| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melanie K B Wills, Nina Jone. Teaching an old dogma new tricks: twenty years of Shc adaptor signalling. The Biochemical journal. vol 447. issue 1. 2012-11-13. PMID:22970934. |
it is clear, however, that the distinctive modular architecture of shc proteins, their promiscuous phosphotyrosine-based interactions with a multitude of membrane receptors, involvement in central cascades including mapk (mitogen-activated protein kinase) and akt, and unconventional contributions to oxidative stress and apoptosis all require intricate regulation, and underlie diverse physiological function. |
2012-11-13 |
2023-08-12 |
Not clear |
| Hui-hui Zhang, Fan Qi, Ying-rui Shi, Jian-guang Miao, Mi Zhou, Wei He, Min-feng Chen, Yuan Li, Xiong-bing Zu, Lin Q. RNA interference-mediated vascular endothelial growth factor-C reduction suppresses malignant progression and enhances mitomycin C sensitivity of bladder cancer T24 cells. Cancer biotherapy & radiopharmaceuticals. vol 27. issue 5. 2012-11-09. PMID:21902544. |
the present study suggests that vegf-c can enhance the proliferation and invasiveness of bladder cancer t24 cells, which is due to suppression of apoptosis and facilitation of migration, accompanied with upregulation of p38 mapk and akt phosphorylation. |
2012-11-09 |
2023-08-12 |
human |
| Mariana H Massaoka, Alisson L Matsuo, Carlos R Figueiredo, Camyla F Farias, Natália Girola, Denise C Arruda, Jorge A B Scutti, Paulete Romoff, Oriana A Favero, Marcelo J P Ferreira, João H G Lago, Luiz R Travasso. Jacaranone induces apoptosis in melanoma cells via ROS-mediated downregulation of Akt and p38 MAPK activation and displays antitumor activity in vivo. PloS one. vol 7. issue 6. 2012-11-08. PMID:22701695. |
jacaranone induces apoptosis in melanoma cells via ros-mediated downregulation of akt and p38 mapk activation and displays antitumor activity in vivo. |
2012-11-08 |
2023-08-12 |
mouse |
| J J Gills, C Zhang, M S Abu-Asab, S S Castillo, C Marceau, J LoPiccolo, A P Kozikowski, M Tsokos, T Goldkorn, P A Denni. Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine. Cell death & disease. vol 3. 2012-11-08. PMID:22764099. |
anticancer phospholipids that inhibit akt such as the alkylphospholipid perifosine (per) and phosphatidylinositol ether lipid analogs (pias) promote cellular detachment and apoptosis and have a similar cytotoxicity profile against cancer cell lines in the nci60 panel. |
2012-11-08 |
2023-08-12 |
Not clear |
| Mark G Waug. Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer. Cancer letters. vol 325. issue 2. 2012-11-07. PMID:22750097. |
alterations to phosphatidylinositol 4-kinase expression levels can modulate map kinase and akt signalling, and are important for chemoresistance, tumour angiogenesis and the suppression of apoptosis and metastases. |
2012-11-07 |
2023-08-12 |
Not clear |
| Pan Huang, Zhengrong Zhou, Hao Wang, Quanwei Wei, Liang Zhang, Xin Zhou, Reinhold J Hutz, Fangxiong Sh. Effect of the IGF-1/PTEN/Akt/FoxO signaling pathway on the development and healing of water immersion and restraint stress-induced gastric ulcers in rats. International journal of molecular medicine. vol 30. issue 3. 2012-11-06. PMID:22735908. |
insulin-like growth factor 1 (igf-1) and akt [also known as protein kinase b (pkb)] proteins have been reported to exhibit gastroprotective effects by reducing water immersion and restraint stress (wrs)-induced gastric mucosal cellular apoptosis. |
