| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Doris Mangiaracina Benbrook, Chioniso Patience Masamh. The pro-survival function of Akt kinase can be overridden or altered to contribute to induction of apoptosis. Current cancer drug targets. vol 11. issue 5. 2011-09-16. PMID:21486222. |
this background provides a basis for understanding how specific chemotherapeutic agents and cellular conditions can overcome the akt pro-survival signal or alter akt signaling in a way that converts akt kinase activity to be directly involved in the induction of apoptosis. |
2011-09-16 |
2023-08-12 |
Not clear |
| Irene Paterniti, Emanuela Esposito, Emanuela Mazzon, Placido Bramanti, Salvatore Cuzzocre. Evidence for the role of PI(3) -kinase-AKT-eNOS signalling pathway in secondary inflammatory process after spinal cord compression injury in mice. The European journal of neuroscience. vol 33. issue 8. 2011-09-16. PMID:21496122. |
in this study we clearly demonstrated that pre-treatment with ly294002 reversed the increased activation of enos and akt observed following sci, and developed a severe trauma characterized by oedema, tissue damage and apoptosis (measured by tunel staining, bax, bcl-2 and fas-l expression). |
2011-09-16 |
2023-08-12 |
mouse |
| Mao Lin, Shan-Shan Lu, Ao-Xue Wang, Xiao-Yi Qi, Dan Zhao, Zhao-Hui Wang, Mao-Qiang Man, Cai-Xia T. Apigenin attenuates dopamine-induced apoptosis in melanocytes via oxidative stress-related p38, c-Jun NH2-terminal kinase and Akt signaling. Journal of dermatological science. vol 63. issue 1. 2011-09-16. PMID:21514118. |
apigenin attenuates dopamine-induced apoptosis in melanocytes via oxidative stress-related p38, c-jun nh2-terminal kinase and akt signaling. |
2011-09-16 |
2023-08-12 |
Not clear |
| Hope M Amm, Patsy G Oliver, Choo Hyung Lee, Yufeng Li, Donald J Buchsbau. Combined modality therapy with TRAIL or agonistic death receptor antibodies. Cancer biology & therapy. vol 11. issue 5. 2011-09-14. PMID:21263219. |
this review provides an overview of the mechanisms associated with chemotherapy enhancement of trail receptor-targeted therapies including modulation of the apoptotic (death receptor expression, flip, and bcl-2 or inhibitors of apoptosis (iap) families) as well as cell signaling (nfκb, akt, p53) pathways. |
2011-09-14 |
2023-08-12 |
human |
| Ragu Kanagasabai, Krishnamurthy Karthikeyan, Kaushik Vedam, Wang Qien, Qianzheng Zhu, Govindasamy Ilangova. Hsp27 protects adenocarcinoma cells from UV-induced apoptosis by Akt and p21-dependent pathways of survival. Molecular cancer research : MCR. vol 8. issue 10. 2011-09-13. PMID:20858736. |
hsp27 protects adenocarcinoma cells from uv-induced apoptosis by akt and p21-dependent pathways of survival. |
2011-09-13 |
2023-08-12 |
human |
| Ana Sofia Martins, José Luis Ordóñez, Ana Teresa Amaral, Frans Prins, Giuseppe Floris, Maria Debiec-Rychter, Pancras C W Hogendoorn, Enrique de Alav. IGF1R signaling in Ewing sarcoma is shaped by clathrin-/caveolin-dependent endocytosis. PloS one. vol 6. issue 5. 2011-09-12. PMID:21611203. |
the blockage of receptor internalization inhibited akt and mapk phosphorylation, reducing the proliferative rate of es cells and increasing the levels of apoptosis. |
2011-09-12 |
2023-08-12 |
Not clear |
| Takayuki Yamaguchi, Reina Kakefuda, Nobuyuki Tajima, Yoshihiro Sowa, Toshiyuki Saka. Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo. International journal of oncology. vol 39. issue 1. 2011-09-09. PMID:21523318. |
treatment with an akt inhibitor enhanced the jtp-74057-induced apoptosis in ht-29 cells. |
2011-09-09 |
2023-08-12 |
mouse |
| Takayuki Yamaguchi, Reina Kakefuda, Nobuyuki Tajima, Yoshihiro Sowa, Toshiyuki Saka. Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo. International journal of oncology. vol 39. issue 1. 2011-09-09. PMID:21523318. |
sensitivity to jtp-74057-induced apoptosis may be an important factor for the estimation of in vivo efficacy, and sensitivity was enhanced by an akt inhibitor. |
2011-09-09 |
2023-08-12 |
mouse |
| Weinong Han, Mei Ming, Yu-Ying H. Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair. The Journal of biological chemistry. vol 286. issue 26. 2011-09-09. PMID:21561856. |
inhibiting atr pathways by sirna targeting atr had little effect on uvb-induced apoptosis or akt activation, indicating that the inhibitory effect of caffeine on apoptosis and the akt pathway does not require the atr pathway. |
2011-09-09 |
2023-08-12 |
mouse |
| Weinong Han, Mei Ming, Yu-Ying H. Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair. The Journal of biological chemistry. vol 286. issue 26. 2011-09-09. PMID:21561856. |
expression of constitutively active akt that was not inhibited by caffeine was found to protect cells from caffeine-promoted apoptosis post-uvb irradiation, indicating that akt is an essential inhibitory target for caffeine to promote apoptosis. |
2011-09-09 |
2023-08-12 |
mouse |
