| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ekta Khattar, Atish Mukherji, Vijay Kuma. Akt augments the oncogenic potential of the HBx protein of hepatitis B virus by phosphorylation. The FEBS journal. vol 279. issue 7. 2012-05-15. PMID:22309289. |
together, these results suggest that oncogenic co-operation between hbx and akt may be important for cell proliferation, abrogation of apoptosis and tumorigenic transformation of cells. |
2012-05-15 |
2023-08-12 |
Not clear |
| H Zhu, B Han, X Pan, H Qi, L X. Thiazolidenediones induce tumour-cell apoptosis through the Akt-GSK3β pathway. Journal of clinical pharmacy and therapeutics. vol 37. issue 1. 2012-05-14. PMID:21410737. |
our objective was to investigate the effects of tzds on apoptosis and on the serine/threonine kinase pathway, akt, and glycogen synthase kinase 3β (gsk3β). |
2012-05-14 |
2023-08-12 |
Not clear |
| Valentina Manfè, Edyta Biskup, Anne Rosbjerg, Maria Kamstrup, Anne Guldhammer Skov, Catharina Margrethe Lerche, Britt Thyssing Lauenborg, Niels Odum, Robert Gniadeck. miR-122 regulates p53/Akt signalling and the chemotherapy-induced apoptosis in cutaneous T-cell lymphoma. PloS one. vol 7. issue 1. 2012-05-14. PMID:22235305. |
surprisingly, mir-122 overexpression decreased the sensitivity to the chemotherapy-induced apoptosis via a signaling circuit involving the activation of akt and inhibition of p53. |
2012-05-14 |
2023-08-12 |
Not clear |
| Ai-Young Le. Role of keratinocytes in the development of vitiligo. Annals of dermatology. vol 24. issue 2. 2012-05-14. PMID:22577260. |
impaired phosphatidylinositol 3-kinase (pi3k)/serine/threonine protein kinase (akt) activation followed by reduced nuclear factor-κb activation under increased tumor necrosis factor-α levels was demonstrated as a mechanism for keratinocyte apoptosis. |
2012-05-14 |
2023-08-12 |
Not clear |
| Masoud Razmara, Glenda Eger, Charlotte Rorsman, Carl-Henrik Heldin, Johan Lennartsso. MKP3 negatively modulates PDGF-induced Akt and Erk5 phosphorylation as well as chemotaxis. Cellular signalling. vol 24. issue 3. 2012-05-10. PMID:22100392. |
although both akt and erk5 have been linked to increased cell survival, downregulation of mkp3 did not alter the ability of pdgf-bb to protect nih3t3 cells from starvation-induced apoptosis. |
2012-05-10 |
2023-08-12 |
Not clear |
| Xia Lei, Jinjin Wu, Bo Liu, Yuangang L. Hepatocyte growth factor promoting the proliferation of human eccrine sweat gland epithelial cells is relative to AKT signal channel and β-catenin. Archives of dermatological research. vol 304. issue 1. 2012-05-09. PMID:21932108. |
after hgf at different concentrations were added into cells, mtt was adopted to detect the cell proliferations, annexin-v/pi the cell apoptosis, and westernblot the expressions of p-akt, akt, p-erk, p-gsk3β, p-ikbα, and β-catenin in hesgc. |
2012-05-09 |
2023-08-12 |
human |
| Shashi Rajput, Mahitosh Manda. Antitumor promoting potential of selected phytochemicals derived from spices: a review. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). vol 21. issue 2. 2012-05-07. PMID:21876437. |
