| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Frans van Valen, Henning Harrer, Marc Hotfilder, Uta Dirksen, Thomas Pap, George Gosheger, Hans-Ulrich Humpf, Heribert Jürgen. A Novel Role of IGF1 in Apo2L/TRAIL-Mediated Apoptosis of Ewing Tumor Cells. Sarcoma. vol 2012. 2012-10-24. PMID:23091403. |
short-term igf1 incubation of cells stimulated survival kinase akt and increased x-linked inhibitor of apoptosis (xiap) protein which was associated with apo2l/trail resistance. |
2012-10-24 |
2023-08-12 |
Not clear |
| Shazia Durrani, Khawaja Husnain Haider, Rafeeq P H Ahmed, Shujia Jiang, Muhammad Ashra. Cytoprotective and proangiogenic activity of ex-vivo netrin-1 transgene overexpression protects the heart against ischemia/reperfusion injury. Stem cells and development. vol 21. issue 10. 2012-10-22. PMID:21936706. |
we concluded that netrin-1 decreased apoptosis in cardiomyocytes and endothelial cells via activation of akt. |
2012-10-22 |
2023-08-12 |
rat |
| Abbas K Samadi, Stephanie M Cohen, Ridhwi Mukerji, Vamsee Chaguturu, Xuan Zhang, Barbara N Timmermann, Mark S Cohen, Erica A Perso. Natural withanolide withaferin A induces apoptosis in uveal melanoma cells by suppression of Akt and c-MET activation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 4. 2012-10-19. PMID:22477711. |
natural withanolide withaferin a induces apoptosis in uveal melanoma cells by suppression of akt and c-met activation. |
2012-10-19 |
2023-08-12 |
Not clear |
| Abbas K Samadi, Stephanie M Cohen, Ridhwi Mukerji, Vamsee Chaguturu, Xuan Zhang, Barbara N Timmermann, Mark S Cohen, Erica A Perso. Natural withanolide withaferin A induces apoptosis in uveal melanoma cells by suppression of Akt and c-MET activation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 4. 2012-10-19. PMID:22477711. |
wa induced apoptosis partly through the suppression of c-met, akt, and raf-1 signaling activation. |
2012-10-19 |
2023-08-12 |
Not clear |
| Abbas K Samadi, Stephanie M Cohen, Ridhwi Mukerji, Vamsee Chaguturu, Xuan Zhang, Barbara N Timmermann, Mark S Cohen, Erica A Perso. Natural withanolide withaferin A induces apoptosis in uveal melanoma cells by suppression of Akt and c-MET activation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 4. 2012-10-19. PMID:22477711. |
wa-mediated apoptosis in um cells is partly mediated though the suppression of c-met and akt activation. |
2012-10-19 |
2023-08-12 |
Not clear |
| Fan-Ji Meng, Su-Min Jiao, Bo Y. Picroside II protects cardiomyocytes from hypoxia/reoxygenation-induced apoptosis by activating the PI3K/Akt and CREB pathways. International journal of molecular medicine. vol 30. issue 2. 2012-10-19. PMID:22581361. |
in addition, we found that picroside ii not only increased the expression of bcl-2, while decreasing bax expression, but also augmented akt and camp response element-binding protein (creb) phosphorylation and ultimately inhibited hypoxia/reoxygenation-induced apoptosis. |
2012-10-19 |
2023-08-12 |
Not clear |
| E Ibáñez, A Agliano, C Prior, P Nguewa, M Redrado, I González-Zubeldia, D Plano, J A Palop, C Sanmartín, A Calv. The quinoline imidoselenocarbamate EI201 blocks the AKT/mTOR pathway and targets cancer stem cells leading to a strong antitumor activity. Current medicinal chemistry. vol 19. issue 18. 2012-10-18. PMID:22455594. |
ei201 blocked the phosphorylation of akt, mtor and several of its downstream regulators (p70s6k and 4e-bp1) and erk1/2 in pc-3, ht-29 and mcf-7 cells in vitro, inducing both autophagy and apoptosis. |
2012-10-18 |
2023-08-12 |
mouse |
| Yuan-Peng Yen, Keh-Sung Tsai, Ya-Wen Chen, Chun-Fa Huang, Rong-Sen Yang, Shing-Hwa Li. Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway. Archives of toxicology. vol 86. issue 6. 2012-10-18. PMID:22622864. |
akt) also significantly attenuated as(2)o(3)-induced myoblast apoptosis. |
2012-10-18 |
2023-08-12 |
Not clear |
| Yuan-Peng Yen, Keh-Sung Tsai, Ya-Wen Chen, Chun-Fa Huang, Rong-Sen Yang, Shing-Hwa Li. Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway. Archives of toxicology. vol 86. issue 6. 2012-10-18. PMID:22622864. |
taken together, these results suggest that as(2)o(3) may exert its cytotoxicity on myoblasts by inducing apoptosis through a ros-induced mitochondrial dysfunction, er stress, and akt inactivation signaling pathway. |
2012-10-18 |
2023-08-12 |
Not clear |
| Tomohisa Nakada, Kazuma Kiyotani, Shunsuke Iwano, Takahiko Uno, Masanao Yokohira, Keiko Yamakawa, Masaki Fujieda, Tetsuya Saito, Hiroshi Yamazaki, Katsumi Imaida, Tetsuya Kamatak. Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway. The Journal of toxicological sciences. vol 37. issue 3. 2012-10-18. PMID:22687995. |
enhanced phosphorylation of akt, a key factor responsible for cell survival and inhibition of apoptosis, was detected after cotinine treatment. |
2012-10-18 |
2023-08-12 |
mouse |
