| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert J Henning, Steve Dennis, Darrell Sawmiller, Lorynn Hunter, Paul Sanberg, Leslie Mille. Human umbilical cord blood mononuclear cells activate the survival protein Akt in cardiac myocytes and endothelial cells that limits apoptosis and necrosis during hypoxia. Translational research : the journal of laboratory and clinical medicine. vol 159. issue 6. 2012-07-27. PMID:22633101. |
we conclude that hucbc can significantly decrease hypoxia-induced myocyte and endothelial cell apoptosis and necrosis by activating akt in these cells and in this manner hucbc can limit myocardial ischemia and injury. |
2012-07-27 |
2023-08-12 |
human |
| Ravi S Akundi, Lianteng Zhi, Hansruedi Büele. PINK1 enhances insulin-like growth factor-1-dependent Akt signaling and protection against apoptosis. Neurobiology of disease. vol 45. issue 1. 2012-07-23. PMID:21945539. |
pink1 enhances insulin-like growth factor-1-dependent akt signaling and protection against apoptosis. |
2012-07-23 |
2023-08-12 |
mouse |
| Jing Zhang, Jin-Shui Zhu, Zhou Zhou, Wei-Xiong Chen, Ni-Wei Che. Inhibitory effects of ethyl pyruvate administration on human gastric cancer growth via regulation of the HMGB1-RAGE and Akt pathways in vitro and in vivo. Oncology reports. vol 27. issue 5. 2012-07-23. PMID:22246223. |
after sgc-7901 gastric cancer cells were treated with ep, the expression of hmgb1, rage, akt, phosphorylated akt (p-akt) and some transcription factors was identified and the effects of ep on cell proliferation, invasion, cell cycle distribution and apoptosis were assessed. |
2012-07-23 |
2023-08-12 |
human |
| S Marchi, M Marinello, A Bononi, M Bonora, C Giorgi, A Rimessi, P Pinto. Selective modulation of subtype III IP₃R by Akt regulates ER Ca²⁺ release and apoptosis. Cell death & disease. vol 3. 2012-07-23. PMID:22552281. |
selective modulation of subtype iii ip₃r by akt regulates er ca²⁺ release and apoptosis. |
2012-07-23 |
2023-08-12 |
Not clear |
| S Marchi, M Marinello, A Bononi, M Bonora, C Giorgi, A Rimessi, P Pinto. Selective modulation of subtype III IP₃R by Akt regulates ER Ca²⁺ release and apoptosis. Cell death & disease. vol 3. 2012-07-23. PMID:22552281. |
the anti-apoptotic protein akt can phosphorylate all ip₃r isoforms and protect cells from apoptosis, reducing er ca²⁺ release. |
2012-07-23 |
2023-08-12 |
Not clear |
| S Marchi, M Marinello, A Bononi, M Bonora, C Giorgi, A Rimessi, P Pinto. Selective modulation of subtype III IP₃R by Akt regulates ER Ca²⁺ release and apoptosis. Cell death & disease. vol 3. 2012-07-23. PMID:22552281. |
here, we show that akt activation in cos7 cells, which lack of ip₃r i, strongly suppresses ip₃-mediated ca²⁺ release and apoptosis. |
2012-07-23 |
2023-08-12 |
Not clear |
| S Marchi, M Marinello, A Bononi, M Bonora, C Giorgi, A Rimessi, P Pinto. Selective modulation of subtype III IP₃R by Akt regulates ER Ca²⁺ release and apoptosis. Cell death & disease. vol 3. 2012-07-23. PMID:22552281. |
moreover, regulating ca²⁺ flux to mitochondria, akt maintains the mitochondrial integrity and delays the trigger of apoptosis, in a type iii-dependent mechanism. |
2012-07-23 |
2023-08-12 |
Not clear |
| S Marchi, M Marinello, A Bononi, M Bonora, C Giorgi, A Rimessi, P Pinto. Selective modulation of subtype III IP₃R by Akt regulates ER Ca²⁺ release and apoptosis. Cell death & disease. vol 3. 2012-07-23. PMID:22552281. |
