| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Yingchun, Qu Xiujuan, Qu Jinglei, Zhang Ye, Liu Jing, Teng Yuee, Hu Xuejun, Hou Kezuo, Liu Yunpen. E3 ubiquitin ligase Cbl-b potentiates the apoptotic action of arsenic trioxide by inhibiting the PI3K/Akt pathway. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 44. issue 2. 2012-07-02. PMID:21180886. |
ato induced cellular apoptosis with transient activation of akt and cbl-b was also up-regulated. |
2012-07-02 |
2023-08-12 |
rat |
| Pratibha Gaur, Priya Ranjan, Shipra Sharma, Jenish R Patel, J Bradford Bowzard, Shah K Rahman, Rashmi Kumari, Shivaprakash Gangappa, Jacqueline M Katz, Nancy J Cox, Renu B Lal, Suryaprakash Sambhara, Sunil K La. Influenza A virus neuraminidase protein enhances cell survival through interaction with carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) protein. The Journal of biological chemistry. vol 287. issue 18. 2012-07-02. PMID:22396546. |
na/c6 interaction leads to increased tyrosyl phosphorylation of src, fak, akt, gsk3β, and bcl-2, which affects cell survival, proliferation, migration, differentiation, and apoptosis. |
2012-07-02 |
2023-08-12 |
human |
| Pratibha Gaur, Priya Ranjan, Shipra Sharma, Jenish R Patel, J Bradford Bowzard, Shah K Rahman, Rashmi Kumari, Shivaprakash Gangappa, Jacqueline M Katz, Nancy J Cox, Renu B Lal, Suryaprakash Sambhara, Sunil K La. Influenza A virus neuraminidase protein enhances cell survival through interaction with carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) protein. The Journal of biological chemistry. vol 287. issue 18. 2012-07-02. PMID:22396546. |
sirna-mediated suppression of c6 resulted in a down-regulation of activated src, fak, and akt, increased apoptosis, and reduced expression of viral proteins and viral titers in influenza virus-infected human lung adenocarcinoma epithelial and normal human bronchial epithelial cells. |
2012-07-02 |
2023-08-12 |
human |
| Wen-Juan Wang, Zhan Ma, Yi-Wen Liu, Yi-Qing He, Ying-Zhi Wang, Cui-Xia Yang, Yan Du, Mu-Qing Zhou, Feng Ga. A monoclonal antibody (Mc178-Ab) targeted to the ecto-ATP synthase β-subunit-induced cell apoptosis via a mechanism involving the MAPKase and Akt pathways. Clinical and experimental medicine. vol 12. issue 1. 2012-06-29. PMID:21505868. |
a monoclonal antibody (mc178-ab) targeted to the ecto-atp synthase β-subunit-induced cell apoptosis via a mechanism involving the mapkase and akt pathways. |
2012-06-29 |
2023-08-12 |
Not clear |
| Yan Cheng, Yi Zhang, Li Zhang, Xingcong Ren, Kathryn J Huber-Keener, Xiaoyuan Liu, Lei Zhou, Jason Liao, Heike Keihack, Li Yan, Eric Rubin, Jin-Ming Yan. MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis. Molecular cancer therapeutics. vol 11. issue 1. 2012-06-29. PMID:22057914. |
mk-2206, a novel allosteric inhibitor of akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis. |
2012-06-29 |
2023-08-12 |
mouse |
| Amit Budhraja, Ning Gao, Zhuo Zhang, Young-Ok Son, Senping Cheng, Xin Wang, Songze Ding, Andrew Hitron, Gang Chen, Jia Luo, Xianglin Sh. Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo. Molecular cancer therapeutics. vol 11. issue 1. 2012-06-29. PMID:22084167. |
in this study, we investigated the functional role of akt and c-jun-nh(2)-kinase (jnk) signaling cascades in apigenin-induced apoptosis in u937 human leukemia cells and anti-leukemic activity of apigenin in vivo. |
2012-06-29 |
2023-08-12 |
human |
| Amit Budhraja, Ning Gao, Zhuo Zhang, Young-Ok Son, Senping Cheng, Xin Wang, Songze Ding, Andrew Hitron, Gang Chen, Jia Luo, Xianglin Sh. Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo. Molecular cancer therapeutics. vol 11. issue 1. 2012-06-29. PMID:22084167. |
