| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Sun, Chia-Wen Huang, Jun Wu, Ko-Jie Chen, Shu-Hong Li, Richard D Weisel, Harry Rakowski, Hsing-Wen Sung, Ren-Ke L. The use of cationic microbubbles to improve ultrasound-targeted gene delivery to the ischemic myocardium. Biomaterials. vol 34. issue 8. 2013-06-04. PMID:23245332. |
akt transfection with the cmb reduced infarct size (p < 0.05), increased infarct thickness (p < 0.05), reduced apoptosis (p < 0.05), increased vascular density (p < 0.05), and improved cardiac perfusion and function (p < 0.05) compared to the definity mb. |
2013-06-04 |
2023-08-12 |
rat |
| M Reis-Sobreiro, G Roué, A Moros, C Gajate, J de la Iglesia-Vicente, D Colomer, F Mollined. Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma. Blood cancer journal. vol 3. 2013-06-04. PMID:23727661. |
atl-induced apoptosis appeared to correlate with the basal akt phosphorylation status in mcl cell lines and primary cultures, and could be potentiated by the pi3k inhibitor wortmannin, or inhibited by the akt activator pervanadate. |
2013-06-04 |
2023-08-12 |
Not clear |
| M Reis-Sobreiro, G Roué, A Moros, C Gajate, J de la Iglesia-Vicente, D Colomer, F Mollined. Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma. Blood cancer journal. vol 3. 2013-06-04. PMID:23727661. |
classical akt inhibitors induced apoptosis in mcl cells. |
2013-06-04 |
2023-08-12 |
Not clear |
| Gamal Badr, Mohamed K Al-Sadoon, Mostafa A Abdel-Maksoud, Danny M Rabah, Ahmed M El-Ton. Cellular and molecular mechanisms underlie the anti-tumor activities exerted by Walterinnesia aegyptia venom combined with silica nanoparticles against multiple myeloma cancer cell types. PloS one. vol 7. issue 12. 2013-06-03. PMID:23251606. |
we found that wev and wev+np clearly decreased the cxcl12/cxcr4-mediated activation of akt, erk, nfκb and rho-a using western blot analysis; abrogated the cxcl12-mediated proliferation of mm cells using the cfse assay; and induced apoptosis in mm cell as determined by pi/annexin v double staining followed by flow cytometry analysis. |
2013-06-03 |
2023-08-12 |
Not clear |
| Dong-Mei Zhang, Jun-Shan Liu, Ming-Kuen Tang, Anita Yiu, Hui-hui Cao, Lei Jiang, Judy Yuet-Wa Chan, Hai-Yan Tian, Kwok-Pui Fung, Wen-Cai Y. Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant HepG2 cells through G2/M cell cycle arrest and apoptosis. European journal of pharmacology. vol 692. issue 1-3. 2013-05-29. PMID:22841670. |
it was also found that the inhibition of akt expression and phosphorylation was involved in apoptosis induction, and specific akt inhibitor ly294002 or sirna targeting akt can synergistically enhanced bufotalin-induced apoptosis. |
2013-05-29 |
2023-08-12 |
Not clear |
| David Romano, Helene Maccario, Carolanne Doherty, Niall P Quinn, Walter Kolch, David Matallana. The differential effects of wild-type and mutated K-Ras on MST2 signaling are determined by K-Ras activation kinetics. Molecular and cellular biology. vol 33. issue 9. 2013-05-29. PMID:23459937. |
mutant (mt) k-ras can stimulate both oncogenic transformation and apoptosis through activation of extracellular signal-regulated kinase (erk) and akt pathways and the mst2 pathway, respectively. |
2013-05-29 |
2023-08-12 |
human |
| Boban M Erovic, Luke Harris, Mina Jamali, David P Goldstein, Jonathan C Irish, Sylvia L Asa, Ozgur Met. Biomarkers of parathyroid carcinoma. Endocrine pathology. vol 23. issue 4. 2013-05-23. PMID:23001705. |
we constructed a tissue microarray of parathyroid carcinomas from 10 patients as well as parathyroid adenomas from 25 patients and stained the slides for 34 proteins involved in angiogenesis (platelet-derived growth factor receptor (pdgfr)-α, pdgfr-β, vascular endothelial growth factor receptor-2 (vegfr-2), and epidermal growth factor receptor (egfr)), inflammation (cyclooxygenase (cox)-1 and cox-2), cell adhesion (matrix metalloproteinase (mmp)-1, cd9, and keratin 7), cell cycle (cdc2p34, cyclin d1, retinoblastoma (rb), p27, p21, parafibromin, bmi-1, 14-3-3σ, and p53), and apoptosis (bcl-2a, mcl-1, bcl-xl, and glutathione-s-transferase-isoenzyme π (gst-π)) along with some markers of the sonic hedgehog (smo, shh, gli-1, gli-2, gli-3, and patched), mtor (akt, mammalian target of rapamycin (mtor), and forkhead box o (foxo)-1), and wnt (wisp-1, wisp-2, and β-catenin) signal transduction pathways. |
2013-05-23 |
2023-08-12 |
Not clear |
| Theresa D Carr, John DiGiovanni, Christopher J Lynch, Lisa M Shant. Inhibition of mTOR suppresses UVB-induced keratinocyte proliferation and survival. Cancer prevention research (Philadelphia, Pa.). vol 5. issue 12. 2013-05-23. PMID:23129577. |
in contrast, mtor deletion, which attenuated uvb-induced phosphorylation of both s6k and the mtorc2 target akt(ser473), significantly increased apoptosis both in vivo and in keratinocyte cultures, in addition to reducing hyperproliferation following uvb irradiation. |
