| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthias D Sury, Lorianne Vorlet-Fawer, Claudia Agarinis, Shida Yousefi, Denis Grandgirard, Stephen L Leib, Stephan Christe. Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis. Neurobiology of disease. vol 41. issue 1. 2011-09-27. PMID:20875857. |
these results indicate that the inhibitory effect of bpv(pic) on apoptosis was mediated by pi3k-dependent activation of akt, strongly suggesting that bpv(pic) acted on pten. |
2011-09-27 |
2023-08-12 |
rat |
| Shun-Chao Yan, Yun-Peng Liu, Ling-Yun Zhang, Jing-Lei Qu, Ling Xu, Jing Liu, Ye Zhang, Ke-Zuo Hou, Yue-E Teng, Xiu-Juan Q. Ubiquitin ligase c-Cbl is involved in tamoxifen-induced apoptosis of MCF-7 cells by downregulating the survival signals. Acta oncologica (Stockholm, Sweden). vol 50. issue 5. 2011-09-27. PMID:21175263. |
in the present study, we investigated the roles of c-src, erk, akt and c-cbl ubiquitin ligases during tam-induced apoptosis of mcf-7 cells. |
2011-09-27 |
2023-08-12 |
Not clear |
| Kunyan He, Sung-Wuk Jang, Jayashree Joshi, Min-Heui Yoo, Keqiang Y. Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner. Molecular biology of the cell. vol 22. issue 11. 2011-09-26. PMID:21460185. |
here we show that akt phosphorylates pike-a and regulates its association with unc5b and inhibits unc5b-provoked apoptosis in a p53-dependent manner. |
2011-09-26 |
2023-08-12 |
mouse |
| Kunyan He, Sung-Wuk Jang, Jayashree Joshi, Min-Heui Yoo, Keqiang Y. Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner. Molecular biology of the cell. vol 22. issue 11. 2011-09-26. PMID:21460185. |
hence our findings support the notion that akt--phosphorylated pike-a inhibits unc5b-elicited apoptosis and reduces its expression level through inactivation of p53. |
2011-09-26 |
2023-08-12 |
mouse |
| Tian Tian, Yang Zhao, Shotaro Nakajima, Tao Huang, Jian Yao, Adrienne W Paton, James C Paton, Masanori Kitamur. Cytoprotective roles of ERK and Akt in endoplasmic reticulum stress triggered by subtilase cytotoxin. Biochemical and biophysical research communications. vol 410. issue 4. 2011-09-23. PMID:21703246. |
we found that subab activated erk and akt, and inhibition of individual kinases enhanced subab-triggered apoptosis. |
2011-09-23 |
2023-08-12 |
Not clear |
| Tian Tian, Yang Zhao, Shotaro Nakajima, Tao Huang, Jian Yao, Adrienne W Paton, James C Paton, Masanori Kitamur. Cytoprotective roles of ERK and Akt in endoplasmic reticulum stress triggered by subtilase cytotoxin. Biochemical and biophysical research communications. vol 410. issue 4. 2011-09-23. PMID:21703246. |
dominant-negative inhibition of perk enhanced subab-induced apoptosis and reduced phosphorylation of erk and akt. |
2011-09-23 |
2023-08-12 |
Not clear |
| Tian Tian, Yang Zhao, Shotaro Nakajima, Tao Huang, Jian Yao, Adrienne W Paton, James C Paton, Masanori Kitamur. Cytoprotective roles of ERK and Akt in endoplasmic reticulum stress triggered by subtilase cytotoxin. Biochemical and biophysical research communications. vol 410. issue 4. 2011-09-23. PMID:21703246. |
these results suggest cytoprotective roles of erk and akt in subab-triggered, er stress-mediated apoptosis. |
2011-09-23 |
2023-08-12 |
Not clear |
| Asli Ozmen, Gozde Unek, Dijle Kipmen-Korgun, Emin Turkay Korgu. The expression of Akt and ERK1/2 proteins decreased in dexamethasone-induced intrauterine growth restricted rat placental development. Journal of molecular histology. vol 42. issue 3. 2011-09-22. PMID:21512721. |
moreover it is still not determined that how akt and erk1/2 proteins related proliferation and apoptosis mechanisms are influenced by dexamethasone-induced iugr (intrauterine growth restriction) placentas. |
2011-09-22 |
2023-08-12 |
human |
| Asli Ozmen, Gozde Unek, Dijle Kipmen-Korgun, Emin Turkay Korgu. The expression of Akt and ERK1/2 proteins decreased in dexamethasone-induced intrauterine growth restricted rat placental development. Journal of molecular histology. vol 42. issue 3. 2011-09-22. PMID:21512721. |
the decrease in akt and erk1/2 activations may result with cell survival inhibition or apoptosis stimulation. |
2011-09-22 |
2023-08-12 |
human |
| Chaoyang Liu, Ke Gong, Xin Mao, Wenhua L. Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma. International journal of cancer. vol 129. issue 6. 2011-09-21. PMID:21128229. |
tetrandrine induces apoptosis by activating reactive oxygen species and repressing akt activity in human hepatocellular carcinoma. |
2011-09-21 |
2023-08-12 |
mouse |