| Felix Junyent, Daniel Alvira, Marc Yeste-Velasco, Aurelio Vazquez de la Torre, Carlos Beas-Zarate, Francesc X Sureda, Jaume Folch, Mercè Pallàs, Antoni Camins, Ester Verdague. Prosurvival role of JAK/STAT and Akt signaling pathways in MPP+-induced apoptosis in neurons. Neurochemistry international. vol 57. issue 7. 2011-09-07. PMID:20817061. |
prosurvival role of jak/stat and akt signaling pathways in mpp+-induced apoptosis in neurons. |
2011-09-07 |
2023-08-12 |
Not clear |
| Felix Junyent, Daniel Alvira, Marc Yeste-Velasco, Aurelio Vazquez de la Torre, Carlos Beas-Zarate, Francesc X Sureda, Jaume Folch, Mercè Pallàs, Antoni Camins, Ester Verdague. Prosurvival role of JAK/STAT and Akt signaling pathways in MPP+-induced apoptosis in neurons. Neurochemistry international. vol 57. issue 7. 2011-09-07. PMID:20817061. |
in the present study the role of jak/stat and akt in apoptosis was evaluated in cerebellar granule cells after treatment with the mitochondrial toxin mpp(+). |
2011-09-07 |
2023-08-12 |
Not clear |
| Felix Junyent, Daniel Alvira, Marc Yeste-Velasco, Aurelio Vazquez de la Torre, Carlos Beas-Zarate, Francesc X Sureda, Jaume Folch, Mercè Pallàs, Antoni Camins, Ester Verdague. Prosurvival role of JAK/STAT and Akt signaling pathways in MPP+-induced apoptosis in neurons. Neurochemistry international. vol 57. issue 7. 2011-09-07. PMID:20817061. |
firstly, we evaluated the role of the prosurvival akt pathway in mpp(+)-induced apoptosis and found that mpp(+) rapidly reduced the phosphorylation of akt at ser473. |
2011-09-07 |
2023-08-12 |
Not clear |
| Felix Junyent, Daniel Alvira, Marc Yeste-Velasco, Aurelio Vazquez de la Torre, Carlos Beas-Zarate, Francesc X Sureda, Jaume Folch, Mercè Pallàs, Antoni Camins, Ester Verdague. Prosurvival role of JAK/STAT and Akt signaling pathways in MPP+-induced apoptosis in neurons. Neurochemistry international. vol 57. issue 7. 2011-09-07. PMID:20817061. |
since pten is an upstream regulator of akt, its inhibition with bpv(pic) (1-30 μm) should activate akt, however, it did not attenuate cgc cell death mediated by mpp(+) but protected cgc from apoptosis mediated by s/k deprivation. |
2011-09-07 |
2023-08-12 |
Not clear |
| Sarit Kahana, Susan Finniss, Simona Cazacu, Cunli Xiang, Hae-Kyung Lee, Shlomit Brodie, Ronald S Goldstein, Vered Roitman, Shimon Slavin, Tom Mikkelsen, Chaya Brodi. Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKCε-dependent downregulation of AKT and XIAP expressions. Cellular signalling. vol 23. issue 8. 2011-09-02. PMID:21440622. |
proteasome inhibitors sensitize glioma cells and glioma stem cells to trail-induced apoptosis by pkcε-dependent downregulation of akt and xiap expressions. |
2011-09-02 |
2023-08-12 |
Not clear |
| Winnie W S Kum, Bernard C Lo, Hong B Yu, B Brett Finla. Protective role of Akt2 in Salmonella enterica serovar typhimurium-induced gastroenterocolitis. Infection and immunity. vol 79. issue 7. 2011-09-02. PMID:21555401. |
the salmonella effector protein sopb has previously been shown to induce activation of akt and protect epithelial cells from apoptosis in vitro. |
2011-09-02 |
2023-08-12 |
mouse |
| Putri A Agustian, Mario Schiffer, Wilfried Gwinner, Irini Schäfer, Katharina Theophile, Friedrich Modde, Clemens L Bockmeyer, Jana Traeder, Ulrich Lehmann, Anika Grosshennig, Hans H Kreipe, Verena Bröcker, Jan U Becke. Diminished met signaling in podocytes contributes to the development of podocytopenia in transplant glomerulopathy. The American journal of pathology. vol 178. issue 5. 2011-08-26. PMID:21514418. |
in vitro, hgf stimulation of podocytes resulted in antiapoptotic phosphorylation of akt and extracellular signal-regulated kinase (erk) and induction of x-linked inhibitor of apoptosis protein (xiap). |
2011-08-26 |
2023-08-12 |
Not clear |
| Wen Ji Li, Seung-June O. PARP inhibition prevents oxidative injury of bladder induced by acute urinary retention and subsequent emptying. Apoptosis : an international journal on programmed cell death. vol 16. issue 6. 2011-08-25. PMID:21416227. |
the degree of bladder apoptosis, levels of malondialdehyde (mda), atp and nicotinamide adenine dinucleotide (nad+); expression of poly(adp-ribose) (par), phosphorylation of protein kinase b (akt); and levels of bcl-2, bax, and caspase 3 activity in the bladder were determined. |
2011-08-25 |
2023-08-12 |
rat |
| Wen Ji Li, Seung-June O. PARP inhibition prevents oxidative injury of bladder induced by acute urinary retention and subsequent emptying. Apoptosis : an international journal on programmed cell death. vol 16. issue 6. 2011-08-25. PMID:21416227. |
these results indicate that parp activation may be involved in apoptosis in the bladder induced by aur and subsequent emptying via energy depletion and suppression of akt activity. |
2011-08-25 |
2023-08-12 |
rat |
| Yong-Mei Jiang, Hui Zhang, Lin Yi. Effect of CIPC and intervention of Ca(2+)-regulated factors on CaN, cbl-b and p-AKT expression in neurons. Brain research. vol 1389. 2011-08-23. PMID:21382357. |
cbl-b reduces the phosphorylated expression of akt, ultimately activating apoptosis. |
2011-08-23 |
2023-08-12 |
rat |