| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kaspar M Keledjian, Bernard S Marasa, Jian-Ying Wang, Jaladanki N Ra. Induced PDK1 kinase activity suppresses apoptosis in intestinal epithelial cells by activating Akt signaling following polyamine depletion. International journal of clinical and experimental medicine. vol 5. issue 3. 2012-08-23. PMID:22837796. |
pdk1 silencing in polyamine-deficient cells not only prevented the induced akt activation but also blocked the increased resistance to apoptosis. |
2012-08-23 |
2023-08-12 |
rat |
| Kaspar M Keledjian, Bernard S Marasa, Jian-Ying Wang, Jaladanki N Ra. Induced PDK1 kinase activity suppresses apoptosis in intestinal epithelial cells by activating Akt signaling following polyamine depletion. International journal of clinical and experimental medicine. vol 5. issue 3. 2012-08-23. PMID:22837796. |
these results indicate that polyamine depletion enhanced akt phosphorylation by increasing pdk1 kinase activity, thereby protecting iecs against apoptosis. |
2012-08-23 |
2023-08-12 |
rat |
| Hector Diez, Juan Jose Garrido, Francisco Wandosel. Specific roles of Akt iso forms in apoptosis and axon growth regulation in neurons. PloS one. vol 7. issue 4. 2012-08-20. PMID:22509246. |
specific roles of akt iso forms in apoptosis and axon growth regulation in neurons. |
2012-08-20 |
2023-08-12 |
Not clear |
| Kimberly Brown Dahlman, Joel S Parker, Tambudzai Shamu, Haley Hieronymus, Caren Chapinski, Brett Carver, Kenneth Chang, Gregory J Hannon, Charles L Sawyer. Modulators of prostate cancer cell proliferation and viability identified by short-hairpin RNA library screening. PloS one. vol 7. issue 4. 2012-08-20. PMID:22509301. |
inhibition of akt with a pharmacologic inhibitor also induced apoptosis when combined with antiandrogens, consistent with recent evidence for pi3k and ar pathway crosstalk in prostate cancer cells. |
2012-08-20 |
2023-08-12 |
human |
| Stephan P Tenbaum, Paloma Ordóñez-Morán, Isabel Puig, Irene Chicote, Oriol Arqués, Stefania Landolfi, Yolanda Fernández, José Raúl Herance, Juan D Gispert, Leire Mendizabal, Susana Aguilar, Santiago Ramón y Cajal, Simó Schwartz, Ana Vivancos, Eloy Espín, Santiago Rojas, José Baselga, Josep Tabernero, Alberto Muñoz, Héctor G Palme. β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer. Nature medicine. vol 18. issue 6. 2012-08-16. PMID:22610277. |
nuclear β-catenin confers resistance to the foxo3a-mediated apoptosis induced by pi3k and akt inhibitors in patient-derived primary cultures and in corresponding xenograft tumors in mice. |
2012-08-16 |
2023-08-12 |
mouse |
| Zhi Ye, Na Wang, Pingping Xia, E Wang, Yajing Yuan, Qulian Gu. Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3β. Neurochemical research. vol 37. issue 2. 2012-08-13. PMID:21964800. |
delayed administration of parecoxib, a specific cox-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation akt and gsk-3β. |
2012-08-13 |
2023-08-12 |
rat |
| Zhi Ye, Na Wang, Pingping Xia, E Wang, Yajing Yuan, Qulian Gu. Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3β. Neurochemical research. vol 37. issue 2. 2012-08-13. PMID:21964800. |
therefore, in this study, we aimed to investigate whether delayed administration of parecoxib inhibited mitochondria-mediated neuronal apoptosis induced by ischemic reperfusion injury via phosphorylating akt and its downstream target protein, glycogen synthase kinase 3β (gsk-3β). |
2012-08-13 |
2023-08-12 |
rat |
| Zhi Ye, Na Wang, Pingping Xia, E Wang, Yajing Yuan, Qulian Gu. Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation Akt and GSK-3β. Neurochemical research. vol 37. issue 2. 2012-08-13. PMID:21964800. |
