| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Feng Ze Wang, Hong Rong Fei, Xiao Qian Li, Renjiu Shi, De Cai Wan. Perifosine as potential anti-cancer agent inhibits proliferation, migration, and tube formation of human umbilical vein endothelial cells. Molecular and cellular biochemistry. vol 368. issue 1-2. 2012-11-30. PMID:21769450. |
the aim of this study is to assess the effects of perifosine, an inhibitor of akt, on cell proliferation, apoptosis, angiogenesis, and vegf-induced cell migration in cultured human umbilical vein endothelial cells (huvecs) in vitro. |
2012-11-30 |
2023-08-12 |
human |
| Rongping Zhang, Xiaohong Cao, Chunling Wang, Lihua Hou, Jianzeng Nie, Minghui Zhou, Yongzhen Fen. An antitumor peptide from Musca domestica pupae (MATP) induces apoptosis in HepG2 cells through a JNK-mediated and Akt-mediated NF-κB pathway. Anti-cancer drugs. vol 23. issue 8. 2012-11-29. PMID:22824823. |
simultaneously, the apoptosis induced by matp was reversed by sp600125 (a jnk inhibitor) whereas it was aggravated by ly294002 (an akt inhibitor). |
2012-11-29 |
2023-08-12 |
human |
| Rongping Zhang, Xiaohong Cao, Chunling Wang, Lihua Hou, Jianzeng Nie, Minghui Zhou, Yongzhen Fen. An antitumor peptide from Musca domestica pupae (MATP) induces apoptosis in HepG2 cells through a JNK-mediated and Akt-mediated NF-κB pathway. Anti-cancer drugs. vol 23. issue 8. 2012-11-29. PMID:22824823. |
these results proved that jnk and akt independently participated in the apoptosis of hepg2 cells, which were treated with matp. |
2012-11-29 |
2023-08-12 |
human |
| Hongyun Wang, Youyuan Xu, Zi Fang, Sen Chen, Steven P Balk, Xin Yua. Doxycycline regulated induction of AKT in murine prostate drives proliferation independently of p27 cyclin dependent kinase inhibitor downregulation. PloS one. vol 7. issue 7. 2012-11-28. PMID:22844460. |
doxycycline withdrawal resulted in apoptosis of cells throughout the lesions and rapid clearing of hyperplastic glands, confirming in vivo the critical antiapoptotic functions of akt. |
2012-11-28 |
2023-08-12 |
mouse |
| Lingling Zhang, Wenjun Ding, Huixing Sun, Qiong Zhou, Jingqun Huang, Xuefen Li, Yonghong Xie, Jianzong Che. Salidroside protects PC12 cells from MPP⁺-induced apoptosis via activation of the PI3K/Akt pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 50. issue 8. 2012-11-26. PMID:22664423. |
sal enhanced akt phosphorylation in pc12 cells, and the protective effects of sal against mpp(+)-induced apoptosis were abolished by ly294002, a specific inhibitor of phosphatidylinositol 3-kinase (pi3k) phosphorylation. |
2012-11-26 |
2023-08-12 |
rat |
| Raghavendra Gowda, Subbarao V Madhunapantula, Dhimant Desai, Shantu Amin, Gavin P Robertso. Selenium-containing histone deacetylase inhibitors for melanoma management. Cancer biology & therapy. vol 13. issue 9. 2012-11-26. PMID:22669577. |
mechanistically, pcp-secn and b(pcp)-2se inhibited hdac activity and had new inhibitory properties by moderating akt activity to induce cellular apoptosis as demonstrated by an increase in the sub-g₀-g₁ cell population, and cleaved caspase-3 as well as parp levels. |
2012-11-26 |
2023-08-12 |
Not clear |
