| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea Rachelle C Santos, Raul G Corredor, Betty Albo Obeso, Ephraim F Trakhtenberg, Ying Wang, Jamie Ponmattam, Galina Dvoriantchikova, Dmitry Ivanov, Valery I Shestopalov, Jeffrey L Goldberg, Mary Elizabeth Fini, Michaela Livia Bajenar. β1 integrin-focal adhesion kinase (FAK) signaling modulates retinal ganglion cell (RGC) survival. PloS one. vol 7. issue 10. 2013-04-12. PMID:23118988. |
finally, in vivo after riri, we observed an up-regulation of mmp-9, proteolytic degradation of laminin, decreased rgc expression of β1 integrin, fak and akt dephosphorylation, and reduced expression of the pro-survival molecule bcl-xl in the period preceding rgc apoptosis. |
2013-04-12 |
2023-08-12 |
mouse |
| Julio C Tobón-Velasco, Jorge H Limón-Pacheco, Marisol Orozco-Ibarra, Marina Macías-Silva, Genaro Vázquez-Victorio, Elvis Cuevas, Syed F Ali, Antonio Cuadrado, José Pedraza-Chaverrí, Abel Santamarí. RETRACTED: 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors. Toxicology. vol 304. 2013-04-08. PMID:23274087. |
mitochondrial function, caspases-dependent apoptosis, kinases signaling (akt, erk 1/2, sap/jnk and p38) and crosstalk between nuclear factor kappa b (nf-κb) and nuclear factor-erythroid-2-related factor 2 (nrf2) were evaluated at early times post-lesion. |
2013-04-08 |
2023-08-12 |
rat |
| Yan Li, Yi Jiang, Yicong Wan, Lin Zhang, Weiwei Tang, Jingjing Ma, Shan Wu, Wenjun Chen. Medroxyprogestogen enhances apoptosis of SKOV-3 cells via inhibition of the PI3K/Akt signaling pathway. Journal of biomedical research. vol 27. issue 1. 2013-04-05. PMID:23554793. |
the findings suggest that medroxyprogestogen can induce skov-3 cell apoptosis by inhibiting akt phosphorylation. |
2013-04-05 |
2023-08-12 |
Not clear |
| Joanna DeSalvo, Jeffim N Kuznetsov, Jianfeng Du, Gilles M Leclerc, Guy J Leclerc, Theodore J Lampidis, Julio C Barred. Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia. Molecular cancer research : MCR. vol 10. issue 7. 2013-04-04. PMID:22692960. |
inhibition of akt potentiates 2-dg-induced apoptosis via downregulation of upr in acute lymphoblastic leukemia. |
2013-04-04 |
2023-08-12 |
Not clear |
| R Wang, L Xia, J Gabrilove, S Waxman, Y Jin. Downregulation of Mcl-1 through GSK-3β activation contributes to arsenic trioxide-induced apoptosis in acute myeloid leukemia cells. Leukemia. vol 27. issue 2. 2013-04-04. PMID:22751450. |
both erk and akt inhibitors decreased mcl-1 levels and enhanced ato-induced apoptosis in hl-60 cells. |
2013-04-04 |
2023-08-12 |
Not clear |
| Hsing-Yu Weng, Ming-Jen Hsu, Ching-Chung Wang, Bing-Chang Chen, Chuang-Ye Hong, Mei-Chieh Chen, Wen-Ta Chiu, Chien-Huang Li. Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells. Journal of biomedical science. vol 19. 2013-04-03. PMID:23035900. |
zerumbone suppresses ikkα, akt, and foxo1 activation, resulting in apoptosis of gbm 8401 cells. |
2013-04-03 |
2023-08-12 |
human |
| Y-L Xie, Y-E Pan, C-J Chang, P-C Tang, Y-F Huang, R L Walzem, S-E Che. Palmitic acid in chicken granulosa cell death-lipotoxic mechanisms mediate reproductive inefficacy of broiler breeder hens. Theriogenology. vol 78. issue 9. 2013-04-02. PMID:23058789. |
based on vital staining of freshly isolated granulosa cells with annexin v/propidium iodide, there were increases in apoptosis consistent with suppressed akt activation (p < 0.05). |
2013-04-02 |
2023-08-12 |
chicken |
