| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Wang, Z-X Wang, J-S Yang, X Pan, W De, L-B Che. MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14). Oncogene. vol 30. issue 23. 2011-08-19. PMID:21358675. |
ectopic mir-451 expression significantly suppressed the in vitro proliferation and colony formation of nsclc cells and the development of tumors in nude mice by enhancing apoptosis, which might be associated with inactivation of akt signaling pathway. |
2011-08-19 |
2023-08-12 |
mouse |
| Jerry A Saunders, LeAnn C Rogers, Chananat Klomsiri, Leslie B Poole, Larry W Danie. Reactive oxygen species mediate lysophosphatidic acid induced signaling in ovarian cancer cells. Free radical biology & medicine. vol 49. issue 12. 2011-08-18. PMID:20934509. |
thus, lpa acts as a growth factor and prevents apoptosis in skov3 cells by signaling through redox-dependent activation of erk, akt, and nf-κb-dependent signaling pathways. |
2011-08-18 |
2023-08-12 |
Not clear |
| Madhulika Singh, Richa Singh, Kulpreet Bhui, Shilpa Tyagi, Zafar Mahmood, Yogeshwer Shukl. Tea polyphenols induce apoptosis through mitochondrial pathway and by inhibiting nuclear factor-kappaB and Akt activation in human cervical cancer cells. Oncology research. vol 19. issue 6. 2011-08-16. PMID:21776820. |
tea polyphenols induce apoptosis through mitochondrial pathway and by inhibiting nuclear factor-kappab and akt activation in human cervical cancer cells. |
2011-08-16 |
2023-08-12 |
human |
| Madhulika Singh, Richa Singh, Kulpreet Bhui, Shilpa Tyagi, Zafar Mahmood, Yogeshwer Shukl. Tea polyphenols induce apoptosis through mitochondrial pathway and by inhibiting nuclear factor-kappaB and Akt activation in human cervical cancer cells. Oncology research. vol 19. issue 6. 2011-08-16. PMID:21776820. |
thus, we can conclude that tea polyphenols inhibit the growth of cervical cancer cells by inducing apoptosis and regulating nf-kappab and akt. |
2011-08-16 |
2023-08-12 |
human |
| Iakovos Lazaridis, Ioannis Charalampopoulos, Vassilia-Ismini Alexaki, Nicolaos Avlonitis, Iosif Pediaditakis, Paschalis Efstathopoulos, Theodora Calogeropoulou, Elias Castanas, Achille Gravani. Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. PLoS biology. vol 9. issue 4. 2011-08-15. PMID:21541365. |
we provide evidence that dhea interacts with pro-survival trka and pro-death p75(ntr) membrane receptors of neurotrophin nerve growth factor (ngf), acting as a neurotrophic factor: (1) the anti-apoptotic effects of dhea were reversed by sirna against trka or by a specific trka inhibitor; (2) [(3)h]-dhea binding assays showed that it bound to membranes isolated from hek293 cells transfected with the cdnas of trka and p75(ntr) receptors (k(d): 7.4 ± 1.75 nm and 5.6 ± 0.55 nm, respectively); (3) immobilized dhea pulled down recombinant and naturally expressed trka and p75(ntr) receptors; (4) dhea induced trka phosphorylation and ngf receptor-mediated signaling; shc, akt, and erk1/2 kinases down-stream to trka receptors and traf6, rip2, and rhogdi interactors of p75(ntr) receptors; and (5) dhea rescued from apoptosis trka receptor positive sensory neurons of dorsal root ganglia in ngf null embryos and compensated ngf in rescuing from apoptosis ngf receptor positive sympathetic neurons of embryonic superior cervical ganglia. |
2011-08-15 |
2023-08-12 |
Not clear |
| M Krzyzowska, A Shestakov, K Eriksson, F Chiod. Role of Fas/FasL in regulation of inflammation in vaginal tissue during HSV-2 infection. Cell death & disease. vol 2. 2011-08-05. PMID:21412278. |
despite upregulation of fas and fasl, hsv-2-infected keratinocytes and epithelial cells showed a moderate level of apoptosis due to upregulated expression of the anti-apoptotic factors bcl-2, akt kinase and nf-κb. |
2011-08-05 |
2023-08-12 |
mouse |
