| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Li, Ling Xu, Xiujuan Qu, Mingfang Zhao, Ping Yu, Jian Kang, Yunpeng Liu, Xuejun H. Cbl-regulated Akt and ERK signals are involved in β-elemene-induced cell apoptosis in lung cancer cells. Molecular medicine reports. vol 4. issue 6. 2012-01-09. PMID:21837364. |
cbl-regulated akt and erk signals are involved in β-elemene-induced cell apoptosis in lung cancer cells. |
2012-01-09 |
2023-08-12 |
Not clear |
| Lei Li, Ling Xu, Xiujuan Qu, Mingfang Zhao, Ping Yu, Jian Kang, Yunpeng Liu, Xuejun H. Cbl-regulated Akt and ERK signals are involved in β-elemene-induced cell apoptosis in lung cancer cells. Molecular medicine reports. vol 4. issue 6. 2012-01-09. PMID:21837364. |
the aim of the present study was to investigate how cbl-regulated akt and erk affect β-elemene-induced cell apoptosis in lung cancer cells. |
2012-01-09 |
2023-08-12 |
Not clear |
| Lei Li, Ling Xu, Xiujuan Qu, Mingfang Zhao, Ping Yu, Jian Kang, Yunpeng Liu, Xuejun H. Cbl-regulated Akt and ERK signals are involved in β-elemene-induced cell apoptosis in lung cancer cells. Molecular medicine reports. vol 4. issue 6. 2012-01-09. PMID:21837364. |
the inhibition of akt and erk activation rapidly enhanced β-elemene-induced apoptosis, and the up-regulation of c-cbl and cbl-b expression was also detected. |
2012-01-09 |
2023-08-12 |
Not clear |
| Lei Li, Ling Xu, Xiujuan Qu, Mingfang Zhao, Ping Yu, Jian Kang, Yunpeng Liu, Xuejun H. Cbl-regulated Akt and ERK signals are involved in β-elemene-induced cell apoptosis in lung cancer cells. Molecular medicine reports. vol 4. issue 6. 2012-01-09. PMID:21837364. |
these results suggest that cbl-regulated akt and erk signals are involved in β-elemene-induced cell apoptosis in lung cancer cells. |
2012-01-09 |
2023-08-12 |
Not clear |
| Marco F Lombardo, Fabiana De Angelis, Luca Bova, Barbara Bartolini, Federico Bertuzzi, Rita Nano, Barbara Capuani, Renato Lauro, Massimo Federici, Davide Lauro, Giulia Donade. Human placental lactogen (hPL-A) activates signaling pathways linked to cell survival and improves insulin secretion in human pancreatic islets. Islets. vol 3. issue 5. 2012-01-05. PMID:21765243. |
we showed that hpl-a inhibits apoptosis, both in insulinoma and human islets, by the phosphorylation of akt protein. |
2012-01-05 |
2023-08-12 |
human |
| Jixia Li, Yeon-Yong Cho, Alyssa Langfald, Andria Carper, Ronald A Lubet, Clinton J Grubbs, Marna E Ericson, Ann M Bod. Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 8. 2012-01-05. PMID:21791570. |
these results combined with immunoreactivity data indicated that, in addition to egfr and her2, lapatinib treatment was associated with changes in a number of other signaling molecules, including igf-1r, akt, and downstream targets such as gsk3, p27, p53, and cyclin d1 presumably leading to impaired proliferation, apoptosis, or cell-cycle arrest. |
2012-01-05 |
2023-08-12 |
human |
| Lilja E Laatikainen, Mariarosaria Incoronato, Maria Domenica Castellone, Juha P Laurila, Massimo Santoro, Mikko O Laukkane. SOD3 decreases ischemic injury derived apoptosis through phosphorylation of Erk1/2, Akt, and FoxO3a. PloS one. vol 6. issue 8. 2012-01-05. PMID:21909393. |
sod3 decreases ischemic injury derived apoptosis through phosphorylation of erk1/2, akt, and foxo3a. |
2012-01-05 |
2023-08-12 |
rat |
| Lilja E Laatikainen, Mariarosaria Incoronato, Maria Domenica Castellone, Juha P Laurila, Massimo Santoro, Mikko O Laukkane. SOD3 decreases ischemic injury derived apoptosis through phosphorylation of Erk1/2, Akt, and FoxO3a. PloS one. vol 6. issue 8. 2012-01-05. PMID:21909393. |