| Poyil Pratheeshkumar, Amit Budhraja, Young-Ok Son, Xin Wang, Zhuo Zhang, Songze Ding, Lei Wang, Andrew Hitron, Jeong-Chae Lee, Mei Xu, Gang Chen, Jia Luo, Xianglin Sh. Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PloS one. vol 7. issue 10. 2013-04-01. PMID:23094058. |
furthermore, quercetin reduced the cell viability and induced apoptosis in prostate cancer cells, which were correlated with the downregulation of akt, mtor and p70s6k expressions. |
2013-04-01 |
2023-08-12 |
mouse |
| Yen-Chuan Ou, Yu-Hsiang Kuan, Jian-Ri Li, Shue-Ling Raung, Chung-Chiang Wang, Yu-Yeh Hung, Chun-Jung Che. Induction of apoptosis by luteolin involving akt inactivation in human 786-o renal cell carcinoma cells. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-04-01. PMID:23476679. |
induction of apoptosis by luteolin involving akt inactivation in human 786-o renal cell carcinoma cells. |
2013-04-01 |
2023-08-12 |
human |
| Yen-Chuan Ou, Yu-Hsiang Kuan, Jian-Ri Li, Shue-Ling Raung, Chung-Chiang Wang, Yu-Yeh Hung, Chun-Jung Che. Induction of apoptosis by luteolin involving akt inactivation in human 786-o renal cell carcinoma cells. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-04-01. PMID:23476679. |
this cytotoxicity was caused by the downregulation of akt and resultant upregulation of apoptosis signal-regulating kinase-1 (ask1), p38, and c-jun n-terminal kinase (jnk) activities, probably via protein phosphatase 2a (pp2a) activation. |
2013-04-01 |
2023-08-12 |
human |
| Soma Seal, Priyajit Chatterjee, Sushmita Bhattacharya, Durba Pal, Suman Dasgupta, Rakesh Kundu, Sandip Mukherjee, Shelley Bhattacharya, Mantu Bhuyan, Pranab R Bhattacharyya, Gakul Baishya, Nabin C Barua, Pranab K Baruah, Paruchuri G Rao, Samir Bhattachary. Vapor of volatile oils from Litsea cubeba seed induces apoptosis and causes cell cycle arrest in lung cancer cells. PloS one. vol 7. issue 10. 2013-03-28. PMID:23091605. |
taken together, vco produces two prong effects on lung cancer cells, it induces apoptosis and blocked cancer cell proliferation, both occurred due to the deactivation of akt. |
2013-03-28 |
2023-08-12 |
human |
| Xian-biao Xie, Jun-qiang Yin, Li-li Wen, Zhen-hua Gao, Chang-ye Zou, Jin Wang, Gang Huang, Qing-lian Tang, Chiara Colombo, Wei-ling He, Qiang Jia, Jing-nan She. Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research. PloS one. vol 7. issue 10. 2013-03-28. PMID:23091618. |
hsp27 over-expression protected against bufalin-induced apoptosis, reversed the dephosphorylation of akt and preserved the level of nuclear nf-κb p65 and co-immunoprecipitated hsp27/cytochrome c. moreover, bufalin inhibited mtx-resistant osteosarcoma xenograft growth, and a down-regulation of hsp27 in vivo was observed. |
2013-03-28 |
2023-08-12 |
human |
| Zhenzhen Zhang, Tingmei Ye, Xueting Cai, Jie Yang, Wuguang Lu, Chunping Hu, Zhigang Wang, Xiaoning Wang, Peng Ca. 5,7-Dihydroxyflavone Enhances the Apoptosis-Inducing Potential of TRAIL in Human Tumor Cells via Regulation of Apoptosis-Related Proteins. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-03-28. PMID:23533482. |
5,7-dihydroxyflavone up-regulated the expression of pro-apoptotic protein bax, attenuated the expression of anti-apoptotic proteins bcl-2, mcl-1, and iaps, and reduced the phosphorylation levels of akt and stat3, weakening the anti-apoptotic signals thus facilitating the process of apoptosis. |
2013-03-28 |
2023-08-12 |
mouse |
| Mahmood S Choudhery, Mohsin Khan, Ruhma Mahmood, Sadia Mohsin, Shoaib Akhtar, Fatima Ali, Shaheen N Khan, Sheikh Riazuddi. Mesenchymal stem cells conditioned with glucose depletion augments their ability to repair-infarcted myocardium. Journal of cellular and molecular medicine. vol 16. issue 10. 2013-03-26. PMID:22435530. |