these results demonstrate a specific activity of akt on ip₃r iii, leading to diminished ca²⁺ transfer to mitochondria and protection from apoptosis, suggesting an additional level of cell death regulation mediated by akt. |
2012-07-23 |
2023-08-12 |
Not clear |
| Wen-Ying Liao, Chia-Ning Shen, Li-Hua Lin, Yu-Liang Yang, Hsin-Ying Han, Jing-Wei Chen, Sheng-Chu Kuo, Shih-Hsiung Wu, Chih-Chuang Lia. Asperjinone, a nor-neolignan, and terrein, a suppressor of ABCG2-expressing breast cancer cells, from thermophilic Aspergillus terreus. Journal of natural products. vol 75. issue 4. 2012-07-20. PMID:22360613. |
this suppressive effect was achieved by inducing apoptosis via activating the caspase-7 pathway and inhibiting the akt signaling pathway, which led to a decrease in abcg2-expressing cells and a reduction in the side-population phenotype. |
2012-07-20 |
2023-08-12 |
Not clear |
| Matilde Y Follo, Sara Mongiorgi, Carlo Finelli, Manuela Piazzi, Irene Faenza, Giulia Ramazzotti, Patrizia Santi, James A McCubrey, Alberto M Martelli, Lucio Cocc. Nuclear PI-PLCβ1 and myelodysplastic syndromes: genetics and epigenetics. Current pharmaceutical design. vol 18. issue 13. 2012-07-19. PMID:22352752. |
indeed, nuclear phosphoinositide- specific phospholipase c (pi-plc) β1 and akt are involved in cell cycle progression and apoptosis. |
2012-07-19 |
2023-08-12 |
Not clear |
| Changhan Lee, Lizzia Raffaghello, Sebastian Brandhorst, Fernando M Safdie, Giovanna Bianchi, Alejandro Martin-Montalvo, Vito Pistoia, Min Wei, Saewon Hwang, Annalisa Merlino, Laura Emionite, Rafael de Cabo, Valter D Long. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Science translational medicine. vol 4. issue 124. 2012-07-09. PMID:22323820. |
in 4t1 breast cancer cells, short-term starvation resulted in increased phosphorylation of the stress-sensitizing akt and s6 kinases, increased oxidative stress, caspase-3 cleavage, dna damage, and apoptosis. |
2012-07-09 |
2023-08-12 |
mouse |
| You-Cheng Hseu, Meng-Shiou Lee, Chi-Rei Wu, Hsin-Ju Cho, Kai-Yuan Lin, Guan-Hua Lai, Sheng-Yang Wang, Yueh-Hsiung Kuo, K J Senthil Kumar, Hsin-Ling Yan. The chalcone flavokawain B induces G2/M cell-cycle arrest and apoptosis in human oral carcinoma HSC-3 cells through the intracellular ROS generation and downregulation of the Akt/p38 MAPK signaling pathway. Journal of agricultural and food chemistry. vol 60. issue 9. 2012-07-09. PMID:22324429. |
moreover, fkb downregulated the phosphorylation of akt and p38 mapk, while their inhibitors ly294002 and sb203580, respectively, induced g(2)/m arrest and apoptosis. |
2012-07-09 |
2023-08-12 |
human |
| You-Cheng Hseu, Meng-Shiou Lee, Chi-Rei Wu, Hsin-Ju Cho, Kai-Yuan Lin, Guan-Hua Lai, Sheng-Yang Wang, Yueh-Hsiung Kuo, K J Senthil Kumar, Hsin-Ling Yan. The chalcone flavokawain B induces G2/M cell-cycle arrest and apoptosis in human oral carcinoma HSC-3 cells through the intracellular ROS generation and downregulation of the Akt/p38 MAPK signaling pathway. Journal of agricultural and food chemistry. vol 60. issue 9. 2012-07-09. PMID:22324429. |
the profound reduction in cell number was observed in combination treatment with fkb and akt/p38 mapk inhibitors, indicating that the disruption of akt and p38 mapk cascades plays a functional role in fkb-induced g(2)/m arrest and apoptosis in hsc-3 cells. |
2012-07-09 |
2023-08-12 |
human |
| Keqiang Zuo, Dan Li, Benjamin Pulli, Fei Yu, Haidong Cai, Xueyu Yuan, Xiaoping Zhang, Zhongwei L. Short-hairpin RNA-mediated Heat shock protein 90 gene silencing inhibits human breast cancer cell growth in vitro and in vivo. Biochemical and biophysical research communications. vol 421. issue 2. 2012-07-09. PMID:22521890. |
