| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrick J M Murphy, Hannah R Franklin, Nathan W Furukaw. Biochemical reconstitution of steroid receptor•Hsp90 protein complexes and reactivation of ligand binding. Journal of visualized experiments : JoVE. issue 55. 2011-12-22. PMID:21968922. |
src, raf, akt kinase) involved in cell cycling, tumorigenesis, apoptosis, and multiple eukaryotic signaling pathways (1,2). |
2011-12-22 |
2023-08-12 |
Not clear |
| Marina V Chuenkova, Mercio Pereiraperri. Neurodegeneration and neuroregeneration in Chagas disease. Advances in parasitology. vol 76. 2011-12-21. PMID:21884893. |
pdnf binding to trk receptors triggers pi3k/akt/gsk-3β and mapk/erk/creb signalling cascades which in neurons translates into resistance to oxidative and nutritional stress, and inhibition of apoptosis, whereas in the cytoplasm of infected cells, pdnf represents a substrate-activator of the host akt kinase, enhancing host-cell survival until completion of the intracellular cycle of the parasite. |
2011-12-21 |
2023-08-12 |
Not clear |
| Xinbo Zhang, Naimei Tang, Timothy J Hadden, Arun K Rish. Akt, FoxO and regulation of apoptosis. Biochimica et biophysica acta. vol 1813. issue 11. 2011-12-20. PMID:21440011. |
akt, foxo and regulation of apoptosis. |
2011-12-20 |
2023-08-12 |
Not clear |
| Misu Lee, Marily Theodoropoulou, Jochen Graw, Federico Roncaroli, Maria Chiara Zatelli, Natalia S Pellegat. Levels of p27 sensitize to dual PI3K/mTOR inhibition. Molecular cancer therapeutics. vol 10. issue 8. 2011-12-19. PMID:21646547. |
consistently, nvp-bez235 treatment decreased akt and s6 phosphorylation and triggered apoptosis. |
2011-12-19 |
2023-08-12 |
human |
| Tai-An Chen, Jui-Ling Wang, Shao-Wen Hung, Chiao-Li Chu, Yung-Chih Cheng, Shu-Mei Lian. Recombinant VP1, an Akt inhibitor, suppresses progression of hepatocellular carcinoma by inducing apoptosis and modulation of CCL2 production. PloS one. vol 6. issue 8. 2011-12-14. PMID:21826248. |
recombinant vp1, an akt inhibitor, suppresses progression of hepatocellular carcinoma by inducing apoptosis and modulation of ccl2 production. |
2011-12-14 |
2023-08-12 |
human |
| Wei Ying Yue, J Jason Clark, Augusta Fernando, Frederick Domann, Marlan R Hanse. Contribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides. Neuro-oncology. vol 13. issue 9. 2011-12-08. PMID:21697181. |
inhibition of erk or akt signaling reduced vs cell proliferation but did not increase apoptosis, whereas inhibition of jnk with sp600125, i-jip, or sirna knock-down reduced vs cell proliferation and survival by inducing apoptosis. |
2011-12-08 |
2023-08-12 |
human |
| Matthew L Bush, Janet Oblinger, Victoria Brendel, Griffin Santarelli, Jie Huang, Elena M Akhmametyeva, Sarah S Burns, Justin Wheeler, Jeremy Davis, Charles W Yates, Abhik R Chaudhury, Samuel Kulp, Ching-Shih Chen, Long-Sheng Chang, D Bradley Welling, Abraham Jaco. AR42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas. Neuro-oncology. vol 13. issue 9. 2011-12-08. PMID:21778190. |
in vivo treatment with ar42 inhibited the growth of schwannoma xenografts, induced apoptosis, and decreased akt activation. |
2011-12-08 |
2023-08-12 |
mouse |
| Hongbo Chen, Lin Mei, Lanzhen Zhou, Xiaomeng Shen, Caiping Guo, Yi Zheng, Huijun Zhu, Yongqiang Zhu, Laiqiang Huan. PTEN restoration and PIK3CB knockdown synergistically suppress glioblastoma growth in vitro and in xenografts. Journal of neuro-oncology. vol 104. issue 1. 2011-12-07. PMID:21188471. |