since both superoxide anion and hydrogen peroxide have a marked impact on signal transduction pathways and could potentially explain a number of apoptosis and survival -related phenomena in different pathological conditions, we clarified the impact of sod3 on akt and erk1/2 cell survival pathways in rat hind limb injury model. |
2012-01-05 |
2023-08-12 |
rat |
| Mio Yamamoto-Sugitani, Junya Kuroda, Eishi Ashihara, Hisao Nagoshi, Tsutomu Kobayashi, Yosuke Matsumoto, Nana Sasaki, Yuji Shimura, Miki Kiyota, Ryuko Nakayama, Kenichi Akaji, Tomohiko Taki, Nobuhiko Uoshima, Yutaka Kobayashi, Shigeo Horiike, Taira Maekawa, Masafumi Taniwak. Galectin-3 (Gal-3) induced by leukemia microenvironment promotes drug resistance and bone marrow lodgment in chronic myelogenous leukemia. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 42. 2011-12-30. PMID:21987825. |
enforced expression of gal-3 activated akt and erk, induced accumulation of mcl-1, and promoted in vitro cell proliferation, multidrug resistance to tyrosine kinase inhibitors for bcr-abl and genotoxic agents as a result of impaired apoptosis induction, and chemotactic cell migration to hs-5-derived soluble factors in cml cell lines independently of bcr-abl tyrosine kinase. |
2011-12-30 |
2023-08-12 |
mouse |
| Pei-Yu Chou, Guan-Jhong Huang, Chun-Hsu Pan, Yi-Chung Chien, Ying-Yi Chen, Chieh-Hsi Wu, Ming-Jyh Sheu, Hsu-Chen Chen. Trilinolein inhibits proliferation of human non-small cell lung carcinoma A549 through the modulation of PI3K/Akt pathway. The American journal of Chinese medicine. vol 39. issue 4. 2011-12-29. PMID:21721158. |
our results demonstrated that the most important regulators of trilinolein-induced apoptosis are bcl-2 family and caspase-3, which are associated with cytochrome c release and dephosphorylation on the akt signaling pathway. |
2011-12-29 |
2023-08-12 |
human |
| Xiaocheng Feng, Bin Lu, Yingying Xu, Qin Li, Wenbai Zhou, Zhihong Yang, Zeng Yang, Weiwei Zhao, Zonghou Shen, Renming H. Aspirin reduces the apoptotic effect of etoposide via Akt activation and up-regulation of p21(cip). International journal of molecular medicine. vol 28. issue 4. 2011-12-28. PMID:21617849. |
p21(cip), an important substrate of akt, is involved in the regulation of cell cycle arrest and apoptosis. |
2011-12-28 |
2023-08-12 |
human |
| Xiaocheng Feng, Bin Lu, Yingying Xu, Qin Li, Wenbai Zhou, Zhihong Yang, Zeng Yang, Weiwei Zhao, Zonghou Shen, Renming H. Aspirin reduces the apoptotic effect of etoposide via Akt activation and up-regulation of p21(cip). International journal of molecular medicine. vol 28. issue 4. 2011-12-28. PMID:21617849. |
these results indicated that the anti-apoptotic effect of aspirin was dependent on activation of akt which inhibited cell apoptosis by up-regulating p21(cip) and blocking caspase-3 activation. |
2011-12-28 |
2023-08-12 |
human |
| Masashi Yanae, Masanobu Tsubaki, Takao Satou, Tatsuki Itoh, Motohiro Imano, Yuzuru Yamazoe, Shozo Nishid. Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma. Journal of experimental & clinical cancer research : CR. vol 30. 2011-12-28. PMID:21831290. |
statin-induced apoptosis via the suppression of erk1/2 and akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma. |
2011-12-28 |
2023-08-12 |
Not clear |
| Ling Zhang, Hui Yang, Huanying Zhao, Chunli Zha. Calcium-related signaling pathways contributed to dopamine-induced cortical neuron apoptosis. Neurochemistry international. vol 58. issue 3. 2011-12-27. PMID:21134408. |
meanwhile, we found that although 24h dopamine and skf83959 treatments have not produced major apoptosis, they induced significant neuronal dendrite retraction as well as reduction of neurotrophic molecules such as phosphorylated akt, erk and bcl-2 through plc-sensitive pathways. |
