| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shu-Er Chow, Yu-Wen Chen, Chi-Ang Liang, Yao-Kuan Huang, Jong-Shyan Wan. Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. Journal of cellular biochemistry. vol 113. issue 11. 2013-02-04. PMID:22689083. |
wogonin induces cross-regulation between autophagy and apoptosis via a variety of akt pathway in human nasopharyngeal carcinoma cells. |
2013-02-04 |
2023-08-12 |
human |
| Shu-Er Chow, Yu-Wen Chen, Chi-Ang Liang, Yao-Kuan Huang, Jong-Shyan Wan. Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. Journal of cellular biochemistry. vol 113. issue 11. 2013-02-04. PMID:22689083. |
this study indicated wogonin-induced both autophagy and apoptosis through a variety of akt pathways and suggested modulation of autophagy might provide profoundly the potential therapeutic effect. |
2013-02-04 |
2023-08-12 |
human |
| Cerrone R Foster, QinQin Zha, Laura L Daniel, Mahipal Singh, Krishna Sing. Lack of ataxia telangiectasia mutated kinase induces structural and functional changes in the heart: role in β-adrenergic receptor-stimulated apoptosis. Experimental physiology. vol 97. issue 4. 2013-02-01. PMID:22179422. |
β-adrenergic receptor-stimulated apoptosis in wt hearts is associated with a p53- and jnks-dependent mechanism, while decreased akt activity may play a role in increased myocyte apoptosis in the absence of atm. |
2013-02-01 |
2023-08-12 |
mouse |
| Yonglin Gao, Chaohua Dong, Jungang Yin, Jingyu Shen, Jingwei Tian, Chunmei L. Neuroprotective effect of fucoidan on H2O2-induced apoptosis in PC12 cells via activation of PI3K/Akt pathway. Cellular and molecular neurobiology. vol 32. issue 4. 2013-01-31. PMID:22222440. |
in addition, fucoidan treatment inhibited apoptosis in h(2)o(2)-induced pc12 cells by increasing the bcl-2/bax ratio and decreasing active caspase-3 expression, as well as enhancing akt phosphorylation (p-akt). |
2013-01-31 |
2023-08-12 |
Not clear |
| Baocai Lu, Wenyu Di, Huimin Wang, Huimin Ma, Jinsong Li, Qunmei Zhan. Tumor suppressor TSLC1 is implicated in cell proliferation, invasion and apoptosis in laryngeal squamous cell carcinoma by regulating Akt signaling pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 6. 2013-01-31. PMID:23136087. |
tumor suppressor tslc1 is implicated in cell proliferation, invasion and apoptosis in laryngeal squamous cell carcinoma by regulating akt signaling pathway. |
2013-01-31 |
2023-08-12 |
Not clear |
| Baocai Lu, Wenyu Di, Huimin Wang, Huimin Ma, Jinsong Li, Qunmei Zhan. Tumor suppressor TSLC1 is implicated in cell proliferation, invasion and apoptosis in laryngeal squamous cell carcinoma by regulating Akt signaling pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 6. 2013-01-31. PMID:23136087. |
elevation of tslc1 level inhibited cell proliferation, reduced cell invasion in vitro and induced cell apoptosis in hep-2 cells, most importantly, tslc1 upregulation decreased the level of pakt, but not changed the level of total akt in hep-2 cells. |
2013-01-31 |
2023-08-12 |
Not clear |
| Bhavani P Madakashira, Daniel A Kobrinski, Andrew D Hancher, Elizabeth C Arneman, Brad D Wagner, Fen Wang, Hailey Shin, Frank J Lovicu, Lixing W Reneker, Michael L Robinso. Frs2α enhances fibroblast growth factor-mediated survival and differentiation in lens development. Development (Cambridge, England). vol 139. issue 24. 2013-01-31. PMID:23136392. |
