| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryo Hashimoto, Jing Yu, Hideki Koizumi, Yasuyoshi Ouchi, Tetsuro Okab. Ginsenoside Rb1 Prevents MPP(+)-Induced Apoptosis in PC12 Cells by Stimulating Estrogen Receptors with Consequent Activation of ERK1/2, Akt and Inhibition of SAPK/JNK, p38 MAPK. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-10-02. PMID:23024694. |
ginsenoside rb1 prevents mpp(+)-induced apoptosis in pc12 cells by stimulating estrogen receptors with consequent activation of erk1/2, akt and inhibition of sapk/jnk, p38 mapk. |
2012-10-02 |
2023-08-12 |
Not clear |
| Ryo Hashimoto, Jing Yu, Hideki Koizumi, Yasuyoshi Ouchi, Tetsuro Okab. Ginsenoside Rb1 Prevents MPP(+)-Induced Apoptosis in PC12 Cells by Stimulating Estrogen Receptors with Consequent Activation of ERK1/2, Akt and Inhibition of SAPK/JNK, p38 MAPK. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-10-02. PMID:23024694. |
these results suggest that ginsenoside rb1 protects pc12 cells from caspase-3-dependent apoptosis through stimulation of estrogen receptor with consequent activation of erk1/2 and akt and inhibition of sapk/jnk and p38. |
2012-10-02 |
2023-08-12 |
Not clear |
| Carlos Turrado, Teresa Puig, Javier García-Cárceles, Marta Artola, Bellinda Benhamú, Silvia Ortega-Gutiérrez, Joana Relat, Gloria Oliveras, Adriana Blancafort, Diego Haro, Pedro F Marrero, Ramón Colomer, María L López-Rodrígue. New synthetic inhibitors of fatty acid synthase with anticancer activity. Journal of medicinal chemistry. vol 55. issue 11. 2012-10-01. PMID:22559865. |
among them, derivative 30 blocks the 90% of fasn activity at low concentration (4 μm), is highly cytotoxic in a broad panel of tumor cells, induces apoptosis, and blocks the activation of her2, akt, and erk pathways. |
2012-10-01 |
2023-08-12 |
mouse |
| Yi Ma, Xiaomeng Hao, Sheng Zhang, Jin Zhan. The in vitro and in vivo effects of human umbilical cord mesenchymal stem cells on the growth of breast cancer cells. Breast cancer research and treatment. vol 133. issue 2. 2012-09-28. PMID:21947651. |
the underlying mechanism is likely related to cell cycle arrest, induction of tumor cell apoptosis, and suppressed activities of pi3k and akt protein kinases. |
2012-09-28 |
2023-08-12 |
mouse |
| H-Q Li, Y Luo, C-H Qia. The mechanisms of anticancer agents by genistein and synthetic derivatives of isoflavone. Mini reviews in medicinal chemistry. vol 12. issue 4. 2012-09-28. PMID:22303948. |
it has been reported that genistein can inhibit activation of nf-κb and akt signaling pathways to induce cell apopt1osis, both pathways are well known for their function to maintain a balance between cell survival and apoptosis. |
2012-09-28 |
2023-08-12 |
Not clear |
| Dorrah Deeb, Xiaohua Gao, Yong Bo Liu, Subhash C Gauta. Inhibition of cell proliferation and induction of apoptosis by CDDO-Me in pancreatic cancer cells is ROS-dependent. Journal of experimental therapeutics & oncology. vol 10. issue 1. 2012-09-26. PMID:22946344. |
in this study, we investigated the role of reactive oxygen species (ros) in induction of apoptosis and inhibition of prosurvival akt, nf-kappab and mtor signaling pro-teins by methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (cddo-me) in pancreatic cancer cells. |
2012-09-26 |
2023-08-12 |
Not clear |