restoration of pten or knockdown of pik3cb, but not pik3ca, in glioblastoma cells markedly down-regulates the phosphorylation level of akt, inhibits cell proliferation and colony formation, arrests the cell cycle at the g0/g1 stage, and promotes caspase-dependent apoptosis. |
2011-12-07 |
2023-08-12 |
mouse |
| Ji-Hyun Kim, Yeong-In Yang, Kyung-Tae Lee, Hee-Juhn Park, Jung-Hye Cho. Costunolide induces apoptosis in human endometriotic cells through inhibition of the prosurvival Akt and nuclear factor kappa B signaling pathway. Biological & pharmaceutical bulletin. vol 34. issue 4. 2011-12-06. PMID:21467650. |
costunolide induces apoptosis in human endometriotic cells through inhibition of the prosurvival akt and nuclear factor kappa b signaling pathway. |
2011-12-06 |
2023-08-12 |
human |
| Ji-Hyun Kim, Yeong-In Yang, Kyung-Tae Lee, Hee-Juhn Park, Jung-Hye Cho. Costunolide induces apoptosis in human endometriotic cells through inhibition of the prosurvival Akt and nuclear factor kappa B signaling pathway. Biological & pharmaceutical bulletin. vol 34. issue 4. 2011-12-06. PMID:21467650. |
we further demonstrated that costunolide inhibited the activation of akt and nuclear factor kappa b (nfκb) and the expression of anti-apoptotic factors b-cell lymphoma-extra lage (bcl-xl) and x-linked inhibitor of apoptosis protein (xiap) in 11z cells. |
2011-12-06 |
2023-08-12 |
human |
| Ji-Hyun Kim, Yeong-In Yang, Kyung-Tae Lee, Hee-Juhn Park, Jung-Hye Cho. Costunolide induces apoptosis in human endometriotic cells through inhibition of the prosurvival Akt and nuclear factor kappa B signaling pathway. Biological & pharmaceutical bulletin. vol 34. issue 4. 2011-12-06. PMID:21467650. |
these results suggest that costunolide induces apoptosis in human endometriotic epithelial cells by inhibiting the prosurvival nfκb and akt pathway, leading to the downregulation of anti-apoptotic protein bcl-xl and xiap and the activation of caspases. |
2011-12-06 |
2023-08-12 |
human |
| Xiangjia Zhu, Kun Guo, Yi L. Selenium effectively inhibits 1,2-dihydroxynaphthalene-induced apoptosis in human lens epithelial cells through activation of PI3-K/Akt pathway. Molecular vision. vol 17. 2011-12-06. PMID:21850177. |
to investigate whether activation of the phosphatidylinositol 3-kinase (pi3-k)/protein kinase b (akt) pathway was necessary for selenium in protecting human lens epithelial cells (hlecs) from 1,2-dihydroxynaphthalene (1,2-dhn)-induced apoptosis. |
2011-12-06 |
2023-08-12 |
human |
| Qiang Guo, Jun Jin, Jason X-J Yuan, Amy Zeifman, Jiwan Chen, Bo Shen, Jianan Huan. VEGF, Bcl-2 and Bad regulated by angiopoietin-1 in oleic acid induced acute lung injury. Biochemical and biophysical research communications. vol 413. issue 4. 2011-12-06. PMID:21939637. |
activation of akt stimulates expression of bcl-2 and inhibits the expression of bad, thus inhibiting the execution of apoptosis. |
2011-12-06 |
2023-08-12 |
mouse |
| Jing Xie, Hua Jiang, Yi-Han Wan, Ai-Ying Du, Kai-Jie Guo, Te Liu, Wei-Yuan Ye, Xin Niu, Jun Wu, Xiao-Qin Dong, Xue-Jun Zhan. Induction of a 55 kDa acetylcholinesterase protein during apoptosis and its negative regulation by the Akt pathway. Journal of molecular cell biology. vol 3. issue 4. 2011-12-02. PMID:21377978. |