loss of frs2α in the lens significantly increases apoptosis and decreases phosphorylation of both erk1/2 and akt. |
2013-01-31 |
2023-08-12 |
Not clear |
| Lin Yang, Xiao-Gang Guo, Chang-Qing Du, Jin-Xiu Yang, Dong-Mei Jiang, Bo Li, Wen-Jing Zhou, Fu-Rong Zhan. Interleukin-1 beta increases activity of human endothelial progenitor cells: involvement of PI3K-Akt signaling pathway. Inflammation. vol 35. issue 4. 2013-01-30. PMID:22371121. |
after ex vivo cultivation, epcs were stimulated with a series of final concentrations (0, 0.1, 1, and 10 ng/ml) of il-1β for 24 h. in some other experiments, epcs were pretreated with 10 μm ly294002 (akt inhibitor) for 30 min and then stimulated with 1 ng/ml il-1β for 24 h. cell proliferation, apoptosis, adhesion, and migration were determined, respectively, by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, annexin v/propidium iodide binding assay, adhesion assay, and transwell migration assay. |
2013-01-30 |
2023-08-12 |
human |
| Wei Cui, Wenming Li, Renwen Han, Shinghung Mak, Huan Zhang, Shengquan Hu, Jianhui Rong, Yifan Ha. PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP+-induced neuronal apoptosis. Neurochemistry international. vol 59. issue 6. 2013-01-29. PMID:21781996. |
both inhibition of the akt pathway and activation of the extracellular signal-regulated kinase (erk) pathway contribute to mpp(+)-induced neuronal apoptosis. |
2013-01-29 |
2023-08-12 |
Not clear |
| Senthilkumar Kalimuthu, Kim Se-Kwo. Cell survival and apoptosis signaling as therapeutic target for cancer: marine bioactive compounds. International journal of molecular sciences. vol 14. issue 2. 2013-01-28. PMID:23348928. |
inhibition of apoptosis leads to activation of cell survival factors (e.g., akt) causes continuous cell proliferation in cancer. |
2013-01-28 |
2023-08-12 |
Not clear |
| María Cristina Estañ, Eva Calviño, Elena de Blas, María del Carmen Boyano-Adánez, Maria Luz Mena, Milagros Gómez-Gómez, Eduardo Rial, Patricio Alle. 2-Deoxy-D-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: involvement of IGF-1R-regulated Akt/mTOR, MEK/ERK and LKB-1/AMPK signaling pathways. Biochemical pharmacology. vol 84. issue 12. 2013-01-25. PMID:23041229. |
the use of kinase-specific pharmacologic inhibitors and/or sirnas reveals that apoptosis is facilitated by ampk inactivation and restrained by akt and erk activation, and that akt and erk activation mediates ampk inhibition. |
2013-01-25 |
2023-08-12 |
human |
| María Cristina Estañ, Eva Calviño, Elena de Blas, María del Carmen Boyano-Adánez, Maria Luz Mena, Milagros Gómez-Gómez, Eduardo Rial, Patricio Alle. 2-Deoxy-D-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: involvement of IGF-1R-regulated Akt/mTOR, MEK/ERK and LKB-1/AMPK signaling pathways. Biochemical pharmacology. vol 84. issue 12. 2013-01-25. PMID:23041229. |
finally, 2-dg stimulates igf-1r phosphorylation/activation, and co-treatment with igf-1r inhibitor prevents 2-dg effects on akt, erk and ampk, and facilitates 2-dg-provoked apoptosis. |
2013-01-25 |
2023-08-12 |
human |
| María Cristina Estañ, Eva Calviño, Elena de Blas, María del Carmen Boyano-Adánez, Maria Luz Mena, Milagros Gómez-Gómez, Eduardo Rial, Patricio Alle. 2-Deoxy-D-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: involvement of IGF-1R-regulated Akt/mTOR, MEK/ERK and LKB-1/AMPK signaling pathways. Biochemical pharmacology. vol 84. issue 12. 2013-01-25. PMID:23041229. |
