| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gen-fa Lv, Mao-long Dong, Da-hai Hu, Wan-fu Zhang, Yun-chuan Wang, Chao-wu Tang, Xiong-xiang Zh. Insulin-mediated inhibition of p38 mitogen-activated protein kinase protects cardiomyocytes in severe burns. Journal of burn care & research : official publication of the American Burn Association. vol 32. issue 6. 2012-03-26. PMID:21841492. |
thermal injury inhibits akt activation and upregulates p38 mitogen-activated protein kinase, which in turn induces inflammation and increases apoptosis. |
2012-03-26 |
2023-08-12 |
rat |
| Noel A Warfel, Alexandra C Newto. Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling. The Journal of biological chemistry. vol 287. issue 6. 2012-03-25. PMID:22144674. |
phlpp isozymes catalyze the dephosphorylation of a conserved regulatory motif, the hydrophobic motif, on the agc kinases akt, pkc, and s6 kinase, as well as an inhibitory site on the kinase mst1, to inhibit cellular proliferation and induce apoptosis. |
2012-03-25 |
2023-08-12 |
mouse |
| Helena Mertlíková-Kaiserová, Michaela Nejedlá, Antonín Holy, Ivan Votrub. Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates. Anticancer research. vol 32. issue 2. 2012-03-25. PMID:22287737. |
here we investigate the role of erk, p38, jnk and akt kinases in pmeg-induced apoptosis. |
2012-03-25 |
2023-08-12 |
Not clear |
| Ching-Chieh Su, Jia-Ying Yang, Hsin-Ban Leu, Yumay Chen, Ping H Wan. Mitochondrial Akt-regulated mitochondrial apoptosis signaling in cardiac muscle cells. American journal of physiology. Heart and circulatory physiology. vol 302. issue 3. 2012-03-20. PMID:22081709. |
this study was to determine whether activation of akt in mitochondria could inhibit apoptosis of cardiac muscle cells. |
2012-03-20 |
2023-08-12 |
Not clear |
| Ching-Chieh Su, Jia-Ying Yang, Hsin-Ban Leu, Yumay Chen, Ping H Wan. Mitochondrial Akt-regulated mitochondrial apoptosis signaling in cardiac muscle cells. American journal of physiology. Heart and circulatory physiology. vol 302. issue 3. 2012-03-20. PMID:22081709. |
these experiments suggested that mitochondrial akt suppressed apoptosis signaling independent of cytosolic akt in cardiac muscle cells. |
2012-03-20 |
2023-08-12 |
Not clear |
| Zhi-Bo Xing, Lei Yao, Guo-Qiang Zhang, Xian-Yu Zhang, You-Xue Zhang, Da Pan. Fangchinoline inhibits breast adenocarcinoma proliferation by inducing apoptosis. Chemical & pharmaceutical bulletin. vol 59. issue 12. 2012-03-19. PMID:22130369. |
our results indicate that fangchinoline can inhibit breast cancer cell proliferation by inducing apoptosis via the mitochondrial apoptotic pathway and decreasing phosphorylated akt. |
2012-03-19 |
2023-08-12 |
human |
| Huanjun Pan, Dongye Li, Fang Fang, Dan Chen, Lingling Qi, Ruiqu Zhang, Tongda Xu, Hong Su. Salvianolic acid A demonstrates cardioprotective effects in rat hearts and cardiomyocytes after ischemia/reperfusion injury. Journal of cardiovascular pharmacology. vol 58. issue 5. 2012-03-15. PMID:21795988. |
in the present study, we tested cell viability, shortening amplitude, necrosis, apoptosis, and the expression levels of akt, phosphorylated akt, bcl-2, bax, and caspase-3 after 3-hour simulated ischemia and 2- or 6-hour simulated reperfusion in cardiomyocytes. |
2012-03-15 |
2023-08-12 |
rat |
| Yu Wang, Yan Zhao, Ying Liu, Linli Tian, Dejun Ji. Chamaejasmine inactivates Akt to trigger apoptosis in human HEp-2 larynx carcinoma cells. Molecules (Basel, Switzerland). vol 16. issue 10. 2012-03-15. PMID:21952497. |
