| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vivek Vaish, Sankar Nath Sanya. Role of Sulindac and Celecoxib in the regulation of angiogenesis during the early neoplasm of colon: exploring PI3-K/PTEN/Akt pathway to the canonical Wnt/β-catenin signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 66. issue 5. 2013-01-04. PMID:22397759. |
nsaids can overcome these carcinogenic effects by controlling various key check points including higher pten and glycogen synthase kinase-3β (gsk-3β) expression and repressing akt, mmps and inos activation while inducing apoptosis among the cancer cells. |
2013-01-04 |
2023-08-12 |
Not clear |
| Hyoun Woo Kang, Jung Mogg Kim, Mi Yeon Cha, Hyun Chae Jung, In Sung Song, Joo Sung Ki. Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice. Digestive diseases and sciences. vol 57. issue 11. 2013-01-04. PMID:22623043. |
deguelin, an akt inhibitor, down-regulates nf-κb signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice. |
2013-01-04 |
2023-08-12 |
mouse |
| Sachiko Murase, Eunyoung Kim, Lin Lin, Dax A Hoffman, Ronald D McKa. Loss of signal transducer and activator of transcription 3 (STAT3) signaling during elevated activity causes vulnerability in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 44. 2013-01-04. PMID:23115188. |
chronically stimulated neurons go through apoptosis when they fail to activate another serine/threonine kinase, akt. |
2013-01-04 |
2023-08-12 |
mouse |
| Hadi Khalil, Nieves Peltzer, Joël Walicki, Jiang-Yan Yang, Gilles Dubuis, Noémie Gardiol, Werner Held, Paul Bigliardi, Benjamin Marsland, Lucas Liaudet, Christian Widman. Caspase-3 protects stressed organs against cell death. Molecular and cellular biology. vol 32. issue 22. 2013-01-03. PMID:22949508. |
mice homozygous for a mutation in rasgap that prevents its cleavage by caspase-3 exhibited a similar defect in akt activation, leading to increased apoptosis in stressed organs, marked deterioration of their physiological functions, and stronger disease development. |
2013-01-03 |
2023-08-12 |
mouse |
| Mamata Singh, Alaina R Martinez, Suman Govindaraju, Beth S Le. HuR inhibits apoptosis by amplifying Akt signaling through a positive feedback loop. Journal of cellular physiology. vol 228. issue 1. 2012-12-31. PMID:22674407. |
hur inhibits apoptosis by amplifying akt signaling through a positive feedback loop. |
2012-12-31 |
2023-08-12 |
human |
| Chien-Ping Liang, Seongah Han, Gang Li, Ira Tabas, Alan R Tal. Impaired MEK signaling and SERCA expression promote ER stress and apoptosis in insulin-resistant macrophages and are reversed by exenatide treatment. Diabetes. vol 61. issue 10. 2012-12-28. PMID:22751695. |
activation of macrophage glucagon-like peptide 1 (glp-1) receptor via the antidiabetic drug exenatide led to improvements in both erk and akt signaling and reversed the increase in upr and apoptosis of insulin-resistant macrophages in atherosclerotic lesions of ob/ob.ldlr(-/-) and insr(-/-).ldlr(-/-) mice. |
2012-12-28 |
2023-08-12 |
mouse |
| Wei Wang, Yizhi Peng, Yuanyuan Wang, Xiaohui Zhao, Zhiqiang Yua. Anti-apoptotic effect of heat shock protein 90 on hypoxia-mediated cardiomyocyte damage is mediated via the phosphatidylinositol 3-kinase/AKT pathway. Clinical and experimental pharmacology & physiology. vol 36. issue 9. 2012-12-27. PMID:19298537. |
key words: apoptosis, cardiomyocyte, heart failure, heat shock protein 90, hypoxia, phosphatidylinositol 3-kinase/akt signalling pathway, serine/threonine protein kinase akt. |
2012-12-27 |
2023-08-12 |
rat |
