| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valentina Caracciolo, Giulio Laurenti, Gaetano Romano, Vincenzo Carnevale, Anna Maria Cimini, Catena Crozier-Fitzgerald, Emilio Gentile Warschauer, Giuseppe Russo, Antonio Giordan. Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development. Cell cycle (Georgetown, Tex.). vol 11. issue 6. 2012-09-13. PMID:22391209. |
akt-ser473 is a hallmark of akt pathway activation and may protect cells from apoptosis. |
2012-09-13 |
2023-08-12 |
human |
| N Hayashi, J W Peacock, E Beraldi, A Zoubeidi, M E Gleave, C J On. Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch. Cell death and differentiation. vol 19. issue 6. 2012-09-10. PMID:22179576. |
these data identify a dual coordinated role of hsp27 in cell proliferation and fas-induced apoptosis via akt and pea-15, and indicate that improved clinical responses to hsp27-targeted therapy may be achieved by stratifying patient populations based on tumor pten expression. |
2012-09-10 |
2023-08-12 |
Not clear |
| Fang Zhao, Fengjie Huang, Mengxiong Tang, Xiaoming Li, Nina Zhang, Akis Amfilochiadis, Yiming Li, Renming Hu, Tianru Jin, Chun Peng, Qinghua Wan. Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells. American journal of physiology. Endocrinology and metabolism. vol 303. issue 1. 2012-09-10. PMID:22550067. |
we demonstrated previously that the activation of alk7 (activin receptor-like kinase-7), a member of the type i receptor serine/threonine kinases of the tgf-β superfamily, resulted in increased apoptosis and reduced proliferation through suppression of akt signaling and the activation of smad2-dependent signaling pathway in pancreatic β-cells. |
2012-09-10 |
2023-08-12 |
rat |
| Fang Zhao, Fengjie Huang, Mengxiong Tang, Xiaoming Li, Nina Zhang, Akis Amfilochiadis, Yiming Li, Renming Hu, Tianru Jin, Chun Peng, Qinghua Wan. Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells. American journal of physiology. Endocrinology and metabolism. vol 303. issue 1. 2012-09-10. PMID:22550067. |
nodal-induced apoptosis was associated with decreased akt phosphorylation and reduced expression level of x-linked inhibitor of apoptosis (xiap). |
2012-09-10 |
2023-08-12 |
rat |
| Fang Zhao, Fengjie Huang, Mengxiong Tang, Xiaoming Li, Nina Zhang, Akis Amfilochiadis, Yiming Li, Renming Hu, Tianru Jin, Chun Peng, Qinghua Wan. Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells. American journal of physiology. Endocrinology and metabolism. vol 303. issue 1. 2012-09-10. PMID:22550067. |
remarkably, overexpression of xiap or constitutively active akt, or ablation of smad2/3 activity partially blocked nodal-induced apoptosis. |
2012-09-10 |
2023-08-12 |
rat |
| Fang Zhao, Fengjie Huang, Mengxiong Tang, Xiaoming Li, Nina Zhang, Akis Amfilochiadis, Yiming Li, Renming Hu, Tianru Jin, Chun Peng, Qinghua Wan. Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells. American journal of physiology. Endocrinology and metabolism. vol 303. issue 1. 2012-09-10. PMID:22550067. |
we suggest that nodal-induced apoptosis in β-cells is mediated through alk7 signaling involving the activation of smad2/3-caspase-3 and the suppression of akt and xiap pathways and that nodal may exert its biological effects on the modulation of β-cell survival and β-cell mass in an autocrine fashion. |
2012-09-10 |
2023-08-12 |
rat |
