| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ido Ben-Ami, Zhong Yao, Zvi Naor, Rony Sege. Gq protein-induced apoptosis is mediated by AKT kinase inhibition that leads to protein kinase C-induced c-Jun N-terminal kinase activation. The Journal of biological chemistry. vol 286. issue 35. 2011-10-25. PMID:21757743. |
gq protein-induced apoptosis is mediated by akt kinase inhibition that leads to protein kinase c-induced c-jun n-terminal kinase activation. |
2011-10-25 |
2023-08-12 |
Not clear |
| Ido Ben-Ami, Zhong Yao, Zvi Naor, Rony Sege. Gq protein-induced apoptosis is mediated by AKT kinase inhibition that leads to protein kinase C-induced c-Jun N-terminal kinase activation. The Journal of biological chemistry. vol 286. issue 35. 2011-10-25. PMID:21757743. |
in a previous study we found that in prostate cancer cells, the g(q)pcr of gonadotropin-releasing hormone (gnrh) induces apoptosis by reducing the pkc-dependent akt activity and elevating jnk phosphorylation. |
2011-10-25 |
2023-08-12 |
Not clear |
| Ido Ben-Ami, Zhong Yao, Zvi Naor, Rony Sege. Gq protein-induced apoptosis is mediated by AKT kinase inhibition that leads to protein kinase C-induced c-Jun N-terminal kinase activation. The Journal of biological chemistry. vol 286. issue 35. 2011-10-25. PMID:21757743. |
in a screen of 21 cell lines we found that pkc activation results in the reduction of akt activity, which correlates nicely with jnk activation and in some cases with apoptosis. |
2011-10-25 |
2023-08-12 |
Not clear |
| Hui Sun, Teng Yu, Jinchao L. Co-administration of perifosine with paclitaxel synergistically induces apoptosis in ovarian cancer cells: more than just AKT inhibition. Cancer letters. vol 310. issue 1. 2011-10-25. PMID:21775054. |
co-administration of perifosine with paclitaxel synergistically induces apoptosis in ovarian cancer cells: more than just akt inhibition. |
2011-10-25 |
2023-08-12 |
human |
| Arun K Sharma, Christina L Kline, Arthur Berg, Shantu Amin, Rosalyn B Irb. The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 17. issue 13. 2011-10-24. PMID:21555373. |
the akt inhibitor isc-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model. |
2011-10-24 |
2023-08-12 |
mouse |
| Xianbiao Xie, Junqiang Yin, Qiang Jia, Jin Wang, Changye Zou, Kari J Brewer, Chiara Colombo, Yaofei Wang, Gang Huang, Jingnan She. Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. Oncology reports. vol 26. issue 3. 2011-10-24. PMID:21617882. |
quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line u2-os/mtx300 via mitochondrial dysfunction and dephosphorylation of akt. |
2011-10-24 |
2023-08-12 |
Not clear |
| Xianbiao Xie, Junqiang Yin, Qiang Jia, Jin Wang, Changye Zou, Kari J Brewer, Chiara Colombo, Yaofei Wang, Gang Huang, Jingnan She. Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. Oncology reports. vol 26. issue 3. 2011-10-24. PMID:21617882. |
taken together, our results demonstrate that quercetin-induced apoptosis in the mtx-resistant osteosarcoma cells u2-os/mtx300 was mediated via mitochondrial dysfunction and dephosphorylation of akt. |
2011-10-24 |
2023-08-12 |
Not clear |
| Hee-Don Chae, Hal E Broxmeye. SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells. Stem cells and development. vol 20. issue 7. 2011-10-20. PMID:21083429. |
since pten is a negative regulator of akt and its activity can be modulated by acetylation, we investigated if sirt1 deacetylated pten to downregulate akt to trigger apoptosis in anti-oxidant-free culture conditions. |
2011-10-20 |
2023-08-12 |
mouse |
| Yorihisa Imanishi, Bo Hu, Gutian Xiao, Xuebiao Yao, Shi-Yuan Chen. Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway. The Journal of biological chemistry. vol 286. issue 33. 2011-10-19. PMID:21680733. |
additionally, sirna knockdown of endogenous ang2 in three human metastatic breast cancer cell lines also inhibits phosphorylation of akt, expression of bcl-2, and tumor cell survival, migration, and increases cell apoptosis. |
2011-10-19 |
2023-08-12 |
human |
| Eun-Ra Jang, Yun Jeong Kim, Soon Chul Myung, Wonyong Kim, Chung Soo Le. Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines. Molecular and cellular biochemistry. vol 353. issue 1-2. 2011-10-18. PMID:21380726. |
however, inhibition of erk and akt activity has different effects on proliferation and apoptosis in cancer cells. |
2011-10-18 |
2023-08-12 |
human |
| Eun-Ra Jang, Yun Jeong Kim, Soon Chul Myung, Wonyong Kim, Chung Soo Le. Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines. Molecular and cellular biochemistry. vol 353. issue 1-2. 2011-10-18. PMID:21380726. |
these results suggest that the akt and erk inhibitors may have a differential effect on trichostatin a-induced apoptosis in human epithelial ovarian carcinoma cell lines. |