| Yuanxiao Wang, Lili Zhang, Genlai Zhou, Zhiyong Liao, Hussain Ahmad, Wenbin Liu, Tian Wan. Dietary L-arginine supplementation improves the intestinal development through increasing mucosal Akt and mammalian target of rapamycin signals in intra-uterine growth retarded piglets. The British journal of nutrition. vol 108. issue 8. 2012-12-26. PMID:22217383. |
iugr piglets had lower (p < 0·05) mucosal concentrations of arg, insulin, insulin growth factor 1, as well as phosphorylated akt, mammalian target of rapamycin (mtor) and p70 s6 kinase but higher (p < 0·05) enterocyte apoptosis index (ai). |
2012-12-26 |
2023-08-12 |
Not clear |
| Yuanxiao Wang, Lili Zhang, Genlai Zhou, Zhiyong Liao, Hussain Ahmad, Wenbin Liu, Tian Wan. Dietary L-arginine supplementation improves the intestinal development through increasing mucosal Akt and mammalian target of rapamycin signals in intra-uterine growth retarded piglets. The British journal of nutrition. vol 108. issue 8. 2012-12-26. PMID:22217383. |
in conclusion, arg has a beneficiary effect in improving the impaired si development in iugr piglets via regulating cell apoptosis and activating akt and mtor signals in si mucosa. |
2012-12-26 |
2023-08-12 |
Not clear |
| Xuqing Wang, Yuezhen Deng, Zhengfa Mao, Xiaoyan Ma, Xin Fan, Lei Cui, Jianguo Qu, Dong Xie, Jianxin Zhan. CCN1 promotes tumorigenicity through Rac1/Akt/NF-κB signaling pathway in pancreatic cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 5. 2012-12-26. PMID:22752926. |
furthermore, we disclosed that activation of ccn1/ras-related c3 botulinum toxin substrate 1 (rac1)/v-akt murine thymoma viral oncogene homolog (akt)/nuclear factor-kappa b pathway inhibited apoptosis in pancreatic cancer cells. |
2012-12-26 |
2023-08-12 |
mouse |
| Hui-Ling Shen, Li-Li Fang, Chen Chen, Xin-Jian Fang, Qiao-Yun Chen, Juan Li, Wen-Lin X. [VEGF shRNA enhances the sensitivity of multidrug-resistant leukemia cells to anticancer agent]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 1. 2012-12-17. PMID:21362217. |
rt-pcr was used to detect the expression of vegf and mrp1 at the mrna level;western blot was used to analyze the expression of vegf, mrp1, akt, p-akt at the protein level; mtt was used to determine the ic(50) value of transfected cells to doxorubicin (dox); flow cytometry was used to detect cell apoptosis and intracellular rho123 retention. |
2012-12-17 |
2023-08-12 |
human |
| Toshiyuki Tsunoda, Takeharu Ota, Takahiro Fujimoto, Keiko Doi, Yoko Tanaka, Yasuhiro Yoshida, Masahiro Ogawa, Hiroshi Matsuzaki, Masato Hamabashiri, Darren R Tyson, Masahide Kuroki, Shingo Miyamoto, Senji Shirasaw. Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model. Molecular cancer. vol 11. 2012-12-13. PMID:22830422. |
inhibition of phosphodiesterase-4 (pde4) activity triggers luminal apoptosis and akt dephosphorylation in a 3-d colonic-crypt model. |
2012-12-13 |
2023-08-12 |
human |
| Joo Hyun Kim, Won Seog Kim, Chaehwa Par. Epstein-Barr virus latent membrane protein-1 protects B-cell lymphoma from rituximab-induced apoptosis through miR-155-mediated Akt activation and up-regulation of Mcl-1. Leukemia & lymphoma. vol 53. issue 8. 2012-12-10. PMID:22268450. |
epstein-barr virus latent membrane protein-1 protects b-cell lymphoma from rituximab-induced apoptosis through mir-155-mediated akt activation and up-regulation of mcl-1. |
2012-12-10 |
2023-08-12 |
Not clear |