taken together, these results suggested that parecoxib ameliorated postischemic mitochondria-mediated neuronal apoptosis induced by focal cerebral ischemia in rats and this neuroprotective potential is involved in phosphorylation of akt and gsk-3β. |
2012-08-13 |
2023-08-12 |
rat |
| Bo Li, Hui Ren, Ping Yue, Mingwei Chen, Fadlo R Khuri, Shi-Yong Su. The novel Akt inhibitor API-1 induces c-FLIP degradation and synergizes with TRAIL to augment apoptosis independent of Akt inhibition. Cancer prevention research (Philadelphia, Pa.). vol 5. issue 4. 2012-08-09. PMID:22345097. |
the novel akt inhibitor api-1 induces c-flip degradation and synergizes with trail to augment apoptosis independent of akt inhibition. |
2012-08-09 |
2023-08-12 |
Not clear |
| Bo Li, Hui Ren, Ping Yue, Mingwei Chen, Fadlo R Khuri, Shi-Yong Su. The novel Akt inhibitor API-1 induces c-FLIP degradation and synergizes with TRAIL to augment apoptosis independent of Akt inhibition. Cancer prevention research (Philadelphia, Pa.). vol 5. issue 4. 2012-08-09. PMID:22345097. |
in this study, we reveal a novel function of api-1 in regulation of cellular flice-inhibitory protein (c-flip) levels and trail-induced apoptosis, independent of akt inhibition. |
2012-08-09 |
2023-08-12 |
Not clear |
| Bo Li, Hui Ren, Ping Yue, Mingwei Chen, Fadlo R Khuri, Shi-Yong Su. The novel Akt inhibitor API-1 induces c-FLIP degradation and synergizes with TRAIL to augment apoptosis independent of Akt inhibition. Cancer prevention research (Philadelphia, Pa.). vol 5. issue 4. 2012-08-09. PMID:22345097. |
because other akt inhibitors including api-2 and mk2206 had minimal effects on reducing c-flip and enhancement of trail-induced apoptosis, it is likely that api-1 reduces c-flip and enhances trail-induced apoptosis independent of its akt-inhibitory activity. |
2012-08-09 |
2023-08-12 |
Not clear |
| Gamal Bad. Supplementation with undenatured whey protein during diabetes mellitus improves the healing and closure of diabetic wounds through the rescue of functional long-lived wound macrophages. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 29. issue 3-4. 2012-08-09. PMID:22508064. |
moreover, in the diabetic mice, the wound-resident macrophages were dysfunctional and demonstrated increased apoptosis, a significant reduction in their phagocytotic ability, aberrant activation of stat3 and a marked reduction in the activation of akt. |
2012-08-09 |
2023-08-12 |
mouse |
| Bin Wu, Xu Wang, Zuo-fei Chi, Rong Hu, Rong Zhang, Wei Yang, Zhuo-gang Li. Ursolic acid-induced apoptosis in K562 cells involving upregulation of PTEN gene expression and inactivation of the PI3K/Akt pathway. Archives of pharmacal research. vol 35. issue 3. 2012-07-31. PMID:22477202. |
here, we demonstrated that ua was able to inhibit growth, induce apoptosis in a human chronic myelogenous leukemia cell line (k562 cells) via upregulation of pten gene expression, inhibit akt kinase activity, change mitochondrial transmembrane potential and reduce the release of cytochrome c and the activity of caspases. |
2012-07-31 |
2023-08-12 |
human |
| Chandrani Chattopadhyay, Julie A Ellerhorst, Suhendan Ekmekcioglu, Victoria R Greene, Michael A Davies, Elizabeth A Grim. Association of activated c-Met with NRAS-mutated human melanomas. International journal of cancer. vol 131. issue 2. 2012-07-30. PMID:22020736. |
compared to braf mutants, nras-mutated melanoma cells were more sensitive to pharmacologic c-met inhibition in terms of c-met activation, akt phosphorylation, tumor cell proliferation, migration and apoptosis. |