chamaejasmine inactivates akt to trigger apoptosis in human hep-2 larynx carcinoma cells. |
2012-03-15 |
2023-08-12 |
human |
| Yu Wang, Yan Zhao, Ying Liu, Linli Tian, Dejun Ji. Chamaejasmine inactivates Akt to trigger apoptosis in human HEp-2 larynx carcinoma cells. Molecules (Basel, Switzerland). vol 16. issue 10. 2012-03-15. PMID:21952497. |
in vivo, chamaejasmine intake through gavage resulted in inactivation of akt and induction of apoptosis in hep-2 tumors. |
2012-03-15 |
2023-08-12 |
human |
| Yu Wang, Yan Zhao, Ying Liu, Linli Tian, Dejun Ji. Chamaejasmine inactivates Akt to trigger apoptosis in human HEp-2 larynx carcinoma cells. Molecules (Basel, Switzerland). vol 16. issue 10. 2012-03-15. PMID:21952497. |
these results suggest that akt inactivation and dephosphorylation of bad is a critical event, at least in part, in chamaejasmine-induced hep-2 cells apoptosis. |
2012-03-15 |
2023-08-12 |
human |
| Praveen K Sobhan, Mahendra Seervi, Jeena Joseph, Bhavya Balan Chandrika, Saneesh Varghese, T R Santhoshkumar, M Radhakrishna Pilla. Identification of heat shock protein 90 inhibitors to sensitize drug resistant side population tumor cells using a cell based assay platform. Cancer letters. vol 317. issue 1. 2012-03-15. PMID:22085491. |
hsp90 inhibitors induced down regulation of akt leading to proteasomal degradation of survivin and consequent mitochondrial apoptosis. |
2012-03-15 |
2023-08-12 |
Not clear |
| Songshu Meng, Zhizhi Zhou, Fei Chen, Xiangang Kong, Huairan Liu, Ke Jiang, Wenbo Liu, Maozhi Hu, Xiaorong Zhang, Chan Ding, Yantao W. Newcastle disease virus induces apoptosis in cisplatin-resistant human lung adenocarcinoma A549 cells in vitro and in vivo. Cancer letters. vol 317. issue 1. 2012-03-15. PMID:22095029. |
we found that ndv induced a549/ddp cell apoptosis via the caspase pathway, particularly involving caspase-9, while the mitogen-activated protein kinase (mapk) and akt pathways also contributed to apoptotic induction. |
2012-03-15 |
2023-08-12 |
mouse |
| Guobin Wang, Wenyuan Wang, Jinning Zhao, Yunlan Ni, Xinping Zhou, Weifang Zhan. Ghrelin prevents neuronal apoptosis and cognitive impairments in sepsis-associated encephalopathy. Neuroreport. vol 22. issue 18. 2012-03-13. PMID:22027512. |
these results indicate that ghrelin alleviates neuronal apoptosis and subsequent cognitive impairments in sepsis-associated encephalopathy through the akt pathway. |
2012-03-13 |
2023-08-12 |
rat |
| Dong Joon Kim, Kanamata Reddy, Myoung Ok Kim, Yan Li, Janos Nadas, Yong-Yeon Cho, Jong-Eun Kim, Jung-Hyun Shim, Nu Ry Song, Andria Carper, Ronald A Lubet, Ann M Bode, Zigang Don. (3-Chloroacetyl)-indole, a novel allosteric AKT inhibitor, suppresses colon cancer growth in vitro and in vivo. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 11. 2012-03-12. PMID:21885813. |
akt is a serine/threonine kinase that plays a pivotal role in promoting transformation and chemoresistance by inducing proliferation and inhibiting apoptosis. |
2012-03-12 |
2023-08-12 |
mouse |
| Dong Joon Kim, Kanamata Reddy, Myoung Ok Kim, Yan Li, Janos Nadas, Yong-Yeon Cho, Jong-Eun Kim, Jung-Hyun Shim, Nu Ry Song, Andria Carper, Ronald A Lubet, Ann M Bode, Zigang Don. (3-Chloroacetyl)-indole, a novel allosteric AKT inhibitor, suppresses colon cancer growth in vitro and in vivo. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 11. 2012-03-12. PMID:21885813. |