| Daniel R Premkumar, Esther P Jane, Joseph D DiDomenico, Natalie A Vukmer, Naomi R Agostino, Ian F Pollac. ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines. The Journal of pharmacology and experimental therapeutics. vol 341. issue 3. 2012-09-24. PMID:22393246. |
this study demonstrates that interference with multiple apoptosis-resistance signaling nodes, including nf-κb, akt, and bcl-2, may be required to induce apoptosis in highly resistant glioma cells, and therapeutic strategies that target the pi3k/akt pathway may have a selective role for cancers lacking pten function. |
2012-09-24 |
2023-08-12 |
human |
| T Ishrat, I Sayeed, F Atif, F Hua, D G Stei. Progesterone is neuroprotective against ischemic brain injury through its effects on the phosphoinositide 3-kinase/protein kinase B signaling pathway. Neuroscience. vol 210. 2012-09-21. PMID:22450229. |
the treatment also increased bdnf, and attenuated apoptosis by increasing akt phosphorylation compared with vehicle alone. |
2012-09-21 |
2023-08-12 |
rat |
| Saida Abdelli, Christophe Bonn. JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling. PloS one. vol 7. issue 5. 2012-09-21. PMID:22563476. |
while it is known that jnk1 or jnk2 may promote apoptosis by inhibiting the activity of the pro-survival akt pathway, the effect of jnk3 on akt has not been documented. |
2012-09-21 |
2023-08-12 |
Not clear |
| Hirofumi Oishi, Ken-ichi Takano, Kengo Tomita, Mariko Takebe, Hiroki Yokoo, Mitsuaki Yamazaki, Yuichi Hattor. Olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through CREB-independent activation of the Akt pathway. American journal of physiology. Lung cellular and molecular physiology. vol 303. issue 2. 2012-09-20. PMID:22610350. |
olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through creb-independent activation of the akt pathway. |
2012-09-20 |
2023-08-12 |
mouse |
| Hirofumi Oishi, Ken-ichi Takano, Kengo Tomita, Mariko Takebe, Hiroki Yokoo, Mitsuaki Yamazaki, Yuichi Hattor. Olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through CREB-independent activation of the Akt pathway. American journal of physiology. Lung cellular and molecular physiology. vol 303. issue 2. 2012-09-20. PMID:22610350. |
wortmannin, which inhibits the akt upstream regulator phosphatidylinositol 3-kinase, abrogated the protective effects of olprinone and corforsin daropate on sepsis-associated lung inflammation and apoptosis. |
2012-09-20 |
2023-08-12 |
mouse |
| Jun-jie Shao, Ai-ping Zhang, Wei Qin, Lin Zheng, Yi-fan Zhu, Xin Che. AMP-activated protein kinase (AMPK) activation is involved in chrysin-induced growth inhibition and apoptosis in cultured A549 lung cancer cells. Biochemical and biophysical research communications. vol 423. issue 3. 2012-09-20. PMID:22659738. |
our study suggests that activation of ampk by chrysin contributes to akt suppression, growth inhibition and apoptosis in human lung cancer cells, and agents that could activate ampk may serve as useful adjuvants for traditional chemotherapy against lung cancer. |
2012-09-20 |
2023-08-12 |
human |
| Li Meng, Hongwen Tao, Guoqiang Dong, Tingting Yang, Wannian Zhang, Weiming Zhu, Caiguo Huan. ERK1/2 and Akt pathway activated during (3R,6R)-bassiatin(1)-induced apoptosis in MCF-7 cells. Cell biology international. vol 36. issue 4. 2012-09-17. PMID:22150072. |
erk1/2 and akt pathway activated during (3r,6r)-bassiatin(1)-induced apoptosis in mcf-7 cells. |
2012-09-17 |
2023-08-12 |
Not clear |
