| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seung Bin Park, Jong Woon Bae, Jong Min Kim, Seung Gee Lee, Myoungseok Ha. Antiproliferative and apoptotic effect of epigallocatechin-3-gallate on Ishikawa cells is accompanied by sex steroid receptor downregulation. International journal of molecular medicine. vol 30. issue 5. 2013-03-07. PMID:22923012. |
this compound interfered with akt activation and mapk signals, and increased apoptosis signals leading to a controlled caspases, bcl-2, bax genes and protein expression. |
2013-03-07 |
2023-08-12 |
human |
| Seung Bin Park, Jong Woon Bae, Jong Min Kim, Seung Gee Lee, Myoungseok Ha. Antiproliferative and apoptotic effect of epigallocatechin-3-gallate on Ishikawa cells is accompanied by sex steroid receptor downregulation. International journal of molecular medicine. vol 30. issue 5. 2013-03-07. PMID:22923012. |
taken together, egcg inhibits cell proliferation and induces apoptosis through akt and mapk signals. |
2013-03-07 |
2023-08-12 |
human |
| R Montgomery Gill, Timothy V Gabor, Amber L Couzens, Michael P Schei. The MYC-associated protein CDCA7 is phosphorylated by AKT to regulate MYC-dependent apoptosis and transformation. Molecular and cellular biology. vol 33. issue 3. 2013-03-07. PMID:23166294. |
the myc-associated protein cdca7 is phosphorylated by akt to regulate myc-dependent apoptosis and transformation. |
2013-03-07 |
2023-08-12 |
Not clear |
| Bingzhang Jie, Xiaoxia Zhang, Xuesi Wu, Yi Xin, Yong Liu, Yongfang Gu. Neuregulin-1 suppresses cardiomyocyte apoptosis by activating PI3K/Akt and inhibiting mitochondrial permeability transition pore. Molecular and cellular biochemistry. vol 370. issue 1-2. 2013-03-05. PMID:22886427. |
rhnrg-1 inhibited mptp and activated akt in the presence of h(2)o(2) and further protected the cells from h(2)o(2)-induced apoptosis. |
2013-03-05 |
2023-08-12 |
human |
| Xiao-Nan Wang, Qing Wu, Xu Yan. [Effect of celastrol on Akt signaling pathway and apoptosis of leukemic K562 cell line]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 31. issue 2. 2013-03-04. PMID:21425580. |
[effect of celastrol on akt signaling pathway and apoptosis of leukemic k562 cell line]. |
2013-03-04 |
2023-08-12 |
human |
| Xiao-Nan Wang, Qing Wu, Xu Yan. [Effect of celastrol on Akt signaling pathway and apoptosis of leukemic K562 cell line]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 31. issue 2. 2013-03-04. PMID:21425580. |
to research the effect and route of celastrol on akt signaling pathway of human leukemia cell line k562 apoptosis. |
2013-03-04 |
2023-08-12 |
human |
| Kuniharu Matsuno, Kazumi Iwata, Misaki Matsumoto, Masato Katsuyama, Wenhao Cui, Ayumi Murata, Hideo Nakamura, Masakazu Ibi, Kanako Ikami, Jia Zhang, Satoaki Matoba, Denan Jin, Shinji Takai, Hiroaki Matsubara, Naoyuki Matsuda, Chihiro Yabe-Nishimur. NOX1/NADPH oxidase is involved in endotoxin-induced cardiomyocyte apoptosis. Free radical biology & medicine. vol 53. issue 9. 2013-03-04. PMID:22982050. |
taken together, ros derived from nox1/nadph oxidase play a pivotal role in endotoxin-induced cardiomyocyte apoptosis by increasing oxidation of akt and subsequent dephosphorylation by pp2a. |
2013-03-04 |
2023-08-12 |
mouse |
| Lixia Ju, Caicun Zho. Association of integrin beta1 and c-MET in mediating EGFR TKI gefitinib resistance in non-small cell lung cancer. Cancer cell international. vol 13. issue 1. 2013-03-01. PMID:23402326. |
