Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Howard Goldberg, Catharine Whiteside, I George Fantu. O-linked β-N-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cells. American journal of physiology. Endocrinology and metabolism. vol 301. issue 4. 2011-11-18. PMID:21712532. |
the high-glucose-stimulated kinase activity of apoptosis signal-regulating kinase 1 (ask1), an upstream mapk kinase kinase for p38 that is negatively regulated by akt, was inhibited by ogt shrna. |
2011-11-18 |
2023-08-12 |
rat |
Tsun-Wen Yao, Woo-Shin Kim, Denise M T Yu, George Sharbeen, Geoffrey W McCaughan, Kang-Yell Choi, Pu Xia, Mark D Gorrel. A novel role of dipeptidyl peptidase 9 in epidermal growth factor signaling. Molecular cancer research : MCR. vol 9. issue 7. 2011-11-14. PMID:21622624. |
dpp9 overexpression caused apoptosis and significantly less epidermal growth factor (egf)-mediated akt activation in hepg2 cells. |
2011-11-14 |
2023-08-12 |
human |
Yan Huang, Qian Liu, Kun Liu, Kazumi Yagasaki, Guoying Zhan. Suppression of growth of highly-metastatic human breast cancer cells by norcantharidin and its mechanisms of action. Cytotechnology. vol 59. issue 3. 2011-11-10. PMID:19603282. |
induction of apoptosis and cell cycle arrest as well as reduction of bcl-2/bax ratio by nctd may be the important mechanisms of action of nctd suppressing the growth of mda-mb-231 cells, which are associated with inhibition of the akt and nf-kappab signaling. |
2011-11-10 |
2023-08-12 |
human |
Hong-Rong Fei, Geng Chen, Jian-Mei Wang, Feng-Ze Wan. Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation. Cytotechnology. vol 62. issue 5. 2011-11-10. PMID:20842425. |
perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of akt phosphorylation. |
2011-11-10 |
2023-08-12 |
human |
Jinjin Guo, Tongbo Zhu, Lihua Chen, Takashi Nishioka, Takanori Tsuji, Zhi-Xiong J Xiao, Chang Yan Che. Differential sensitization of different prostate cancer cells to apoptosis. Genes & cancer. vol 1. issue 8. 2011-11-10. PMID:21132068. |
in contrast, the addition of hmg sensitizes lncap or pc3 prostate cancer cells harboring an active akt to apoptosis, in which ros is upregulated to induce the upr and gadd153 expression. |
2011-11-10 |
2023-08-12 |
Not clear |
Jinjin Guo, Tongbo Zhu, Lihua Chen, Takashi Nishioka, Takanori Tsuji, Zhi-Xiong J Xiao, Chang Yan Che. Differential sensitization of different prostate cancer cells to apoptosis. Genes & cancer. vol 1. issue 8. 2011-11-10. PMID:21132068. |
the concurrent activation of jnk1 and akt has an additive effect on apoptosis following pkc suppression. |
2011-11-10 |
2023-08-12 |
Not clear |
Jinjin Guo, Tongbo Zhu, Lihua Chen, Takashi Nishioka, Takanori Tsuji, Zhi-Xiong J Xiao, Chang Yan Che. Differential sensitization of different prostate cancer cells to apoptosis. Genes & cancer. vol 1. issue 8. 2011-11-10. PMID:21132068. |
thus, the data identify akt and jnk1 as potential targets in prostate cancer cells for pkc inhibition-induced apoptosis. |
2011-11-10 |
2023-08-12 |
Not clear |
Mai Yamauchi, Ikuyo Yoshino, Rui Yamaguchi, Teppei Shimamura, Masao Nagasaki, Seiya Imoto, Atsushi Niida, Fumiaki Koizumi, Takashi Kohno, Jun Yokota, Satoru Miyano, Noriko Goto. N-cadherin expression is a potential survival mechanism of gefitinib-resistant lung cancer cells. American journal of cancer research. vol 1. issue 7. 2011-11-10. PMID:22016830. |
inhibition of n-cadherin expression by sirna or treatment with antibodies against n-cadherin induced apoptosis of pc9/zd cells in association with reduced phosphorylation of akt and bad, a proapoptotic protein. |
2011-11-10 |
2023-08-12 |
Not clear |
Jenny E Hernandez-Davies, Joan P Zape, Elliot M Landaw, Xiaolin Tan, Ajia Presnell, Diana Griffith, Michael C Heinrich, Keith B Glaser, Kathleen M Sakamot. The multitargeted receptor tyrosine kinase inhibitor linifanib (ABT-869) induces apoptosis through an Akt and glycogen synthase kinase 3β-dependent pathway. Molecular cancer therapeutics. vol 10. issue 6. 2011-11-09. PMID:21471285. |
the multitargeted receptor tyrosine kinase inhibitor linifanib (abt-869) induces apoptosis through an akt and glycogen synthase kinase 3β-dependent pathway. |
2011-11-09 |
2023-08-12 |
Not clear |
Jonathan R Hart, Peter K Vog. Phosphorylation of AKT: a mutational analysis. Oncotarget. vol 2. issue 6. 2011-11-08. PMID:21670491. |
a gain of function in akt can lead to uncontrolled cell proliferation and resistance to apoptosis, both hallmarks of oncogenic transformation. |
2011-11-08 |
2023-08-12 |
Not clear |
