| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wilfred Lieberthal, Leiqing Zhang, Vimal A Patel, Jerrold S Levin. AMPK protects proximal tubular cells from stress-induced apoptosis by an ATP-independent mechanism: potential role of Akt activation. American journal of physiology. Renal physiology. vol 301. issue 6. 2012-02-01. PMID:21957177. |
the augmentation of apoptosis induced by inhibition of ampk was comparable to that induced by inhibition of akt. |
2012-02-01 |
2023-08-12 |
mouse |
| Xiuhong Qin, Zhenzhen Zhang, Haitao Xu, Yazhen W. Notch signaling protects retina from nuclear factor-κB- and poly-ADP-ribose-polymerase-mediated apoptosis under high-glucose stimulation. Acta biochimica et biophysica Sinica. vol 43. issue 9. 2012-01-30. PMID:21813561. |
thus, our study demonstrated that notch1 signaling protects cells from parp- and nf-κb-induced apoptosis under high glucose through the activation of akt. |
2012-01-30 |
2023-08-12 |
mouse |
| Sung-Bum Cho, Young-Lan Park, Young-A Song, Kyu-Yeol Kim, Gi-Hoon Lee, Dae-Ho Cho, Dae-Seong Myung, Kang-Jin Park, Wan-Sik Lee, Ik-Joo Chung, Sung-Kyu Choi, Kyung-Keun Kim, Young-Eun Jo. Small interfering RNA-directed targeting of RON alters invasive and oncogenic phenotypes of human hepatocellular carcinoma cells. Oncology reports. vol 26. issue 6. 2012-01-27. PMID:21874262. |
these results suggest that ron is associated with invasive and oncogenic phenotypes such as tumor cell migration, invasion, resistance to apoptosis and cell cycle arrest through the modulation of akt, c-raf and erk signaling cascades in hcc cells. |
2012-01-27 |
2023-08-12 |
human |
| N Fenouille, A Puissant, M Tichet, G Zimniak, P Abbe, A Mallavialle, S Rocchi, J-P Ortonne, M Deckert, R Ballotti, S Tartare-Decker. SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival. Oncogene. vol 30. issue 49. 2012-01-26. PMID:21685937. |
inhibition of akt signaling pathway is important for the observed changes as overexpression of constitutively active akt protects cells against apoptosis induced by sparc depletion. |
2012-01-26 |
2023-08-12 |
human |
| Roberta Castino, Ilaria Fiorentino, Monica Cagnin, Antonino Giovia, Ciro Isidor. Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation. Toxicological sciences : an official journal of the Society of Toxicology. vol 123. issue 2. 2012-01-26. PMID:21742779. |
in conclusion, exogenous h(2)o(2) triggers two parallel independent pathways, one leading to autophagy and autophagy-dependent apoptosis, the other to transient akt phosphorylation, and both are inhibited by dfo. |
2012-01-26 |
2023-08-12 |
human |
| Ki-Eun Hwang, Kyoung-Suk Na, Do-Sim Park, Keum-Ha Choi, Byoung-Ryun Kim, Hyeok Shim, Eun-Taik Jeong, Hak-Ryul Ki. Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Investigational new drugs. vol 29. issue 5. 2012-01-24. PMID:20464445. |
taken together, these data suggest that the anti-cancer effect of simvastatin via induction of apoptosis is related to akt signaling dependent down-regulation of survivin in lung cancer a549 cells. |
2012-01-24 |
2023-08-12 |
human |
| Nan Gao, Jia Yin, Gi Sang Yoon, Qing-Sheng Mi, Fu-Shin X Y. Dendritic cell-epithelium interplay is a determinant factor for corneal epithelial wound repair. The American journal of pathology. vol 179. issue 5. 2012-01-24. PMID:21924232. |
on the other hand, dc depletion resulted in suppressed epithelial akt activation, increased cell apoptosis, and decreased polymorphonuclear leukocyte infiltration in the healing cornea. |
2012-01-24 |
2023-08-12 |
mouse |