| Seung Hyun Oh, Young Mi Whang, Hye-Young Min, Seung Ho Han, Ju-Hee Kang, Ki-Hoon Song, Bonnie S Glisson, Yeul Hong Kim, Ho-Young Le. Histone deacetylase inhibitors enhance the apoptotic activity of insulin-like growth factor binding protein-3 by blocking PKC-induced IGFBP-3 degradation. International journal of cancer. vol 131. issue 10. 2012-12-10. PMID:22362554. |
in addition, combined treatment of igfbp-3 with an hdac inhibitor facilitates apoptosis through upregulation of rigfbp-3 stability and akt signaling inhibition. |
2012-12-10 |
2023-08-12 |
Not clear |
| Brahma N Singh, Dhruv Kumar, Sharmila Shankar, Rakesh K Srivastav. Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells. Biochemical pharmacology. vol 84. issue 9. 2012-12-10. PMID:22902833. |
prolonged exposure of cscs to rot eventually caused apoptosis which was associated with the suppression of phosphorylated akt (ser473) and mtor (ser2448), downregulation of xiap, ciap-1, bcl-2 and bcl-x(l), induction of bax, activation of caspase-3 and -9, and concomitant degradation of parp. |
2012-12-10 |
2023-08-12 |
human |
| Brahma N Singh, Dhruv Kumar, Sharmila Shankar, Rakesh K Srivastav. Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells. Biochemical pharmacology. vol 84. issue 9. 2012-12-10. PMID:22902833. |
rot-induced apoptosis was enhanced by dominant negative akt, akt1/2 inhibitor, and rapamycin. |
2012-12-10 |
2023-08-12 |
human |
| Suhayla Mukaddam-Dahe. An "I" on cardiac hypertrophic remodelling: imidazoline receptors and heart disease. The Canadian journal of cardiology. vol 28. issue 5. 2012-12-07. PMID:22483786. |
our studies have shown that i(1)-receptor is expressed in cardiac fibroblasts and myocytes and that in vitro i(1)-receptor activation inhibits norepinephrine-induced cardiomyocyte apoptosis and fibroblast proliferation, through differential effects on mitogen-activated protein kinases and akt. |
2012-12-07 |
2023-08-12 |
rat |
| Xu-Chun He, Jian-Da H. [Effects of emodin on human erythroleukemia cell line HEL]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 5. 2012-12-06. PMID:22040955. |
the proliferation inhibition was detected by mtt method; the change of morphology was observed by ao/eb stains; the cell cycle and apoptosis was analyzed by flow cytometry; the expressions of akt, p-akt, p-gsk3β and hsp70 proteins were determined by western blot. |
2012-12-06 |
2023-08-12 |
human |
| Ramiro Vázquez, María E Riveiro, Mónica Vermeulen, Carolina Mondillo, Philip H Coombes, Neil R Crouch, Fathima Ismail, Dulcie A Mulholland, Alberto Baldi, Carina Shayo, Carlos Davi. Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 19. issue 8-9. 2012-12-04. PMID:22537907. |
interestingly, while toddaculin at 250 μm was able to induce apoptosis in u-937 cells, involving decreased phosphorylation levels of erk and akt, 50 μm toddaculin exerted differentiating effects, inducing both the capacity of u-937 cells to reduce nbt and the expression of differentiation markers cd88 and cd11b, but no change in p-akt or p-erk levels. |
2012-12-04 |
2023-08-12 |
Not clear |
| Toru Hiraga, Akira Myoui, Nobuyuki Hashimoto, Akira Sasaki, Kenji Hata, Yoshihiro Morita, Hideki Yoshikawa, Clifford J Rosen, Gregory R Mundy, Toshiyuki Yoned. Bone-derived IGF mediates crosstalk between bone and breast cancer cells in bony metastases. Cancer research. vol 72. issue 16. 2012-12-04. PMID:22738911. |
although recombinant human igf-i caused igf-ir tyrosine autophosphorylation, followed by activation of akt and nf-κb in cancer cells, dominant-negative inhibition of igf-ir, akt, or nf-κb significantly reduced bone metastases with increased apoptosis and decreased mitosis in metastatic cells. |
2012-12-04 |
2023-08-12 |
human |