2012-07-30 |
2023-08-12 |
human |
| Min Ho Han, Won Sup Lee, Jing Nan Lu, Gonsup Kim, Jin Myung Jung, Chung Ho Ryu, Gi-Young Kim, Hye Jin Hwang, Taeg Kyu Kwon, Yung Hyun Cho. Citrus aurantium L. exhibits apoptotic effects on U937 human leukemia cells partly through inhibition of Akt. International journal of oncology. vol 40. issue 6. 2012-07-30. PMID:22307395. |
in conclusion, this study suggested that cme should induce caspase-dependent apoptosis at least in part through akt inhibition, providing evidence that cmes have anticancer activity on human leukemia cells. |
2012-07-30 |
2023-08-12 |
human |
| Christine Unger, Ruxandra Popescu, Benedikt Giessrigl, Lucie Rarova, Irene Herbacek, Mareike Seelinger, Rene Diaz, Bruno Wallnöfer, Monika Fritzer-Szekeres, Thomas Szekeres, Richard Frisch, Karel Doležal, Miroslav Strnad, Rainer De Martin, Michael Grusch, Brigitte Kopp, Georg Krupitz. An apolar extract of Critonia morifolia inhibits c-Myc, cyclin D1, Cdc25A, Cdc25B, Cdc25C and Akt and induces apoptosis. International journal of oncology. vol 40. issue 6. 2012-07-30. PMID:22446629. |
an apolar extract of critonia morifolia inhibits c-myc, cyclin d1, cdc25a, cdc25b, cdc25c and akt and induces apoptosis. |
2012-07-30 |
2023-08-12 |
Not clear |
| Robert J Henning, Steve Dennis, Darrell Sawmiller, Lorynn Hunter, Paul Sanberg, Leslie Mille. Human umbilical cord blood mononuclear cells activate the survival protein Akt in cardiac myocytes and endothelial cells that limits apoptosis and necrosis during hypoxia. Translational research : the journal of laboratory and clinical medicine. vol 159. issue 6. 2012-07-27. PMID:22633101. |
human umbilical cord blood mononuclear cells activate the survival protein akt in cardiac myocytes and endothelial cells that limits apoptosis and necrosis during hypoxia. |
2012-07-27 |
2023-08-12 |
human |
| Robert J Henning, Steve Dennis, Darrell Sawmiller, Lorynn Hunter, Paul Sanberg, Leslie Mille. Human umbilical cord blood mononuclear cells activate the survival protein Akt in cardiac myocytes and endothelial cells that limits apoptosis and necrosis during hypoxia. Translational research : the journal of laboratory and clinical medicine. vol 159. issue 6. 2012-07-27. PMID:22633101. |
thereafter, we inhibited with api, a specific and sensitive akt inhibitor, akt activation in myocytes and endothelial cells cultured with hucbc during hypoxia and determined cell apoptosis and necrosis. |
2012-07-27 |
2023-08-12 |
human |
| Robert J Henning, Steve Dennis, Darrell Sawmiller, Lorynn Hunter, Paul Sanberg, Leslie Mille. Human umbilical cord blood mononuclear cells activate the survival protein Akt in cardiac myocytes and endothelial cells that limits apoptosis and necrosis during hypoxia. Translational research : the journal of laboratory and clinical medicine. vol 159. issue 6. 2012-07-27. PMID:22633101. |
akt activation decreased myocyte apoptosis by 76% and necrosis by 35%. |
2012-07-27 |
2023-08-12 |
human |
| Robert J Henning, Steve Dennis, Darrell Sawmiller, Lorynn Hunter, Paul Sanberg, Leslie Mille. Human umbilical cord blood mononuclear cells activate the survival protein Akt in cardiac myocytes and endothelial cells that limits apoptosis and necrosis during hypoxia. Translational research : the journal of laboratory and clinical medicine. vol 159. issue 6. 2012-07-27. PMID:22633101. |
inhibition of akt with api in myocytes and endothelial cells cultured with hucbc during hypoxia nearly totally prevented the hucbc-induced decrease in apoptosis and necrosis. |
2012-07-27 |
2023-08-12 |
human |