| Su Jung Oh, Holger H H Erb, Alfred Hobisch, Frédéric R Santer, Zoran Culi. Sorafenib decreases proliferation and induces apoptosis of prostate cancer cells by inhibition of the androgen receptor and Akt signaling pathways. Endocrine-related cancer. vol 19. issue 3. 2012-09-07. PMID:22383427. |
sorafenib decreases proliferation and induces apoptosis of prostate cancer cells by inhibition of the androgen receptor and akt signaling pathways. |
2012-09-07 |
2023-08-12 |
Not clear |
| Su Jung Oh, Holger H H Erb, Alfred Hobisch, Frédéric R Santer, Zoran Culi. Sorafenib decreases proliferation and induces apoptosis of prostate cancer cells by inhibition of the androgen receptor and Akt signaling pathways. Endocrine-related cancer. vol 19. issue 3. 2012-09-07. PMID:22383427. |
sorafenib stimulated apoptosis in prostate cancer cell lines through downregulation of myeloid cell leukemia-1 (mcl-1) expression and akt phosphorylation. |
2012-09-07 |
2023-08-12 |
Not clear |
| Kathrin Zitzmann, George Vlotides, Stephan Brand, Harald Lahm, Gerald Spöttl, Burkhard Göke, Christoph J Auernhamme. Perifosine-mediated Akt inhibition in neuroendocrine tumor cells: role of specific Akt isoforms. Endocrine-related cancer. vol 19. issue 3. 2012-09-07. PMID:22499437. |
perifosine treatment suppressed the phosphorylation of akt downstream targets such as gsk3α/β, mdm2, and p70s6k and induced apoptosis. |
2012-09-07 |
2023-08-12 |
human |
| Fu-Chao Liu, Tsong-Long Hwang, Fu-Wei Liu, Huang-Ping Y. Tropisetron attenuates cardiac injury in a rat trauma-hemorrhage model. Shock (Augusta, Ga.). vol 38. issue 1. 2012-09-06. PMID:22575997. |
cardiac myeloperoxidase activity, interleukin 6 and intercellular adhesion molecule 1 levels, akt activity, and apoptosis were measured. |
2012-09-06 |
2023-08-12 |
rat |
| Nam-Hui Yim, Won-Kyung Cho, Ju Hye Lee, Young Pil Jung, Hye Jin Yang, Jin Yeul M. HRT, Herbal Formula, Induces G(2)/M Cell Cycle Arrest and Apoptosis via Suppressing Akt Signaling Pathway in Human Colon Cancer Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-09-04. PMID:22899960. |
hrt, herbal formula, induces g(2)/m cell cycle arrest and apoptosis via suppressing akt signaling pathway in human colon cancer cells. |
2012-09-04 |
2023-08-12 |
human |
| Vicki L J Whitehall, Celestine Rickman, Catherine E Bond, Ingunn Ramsnes, Sonia A Greco, Aarti Umapathy, Diane McKeone, Rebecca J Faleiro, Ron L Buttenshaw, Daniel L Worthley, Sam Nayler, Zhen Zhen Zhao, Grant W Montgomery, Kylie-Ann Mallitt, Jeremy R Jass, Nagahide Matsubara, Kenji Notohara, Tatsuhiro Ishii, Barbara A Legget. Oncogenic PIK3CA mutations in colorectal cancers and polyps. International journal of cancer. vol 131. issue 4. 2012-08-31. PMID:21932420. |
oncogenic pik3ca mutations contribute to colorectal tumorigenesis by activating akt signaling to decrease apoptosis and increase tumor invasion. |
2012-08-31 |
2023-08-12 |
Not clear |
| Manabu Tatokoro, Fumitaka Koga, Soichiro Yoshida, Satoru Kawakami, Yasuhisa Fujii, Len Neckers, Kazunori Kihar. Potential role of Hsp90 inhibitors in overcoming cisplatin resistance of bladder cancer-initiating cells. International journal of cancer. vol 131. issue 4. 2012-08-31. PMID:21964864. |
the hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-dmag), which simultaneously inactivated both akt and erk signaling at noncytocidal concentrations, synergistically potentiated the cytotoxicity of cddp against bcics by enhancing cddp-induced apoptosis in vitro. |
2012-08-31 |
2023-08-12 |
mouse |