| Nian-Gu Chen, Chi-Cheng Lu, Yu-Hsin Lin, Wu-Chung Shen, Cheng-Hung Lai, Yung-Jen Ho, Jing-Gung Chung, Tsai-Hsiu Lin, Yung-Chang Lin, Jai-Sing Yan. Proteomic approaches to study epigallocatechin gallate-provoked apoptosis of TSGH-8301 human urinary bladder carcinoma cells: roles of AKT and heat shock protein 27-modulated intrinsic apoptotic pathways. Oncology reports. vol 26. issue 4. 2012-01-23. PMID:21743966. |
proteomic approaches to study epigallocatechin gallate-provoked apoptosis of tsgh-8301 human urinary bladder carcinoma cells: roles of akt and heat shock protein 27-modulated intrinsic apoptotic pathways. |
2012-01-23 |
2023-08-12 |
mouse |
| Hong Lin, Wei Xiong, Xiang Zhang, Bolin Liu, Wei Zhang, Yongqiang Zhang, Jinxiang Cheng, Huiyong Huan. Notch-1 activation-dependent p53 restoration contributes to resveratrol-induced apoptosis in glioblastoma cells. Oncology reports. vol 26. issue 4. 2012-01-23. PMID:21743969. |
significant de-phosphorylation of akt, increased bax expression, decreased bcl-2 expression and cleavage of caspase-3 were also observed in resveratrol-induced apoptosis in glioblastoma cells. |
2012-01-23 |
2023-08-12 |
Not clear |
| Hong Lin, Wei Xiong, Xiang Zhang, Bolin Liu, Wei Zhang, Yongqiang Zhang, Jinxiang Cheng, Huiyong Huan. Notch-1 activation-dependent p53 restoration contributes to resveratrol-induced apoptosis in glioblastoma cells. Oncology reports. vol 26. issue 4. 2012-01-23. PMID:21743969. |
in addition, the de-phosphorylation of akt, increased expression of bax and cleavage of caspase-3 were not fully reversed by mrk-003 treatment, suggesting that p53 restoration is not the only mechanism underlying resveratrol-induced apoptosis. |
2012-01-23 |
2023-08-12 |
Not clear |
| Yoram Cohen, Nitza Goldenberg-Cohen, Bruria Shalmon, Tali Shani, Shirley Oren, Ninette Amariglio, Olga Dratviman-Storobinsky, Anna Shnaiderman-Shapiro, Ran Yahalom, Ilana Kaplan, Abraham Hirshber. Mutational analysis of PTEN/PIK3CA/AKT pathway in oral squamous cell carcinoma. Oral oncology. vol 47. issue 10. 2012-01-20. PMID:21824802. |
the phosphoinositide 3-kinase (pi3k)/v-akt murine thymoma (akt) viral oncogene pathway is involved in regulating the signaling of multiple biological processes such as apoptosis, metabolism, cell proliferation, and cell growth. |
2012-01-20 |
2023-08-12 |
Not clear |
| Takashi Seki, Toshio Kokuryo, Yukihiro Yokoyama, Hisanori Suzuki, Keita Itatsu, Akifumi Nakagawa, Tetsushi Mizutani, Takashi Miyake, Masanori Uno, Kohei Yamauchi, Masato Nagin. Antitumor effects of α-bisabolol against pancreatic cancer. Cancer science. vol 102. issue 12. 2012-01-20. PMID:21883695. |
α-bisabolol treatment induced apoptosis and suppressed akt activation in pancreatic cancer cell lines. |
2012-01-20 |
2023-08-12 |
mouse |
| Guang-Fen Xiao, Chen-Jiao Yao, Cheng-Hong Wang, Xue-Yuan Tan. [Apoptosis-inducing Effect of 8-Bromo-7-Methoxychrysin on K562 cells]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 3. 2012-01-19. PMID:21729537. |
this study was purposed to investigate the apoptosis-inducing effect of 8-bromo-7-methoxychrysin (brmchr) on leukemia k562 cells as well as the variation of caspase-3 activity and phosphorylated akt (p-akt) expression of k562 cells during the process of apoptosis. |
2012-01-19 |
2023-08-12 |
Not clear |
| Inês Falcão-Pires, Giuseppina Palladini, Nádia Gonçalves, Jolanda van der Velden, Daniel Moreira-Gonçalves, Daniela Miranda-Silva, Francesco Salinaro, Walter J Paulus, Hans W M Niessen, Stefano Perlini, Adelino F Leite-Moreir. Distinct mechanisms for diastolic dysfunction in diabetes mellitus and chronic pressure-overload. Basic research in cardiology. vol 106. issue 5. 2012-01-18. PMID:21533831. |