| Li Meng, Hongwen Tao, Guoqiang Dong, Tingting Yang, Wannian Zhang, Weiming Zhu, Caiguo Huan. ERK1/2 and Akt pathway activated during (3R,6R)-bassiatin(1)-induced apoptosis in MCF-7 cells. Cell biology international. vol 36. issue 4. 2012-09-17. PMID:22150072. |
we have investigated the interaction between (3r,6r)-bassiatin(1) and erα and followed the roles of erk (extracellular-signal-regulated kinase), akt and gsk3β (glycogen synthase kinase 3β) during (3r,6r)-bassiatin(1)-induced apoptosis of mcf-7 cells. |
2012-09-17 |
2023-08-12 |
Not clear |
| Li Meng, Hongwen Tao, Guoqiang Dong, Tingting Yang, Wannian Zhang, Weiming Zhu, Caiguo Huan. ERK1/2 and Akt pathway activated during (3R,6R)-bassiatin(1)-induced apoptosis in MCF-7 cells. Cell biology international. vol 36. issue 4. 2012-09-17. PMID:22150072. |
however, while erk1/2 and akt were activated, gsk3β was inactivated during (3r,6r)-bassiatin(1)-induced apoptosis, suggesting that this compound is indeed an anti-oestrogen agent that can also activate the survival signalling pathway. |
2012-09-17 |
2023-08-12 |
Not clear |
| Chengzhen Liang, Hao Li, Chengchun Shen, Jianbo Lai, Zhongli Shi, Bing Liu, Hui-min Ta. Genistein potentiates the anti-cancer effects of gemcitabine in human osteosarcoma via the downregulation of Akt and nuclear factor-κB pathway. Anti-cancer agents in medicinal chemistry. vol 12. issue 5. 2012-09-17. PMID:22263786. |
in vitro, by mtt, electron microscopy, immunobloting and qrt-pcr assay, we found that the combination treatment of genistein and gemcitabine resulted in stronger growth inhibition and apoptosis induction through the downregulation of nf-κb activity and akt activation in osteosarcoma cells. |
2012-09-17 |
2023-08-12 |
human |
| Changju Qu, Zhihui Liang, JiaLing Huang, Ruiying Zhao, Chunhui Su, Sumei Wang, Xudan Wang, Rong Zhang, Mong-Hong Lee, Huiling Yan. MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN. Cell cycle (Georgetown, Tex.). vol 11. issue 4. 2012-09-14. PMID:22374676. |
introducing mir-205 into cne-2 cells suppresses pten protein expression, followed by activation of akt, increased number of foci formation and reduction of cell apoptosis postirradiation. |
2012-09-14 |
2023-08-12 |
human |
| Xiaohui Huang, Zhixiang Cheng, Qiao Su, Xiaonan Zhu, Qin Wang, Ruzhu Chen, Xuelan Wan. Neuroprotection by nicotine against colchicine-induced apoptosis is mediated by PI3-kinase--Akt pathways. The International journal of neuroscience. vol 122. issue 6. 2012-09-13. PMID:22248034. |
neuroprotection by nicotine against colchicine-induced apoptosis is mediated by pi3-kinase--akt pathways. |
2012-09-13 |
2023-08-12 |
Not clear |
| Yen-Ling Chen, Shih-Hurng Loh, Jin-Jer Chen, Chien-Sung Tsa. Urotensin II prevents cardiomyocyte apoptosis induced by doxorubicin via Akt and ERK. European journal of pharmacology. vol 680. issue 1-3. 2012-09-13. PMID:22329895. |
urotensin ii prevents cardiomyocyte apoptosis induced by doxorubicin via akt and erk. |
2012-09-13 |
2023-08-12 |
rat |
| Yen-Ling Chen, Shih-Hurng Loh, Jin-Jer Chen, Chien-Sung Tsa. Urotensin II prevents cardiomyocyte apoptosis induced by doxorubicin via Akt and ERK. European journal of pharmacology. vol 680. issue 1-3. 2012-09-13. PMID:22329895. |
these findings suggest that urotensin ii protects cardiomyocytes from doxorubicin-induced apoptosis partly via akt and erk, which may promote cell survival and cardioprotection. |
2012-09-13 |
2023-08-12 |
rat |