2012-11-06 |
2023-08-12 |
rat |
| B Casar, Y He, M Iconomou, J D Hooper, J P Quigley, E I Deryugin. Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells. Oncogene. vol 31. issue 35. 2012-11-05. PMID:22179830. |
the in vivo cleavage of cdcp1 triggers a survival program involving recruitment of src and pkcδ, src-mediated phosphorylation of cell-surface-retained 70-kda cdcp1, activation of akt and suppression of parp1-induced apoptosis. |
2012-11-05 |
2023-08-12 |
mouse |
| Chih-Chien Tsai, Tu-Lai Yew, Der-Chi Yang, Wei-Hua Huang, Shih-Chieh Hun. Benefits of hypoxic culture on bone marrow multipotent stromal cells. American journal of blood research. vol 2. issue 3. 2012-11-05. PMID:23119226. |
after transplantation, an ischemic environment, that is the combination of hypoxia and lack of nutrition, can lead to apoptosis or cell death, which can be overcome by the hypoxic preconditioning of mscs and overexpression of prosurvival genes like akt, ho-1 and hsp70. |
2012-11-05 |
2023-08-12 |
Not clear |
| J A Brazzatti, M Klingler-Hoffmann, S Haylock-Jacobs, Y Harata-Lee, M Niu, M D Higgins, M Kochetkova, P Hoffmann, S R McCol. Differential roles for the p101 and p84 regulatory subunits of PI3Kγ in tumor growth and metastasis. Oncogene. vol 31. issue 18. 2012-11-01. PMID:21996737. |
knockdown of p110γ or p101 inhibited apoptosis, akt phosphorylation and lung colonization in scid mice. |
2012-11-01 |
2023-08-12 |
mouse |
| Mark Rosenberg, Matthias Lutz, Constantin Kühl, Rainer Will, Volker Eckstein, Jutta Krebs, Hugo A Katus, Norbert Fre. Coculture with hematopoietic stem cells protects cardiomyocytes against apoptosis via paracrine activation of AKT. Journal of translational medicine. vol 10. 2012-10-31. PMID:22672705. |
coculture with hematopoietic stem cells protects cardiomyocytes against apoptosis via paracrine activation of akt. |
2012-10-31 |
2023-08-12 |
Not clear |
| Minghai Shao, Stacy Hollar, Daphne Chambliss, Jordan Schmitt, Robert Emerson, Bhadrani Chelladurai, Susan Perkins, Mircea Ivan, Daniela Mate. Targeting the insulin growth factor and the vascular endothelial growth factor pathways in ovarian cancer. Molecular cancer therapeutics. vol 11. issue 7. 2012-10-31. PMID:22700681. |
immunohistochemistry measured multivessel density, akt activation, and cell proliferation, whereas terminal deoxynucleotidyl transferase-mediated dutp nick end labeling (tunel) assay measured apoptosis in ovarian cancer xenografts. |
2012-10-31 |
2023-08-12 |
Not clear |
| Wataru Okamoto, Isamu Okamoto, Tokuzo Arao, Kiyoko Kuwata, Erina Hatashita, Haruka Yamaguchi, Kazuko Sakai, Kazuyoshi Yanagihara, Kazuto Nishio, Kazuhiko Nakagaw. Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Molecular cancer therapeutics. vol 11. issue 7. 2012-10-31. PMID:22729845. |
inhibition of met signaling by crizotinib or rna interference-mediated met depletion resulted in induction of apoptosis accompanied by inhibition of akt and extracellular signal-regulated kinase phosphorylation in gastric cancer cells with met amplification but not in those without it, suggesting that met signaling is essential for the survival of met amplification-positive cells. |
2012-10-31 |
2023-08-12 |
Not clear |
| Qingzhi Chen, Bing Zhang, Tingting Yi, Chun Xi. Increased apoptosis in human knee osteoarthritis cartilage related to the expression of protein kinase B and protein kinase Cα in chondrocytes. Folia histochemica et cytobiologica. vol 50. issue 1. 2012-10-29. PMID:22532149. |