we found that the ligands of integrin beta1 and c-met could synergistically promote cell proliferation and their inhibitors could synergistically improve the sensitivity to gfitinib, increase apoptosis, and inhibit the downstream signal transduction: focal adhesion kinase (fak) and akt. |
2013-03-01 |
2023-08-12 |
Not clear |
| Guang-Hui Wang, Fu-Quan Jiang, Ying-Hui Duan, Zhi-Ping Zeng, Fan Chen, Yi Dai, Jie-Bo Chen, Jin-Xing Liu, Jie Liu, Hu Zhou, Hai-Feng Chen, Jin-Zhang Zeng, Ying Su, Xin-Sheng Yao, Xiao-Kun Zhan. Targeting truncated retinoid X receptor-α by CF31 induces TNF-α-dependent apoptosis. Cancer research. vol 73. issue 1. 2013-02-27. PMID:23151904. |
cf31 inhibition of tnf-α activation of akt also results in tnf-α-dependent activation of caspase-8 and apoptosis. |
2013-02-27 |
2023-08-12 |
Not clear |
| Matt D Urbanowski, Tom C Hobma. The West Nile virus capsid protein blocks apoptosis through a phosphatidylinositol 3-kinase-dependent mechanism. Journal of virology. vol 87. issue 2. 2013-02-25. PMID:23115297. |
specifically, expression of this protein in the absence of other viral proteins increases the levels of phosphorylated akt, a prosurvival kinase that blocks apoptosis through multiple mechanisms. |
2013-02-25 |
2023-08-12 |
Not clear |
| Yun-Fei Bian, Dong-Xue Wang, Hui-Yu Yang, Chuan-Shi Xia. [Glucagon like peptide-1 inhibits high glucose-induced injury of oxidative stress in cardiomyocytes of neonatal rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 63. issue 4. 2013-02-21. PMID:21861059. |
the dna ladder was examined by agarose gel electrophoresis, and the cell apoptosis was determined by annexin-v-fitc/pi flow cytometry, and the phosphorylation of akt was determined by western blotting. |
2013-02-21 |
2023-08-12 |
rat |
| Yun-Fei Bian, Dong-Xue Wang, Hui-Yu Yang, Chuan-Shi Xia. [Glucagon like peptide-1 inhibits high glucose-induced injury of oxidative stress in cardiomyocytes of neonatal rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 63. issue 4. 2013-02-21. PMID:21861059. |
compared with those in the normal control group, in the high glucose group, the cells grew poorly, and the beating rate was significantly lower (p < 0.05); the apoptotic rate was significantly increased (p < 0.05); the mda content was increased (p < 0.05); it showed the typical dna ladder, which is the characteristic of apoptosis; the sod activity was decreased (p < 0.05); the level of intracellular ros increased (p < 0.05); and the expression of nadph p47phox subunit mrna was increased; however the phosphorylation level of akt was decreased. |
2013-02-21 |
2023-08-12 |
rat |
| Yuanji Lin, Ying Yang, Weihua Li, Qi Chen, Jie Li, Xiao Pan, Lina Zhou, Changwei Liu, Chunsong Chen, Jianqin He, Hongcui Cao, Hangping Yao, Li Zheng, Xiaowei Xu, Zongping Xia, Jiangtao Ren, Lei Xiao, Lanjuan Li, Binghui Shen, Honglin Zhou, Ying-Jie Wan. Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells. Molecular cell. vol 48. issue 4. 2013-02-21. PMID:23041284. |
here we show that in eccs, akt phosphorylated the master pluripotency factor oct4 at threonine 235, and that the levels of phosphorylated oct4 in eccs correlated with resistance to apoptosis and tumorigenic potential. |
2013-02-21 |
2023-08-12 |
Not clear |
| Naveen Sharma, Donel A Sequea, Edward B Arias, Gregory D Carte. Greater insulin-mediated Akt phosphorylation concomitant with heterogeneous effects on phosphorylation of Akt substrates in soleus of calorie-restricted rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 303. issue 12. 2013-02-21. PMID:23115120. |