apigenin induced apoptosis by inactivation of akt with a concomitant activation of jnk, mcl-1 and bcl-2 downregulation, cytochrome c release from mitochondria, and activation of caspases. |
2012-06-29 |
2023-08-12 |
human |
| Amit Budhraja, Ning Gao, Zhuo Zhang, Young-Ok Son, Senping Cheng, Xin Wang, Songze Ding, Andrew Hitron, Gang Chen, Jia Luo, Xianglin Sh. Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo. Molecular cancer therapeutics. vol 11. issue 1. 2012-06-29. PMID:22084167. |
constitutively active myristolated akt prevented apigenin-induced jnk, caspase activation, and apoptosis. |
2012-06-29 |
2023-08-12 |
human |
| Amit Budhraja, Ning Gao, Zhuo Zhang, Young-Ok Son, Senping Cheng, Xin Wang, Songze Ding, Andrew Hitron, Gang Chen, Jia Luo, Xianglin Sh. Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo. Molecular cancer therapeutics. vol 11. issue 1. 2012-06-29. PMID:22084167. |
conversely, ly294002 and a dominant-negative construct of akt potentiated apigenin-induced apoptosis in leukemia cells. |
2012-06-29 |
2023-08-12 |
human |
| Su-Hwa Kim, Eun-Jung Park, Chae Ryun Lee, Jung Nyeo Chun, Nam-Hyuk Cho, In-Gyu Kim, Sanghoon Lee, Tae Woo Kim, Hyun Ho Park, Insuk So, Ju-Hong Jeo. Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells. International journal of oncology. vol 40. issue 5. 2012-06-29. PMID:22200837. |
our findings provide insight into future investigations that are aimed at elucidating the role of apoptosis and autophagy in prostate cancer therapy and at developing anticancer strategies co-targeting akt and ampk. |
2012-06-29 |
2023-08-12 |
Not clear |
| Karen A Nahmod, Thomas Walther, Nadia Cambados, Natalia Fernandez, Roberto Meiss, Nils Tappenbeck, Yong Wang, Diego Raffo, Marina Simian, Anja Schwiebs, Roberto G Pozner, Juan I Fuxman Bass, Andrea G Pozzi, Jorge R Geffner, Edith C Kordon, Carolina Schere-Lev. AT1 receptor blockade delays postlactational mammary gland involution: a novel role for the renin angiotensin system. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 26. issue 5. 2012-06-29. PMID:22286690. |
mammary glands from losartan-treated mice showed activation of the survival factors akt and bcl-(xl), significantly lower lif and tnf-α mrna expression (p<0.05), reduced apoptosis [12.1±2.1% (control) vs. 4.8±0.7% (losartan); p<0.001] and shedding of epithelial cells, inhibition of mmp-9 activity in a dose-dependent manner (80%; p<0.05; with losartan ic(50) value of 6.9 mg/kg/d] and lower collagen deposition and adipocyte invasion causing a delayed involution compared to vehicle-treated mice. |
2012-06-29 |
2023-08-12 |
mouse |
| Ning Gao, Senping Cheng, Amit Budhraja, E-Hu Liu, Jieping Chen, Deying Chen, Zailin Yang, Jia Luo, Xianglin Shi, Zhuo Zhan. 3,3'-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process. PloS one. vol 7. issue 2. 2012-06-29. PMID:22363731. |
enforced activation of akt by a constitutively active akt construct prevented dim-mediated caspase activation, mcl-1 down-regulation, jnk activation, and apoptosis. |
2012-06-29 |
2023-08-12 |
mouse |
| Ning Gao, Senping Cheng, Amit Budhraja, E-Hu Liu, Jieping Chen, Deying Chen, Zailin Yang, Jia Luo, Xianglin Shi, Zhuo Zhan. 3,3'-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process. PloS one. vol 7. issue 2. 2012-06-29. PMID:22363731. |
lastly, dim inhibits tumor growth of mouse u937 xenograft, which was related to induction of apoptosis and inactivation of akt, as well as activation of jnk. |
2012-06-29 |
2023-08-12 |
mouse |
| Ning Gao, Senping Cheng, Amit Budhraja, E-Hu Liu, Jieping Chen, Deying Chen, Zailin Yang, Jia Luo, Xianglin Shi, Zhuo Zhan. 3,3'-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process. PloS one. vol 7. issue 2. 2012-06-29. PMID:22363731. |