diabetes increased cardiomyocyte diameter, fibrosis (dm 21.4 ± 0.4 μm, 13.9 ± 1.8%, db 20.6 ± 0.4 μm, 13.8 ± 0.8%, respectively), myofilament ca(2+)sensitivity (dm 5.57 ± 0.02, db 5.57 ± 0.01), advanced glycation end-product deposition (dm 4.9 ± 0.6 score/mm(2), db 5.1 ± 0.4 score/mm(2), sham 2.1 ± 0.3 score/mm(2)), and apoptosis, while decreasing k (tr) (dm 13.5 ± 1.9 s(-1), db 15.2 ± 1.4 s(-1)), akt phosphorylation and mmp-9/timp-1 and mmp-1/timp-1 ratios. |
2012-01-18 |
2023-08-12 |
rat |
| Kévin Ragot, Dominique Delmas, Anne Athias, Thomas Nury, Mauhamad Baarine, Gérard Lizar. α-Tocopherol impairs 7-ketocholesterol-induced caspase-3-dependent apoptosis involving GSK-3 activation and Mcl-1 degradation on 158N murine oligodendrocytes. Chemistry and physics of lipids. vol 164. issue 6. 2012-01-18. PMID:21575614. |
with α-tocopherol (400 μm), which was capable of counteracting 7-ketocholesterol-induced apoptosis, akt and gsk3β dephosphorylation were inhibited as well as mcl-1 degradation. |
2012-01-18 |
2023-08-12 |
Not clear |
| Alison Maddigan, Luke Truitt, Ryan Arsenault, Tanya Freywald, Odette Allonby, Jonathan Dean, Aru Narendran, Jim Xiang, Andrew Weng, Scott Napper, Andrew Freywal. EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 11. 2012-01-13. PMID:22039307. |
ephb receptors trigger akt activation and suppress fas receptor-induced apoptosis in malignant t lymphocytes. |
2012-01-13 |
2023-08-12 |
Not clear |
| Alison Maddigan, Luke Truitt, Ryan Arsenault, Tanya Freywald, Odette Allonby, Jonathan Dean, Aru Narendran, Jim Xiang, Andrew Weng, Scott Napper, Andrew Freywal. EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 11. 2012-01-13. PMID:22039307. |
overall, this demonstrates a new role for ephb receptors in the protection of malignant t cells from fas-induced apoptosis through akt engagement and prevention of caspase activation. |
2012-01-13 |
2023-08-12 |
Not clear |
| Radhamani Kannaiyan, Kanjoormana Aryan Manu, Luxi Chen, Feng Li, Peramaiyan Rajendran, Aruljothi Subramaniam, Paula Lam, Alan Prem Kumar, Gautam Seth. Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways. Apoptosis : an international journal on programmed cell death. vol 16. issue 10. 2012-01-12. PMID:21786165. |
overall, our results indicate that celastrol can inhibit cell proliferation and induce apoptosis through the activation of jnk, suppression of akt, and down-regulation of anti-apoptotic protein expression. |
2012-01-12 |
2023-08-12 |
human |
| Stephen M Weber, Sophia Bornstein, Yuexin Li, Stephen P Malkoski, Donna Wang, Anil K Rustgi, Molly F Kulesz-Martin, Xiao-Jing Wang, Shi-Long L. Tobacco-specific carcinogen nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces AKT activation in head and neck epithelia. International journal of oncology. vol 39. issue 5. 2012-01-09. PMID:21822536. |
finally, nnk exposure to mouse head and neck epithelia resulted in epithelial hyperproliferation and reduced apoptosis, which is correlated with akt activation. |
2012-01-09 |
2023-08-12 |
mouse |
| Jing-Ju Pan, Qing-Shan Chang, Xin Wang, Young-Ok Son, Jiankang Liu, Zhuo Zhang, Yong-Yi Bi, Xianglin Sh. Activation of Akt/GSK3β and Akt/Bcl-2 signaling pathways in nickel-transformed BEAS-2B cells. International journal of oncology. vol 39. issue 5. 2012-01-09. PMID:21837363. |
taken together, these findings demonstrate that activation of akt, followed by gsk3β inhibition and bcl-2, bcl-xl up-regulation and decrease of ros generation, along with a synergistic effect of rb down-regulation may cause apoptosis resistance, contributing to the overall mechanism of nickel carcinogenesis. |
2012-01-09 |
2023-08-12 |
human |