induction of a 55 kda acetylcholinesterase protein during apoptosis and its negative regulation by the akt pathway. |
2011-12-02 |
2023-08-12 |
mouse |
| Jing Xie, Hua Jiang, Yi-Han Wan, Ai-Ying Du, Kai-Jie Guo, Te Liu, Wei-Yuan Ye, Xin Niu, Jun Wu, Xiao-Qin Dong, Xue-Jun Zhan. Induction of a 55 kDa acetylcholinesterase protein during apoptosis and its negative regulation by the Akt pathway. Journal of molecular cell biology. vol 3. issue 4. 2011-12-02. PMID:21377978. |
furthermore, activation of the akt cascade abolished the 55 kda protein, and both ache protein forms (68 and 55 kda) accumulated in the nucleus during apoptosis. |
2011-12-02 |
2023-08-12 |
mouse |
| Jing Xie, Hua Jiang, Yi-Han Wan, Ai-Ying Du, Kai-Jie Guo, Te Liu, Wei-Yuan Ye, Xin Niu, Jun Wu, Xiao-Qin Dong, Xue-Jun Zhan. Induction of a 55 kDa acetylcholinesterase protein during apoptosis and its negative regulation by the Akt pathway. Journal of molecular cell biology. vol 3. issue 4. 2011-12-02. PMID:21377978. |
in summary, a 55 kda ache protein resulting from the cleavage of 68 kda ache is induced during apoptosis, and it is negatively regulated by the akt pathway. |
2011-12-02 |
2023-08-12 |
mouse |
| Nikki L Neubauer, Erin C Ward, Parin Patel, Zhenxiao Lu, Irene Lee, Leen J Blok, Payman Hanifi-Moghaddam, Julian Schink, J Julie Ki. Progesterone receptor-B induction of BIRC3 protects endometrial cancer cells from AP1-59-mediated apoptosis. Hormones & cancer. vol 2. issue 3. 2011-11-29. PMID:21760855. |
treatment of pra and prb-expressing ishikawa cells (pra14, prb23), with an akt inhibitor api-59cj-ome (api-59) promoted apoptosis in the presence and absence of the ligand, r5020 preferentially in pra14 cells. |
2011-11-29 |
2023-08-12 |
Not clear |
| Najoua Lalaoui, Aymeric Morlé, Delphine Mérino, Guillaume Jacquemin, Elisabetta Iessi, Alexandre Morizot, Sarah Shirley, Bruno Robert, Eric Solary, Carmen Garrido, Olivier Michea. TRAIL-R4 promotes tumor growth and resistance to apoptosis in cervical carcinoma HeLa cells through AKT. PloS one. vol 6. issue 5. 2011-11-28. PMID:21625476. |
trail-r4 promotes tumor growth and resistance to apoptosis in cervical carcinoma hela cells through akt. |
2011-11-28 |
2023-08-12 |
Not clear |
| B Liu, J K Wen, B H Li, X M Fang, J J Wang, Y P Zhang, C J Shi, D Q Zhang, M Ha. Celecoxib and acetylbritannilactone interact synergistically to suppress breast cancer cell growth via COX-2-dependent and -independent mechanisms. Cell death & disease. vol 2. 2011-11-28. PMID:21796157. |
in addition, inhibition of akt and p38 signaling pathways was required by the synergism, as the constitutively active akt and p38 protected cells against apoptosis and cell cycle arrest induced by the combination treatment. |
2011-11-28 |
2023-08-12 |
Not clear |
| Ruth L Vinall, Christopher M Mahaffey, Ryan R Davis, Zunping Luo, Regina Gandour-Edwards, Paramita M Ghosh, Clifford G Tepper, Ralph W de Vere Whit. Dual blockade of PKA and NF-κB inhibits H2 relaxin-mediated castrate-resistant growth of prostate cancer sublines and induces apoptosis. Hormones & cancer. vol 2. issue 4. 2011-11-25. PMID:21789713. |
combined inhibition of the pka and nf-κb signaling pathways via inhibition of pka and akt induced significant apoptosis and dramatically reduced clonogenic potential, outperforming docetaxel, the standard of care treatment for cr cap. |
2011-11-25 |
2023-08-12 |
Not clear |