however, the in-vitro and in-vivo studies in the last few decades have demonstrated that some phytochemicals derived from 'natural products' such as fruits, vegetables and certain spices, referred to as chemopreventive agents, including capsaicin, trans-anethole, thymoquinone, diosgenin, allicin, can not only reduce the risk of acquiring specific cancer but also have been shown to suppress cancer cell proliferation, inhibit growth factor signaling pathways, induce apoptosis, inhibit nuclear factor-κb, ap-1, akt, mapk, wnt, notch, p53, ar, er, and jak-stat, etc., activation pathways, inhibit angiogenesis, suppress the expression of antiapoptotic proteins, and inhibit cyclooxygenase-2. |
2012-05-07 |
2023-08-12 |
Not clear |
| Lei Lv, Shi-Sen Jiang, Jun Xu, Jian-Bin Gong, Yan Chen. Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: the role of endothelial nitric oxide synthase. Clinical and experimental pharmacology & physiology. vol 39. issue 1. 2012-05-04. PMID:22004361. |
myocardial infarct size, oxidative stress, myocardial apoptosis, nitric oxide (no) production, and expression of phosphorylated protein kinase b (akt) and enos were measured. |
2012-05-04 |
2023-08-12 |
rat |
| H Kato, S Nakajima, Y Saito, S Takahashi, R Katoh, M Kitamur. mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway. Cell death and differentiation. vol 19. issue 2. 2012-05-01. PMID:21779001. |
activation of mtorc1 reduced akt phosphorylation, which was an event upstream of ire-jnk signaling and consequent apoptosis. |
2012-05-01 |
2023-08-12 |
mouse |
| H Kato, S Nakajima, Y Saito, S Takahashi, R Katoh, M Kitamur. mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway. Cell death and differentiation. vol 19. issue 2. 2012-05-01. PMID:21779001. |
these results disclosed that, under er stress conditions, mtorc1 causes apoptosis through suppression of akt and consequent induction of the ire1-jnk pathway. |
2012-05-01 |
2023-08-12 |
mouse |
| Yuria Saito, Yuko Tanaka, Yuichi Aita, Kiyo-Aki Ishii, Tatsuhiko Ikeda, Kazumasa Isobe, Yasushi Kawakami, Hitoshi Shimano, Hisato Hara, Kazuhiro Takekosh. Sunitinib induces apoptosis in pheochromocytoma tumor cells by inhibiting VEGFR2/Akt/mTOR/S6K1 pathways through modulation of Bcl-2 and BAD. American journal of physiology. Endocrinology and metabolism. vol 302. issue 6. 2012-05-01. PMID:21878661. |
knockdown of vegfr-2 attenuated the sunitinib-induced effects, including apoptosis and inhibition of signaling pathways such as the phosphorylation of akt as well as mtor, and bcl-2, which confirmed that these effects could be mediated by vegfr-2. |
2012-05-01 |
2023-08-12 |
human |
| Tian Li, Yuebo Yang, Xiaomao Li, Chengfang Xu, Lirong Men. EGFR- and AKT-mediated reduction in PTEN expression contributes to tyrphostin resistance and is reversed by mTOR inhibition in endometrial cancer cells. Molecular and cellular biochemistry. vol 361. issue 1-2. 2012-04-27. PMID:21952748. |
cell apoptosis and the cell cycle were studied, and activation of egfr, akt, and p70s6 were detected by western blot analysis. |
2012-04-27 |
2023-08-12 |
Not clear |
| Liang Guo, Liang Chen, Sheng Bi, Linlin Chai, Zengxiang Wang, Chuan Cao, Ling Tao, Shirong L. PTEN inhibits proliferation and functions of hypertrophic scar fibroblasts. Molecular and cellular biochemistry. vol 361. issue 1-2. 2012-04-27. PMID:21989717. |
furthermore, we found that adenovirus-mediated pten overexpression led to decreased akt activation, and significantly reduced cell proliferation and collagen synthesis of hsfbs, while increased the apoptosis. |