| Xun Zhu, Zhenjian He, Jueheng Wu, Jie Yuan, Weitao Wen, Yiwen Hu, Yi Jiang, Cuiji Lin, Qianhui Zhang, Min Lin, Henan Zhang, Wan Yang, Hong Chen, Lili Zhong, Zhigang She, Shengping Chen, Yongcheng Lin, Mengfeng L. A marine anthraquinone SZ-685C overrides adriamycin-resistance in breast cancer cells through suppressing Akt signaling. Marine drugs. vol 10. issue 4. 2012-11-26. PMID:22690138. |
we found that sz-685c suppressed the akt pathway and induced apoptosis in mcf-7/adr and mcf-7/akt cells that are resistant to adr treatment, leading to antitumor effects both in vitro and in vivo. |
2012-11-26 |
2023-08-12 |
human |
| Zhang Yuan, Chen Long, Tang Junming, Liu Qihuan, Zhang Youshun, Zou Cha. Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt. Molecular biology reports. vol 39. issue 7. 2012-11-23. PMID:22555976. |
quercetin caused leukemia cells apoptosis by decreasing the protein expression of pi3k and bax, the inhibitory phosphorylation of akt, the decreased levels of bcl-2 protein and increased activations of caspase-2 and -3, and increased poly(adp-ribose) polymerase cleavage. |
2012-11-23 |
2023-08-12 |
Not clear |
| P Villagrasa, V M Díaz, R Viñas-Castells, S Peiró, B Del Valle-Pérez, N Dave, A Rodríguez-Asiain, J I Casal, J M Lizcano, M Duñach, A García de Herrero. Akt2 interacts with Snail1 in the E-cadherin promoter. Oncogene. vol 31. issue 36. 2012-11-21. PMID:22158034. |
moreover, snail1 promotes resistance to apoptosis, an effect associated to pten gene repression and akt stimulation. |
2012-11-21 |
2023-08-12 |
Not clear |
| Rong-Jane Chen, Chin-Ming Hung, Yen-Lin Chen, Ming-Der Wu, Gwo-Fang Yuan, Ying-Jan Wan. Monascuspiloin induces apoptosis and autophagic cell death in human prostate cancer cells via the Akt and AMPK signaling pathways. Journal of agricultural and food chemistry. vol 60. issue 29. 2012-11-21. PMID:22738037. |
monascuspiloin induces apoptosis and autophagic cell death in human prostate cancer cells via the akt and ampk signaling pathways. |
2012-11-21 |
2023-08-12 |
mouse |
| Toyofumi Abe, Yoshitaka Isaka, Ryoichi Imamura, Yoichi Kakuta, Masayoshi Okumi, Koji Yazawa, Naotsugu Ichimaru, Hidetoshi Tsuda, Norio Nonomura, Shiro Takahara, Akihiko Okuyam. Carbamylated erythropoietin ameliorates cyclosporine nephropathy without stimulating erythropoiesis. Cell transplantation. vol 21. issue 2-3. 2012-11-20. PMID:22410315. |
csa treatment induced tubular apoptosis, while epo/cepo administration inhibited it and increased pi3 kinase activation and akt phosphorylation. |
2012-11-20 |
2023-08-12 |
Not clear |
| Chongchong Xu, Lei Lv, Guoli Zheng, Beiya Li, Lu Gao, Yan Su. Neuregulin1β1 protects oligodendrocyte progenitor cells from oxygen glucose deprivation injury induced apoptosis via ErbB4-dependent activation of PI3-kinase/Akt. Brain research. vol 1467. 2012-11-20. PMID:22659027. |
escalating dosages of nrg1β1 were used to treat opcs with ogd, and the apoptosis was measured, as well as the expression of erbb receptors, akt and erk phosphorylation and caspase3 activation. |
2012-11-20 |
2023-08-12 |
Not clear |
| Yu-Jia Chang, Yi-Ping Huang, Zih-Ling Li, Ching-Hsein Che. GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and Akt pathway after epirubicin treatment in colon cancer DLD-1 cells. PloS one. vol 7. issue 4. 2012-11-19. PMID:22529978. |
grp78 knockdown enhances apoptosis via the down-regulation of oxidative stress and akt pathway after epirubicin treatment in colon cancer dld-1 cells. |
2012-11-19 |
2023-08-12 |
Not clear |