| N Gao, A Budhraja, S Cheng, E-H Liu, J Chen, Z Yang, D Chen, Z Zhang, X Sh. Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways. Cell death & disease. vol 2. 2011-08-05. PMID:21472003. |
conversely, enforced activation of akt by a constitutively active akt construct markedly abrogated peitc-mediated jnk activation, mcl-1 downregulation, caspase activation, and apoptosis, and also interruption of the jnk pathway by pharmacological or genetically (e.g., sirna) attenuated peitc-induced apoptosis. |
2011-08-05 |
2023-08-12 |
human |
| N Gao, A Budhraja, S Cheng, E-H Liu, J Chen, Z Yang, D Chen, Z Zhang, X Sh. Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways. Cell death & disease. vol 2. 2011-08-05. PMID:21472003. |
finally, administration of peitc markedly inhibited tumor growth and induced apoptosis in u937 xenograft model in association with inactivation of akt, activation of jnk, as well as downregulation of mcl-1. |
2011-08-05 |
2023-08-12 |
human |
| Shih-Ming Huang, Jai-Sing Yang, Shih-Chang Tsai, Ming-Hua Chen, Mei-Hua Hsu, Hui-Yi Lin, Li-Chen Chou, Jo-Hua Chinag, Kuo-Hsiung Lee, Li-Jiau Huang, Sheng-Chu Ku. The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells. International journal of oncology. vol 38. issue 5. 2011-08-03. PMID:21344160. |
strikingly, smh-3 induced apoptosis in hl-60 cells by simultaneously suppressing protein levels of akt, p-akt, p-mtor and p-bad and inducing bad protein levels. |
2011-08-03 |
2023-08-12 |
human |
| X Wang, Y Liu, Z Yang, Z Zhang, W Zhou, Z Ye, W Zhang, S Zhang, Z Yang, X Feng, F Chen, R H. Glucose metabolism-related protein 1 (GMRP1) regulates pancreatic beta cell proliferation and apoptosis via activation of Akt signalling pathway in rats and mice. Diabetologia. vol 54. issue 4. 2011-08-01. PMID:21267538. |
glucose metabolism-related protein 1 (gmrp1) regulates pancreatic beta cell proliferation and apoptosis via activation of akt signalling pathway in rats and mice. |
2011-08-01 |
2023-08-12 |
mouse |
| Faisal Thayyullathil, Shahanas Chathoth, Allen Shahin, Jaleel Kizhakkayil, Abdulkader Hago, Mahendra Patel, Sehamuddin Galadar. Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells. Journal of cellular biochemistry. vol 112. issue 4. 2011-08-01. PMID:21308747. |
protein phosphatase 1-dependent dephosphorylation of akt is the prime signaling event in sphingosine-induced apoptosis in jurkat cells. |
2011-08-01 |
2023-08-12 |
Not clear |
| Faisal Thayyullathil, Shahanas Chathoth, Allen Shahin, Jaleel Kizhakkayil, Abdulkader Hago, Mahendra Patel, Sehamuddin Galadar. Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells. Journal of cellular biochemistry. vol 112. issue 4. 2011-08-01. PMID:21308747. |
this study demonstrates that treatment of jurkat cells with sph leads to akt dephosphorylation as early as 15 min, and the cells undergo apoptosis after 6 h. |
2011-08-01 |
2023-08-12 |
Not clear |
| Faisal Thayyullathil, Shahanas Chathoth, Allen Shahin, Jaleel Kizhakkayil, Abdulkader Hago, Mahendra Patel, Sehamuddin Galadar. Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells. Journal of cellular biochemistry. vol 112. issue 4. 2011-08-01. PMID:21308747. |
moreover, sph-induced dephosphorylation of akt at ser(473) subsequently leads to the activation of gsk-3β, caspase 3, parp cleavage, and ultimately apoptosis. |
2011-08-01 |
2023-08-12 |
Not clear |
| Faisal Thayyullathil, Shahanas Chathoth, Allen Shahin, Jaleel Kizhakkayil, Abdulkader Hago, Mahendra Patel, Sehamuddin Galadar. Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells. Journal of cellular biochemistry. vol 112. issue 4. 2011-08-01. PMID:21308747. |
altogether, these results demonstrate that pp1-mediated inhibition of the key anti-apoptotic protein, akt, plays an important role in sph-mediated apoptosis in jurkat cells. |