in summary 2-dg elicits igf-1r-mediated ampk inactivation and akt and erk activation, which facilitates or restrain apoptosis, respectively. |
2013-01-25 |
2023-08-12 |
human |
| Sifan Chen, Xincai Xiao, Xiang Feng, Wenxue Li, Niman Zhou, Lin Zheng, Yanshuang Sun, Zili Zhang, Wei Zh. Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression. The Journal of nutritional biochemistry. vol 23. issue 9. 2013-01-24. PMID:22137261. |
resveratrol induces sirt1-dependent apoptosis in 3t3-l1 preadipocytes by activating ampk and suppressing akt activity and survivin expression. |
2013-01-24 |
2023-08-12 |
Not clear |
| Dong Zhou, Yingjian Li, Lin Lin, Lili Zhou, Peter Igarashi, Youhua Li. Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice. Kidney international. vol 82. issue 5. 2013-01-24. PMID:22622501. |
consistently, apoptosis was more prevalent in kidneys of the knockout mice, which was accompanied by increased expression of p53 and bax, and decreased phosphorylated akt and survivin. |
2013-01-24 |
2023-08-12 |
mouse |
| Dong Zhou, Yingjian Li, Lin Lin, Lili Zhou, Peter Igarashi, Youhua Li. Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice. Kidney international. vol 82. issue 5. 2013-01-24. PMID:22622501. |
in vitro activation of β-catenin by wnt1 or stabilization of β-catenin protected tubular epithelial cells from apoptosis, activated akt, induced survivin, and repressed p53 and bax expression. |
2013-01-24 |
2023-08-12 |
mouse |
| Babasaheb Yadav, Sebastien Taurin, Lesley Larsen, Rhonda J Rosengre. RL71, a second-generation curcumin analog, induces apoptosis and downregulates Akt in ER-negative breast cancer cells. International journal of oncology. vol 41. issue 3. 2013-01-23. PMID:22710975. |
rl71, a second-generation curcumin analog, induces apoptosis and downregulates akt in er-negative breast cancer cells. |
2013-01-23 |
2023-08-12 |
Not clear |
| Alberto M Martelli, Giovanna Tabellini, Daniela Bressanin, Andrea Ognibene, Kaoru Goto, Lucio Cocco, Camilla Evangelist. The emerging multiple roles of nuclear Akt. Biochimica et biophysica acta. vol 1823. issue 12. 2013-01-18. PMID:22960641. |
for example, nuclear akt counteracts apoptosis through a block of caspase-activated dnase: deoxyribonuclease and inhibition of chromatin condensation, and is also involved in cell cycle progression control, cell differentiation, mrna: messenger rna export, dna repair, and tumorigenesis. |
2013-01-18 |
2023-08-12 |
Not clear |
| Md Asaduzzaman Khan, Han-chun Chen, Mousumi Tania, Dian-zheng Zhan. Anticancer activities of Nigella sativa (black cumin). African journal of traditional, complementary, and alternative medicines : AJTCAM. vol 8. issue 5 Suppl. 2013-01-09. PMID:22754079. |
the molecular mechanisms behind its anticancer role is still not clearly understood, however, some studies showed that tq has antioxidant role and improves body's defense system, induces apoptosis and controls akt pathway. |
2013-01-09 |
2023-08-12 |
Not clear |
| Li Yuan, Jing Wang, Haifang Xiao, Chunxia Xiao, Yutang Wang, Xuebo Li. Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells. Toxicology and applied pharmacology. vol 265. issue 1. 2013-01-08. PMID:23026832. |
furthermore, the addition of a ros inhibitor (n-acetyl cysteine, nac) or inos inhibitor (n-[3-(aminomethyl) benzyl] acetamidine, dihydrochloride, 1400w) significantly diminished the apoptosis induced by iso and also blocked the phosphorylation of akt. |
2013-01-08 |
2023-08-12 |
human |