2012-04-27 |
2023-08-12 |
Not clear |
| Maxim A Komandirov, Evgeniya A Knyazeva, Yulia P Fedorenko, Mikhail V Rudkovskii, Denis A Stetsurin, Anatoly B Uzdensk. On the role of phosphatidylinositol 3-kinase, protein kinase b/Akt, and glycogen synthase kinase-3β in photodynamic injury of crayfish neurons and glial cells. Journal of molecular neuroscience : MN. vol 45. issue 2. 2012-04-24. PMID:21318403. |
akt was involved in photoinduced necrosis but not in apoptosis of neurons and glia. |
2012-04-24 |
2023-08-12 |
Not clear |
| Cordelia J Barrick, Patricia M Lenhart, Ryan T Dackor, Elizabeth Nagle, Kathleen M Caro. Loss of receptor activity-modifying protein 3 exacerbates cardiac hypertrophy and transition to heart failure in a sex-dependent manner. Journal of molecular and cellular cardiology. vol 52. issue 1. 2012-04-24. PMID:22100352. |
consistent with these measures of heart failure, male rentgmk:ramp3(-/-) mice had increased cardiac apoptosis and elevated activation of akt. |
2012-04-24 |
2023-08-12 |
mouse |
| Gong-Ping Liu, Wei Wei, Xin Zhou, Yao Zhang, Hai-Hong Shi, Jun Yin, Xiu-Qing Yao, Cai-Xia Peng, Juan Hu, Qun Wang, Hong-Lian Li, Jian-Zhi Wan. I(2)(PP2A) regulates p53 and Akt correlatively and leads the neurons to abort apoptosis. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:20138402. |
i(2)(pp2a) regulates p53 and akt correlatively and leads the neurons to abort apoptosis. |
2012-04-19 |
2023-08-12 |
mouse |
| Gong-Ping Liu, Wei Wei, Xin Zhou, Yao Zhang, Hai-Hong Shi, Jun Yin, Xiu-Qing Yao, Cai-Xia Peng, Juan Hu, Qun Wang, Hong-Lian Li, Jian-Zhi Wan. I(2)(PP2A) regulates p53 and Akt correlatively and leads the neurons to abort apoptosis. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:20138402. |
more importantly, we demonstrate that the simultaneous activation of akt induced by i(2)(pp2a) counteracts the hyperactivated p53-induced cell apoptosis. |
2012-04-19 |
2023-08-12 |
mouse |
| Gong-Ping Liu, Wei Wei, Xin Zhou, Yao Zhang, Hai-Hong Shi, Jun Yin, Xiu-Qing Yao, Cai-Xia Peng, Juan Hu, Qun Wang, Hong-Lian Li, Jian-Zhi Wan. I(2)(PP2A) regulates p53 and Akt correlatively and leads the neurons to abort apoptosis. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:20138402. |
our results suggest that the increased i(2)(pp2a) may trigger apoptosis by p53 upregulation, but due to simultaneous activation of akt, the neurons are aborted from the apoptotic pathway. |
2012-04-19 |
2023-08-12 |
mouse |
| Ravindresh Chhabra, Richa Dubey, Neeru Sain. Gene expression profiling indicate role of ER stress in miR-23a~27a~24-2 cluster induced apoptosis in HEK293T cells. RNA biology. vol 8. issue 4. 2012-04-19. PMID:21593605. |
additionally, components of er stress-mediated apoptosis pathway i.e., c/ebp homologous protein (chop/ddit3/gadd153) and trib3, an akt inhibitor were found to be significantly enriched. |
2012-04-19 |
2023-08-12 |
human |
| Tuanlao Wang, Ming Zhang, Zexu Ma, Ke Guo, Vinay Tergaonkar, Qi Zeng, Wanjin Hon. A role of Rab7 in stabilizing EGFR-Her2 and in sustaining Akt survival signal. Journal of cellular physiology. vol 227. issue 6. 2012-04-19. PMID:21928319. |
anoikis (matrix-detachment triggered apoptosis) was enhanced, while the level of phosphorylated (active) akt (which is a key survival factor) was significantly reduced. |
2012-04-19 |
2023-08-12 |
Not clear |