| Jun Hong, Ahmed Katsha, Pengcheng Lu, Yu Shyr, Abbes Belkhiri, Wael El-Rifa. Regulation of ERBB2 receptor by t-DARPP mediates trastuzumab resistance in human esophageal adenocarcinoma. Cancer research. vol 72. issue 17. 2012-11-19. PMID:22745369. |
the annexin-v staining and western blot analysis indicated that t-darpp effectively abrogated trastuzumab-induced apoptosis, inhibited cleavage of caspase-3, and blocked trastuzumab-induced dephosphorylation of erbb2 and akt proteins. |
2012-11-19 |
2023-08-12 |
mouse |
| Hsiao-Ling Tseng, Chia-Jung Li, Lin-Huang Huang, Chun-Yao Chen, Chun-Hao Tsai, Chun-Nan Lin, Hsue-Yin Hs. Quercetin 3-O-methyl ether protects FL83B cells from copper induced oxidative stress through the PI3K/Akt and MAPK/Erk pathway. Toxicology and applied pharmacology. vol 264. issue 1. 2012-11-19. PMID:22842013. |
our results indicated that cu(2+)-induced apoptosis in fl83b cells occurred via the generation of ros, upregulation and phosphorylation of erk, overexpression of 14-3-3, inactivation of akt, and the downregulation of foxo3a and mnsod. |
2012-11-19 |
2023-08-12 |
mouse |
| Jingshu Wang, Xiangsheng Xiao, Yun Zhang, Dingbo Shi, Wangbing Chen, Lingyi Fu, Liqun Liu, Fangyun Xie, Tiebang Kang, Wenlin Huang, Wuguo Den. Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells. Journal of pineal research. vol 53. issue 1. 2012-11-13. PMID:22335196. |
simultaneous modulation of cox-2, p300, akt, and apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells. |
2012-11-13 |
2023-08-12 |
human |
| Yu-Chin Lin, Kuei-Chiu Chen, Ching-Chow Chen, Ann-Lii Cheng, Kuen-Feng Che. CIP2A-mediated Akt activation plays a role in bortezomib-induced apoptosis in head and neck squamous cell carcinoma cells. Oral oncology. vol 48. issue 7. 2012-11-13. PMID:22342571. |
cip2a-mediated akt activation plays a role in bortezomib-induced apoptosis in head and neck squamous cell carcinoma cells. |
2012-11-13 |
2023-08-12 |
Not clear |
| Yu-Chin Lin, Kuei-Chiu Chen, Ching-Chow Chen, Ann-Lii Cheng, Kuen-Feng Che. CIP2A-mediated Akt activation plays a role in bortezomib-induced apoptosis in head and neck squamous cell carcinoma cells. Oral oncology. vol 48. issue 7. 2012-11-13. PMID:22342571. |
here, we disclose that bortezomib induced apoptosis of hnscc cells in vitro and in vivo through inhibition of cancerous inhibitor of protein phosphatase 2a (cip2a)-mediated pp2a dependent akt activation. |
2012-11-13 |
2023-08-12 |
Not clear |
| Yu-Chin Lin, Kuei-Chiu Chen, Ching-Chow Chen, Ann-Lii Cheng, Kuen-Feng Che. CIP2A-mediated Akt activation plays a role in bortezomib-induced apoptosis in head and neck squamous cell carcinoma cells. Oral oncology. vol 48. issue 7. 2012-11-13. PMID:22342571. |
silencing pp2a by small interference rna (sirna) abolished bortezomib-induced akt inhibition and apoptosis. |
2012-11-13 |
2023-08-12 |
Not clear |
| Yu-Chin Lin, Meng-Hsuan Wu, Tzu-Tang Wei, Shu-Hui Chuang, Kuen-Feng Chen, Ann-Lii Cheng, Ching-Chow Che. Degradation of epidermal growth factor receptor mediates dasatinib-induced apoptosis in head and neck squamous cell carcinoma cells. Neoplasia (New York, N.Y.). vol 14. issue 6. 2012-11-13. PMID:22787428. |
growth inhibition and apoptosis were correlated with its inhibition on akt, erk, and bcl-2, irrespective of src inhibition. |
2012-11-13 |
2023-08-12 |
Not clear |