akt is a serine/threonine kinase that plays a key role in numerous cellular functions including metabolism, growth, protein synthesis, apoptosis, and cell proliferation. |
2013-02-21 |
2023-08-12 |
rat |
| Te-Chao Fang, Cheng-Yoong Pang, Sheng-Chun Chiu, Dah-Ching Ding, Rong-Kung Tsa. Renoprotective effect of human umbilical cord-derived mesenchymal stem cells in immunodeficient mice suffering from acute kidney injury. PloS one. vol 7. issue 9. 2013-02-20. PMID:23029541. |
furthermore, this study is the first one to show that the reduced apoptosis of renal tubular cells by huc-mscs in this xenogeneic model is mediated through the mitochondrial pathway, and through the increase of akt phosphorylation. |
2013-02-20 |
2023-08-12 |
mouse |
| Sivakumar Loganathan, Prabodh K Kandala, Parul Gupta, Sanjay K Srivastav. Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model. PloS one. vol 7. issue 8. 2013-02-19. PMID:22952709. |
akt overexpression or tgf treatment blocked peitc induced apoptosis in ovarian cancer cells. |
2013-02-19 |
2023-08-12 |
mouse |
| Deepali Kurundkar, Ritesh K Srivastava, Sandeep C Chaudhary, Mary E Ballestas, Levy Kopelovich, Craig A Elmets, Mohammad Atha. Vorinostat, an HDAC inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine model. Toxicology and applied pharmacology. vol 266. issue 2. 2013-02-19. PMID:23147569. |
the mechanism by which vorinostat blocks proliferation and makes tumor cells prone to apoptosis, involved inhibition of mtor signaling which was accompanied by reduction in cell survival akt and extracellular-signal regulated kinase (erk) signaling pathways. |
2013-02-19 |
2023-08-12 |
mouse |
| Girija Dasmahapatra, Dmitry Lembersky, Minkyeong P Son, Hiral Patel, Derick Peterson, Elisa Attkisson, Richard I Fisher, Jonathan W Friedberg, Paul Dent, Steven Gran. Obatoclax interacts synergistically with the irreversible proteasome inhibitor carfilzomib in GC- and ABC-DLBCL cells in vitro and in vivo. Molecular cancer therapeutics. vol 11. issue 5. 2013-02-18. PMID:22411899. |
genetic interruption of c-jun-nh(2)-kinase (jnk) and noxa by short hairpin rna knockdown, ectopic mcl-1 expression, or enforced activation of akt significantly attenuated carfilzomib/obatoclax-mediated apoptosis. |
2013-02-18 |
2023-08-12 |
mouse |
| Terence M Williams, Athena R Flecha, Paul Keller, Ashwin Ram, David Karnak, Stefanie Galbán, Craig J Galbán, Brian D Ross, Theodore S Lawrence, Alnawaz Rehemtulla, Judith Sebolt-Leopol. Cotargeting MAPK and PI3K signaling with concurrent radiotherapy as a strategy for the treatment of pancreatic cancer. Molecular cancer therapeutics. vol 11. issue 5. 2013-02-18. PMID:22411900. |
in conclusion, mek inhibition results in growth arrest, apoptosis, and radiosensitization of multiple preclinical pancreatic tumor models, and the effects can be enhanced by combination with an akt inhibitor. |
2013-02-18 |
2023-08-12 |
Not clear |
| A Neesse, T M Gress, P Mich. Therapeutic targeting of apoptotic pathways: novel aspects in pancreatic cancer. Current pharmaceutical biotechnology. vol 13. issue 11. 2013-02-12. PMID:21605073. |
this review focuses on current knowledge of apoptotic pathways involved in pancreatic cancer and mechanisms of resistance to apoptosis, including alterations in the death receptor and mitochondrial pathways, as well as anti-apoptotic effects of nf-kb and akt signalling and the impact of histone-modifying enzymes such as histondeacetylases (hdac). |
2013-02-12 |
2023-08-12 |
Not clear |