this compound showed significant inhibition of akt in an in vitro kinase assay and suppressed expression of akt direct downstream targets such as mtor and gsk3β as well as induced growth inhibition and apoptosis in colon cancer cells. |
2012-03-12 |
2023-08-12 |
mouse |
| Takashi Shimizu, Takefumi Kayamori, Chiaki Murayama, Akio Miyamot. Bone morphogenetic protein (BMP)-4 and BMP-7 suppress granulosa cell apoptosis via different pathways: BMP-4 via PI3K/PDK-1/Akt and BMP-7 via PI3K/PDK-1/PKC. Biochemical and biophysical research communications. vol 417. issue 2. 2012-03-12. PMID:22209843. |
akt inhibitor did not induce apoptosis in the bmp-4-treated granulosa cells, whereas it did induce apoptosis of the bmp-7-treated granulosa cells. |
2012-03-12 |
2023-08-12 |
Not clear |
| Mamta Gupta, Andrea E Wahner Hendrickson, Seong Seok Yun, Jing Jing Han, Paula A Schneider, Brian D Koh, Mary J Stenson, Linda E Wellik, Jennifer C Shing, Kevin L Peterson, Karen S Flatten, Allan D Hess, B Douglas Smith, Judith E Karp, Sharon Barr, Thomas E Witzig, Scott H Kaufman. Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies. Blood. vol 119. issue 2. 2012-03-06. PMID:22080480. |
dual mtorc1/mtorc2 inhibition diminishes akt activation and induces puma-dependent apoptosis in lymphoid malignancies. |
2012-03-06 |
2023-08-12 |
Not clear |
| Sang Hun Lee, Han Na Suh, Yu Jin Lee, Bit Na Seo, Jeong Won Ha, Ho Jae Ha. Midkine prevented hypoxic injury of mouse embryonic stem cells through activation of Akt and HIF-1α via low-density lipoprotein receptor-related protein-1. Journal of cellular physiology. vol 227. issue 4. 2012-03-05. PMID:21688265. |
moreover, inhibition of akt, ho-1, and hif-1α signaling pathways abolished the mk-induced blockage of apoptosis. |
2012-03-05 |
2023-08-12 |
mouse |
| I Fatima, V Chandra, R Saxena, M Manohar, Y Sanghani, K Hajela, M P S Negi, P L Sankhwar, S K Jain, A Dwived. 2,3-Diaryl-2H-1-benzopyran derivatives interfere with classical and non-classical estrogen receptor signaling pathways, inhibit Akt activation and induce apoptosis in human endometrial cancer cells. Molecular and cellular endocrinology. vol 348. issue 1. 2012-03-05. PMID:21878365. |
2,3-diaryl-2h-1-benzopyran derivatives interfere with classical and non-classical estrogen receptor signaling pathways, inhibit akt activation and induce apoptosis in human endometrial cancer cells. |
2012-03-05 |
2023-08-12 |
human |
| Larysa V Yuzefovych, Viktoriya A Solodushko, Glenn L Wilson, Lyudmila I Rache. Protection from palmitate-induced mitochondrial DNA damage prevents from mitochondrial oxidative stress, mitochondrial dysfunction, apoptosis, and impaired insulin signaling in rat L6 skeletal muscle cells. Endocrinology. vol 153. issue 1. 2012-03-05. PMID:22128025. |
protection of mtdna from palmitate-induced damage by overexpression of hogg1 targeted to mitochondria significantly diminished palmitate-induced mitochondrial superoxide production, restored the decline in atp levels, reduced activation of c-jun n-terminal kinase (jnk) kinase, prevented cells from entering apoptosis, increased insulin-stimulated phosphorylation of serine-threonine kinase (akt) (ser473) and tyrosine phosphorylation of insulin receptor substrate-1, and thereby enhanced glucose transporter 4 translocation to plasma membrane, and restored insulin signaling. |
2012-03-05 |
2023-08-12 |
human |