nf-kb and akt protein levels were down-regulated in hsp90-shrna transfected cells, indicating that hsp90 knockout caused a reduction of survival factors and induced apoptosis. |
2012-07-09 |
2023-08-12 |
mouse |
| Kwai Wa Cheng, Roshan Agarwal, Shreya Mitra, Ju-Seog Lee, Mark Carey, Joe W Gray, Gordon B Mill. Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress. EMBO molecular medicine. vol 4. issue 2. 2012-07-06. PMID:22253197. |
rab25 enhanced survival during nutrient stress by preventing apoptosis and autophagy via binding and activating akt leading to increased glucose uptake and improved cellular bioenergetics. |
2012-07-06 |
2023-08-12 |
Not clear |
| K K Yip, S C L Lo, M C P Leung, K F So, C Y Tang, D M Y Poo. The effect of low-energy laser irradiation on apoptotic factors following experimentally induced transient cerebral ischemia. Neuroscience. vol 190. 2012-07-05. PMID:21712070. |
apoptosis, or programmed cell death, resulting from cerebral ischemia may be related to decreased levels of anti-apoptotic factors, such as serine/threonine kinase (akt), phosphorylated akt (pakt), pbad, and bcl-2, and increased levels of pro-apoptotic factors, such as bad, caspase 9, and caspase 3 activities. |
2012-07-05 |
2023-08-12 |
rat |
| G Fuka, H-P Kantner, R Grausenburger, A Inthal, E Bauer, G Krapf, U Kaindl, M Kauer, M N Dworzak, D Stoiber, O A Haas, R Panzer-Grümaye. Silencing of ETV6/RUNX1 abrogates PI3K/AKT/mTOR signaling and impairs reconstitution of leukemia in xenografts. Leukemia. vol 26. issue 5. 2012-07-05. PMID:22094587. |
in line with the observed concurrent inactivation of the phosphoinositide 3-kinase (pi3k)/akt/mammalian target of rapamycin (mtor) pathway, pharmacological inhibition diminished the phosphorylation of akt and ribosomal protein s6, and significantly increased the apoptosis rate in e/r-positive leukemias. |
2012-07-05 |
2023-08-12 |
mouse |
| Yuying Fan, Chengxin Sun, Xiaoge Gao, Fang Wang, Xinzhi Li, Rajab M Kassim, Guihua Tai, Yifa Zho. Neuroprotective effects of ginseng pectin through the activation of ERK/MAPK and Akt survival signaling pathways. Molecular medicine reports. vol 5. issue 5. 2012-07-03. PMID:22378568. |
these results suggest that the protective effects of gp against h2o2-induced apoptosis may be due to the activation of the phosphorylation of erk1/2 and akt; however, the mechanisms involved differ depending on the cell line. |
2012-07-03 |
2023-08-12 |
human |
| Jagannath Pal, Mariateresa Fulciniti, Puru Nanjappa, Leutz Buon, Yu-Tzu Tai, Pierfrancesco Tassone, Nikhil C Munshi, Masood A Shamma. Targeting PI3K and RAD51 in Barrett's adenocarcinoma: impact on DNA damage checkpoints, expression profile and tumor growth. Cancer genomics & proteomics. vol 9. issue 2. 2012-07-03. PMID:22399496. |
wortmannin induced growth arrest and apoptosis in two bac cell lines (oe33 and oe19), which had relatively higher expression of akt. |
2012-07-03 |
2023-08-12 |
Not clear |
| Li Yingchun, Qu Xiujuan, Qu Jinglei, Zhang Ye, Liu Jing, Teng Yuee, Hu Xuejun, Hou Kezuo, Liu Yunpen. E3 ubiquitin ligase Cbl-b potentiates the apoptotic action of arsenic trioxide by inhibiting the PI3K/Akt pathway. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 44. issue 2. 2012-07-02. PMID:21180886. |
ato decreased the viability of hl60 cells and induced cellular apoptosis, which was accompanied by transient activation of akt. |
2012-07-02 |
2023-08-12 |
rat |