06-29. PMID:21218173. |
differential effects of the phosphatidylinositol 4-kinases, pi4kiiα and pi4kiiiβ, on akt activation and apoptosis. |
2011-06-29 |
2023-08-12 |
Not clear |
| K M E Chu, S Minogue, J J Hsuan, M G Waug. Differential effects of the phosphatidylinositol 4-kinases, PI4KIIα and PI4KIIIβ, on Akt activation and apoptosis. Cell death & disease. vol 1. 2011-06-29. PMID:21218173. |
however, in mda-mb-231 breast cancer cells, apoptosis was observed subsequent to knockdown of either pi4kiiα or pi4kiiiβ and this correlated with enhanced proapoptotic akt phosphorylation. |
2011-06-29 |
2023-08-12 |
Not clear |
| Yaxiong Tang, Basmina Parmakhtiar, Anne R Simoneau, Jun Xie, John Fruehauf, Michael Lilly, Xiaolin Z. Lycopene enhances docetaxel's effect in castration-resistant prostate cancer associated with insulin-like growth factor I receptor levels. Neoplasia (New York, N.Y.). vol 13. issue 2. 2011-06-28. PMID:21403837. |
downstream effects include inhibition of akt kinase activity and survivin expression, followed by apoptosis. |
2011-06-28 |
2023-08-12 |
Not clear |
| Tsutomu Kobayashi, Tatsuo Shimura, Toshiki Yajima, Norio Kubo, Kenichiro Araki, Wataru Wada, Soichi Tsutsumi, Hideki Suzuki, Hiroyuki Kuwano, Avraham Ra. Transient silencing of galectin-3 expression promotes both in vitro and in vivo drug-induced apoptosis of human pancreatic carcinoma cells. Clinical & experimental metastasis. vol 28. issue 4. 2011-06-23. PMID:21331750. |
akt phosphorylation was significantly downregulated in gal-3- silenced cells in association with apoptosis. |
2011-06-23 |
2023-08-12 |
mouse |