protein kinase b (akt) and protein kinase cα (pkcα) play important roles in the regulation of cell apoptosis. |
2012-10-29 |
2023-08-12 |
human |
| Qingzhi Chen, Bing Zhang, Tingting Yi, Chun Xi. Increased apoptosis in human knee osteoarthritis cartilage related to the expression of protein kinase B and protein kinase Cα in chondrocytes. Folia histochemica et cytobiologica. vol 50. issue 1. 2012-10-29. PMID:22532149. |
the aim of this study was to investigate the expression of akt and pkca in chondrocytes of human knee osteoarthritic (oa) cartilage, further evaluating their role in chondrocyte apoptosis during oa progression. |
2012-10-29 |
2023-08-12 |
human |
| Qingzhi Chen, Bing Zhang, Tingting Yi, Chun Xi. Increased apoptosis in human knee osteoarthritis cartilage related to the expression of protein kinase B and protein kinase Cα in chondrocytes. Folia histochemica et cytobiologica. vol 50. issue 1. 2012-10-29. PMID:22532149. |
the results indicated that akt and pkca were involved in oa progression, along with the increase of cell apoptosis. |
2012-10-29 |
2023-08-12 |
human |
| Qingzhi Chen, Bing Zhang, Tingting Yi, Chun Xi. Increased apoptosis in human knee osteoarthritis cartilage related to the expression of protein kinase B and protein kinase Cα in chondrocytes. Folia histochemica et cytobiologica. vol 50. issue 1. 2012-10-29. PMID:22532149. |
these results demonstrated that both akt and pkcα are related to increased chondrocyte apoptosis in human oa cartilage. |
2012-10-29 |
2023-08-12 |
human |
| Qingzhi Chen, Bing Zhang, Tingting Yi, Chun Xi. Increased apoptosis in human knee osteoarthritis cartilage related to the expression of protein kinase B and protein kinase Cα in chondrocytes. Folia histochemica et cytobiologica. vol 50. issue 1. 2012-10-29. PMID:22532149. |
the correlation between human oa progression, the role of akt and pkcα, and chondrocyte apoptosis allows for new therapeutic strategies to be considered. |
2012-10-29 |
2023-08-12 |
human |
| Xianjuan Kou, Keyin Shen, Yuhui An, Shimei Qi, Wu-Xing Dai, Zhimin Yi. Ampelopsin inhibits H₂O₂-induced apoptosis by ERK and Akt signaling pathways and up-regulation of heme oxygenase-1. Phytotherapy research : PTR. vol 26. issue 7. 2012-10-26. PMID:22144097. |
ampelopsin inhibits h₂o₂-induced apoptosis by erk and akt signaling pathways and up-regulation of heme oxygenase-1. |
2012-10-26 |
2023-08-12 |
Not clear |
| Xianjuan Kou, Keyin Shen, Yuhui An, Shimei Qi, Wu-Xing Dai, Zhimin Yi. Ampelopsin inhibits H₂O₂-induced apoptosis by ERK and Akt signaling pathways and up-regulation of heme oxygenase-1. Phytotherapy research : PTR. vol 26. issue 7. 2012-10-26. PMID:22144097. |
these results suggest that ampelopsin increases cellular antioxidant defense through activation of the erk and akt signaling pathways, which induces ho-1 expression and thereby protects pc12 cells from h₂o₂-induced apoptosis. |
2012-10-26 |
2023-08-12 |
Not clear |
| Christine K Cheng, W Clay Gustafson, Elizabeth Charron, Benjamin T Houseman, Eli Zunder, Andrei Goga, Nathanael S Gray, Brian Pollok, Scott A Oakes, C David James, Kevan M Shokat, William A Weiss, Qi-Wen Fa. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 31. 2012-10-26. PMID:22802621. |
we also tested clinical akt and cdk inhibitors, demonstrating induction of apoptosis in vitro and providing a preclinical rationale to test this combination therapy in patients. |
2012-10-26 |
2023-08-12 |
human |