2011-08-01 |
2023-08-12 |
Not clear |
| Jinu Abraham, Suresh I Prajapati, Koichi Nishijo, Beverly S Schaffer, Eri Taniguchi, Aoife Kilcoyne, Amanda T McCleish, Laura D Nelon, Francis G Giles, Argiris Efstratiadis, Robin D LeGallo, Brent M Nowak, Brian P Rubin, Suman Malempati, Charles Kelle. Evasion mechanisms to Igf1r inhibition in rhabdomyosarcoma. Molecular cancer therapeutics. vol 10. issue 4. 2011-08-01. PMID:21447712. |
using a genetically engineered mouse model of arms, validated for active igf1r signaling, we show that the prototypic igf1r inhibitor nvp-aew541 can inhibit cell growth and induce apoptosis in vitro in association with decreased akt and mapk phosphorylation. |
2011-08-01 |
2023-08-12 |
mouse |
| Jia-Huan Li, Min Xu, Xiao-Yan Xie, Qi-Xin Fan, De-Guang Mu, Yong Zhang, Fa-Le Cao, Yan-Xia Wang, Peng-Tao Zhao, Bo Zhang, Fa-Guang Jin, Zhi-Chao L. Tanshinone IIA suppresses lung injury and apoptosis, and modulates protein kinase B and extracellular signal-regulated protein kinase pathways in rats challenged with seawater exposure. Clinical and experimental pharmacology & physiology. vol 38. issue 4. 2011-07-28. PMID:21314841. |
in the present study, we investigated the role of apoptosis in seawater exposure-induced acute lung injury (ali), and explored the effects of tiia on lung injury, apoptosis, and protein kinase b (akt) and extracellular signal-regulated protein kinase (erk) pathways in seawater-challenged rats. |
2011-07-28 |
2023-08-12 |
rat |
| Jia-Huan Li, Min Xu, Xiao-Yan Xie, Qi-Xin Fan, De-Guang Mu, Yong Zhang, Fa-Le Cao, Yan-Xia Wang, Peng-Tao Zhao, Bo Zhang, Fa-Guang Jin, Zhi-Chao L. Tanshinone IIA suppresses lung injury and apoptosis, and modulates protein kinase B and extracellular signal-regulated protein kinase pathways in rats challenged with seawater exposure. Clinical and experimental pharmacology & physiology. vol 38. issue 4. 2011-07-28. PMID:21314841. |
in conclusion, the data suggest that apoptosis might play an important role in seawater exposure-induced lung injury and that tiia could significantly attenuate the severity of ali and apoptosis in seawater-challenged rats, which is possibly through modulation of akt and erk1/2 pathways. |
2011-07-28 |
2023-08-12 |
rat |
| Xiaohua Gao, Dorrah Deeb, Patricia Liu, Yongbo Liu, Syed Arbab-Ali, Scott A Dulchavsky, Subhash C Gauta. Role of reactive oxygen species (ROS) in CDDO-Me-mediated growth inhibition and apoptosis in colorectal cancer cells. Journal of experimental therapeutics & oncology. vol 9. issue 2. 2011-07-27. PMID:21699019. |
furthermore, induction of apoptosis by cddo-me was associated with the inhibition of antiapoptotic/ prosurvival akt, mtor and nf-kappab signaling proteins and the inhibition of these signaling molecules was blocked by nag. |
2011-07-27 |
2023-08-12 |
Not clear |
| Josemaria Paterno, Ivan N Vial, Victor W Wong, Kristine C Rustad, Michael Sorkin, Yubin Shi, Kirit A Bhatt, Hariharan Thangarajah, Jason P Glotzbach, Geoffrey C Gurtne. Akt-mediated mechanotransduction in murine fibroblasts during hypertrophic scar formation. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 19. issue 1. 2011-07-26. PMID:21134033. |
in vivo inhibition of akt increased apoptosis but did not significantly abrogate hypertrophic scar development. |
2011-07-26 |
2023-08-12 |
Not clear |
| Min Jung Choi, Eun Jung Park, Jung Hwa Oh, Kyoung-Jin Min, Eun Sun Yang, Young Ho Kim, Tae Jin Lee, Sang Hyun Kim, Yung Hyun Choi, Jong-Wook Park, Taeg Kyu Kwo. Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation. Chemico-biological interactions. vol 190. issue 2-3. 2011-07-26. PMID:21334318. |
cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma caki cells through down-regulation of anti-apoptotic proteins and akt phosphorylation. |
2011-07-26 |
2023-08-12 |
human |