| Chaoyang Liu, Ke Gong, Xin Mao, Wenhua L. Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma. International journal of cancer. vol 129. issue 6. 2011-09-21. PMID:21128229. |
in contrast, akt activity was found to be closely related to tetrandrine-induced apoptosis. |
2011-09-21 |
2023-08-12 |
mouse |
| Chaoyang Liu, Ke Gong, Xin Mao, Wenhua L. Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma. International journal of cancer. vol 129. issue 6. 2011-09-21. PMID:21128229. |
the data demonstrated that akt activity inhibitor ly294002 synergistically promoted tetrandrine-induced apoptosis of hcc, whereas ectopic expression of akt contrastly abrogated partial of the tetrandrine-induced apoptosis. |
2011-09-21 |
2023-08-12 |
mouse |
| Chaoyang Liu, Ke Gong, Xin Mao, Wenhua L. Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma. International journal of cancer. vol 129. issue 6. 2011-09-21. PMID:21128229. |
these data suggest that akt signal is the downstream event of ros generation in the tetrandrine-induced hcc cell apoptosis. |
2011-09-21 |
2023-08-12 |
mouse |
| Jeffim N Kuznetsov, Guy J Leclerc, Gilles M Leclerc, Julio C Barred. AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia. Molecular cancer therapeutics. vol 10. issue 3. 2011-09-21. PMID:21262957. |
under these conditions, the concomitant inhibition of akt, a cellular antagonist of ampk, leads to further upregulation of ampk activity and alleviates aicar plus mtx-induced er stress and apoptosis. |
2011-09-21 |
2023-08-12 |
Not clear |
| Joachim Størling, Lisa Juntti-Berggren, Gunilla Olivecrona, Michala C Prause, Per-Olof Berggren, Thomas Mandrup-Poulse. Apolipoprotein CIII reduces proinflammatory cytokine-induced apoptosis in rat pancreatic islets via the Akt prosurvival pathway. Endocrinology. vol 152. issue 8. 2011-09-21. PMID:21693679. |
apolipoprotein ciii reduces proinflammatory cytokine-induced apoptosis in rat pancreatic islets via the akt prosurvival pathway. |
2011-09-21 |
2023-08-12 |
mouse |
| Joachim Størling, Lisa Juntti-Berggren, Gunilla Olivecrona, Michala C Prause, Per-Olof Berggren, Thomas Mandrup-Poulse. Apolipoprotein CIII reduces proinflammatory cytokine-induced apoptosis in rat pancreatic islets via the Akt prosurvival pathway. Endocrinology. vol 152. issue 8. 2011-09-21. PMID:21693679. |
inhibition of the akt signaling pathway by the phosphatidylinositol 3 kinase inhibitor ly294002 counteracted the antiapoptotic effect of apociii on cytokine-induced apoptosis. |
2011-09-21 |
2023-08-12 |
mouse |
| Joachim Størling, Lisa Juntti-Berggren, Gunilla Olivecrona, Michala C Prause, Per-Olof Berggren, Thomas Mandrup-Poulse. Apolipoprotein CIII reduces proinflammatory cytokine-induced apoptosis in rat pancreatic islets via the Akt prosurvival pathway. Endocrinology. vol 152. issue 8. 2011-09-21. PMID:21693679. |
we conclude that apociii in the presence of t1d-relevant proinflammatory cytokines reduces rat pancreatic islet cell apoptosis via akt. |
2011-09-21 |
2023-08-12 |
mouse |
| Nicolaus Friedrichs, Marcel Trautmann, Elmar Endl, Elisabeth Sievers, Dagmar Kindler, Peter Wurst, Jacqueline Czerwitzki, Susanne Steiner, Marcus Renner, Roland Penzel, Arend Koch, Olle Larsson, Shinya Tanaka, Akira Kawai, Peter Schirmacher, Gunhild Mechtersheimer, Eva Wardelmann, Reinhard Buettner, Wolfgang Hartman. Phosphatidylinositol-3'-kinase/AKT signaling is essential in synovial sarcoma. International journal of cancer. vol 129. issue 7. 2011-09-20. PMID:21128248. |
phosphorylation of akt, gsk-3β and mtor was assessed, and cellular proliferation and apoptosis were analyzed to functionally characterize the effects of pi3k inhibition. |
2011-09-20 |
2023-08-12 |
Not clear |
| Doris Mangiaracina Benbrook, Chioniso Patience Masamh. The pro-survival function of Akt kinase can be overridden or altered to contribute to induction of apoptosis. Current cancer drug targets. vol 11. issue 5. 2011-09-16. PMID:21486222. |
the pro-survival function of akt kinase can be overridden or altered to contribute to induction of apoptosis. |
2011-09-16 |
2023-08-12 |
Not clear |
| Doris Mangiaracina Benbrook, Chioniso Patience Masamh. The pro-survival function of Akt kinase can be overridden or altered to contribute to induction of apoptosis. Current cancer drug targets. vol 11. issue 5. 2011-09-16. PMID:21486222. |
the serine/threonine protein kinase b (pkb), which is now called akt, has well-documented oncogenic potential and pro-survival activities that can counteract apoptosis induced by anti-cancer drugs. |
2011-09-16 |
2023-08-12 |
Not clear |