2011-12-27 |
2023-08-12 |
Not clear |
| Arie J Hoogendijk, Sander H Diks, Maikel P Peppelenbosch, Tom Van Der Poll, Catharina W Wielan. Kinase activity profiling of gram-negative pneumonia. Molecular medicine (Cambridge, Mass.). vol 17. issue 7-8. 2011-12-27. PMID:21424109. |
akt signaling was represented in both metabolic and inflammatory (mitogen-activated protein kinase kinase 2 [mkk], apoptosis signal-regulating kinase/mitogen-activated protein kinase kinase kinase 5 [ask] and v-raf murine sarcoma viral oncogene homolog b1 [b-raf]) context. |
2011-12-27 |
2023-08-12 |
mouse |
| Shahab Uddin, Zeenath Jehan, Maqbool Ahmed, Aisha Alyan, Fouad Al-Dayel, Azhar Hussain, Prashant Bavi, Khawla S Al-Kuray. Overexpression of fatty acid synthase in Middle Eastern epithelial ovarian carcinoma activates AKT and Its inhibition potentiates cisplatin-induced apoptosis. Molecular medicine (Cambridge, Mass.). vol 17. issue 7-8. 2011-12-27. PMID:21442130. |
overexpression of fatty acid synthase in middle eastern epithelial ovarian carcinoma activates akt and its inhibition potentiates cisplatin-induced apoptosis. |
2011-12-27 |
2023-08-12 |
mouse |
| Dayanidhi Raman, Snjezana-Zaja Milatovic, Dejan Milatovic, Ryan Splittgerber, Guo-Huang Fan, Ann Richmon. Chemokines, macrophage inflammatory protein-2 and stromal cell-derived factor-1α, suppress amyloid β-induced neurotoxicity. Toxicology and applied pharmacology. vol 256. issue 3. 2011-12-27. PMID:21704645. |
pretreatment with mip-2 or sdf-1α significantly protected neurons from aβ-induced dendritic regression and apoptosis in vitro through activation of akt, erk1/2 and maintenance of metalloproteinase adam17 especially with sdf-1α. |
2011-12-27 |
2023-08-12 |
mouse |
| Chung-Jung Liu, Jeng-Fan Lo, Chia-Hua Kuo, Chun-Hsien Chu, Li-Ming Chen, Fuu-Jen Tsai, Chang-Hai Tsai, Bor-Show Tzang, Wei-Wen Kuo, Chih-Yang Huan. Akt mediates 17beta-estradiol and/or estrogen receptor-alpha inhibition of LPS-induced tumor necresis factor-alpha expression and myocardial cell apoptosis by suppressing the JNK1/2-NFkappaB pathway. Journal of cellular and molecular medicine. vol 13. issue 9B. 2011-12-23. PMID:20196785. |
akt mediates 17beta-estradiol and/or estrogen receptor-alpha inhibition of lps-induced tumor necresis factor-alpha expression and myocardial cell apoptosis by suppressing the jnk1/2-nfkappab pathway. |
2011-12-23 |
2023-08-12 |
Not clear |
| Chung-Jung Liu, Jeng-Fan Lo, Chia-Hua Kuo, Chun-Hsien Chu, Li-Ming Chen, Fuu-Jen Tsai, Chang-Hai Tsai, Bor-Show Tzang, Wei-Wen Kuo, Chih-Yang Huan. Akt mediates 17beta-estradiol and/or estrogen receptor-alpha inhibition of LPS-induced tumor necresis factor-alpha expression and myocardial cell apoptosis by suppressing the JNK1/2-NFkappaB pathway. Journal of cellular and molecular medicine. vol 13. issue 9B. 2011-12-23. PMID:20196785. |
these findings suggest that e(2), bsa-e(2) and eralpha expression exert their cardioprotective effects by inhibiting jnk1/2-mediated lps-induced tnf-alpha expression and cardiomyocyte apoptosis through activation of akt. |
2011-12-23 |
2023-08-12 |
Not clear |
| Somsankar Dasgupta, Guanghu Wang, Robert K Y. Sulfoglucuronosyl paragloboside promotes endothelial cell apoptosis in inflammation: elucidation of a novel glycosphingolipid-signaling pathway. Journal of neurochemistry. vol 119. issue 4. 2011-12-23. PMID:21916893. |
although sgpg-mediated endothelial cell apoptosis was preceded by inhibiting the intracellular nf-κb activity, interfering with akt and erk activation and stimulating caspase 3 in sv-hcecs, hnk-1st sirna transfection also interfered with iκb phosphorylation but stimulated erk activation. |
2011-12-23 |
2023-08-12 |
human |