in this study, mscs from young (2 months) and aged (24 months) c57bl/6 mice were characterized for gene expression of igf-1, fgf-2, vegf, sirt-1, akt, p16(ink4a) , p21 and p53 along with measurements of population doubling (pd), superoxide dismutase (sod) activity and apoptosis. |
2013-03-26 |
2023-08-12 |
mouse |
| Tracy M Crotty, Tomoyuki Nakano, Diana M Stafforini, Matthew K Topha. Diacylglycerol kinase δ modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2). The Journal of biological chemistry. vol 288. issue 3. 2013-03-26. PMID:23184957. |
because of its ability to reduce akt phosphorylation, we tested whether depletion of dgkδ could attenuate tumorigenic properties of cultured cells and found that dgkδ deficiency reduced cell proliferation and migration and enhanced apoptosis. |
2013-03-26 |
2023-08-12 |
Not clear |
| Xian-Ying Fang, Wei Chen, Jun-Ting Fan, Ran Song, Lu Wang, Yan-Hong Gu, Guang-Zhi Zeng, Yan Shen, Xue-Feng Wu, Ning-Hua Tan, Qiang Xu, Yang Su. Plant cyclopeptide RA-V kills human breast cancer cells by inducing mitochondria-mediated apoptosis through blocking PDK1-AKT interaction. Toxicology and applied pharmacology. vol 267. issue 1. 2013-03-25. PMID:23274515. |
furthermore, ra-v-induced apoptosis could be enhanced by phosphatidylinositol 3-kinase inhibitor or attenuated by over-expression of akt in all the three kinds of breast cancer cells. |
2013-03-25 |
2023-08-12 |
human |
| Subhasis Das, Kaushik Kumar Dey, Goutam Dey, Ipsita Pal, Abhijit Majumder, Sujata MaitiChoudhury, Subhas C kundu, Mahitosh Manda. Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma. PloS one. vol 7. issue 10. 2013-03-20. PMID:23077516. |
these drugs inhibited akt and jnk phosphorylations, thus inhibiting cell proliferation while inducing apoptosis. |
2013-03-20 |
2023-08-12 |
mouse |
| Sivalokanathan Sarveswaran, Vijayalakshmi Thamilselvan, Chaya Brodie, Jagadananda Ghos. Inhibition of 5-lipoxygenase triggers apoptosis in prostate cancer cells via down-regulation of protein kinase C-epsilon. Biochimica et biophysica acta. vol 1813. issue 12. 2013-03-19. PMID:21824498. |
recently, we reported that mk591, a specific inhibitor of 5-lox activity, induces apoptosis in prostate cancer cells without inhibition of akt, or erk, two well-characterized regulators of pro-survival mechanisms, suggesting the existence of an akt and erk-independent survival mechanism in prostate cancer cells regulated by 5-lox. |
2013-03-19 |
2023-08-12 |
human |
| Alan L Ho, Elgilda Musi, Grazia Ambrosini, Jayasree S Nair, Shyamprasad Deraje Vasudeva, Elisa de Stanchina, Gary K Schwart. Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype. PloS one. vol 7. issue 7. 2013-03-19. PMID:22808163. |
for braf mutant cells, both akt and 4e-bp1 phosphorylation were modulated by the combination; however, decreasing akt phosphorylation alone was not sufficient and decreasing 4e-bp1 phosphorylation was not required for apoptosis. |
2013-03-19 |
2023-08-12 |
Not clear |
| Yan Song, Richard J Santen, Ji-Ping Wang, Wei Yu. Inhibitory effects of a bazedoxifene/conjugated equine estrogen combination on human breast cancer cells in vitro. Endocrinology. vol 154. issue 2. 2013-03-19. PMID:23254198. |
both ce and e(2) alone increased dna synthesis and reduced apoptosis with activation of mapk, akt, and p70s6k and up-regulation of antiapoptotic factors survivin, bcl-2, and x-linked inhibitor of apoptosis protein, these effects could be completely blocked by bza. |
2013-03-19 |
2023-08-12 |
human |