| Abubaker M E Sidahmed, Alberto J León, Steven E Bosinger, David Banner, Ali Danesh, Mark J Cameron, David J Kelvi. CXCL10 contributes to p38-mediated apoptosis in primary T lymphocytes in vitro. Cytokine. vol 59. issue 2. 2012-10-16. PMID:22652417. |
the analysis of the downstream signaling kinases shows that apoptosis is p38 mapk-dependent and the pro-survival signals rely on the sustained activation of pi3k and the transient activation of akt. |
2012-10-16 |
2023-08-12 |
human |
| Xin Ye, Yaoting Deng, Zhi-Chun La. Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila. Developmental biology. vol 369. issue 1. 2012-10-16. PMID:22732571. |
thus, hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the akt pathway activity. |
2012-10-16 |
2023-08-12 |
drosophila_melanogaster |
| Wei-Tian Wei, Hui Chen, Zhao-Hong Wang, Zhong-Lin Ni, Hai-Bin Liu, Hong-Fei Tong, Hong-Chun Guo, Dian-Lei Liu, Sheng-Zhang Li. Enhanced antitumor efficacy of gemcitabine by evodiamine on pancreatic cancer via regulating PI3K/Akt pathway. International journal of biological sciences. vol 8. issue 1. 2012-10-09. PMID:22211100. |
in vitro application of the combination therapy triggered significantly higher frequency of pancreatic cancer cells apoptosis, inhibited the activities of pi3k, akt, pka, mtor and pten, and decreased the activation of nf-κb and expression of nf-κb-regulated products. |
2012-10-09 |
2023-08-12 |
Not clear |
| Simona Tavolari, Alessandra Munarini, Gianluca Storci, Stefan Laufer, Pasquale Chieco, Tiziana Guarnier. The decrease of cell membrane fluidity by the non-steroidal anti-inflammatory drug Licofelone inhibits epidermal growth factor receptor signalling and triggers apoptosis in HCA-7 colon cancer cells. Cancer letters. vol 321. issue 2. 2012-10-09. PMID:22343320. |
such phenomenon was associated with the block of egfr kinase activity and of its downstream targets, the p44-42 mitogen-activated protein kinase (mapk) and akt cascades, whose inhibitions were found to induce apoptosis in hca-7 cells. |
2012-10-09 |
2023-08-12 |
Not clear |
| Li Wang, Chao Sun, Zhen-Hua Wang, Guang-Qin Gu. Mechanism of apoptotosis induced by ortho-topolin riboside in human hepatoma cell line SMMC-7721. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 50. issue 6. 2012-10-09. PMID:22465833. |
these results suggest that otr interferes with the mitogen-activated protein kinase (mapk) and akt pathways and induces the apoptosis of human smmc-7721 cells through the activation of intrinsic mitochondria-mediated pathways. |
2012-10-09 |
2023-08-12 |
human |
| Rong Deng, Fen Yang, Shao-hua Chang, Jun Tang, Juan Qin, Gong-Kan Feng, Ke Ding, Xiao-Feng Zh. DC120, a novel and potent inhibitor of AKT kinase, induces tumor cell apoptosis and suppresses tumor growth. Molecular pharmacology. vol 82. issue 2. 2012-10-09. PMID:22553359. |
dc120, a novel and potent inhibitor of akt kinase, induces tumor cell apoptosis and suppresses tumor growth. |
2012-10-09 |
2023-08-12 |
human |
| Mi-Ae Lyu, Lan V Pham, Bokyung Sung, Archito T Tamayo, Kwang Seok Ahn, Walter N Hittelman, Lawrence H Cheung, John W Marks, Min-Jeong Cho, Richard J Ford, Bharat B Aggarwal, Michael G Rosenblu. The therapeutic effects of rGel/BLyS fusion toxin in in vitro and in vivo models of mantle cell lymphoma. Biochemical pharmacology. vol 84. issue 4. 2012-10-08. PMID:22687624. |
combination treatment resulted in a synergistic growth inhibition, down-regulation of nf-κb dna-binding activity, inhibition of cyclin d1, bcl-x(l), p-akt, akt, p-mtor, and p-bad, up-regulation of bax, and induction of cellular apoptosis. |
2012-10-08 |
2023-08-12 |
mouse |
| Timothy P Devarenne, Gregory B Marti. Manipulation of plant programmed cell death pathways during plant-pathogen interactions. Plant signaling & behavior. vol 2. issue 3. 2012-10-02. PMID:19704693. |
the plant pdk1/adi3 pathway appears to function similarly to the pdk1/pkb (akt) pathway in mammals which functions as a major apoptosis negative regulation pathway. |
2012-10-02 |
2023-08-12 |
Not clear |
| Liping Zhou, Hong Luan, Xihua Dong, Yan L. Activation of the PI3K/Akt and MAPK signaling pathways antagonizes adriamycin-induced HL-60 leukemia cell apoptosis. Molecular medicine reports. vol 3. issue 4. 2012-10-02. PMID:21472291. |
akt and erk activation was also detected, and the inhibition of these two pathways resulted in the enhancement of adm-induced apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| Weili Sun, Shakeel Moda. Emerging treatment options for the treatment of neuroblastoma: potential role of perifosine. OncoTargets and therapy. vol 5. 2012-10-02. PMID:22419878. |
it decreases akt phosphorylation and increases caspase-dependent apoptosis in neuroblastoma cell lines, inhibits growth of neuroblastoma xenografts, and overcomes rtk/ligand-mediated chemoresistance. |
2012-10-02 |
2023-08-12 |
Not clear |