collectively, these findings suggest that dim induces apoptosis in human leukemia cell lines and primary human leukemia cells, and exhibits antileukemic activity in vivo through akt inactivation and jnk activation. |
2012-06-29 |
2023-08-12 |
mouse |
| Hyunsoo Kim, Han-Jong Kim, Kyunghee Lee, Jin-Man Kim, Hee Sun Kim, Jae-Ryong Kim, Chae-Myeong Ha, Young-Keun Choi, Sun Joo Lee, Joon-Young Kim, Robert A Harris, Daewon Jeong, In-Kyu Le. α-Lipoic acid attenuates vascular calcification via reversal of mitochondrial function and restoration of Gas6/Axl/Akt survival pathway. Journal of cellular and molecular medicine. vol 16. issue 2. 2012-06-25. PMID:21362131. |
moreover, ala inhibited pi-induced down-regulation of cell survival signals through the binding of growth arrest-specific gene 6 (gas6) to its cognate receptor axl and subsequent akt activation, resulting in increased survival and decreased apoptosis. |
2012-06-25 |
2023-08-12 |
mouse |
| Zhi Peng, Ying Yuan, Ya-Juan Li, Hai-Xia Wang, Jing Shi, Wei-Xi Cao, Hong-Wei Luo, Jing-Rong Deng, Wen-Li Fen. Targeting BCR tyrosine177 site with novel SH2-DED causes selective leukemia cell death in vitro and in vivo. The international journal of biochemistry & cell biology. vol 44. issue 6. 2012-06-25. PMID:22349215. |
further exploration into the underlying mechanisms revealed that ad5/f35-sd exerted its function by binding to the phospho-bcr/abl tyr177 site, reducing ras, mapk and akt kinase activities, and activating caspase-8 induced apoptosis signal by ded protein binding to ded domain of precursor caspase-8. |
2012-06-25 |
2023-08-12 |
mouse |
| Katharina Tomek, Renate Wagner, Franz Varga, Christian F Singer, Heidrun Karlic, Thomas W Grun. Blockade of fatty acid synthase induces ubiquitination and degradation of phosphoinositide-3-kinase signaling proteins in ovarian cancer. Molecular cancer research : MCR. vol 9. issue 12. 2012-06-21. PMID:21970855. |
here, we show that the fasn inhibitor c75 and fasn-targeting sirnas abrogate growth, induce apoptosis, and downregulate phosphorylation/expression of the pi3k effectors akt, mtor, p70s6k, s6, and 4ebp1. |
2012-06-21 |
2023-08-12 |
Not clear |
| Ivana Knezevic, Aalok Patel, Nagalingam R Sundaresan, Mahesh P Gupta, R John Solaro, Raghu S Nagalingam, Madhu Gupt. A novel cardiomyocyte-enriched microRNA, miR-378, targets insulin-like growth factor 1 receptor: implications in postnatal cardiac remodeling and cell survival. The Journal of biological chemistry. vol 287. issue 16. 2012-06-19. PMID:22367207. |
overexpression of mir-378 enhanced apoptosis of cardiomyocytes by direct targeting of igf1r and reduced signaling in akt cascade. |
2012-06-19 |
2023-08-12 |
mouse |
| Lifei Wang, Ping Wang, Yunhui Liu, Yixue Xu. Regulation of cellular growth, apoptosis, and Akt activity in human U251 glioma cells by a combination of cisplatin with CRM197. Anti-cancer drugs. vol 23. issue 1. 2012-06-18. PMID:21934602. |
regulation of cellular growth, apoptosis, and akt activity in human u251 glioma cells by a combination of cisplatin with crm197. |
2012-06-18 |
2023-08-12 |
human |
| Hyun-Jin Nam, Keith A Ching, Julie Kan, Hwang-Phill Kim, Sae-Won Han, Seock-Ah Im, Tae-You Kim, James G Christensen, Do-Youn Oh, Yung-Jue Ban. Evaluation of the antitumor effects and mechanisms of PF00299804, a pan-HER inhibitor, alone or in combination with chemotherapy or targeted agents in gastric cancer. Molecular cancer therapeutics. vol 11. issue 2. 2012-06-18. PMID:22135232. |
pf00299804 induced apoptosis and g(1) arrest and inhibited phosphorylation of receptors in the her family and downstream signaling pathways including stat3, akt, and extracellular signal-regulated kinases (erk) in her2-amplified gastric cancer cells. |
2012-06-18 |
2023-08-12 |
Not clear |