| Soichiro Yoshida, Fumitaka Koga, Manabu Tatokoro, Satoru Kawakami, Yasuhisa Fujii, Jiro Kumagai, Len Neckers, Kazunori Kihar. Low-dose Hsp90 inhibitors tumor-selectively sensitize bladder cancer cells to chemoradiotherapy. Cell cycle (Georgetown, Tex.). vol 10. issue 24. 2012-08-29. PMID:22134243. |
hsp90 inhibitors at low concentrations, which did not exert cytocidal effects but inactivated key anti-apoptotic proteins including erbb2, akt, and nf-κb, efficiently sensitized bladder cancer cells (t24, 5637 and um-uc-3 cells) to in vitro crt by enhancing apoptosis. |
2012-08-29 |
2023-08-12 |
mouse |
| Manpreet Kaur Saini, Sankar Nath Sanya. PTEN regulates apoptotic cell death through PI3-K/Akt/GSK3β signaling pathway in DMH induced early colon carcinogenesis in rat. Experimental and molecular pathology. vol 93. issue 1. 2012-08-24. PMID:22561258. |
western blotting and immunofluorescence results indicated that the expression of pi3-k and akt was promoted in the dmh group while least apoptosis was detected in this group as analyzed by hoechst 33342-propidium iodide co-staining. |
2012-08-24 |
2023-08-12 |
rat |
| Fang Yan, D Brent Pol. Characterization of a probiotic-derived soluble protein which reveals a mechanism of preventive and treatment effects of probiotics on intestinal inflammatory diseases. Gut microbes. vol 3. issue 1. 2012-08-23. PMID:22356855. |
this protein ameliorated cytokine-induced apoptosis in intestinal epithelial cells through activation of the egf receptor and its down-stream target, akt. |
2012-08-23 |
2023-08-12 |
mouse |
| Dowluru Svgk Kaladhar, Potladurthi Chandra Sai, Padmanabhuni V Nageswara Rao, Amajala Krishna Chaitanya, Duddukuri Govinda Rao, Vadlapudi Varahala Rao, Erva Rajeswara Reddy, Sudabattula Vijaya Kumar, Divyakolu Vinod Kuma. Towards an understating of signal transduction protein interaction networks. Bioinformation. vol 8. issue 9. 2012-08-23. PMID:22715315. |
this pathway is also involved in maintaining cell survival by modulating the activity of apoptosis through ras, p13k, akt and bad activities. |
2012-08-23 |
2023-08-12 |
Not clear |
| Ryan H Newton, Laurence A Turk. Regulation of T cell homeostasis and responses by pten. Frontiers in immunology. vol 3. 2012-08-23. PMID:22715338. |
members of the foxo family of transcription factors are also regulated by akt, thus linking control over homing and migration of t cells, as well cell cycle entry, apoptosis, and dna damage and oxidative stress responses, to pi3k signaling. |
2012-08-23 |
2023-08-12 |
Not clear |
| Kaspar M Keledjian, Bernard S Marasa, Jian-Ying Wang, Jaladanki N Ra. Induced PDK1 kinase activity suppresses apoptosis in intestinal epithelial cells by activating Akt signaling following polyamine depletion. International journal of clinical and experimental medicine. vol 5. issue 3. 2012-08-23. PMID:22837796. |
induced pdk1 kinase activity suppresses apoptosis in intestinal epithelial cells by activating akt signaling following polyamine depletion. |
2012-08-23 |
2023-08-12 |
rat |
| Kaspar M Keledjian, Bernard S Marasa, Jian-Ying Wang, Jaladanki N Ra. Induced PDK1 kinase activity suppresses apoptosis in intestinal epithelial cells by activating Akt signaling following polyamine depletion. International journal of clinical and experimental medicine. vol 5. issue 3. 2012-08-23. PMID:22837796. |
decreasing cellular polyamines promotes the resistance of intestinal epithelial cells (iecs) to apoptosis by increasing akt kinase activity, but the exact mechanisms by which polyamine depletion activates akt remain unknown. |
2012-08-23 |
2023-08-12 |
rat |