Dong-Oh Moon, Yung Hyun Choi, Gi-Young Ki. Role of p21 in SP600125-induced cell cycle arrest, endoreduplication, and apoptosis. Cellular and molecular life sciences : CMLS. vol 68. issue 19. 2011-11-07. PMID:21311948. |
akt-mediated phosphorylation of p21 and protection of apoptosis are completely abolished by inhibitors of pi3k and akt. |
2011-11-07 |
2023-08-12 |
human |
Gang Yin, Ling-Yun Li, Min Qu, Hong-Bin Luo, Jian-Zhi Wang, Xin-Wen Zho. Upregulation of AKT attenuates amyloid-β-induced cell apoptosis. Journal of Alzheimer's disease : JAD. vol 25. issue 2. 2011-11-04. PMID:21422525. |
upregulation of akt attenuates amyloid-β-induced cell apoptosis. |
2011-11-04 |
2023-08-12 |
Not clear |
Gang Yin, Ling-Yun Li, Min Qu, Hong-Bin Luo, Jian-Zhi Wang, Xin-Wen Zho. Upregulation of AKT attenuates amyloid-β-induced cell apoptosis. Journal of Alzheimer's disease : JAD. vol 25. issue 2. 2011-11-04. PMID:21422525. |
akt is a pivotal molecule in regulating neuronal survival, however, it is still not known whether upregulation of akt can protect the cells from the aβ-induced apoptosis. |
2011-11-04 |
2023-08-12 |
Not clear |
Gang Yin, Ling-Yun Li, Min Qu, Hong-Bin Luo, Jian-Zhi Wang, Xin-Wen Zho. Upregulation of AKT attenuates amyloid-β-induced cell apoptosis. Journal of Alzheimer's disease : JAD. vol 25. issue 2. 2011-11-04. PMID:21422525. |
by using cell viability assay and flow cytometry, we demonstrated in the present study that overexpression of akt could significantly attenuate the cell apoptosis induced by aβ1-42, whereas simultaneous inhibition of pi3 k, the immediate upstream stimulator of akt, abolished the protective effect of akt in hek293 cells. |
2011-11-04 |
2023-08-12 |
Not clear |
Lei Pei, Pingfang Xie, Enxiang Zhou, Qian Yang, Yi Luo, Zhonghua Tan. Overexpression of DEP domain containing mTOR-interacting protein correlates with poor prognosis in differentiated thyroid carcinoma. Molecular medicine reports. vol 4. issue 5. 2011-11-01. PMID:21643629. |
previous studies reveal that high deptor expression is required to maintain pi3k and akt activation and to inhibit apoptosis. |
2011-11-01 |
2023-08-12 |
Not clear |
Naotoshi Sugimoto, Shinji Miwa, Takako Ohno-Shosaku, Hiroyuki Tsuchiya, Yoshiaki Hitomi, Hiroyuki Nakamura, Katsuro Tomita, Akihiro Yachie, Shoichi Koizum. Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells. Neuroscience letters. vol 497. issue 1. 2011-10-31. PMID:21529704. |
the phosphorylation of akt, which is one of the key molecules downstream of pi3k, inhibits apoptosis. |
2011-10-31 |
2023-08-12 |
rat |
Naotoshi Sugimoto, Shinji Miwa, Takako Ohno-Shosaku, Hiroyuki Tsuchiya, Yoshiaki Hitomi, Hiroyuki Nakamura, Katsuro Tomita, Akihiro Yachie, Shoichi Koizum. Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells. Neuroscience letters. vol 497. issue 1. 2011-10-31. PMID:21529704. |
these results suggested that camp-induced apoptosis may be mediated by pten activation and akt inhibition through protein phosphatase in b92 cells. |
2011-10-31 |
2023-08-12 |
rat |
Nakhle S Saba, Laura S Lev. Apoptotic induction in B-cell acute lymphoblastic leukemia cell lines treated with a protein kinase Cβ inhibitor. Leukemia & lymphoma. vol 52. issue 5. 2011-10-27. PMID:21271861. |
treatment resulted in a rapid induction of poly(adp-ribose) polymerase (parp) cleavage, indicating caspase-3-mediated apoptosis, and a rapid reduction in phosphorylation of akt and its downstream target glycogen synthase kinase 3β (gsk3β). |
2011-10-27 |
2023-08-12 |
Not clear |
Steve A Maxwell, Evan M Cherry, Kayla J Bayles. Akt, 14-3-3ζ, and vimentin mediate a drug-resistant invasive phenotype in diffuse large B-cell lymphoma. Leukemia & lymphoma. vol 52. issue 5. 2011-10-27. PMID:21323512. |
two-dimensional differential in-gel (dige) analysis identified 10 differentially expressed proteins between chop-sensitive and -resistant dlbcl cells that play roles in glycolysis (triosephosphate isomerase-1, enolase-1), cytoskeletal structure (ezrin, vimentin, tubulin-specific chaperone b), purine biosynthesis (serine hydroxymethyltransferase), calcium binding (sorcin), and apoptosis (p53, 14-3-3ζ, akt). |
2011-10-27 |
2023-08-12 |
Not clear |
Miroslav Zavoral, Petra Minarikova, Filip Zavada, Cyril Salek, Marek Minari. Molecular biology of pancreatic cancer. World journal of gastroenterology. vol 17. issue 24. 2011-10-27. PMID:21734801. |
the most characteristic aberrations (somatic point mutations and allelic losses) affect oncogenes and tumor-suppressor genes within ras, akt and wnt signaling, and have a key role in transcription and proliferation, as well as systems that regulate the cell cycle (smad/dpc, cdkn2a/p16) and apoptosis (tp53). |
2011-10-27 |
2023-08-12 |
Not clear |