2011-10-18 |
2023-08-12 |
human |
| Yi-Lin Cheng, Wei-Ching Huang, Chia-Ling Chen, Cheng-Chieh Tsai, Chi-Yun Wang, Wei-Hsin Chiu, Yuh-Ling Chen, Yee-Shin Lin, Chuan-Fa Chang, Chiou-Feng Li. Increased galectin-3 facilitates leukemia cell survival from apoptotic stimuli. Biochemical and biophysical research communications. vol 412. issue 2. 2011-10-17. PMID:21821001. |
under apoptotic stimulation, gsk-3β was activated after akt was inactivated and gsk-3β was inhibited-either pharmacologically or using short hairpin rna to abolish galectin-3, increase apoptosis, and inhibit colony formation-which suggests a pro-survival role for gsk-3β. |
2011-10-17 |
2023-08-12 |
Not clear |
| Daniela Opel, Ivonne Naumann, Maxi Schneider, Daniela Bertele, Klaus-Michael Debatin, Simone Fuld. Targeting aberrant PI3K/Akt activation by PI103 restores sensitivity to TRAIL-induced apoptosis in neuroblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 17. issue 10. 2011-10-07. PMID:21355080. |
because we recently identified akt activation as a novel poor prognostic indicator in neuroblastoma, we investigated whether phosphoinositide 3'-kinase (pi3k) inhibition sensitizes neuroblastoma cells for trail-induced apoptosis. |
2011-10-07 |
2023-08-12 |
Not clear |
| Yan Cheng, Li Yan, Xingcong Ren, Jin-Ming Yan. eEF-2 kinase, another meddler in the "yin and yang" of Akt-mediated cell fate? Autophagy. vol 7. issue 6. 2011-10-07. PMID:21460616. |
akt inhibition leads to activation of both apoptosis, type i programmed cell death and autophagy, a cellular degradation process via lysosomal machinery (also termed type ii programmed cell death). |
2011-10-07 |
2023-08-12 |
human |
| Yan Cheng, Li Yan, Xingcong Ren, Jin-Ming Yan. eEF-2 kinase, another meddler in the "yin and yang" of Akt-mediated cell fate? Autophagy. vol 7. issue 6. 2011-10-07. PMID:21460616. |
however, the underlying mechanisms that dictate functional relationship between autophagy and apoptosis in response to akt inhibition remain to be delineated. |
2011-10-07 |
2023-08-12 |
human |
| Yan Cheng, Li Yan, Xingcong Ren, Jin-Ming Yan. eEF-2 kinase, another meddler in the "yin and yang" of Akt-mediated cell fate? Autophagy. vol 7. issue 6. 2011-10-07. PMID:21460616. |
our recent study demonstrated that inhibition of eef-2 kinase can suppress autophagy but promote apoptosis in tumor cells subjected to akt inhibition, indicating a role of eef-2 kinase as a controller in the crosstalk between autophagy and apoptosis. |
2011-10-07 |
2023-08-12 |
human |
| Benchun Miao, Alexei Degtere. Targeting phospshatidylinositol 3-kinase signaling with novel phosphatidylinositol 3,4,5-triphosphate antagonists. Autophagy. vol 7. issue 6. 2011-10-07. PMID:21460619. |
further cellular analysis revealed that both pits inhibit ptdins(3,4,5) p 3-dependent signaling mediated by akt kinase, leading to the induction of apoptosis, metabolic stress and autophagy. |
2011-10-07 |
2023-08-12 |
mouse |
| Stephen E McGowan, Diann M McCo. Fibroblasts expressing PDGF-receptor-alpha diminish during alveolar septal thinning in mice. Pediatric research. vol 70. issue 1. 2011-10-07. PMID:21659960. |
using cultures of neonatal mouse lf, we showed that imatinib did not suppress pdgf-rα gene expression but reduced pdgf-a-mediated akt phosphorylation, potentially explaining the increase in apoptosis. |
2011-10-07 |
2023-08-12 |
mouse |
| Bin Wu, Xu Wang, Hui-Han Wang, Hong-Tao Wang, Wei Yang, Zuo-Fei Chi, Zhuo-Gang Li. [Apoptosis of jurkat cells induced by ursolic acid and its mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 18. issue 1. 2011-10-06. PMID:20137120. |
the cytotoxic effect of different concentration ua on jurkat cells and inhibitory effect of caspase-9 inhibitor on cytotoxicity of ua were assayed by using wst-8 method; the jurkat cells treated with 20 or 40 micromol/l ua for 2 or 4 hours were collected and were stained by annexin/pi, then the apoptosis rate of jurkat cells was detected by flow cytometry; the jurkat cells in logarithmic growth phase were collected after treatment with different concentrations of ua for different times, the cell protein was extracted, then the activation of caspase-9, -3 and cytochrome c as well as phosphorylation level of akt were determined by western blot. |
2011-10-06 |
2023-08-12 |
Not clear |
| Bin Wu, Xu Wang, Hui-Han Wang, Hong-Tao Wang, Wei Yang, Zuo-Fei Chi, Zhuo-Gang Li. [Apoptosis of jurkat cells induced by ursolic acid and its mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 18. issue 1. 2011-10-06. PMID:20137120. |
caspase-9, caspase-3 and cytochrome c were activated, and the phosphorylation of akt was inhibited in the jurkat cell apoptosis process induced by ua. |
2011-10-06 |
2023-08-12 |
Not clear |