2013-05-23 |
2023-08-12 |
mouse |
| Boban M Erovic, Dae Kim, Clarissa Cassol, David P Goldstein, Jonathan C Irish, Sylvia L Asa, Ozgur Met. Prognostic and predictive markers in medullary thyroid carcinoma. Endocrine pathology. vol 23. issue 4. 2013-05-23. PMID:23150029. |
we therefore examined morphologic features of aggressive behavior and the expression of 41 proteins involved in apoptosis, cell cycle, angiogenesis, inflammation, cell adhesion, tumor-specific markers, and wnt, shh, and akt pathways using tissue microarray from 23 patients with medullary thyroid carcinoma. |
2013-05-23 |
2023-08-12 |
Not clear |
| Stephan Wiedemann, Teresa Wessela, Kerstin Schwarz, Dirk Joachim, Marcel Jercke, Ruth H Strasser, Bernd Ebner, Gregor Simoni. Inhibition of anti-apoptotic signals by Wortmannin induces apoptosis in the remote myocardium after LAD ligation: evidence for a protein kinase C-δ-dependent pathway. Molecular and cellular biochemistry. vol 372. issue 1-2. 2013-05-15. PMID:23010893. |
it has been shown that, in the remote myocardium after infarction (mi), protein kinase c (pkc) inhibition reduces apoptosis both by blocking proapoptotic pathways and by activating antiapoptotic signals including the akt pathway. |
2013-05-15 |
2023-08-12 |
rat |
| Stephan Wiedemann, Teresa Wessela, Kerstin Schwarz, Dirk Joachim, Marcel Jercke, Ruth H Strasser, Bernd Ebner, Gregor Simoni. Inhibition of anti-apoptotic signals by Wortmannin induces apoptosis in the remote myocardium after LAD ligation: evidence for a protein kinase C-δ-dependent pathway. Molecular and cellular biochemistry. vol 372. issue 1-2. 2013-05-15. PMID:23010893. |
after 24 h, pro- and anti-apoptotic signals (caspase-3, pkc isoforms, p38-mapk, p42/44-mapk, akt, bad), and marker of apoptosis execution (tunel) were quantified in the myocardium remote from the infarction. |
2013-05-15 |
2023-08-12 |
rat |
| Muralidharan Suganthi, Gopalakrishnan Sangeetha, Govindaraj Gayathri, Bhaskaran Ravi Sanka. Biphasic dose-dependent effect of lithium chloride on survival of human hormone-dependent breast cancer cells (MCF-7). Biological trace element research. vol 150. issue 1-3. 2013-05-14. PMID:23054864. |
the results showed breast cancer cells respond in a diverse manner to licl, i.e., at lower concentrations (1, 5, and 10 mm), licl induces cell survival by inhibiting apoptosis through regulation of gsk-3β, caspase-2, bax, and cleaved caspase-7 and by activating anti-apoptotic proteins (akt, β-catenin, bcl-2, and cyclin d1). |
2013-05-14 |
2023-08-12 |
human |
| Julie Dufour, Emilie Viennois, Hugues De Boussac, Silvère Baron, Jean-Marc Lobaccar. Oxysterol receptors, AKT and prostate cancer. Current opinion in pharmacology. vol 12. issue 6. 2013-05-10. PMID:22819197. |
the decrease of membrane cholesterol causes a down regulation of akt survival pathway and consequently apoptosis. |
2013-05-10 |
2023-08-12 |
Not clear |
| Lin Wang, Xinkui Liu, Yongjun Wu, Weidong Wu, Yiming W. Involvement of ROS in the inhibitory effect of thermotherapy combined with chemotherapy on A549 human lung adenocarcinoma cell growth through the Akt pathway. Oncology reports. vol 28. issue 4. 2013-05-09. PMID:22895800. |
phosphorylation of akt and caspase-3 expression were determined by western blotting and the cell apoptosis rates were examined by flow cytometry. |
2013-05-09 |
2023-08-12 |
human |
| Lin Wang, Xinkui Liu, Yongjun Wu, Weidong Wu, Yiming W. Involvement of ROS in the inhibitory effect of thermotherapy combined with chemotherapy on A549 human lung adenocarcinoma cell growth through the Akt pathway. Oncology reports. vol 28. issue 4. 2013-05-09. PMID:22895800. |
thus, the combination of thermotherapy with chemotherapy showed a stronger inhibitory effect on a549 cell growth compared to chemotherapy alone, which may be able to cause additional cell apoptosis through inhibition of akt phosphorylation and activation of caspases by increased intracellular ros production. |
2013-05-09 |
2023-08-12 |
human |
| Yash Somnay, Kevin Simon, April D Harrison, Selvi Kunnimalaiyaan, Herbert Chen, Muthusamy Kunnimalaiyaa. Neuroendocrine phenotype alteration and growth suppression through apoptosis by MK-2206, an allosteric inhibitor of AKT, in carcinoid cell lines in vitro. Anti-cancer drugs. vol 24. issue 1. 2013-05-09. PMID:23147412. |
neuroendocrine phenotype alteration and growth suppression through apoptosis by mk-2206, an allosteric inhibitor of akt, in carcinoid cell lines in vitro. |
2013-05-09 |
2023-08-12 |
Not clear |
| Shenghui Zhang, Yan Zhang, Yan Zhuang, Jiajie Wang, Jianqin Ye, Si Zhang, Jianbo Wu, Kang Yu, Yixiang Ha. Matrine induces apoptosis in human acute myeloid leukemia cells via the mitochondrial pathway and Akt inactivation. PloS one. vol 7. issue 10. 2013-05-07. PMID:23056487. |
matrine induces apoptosis in human acute myeloid leukemia cells via the mitochondrial pathway and akt inactivation. |
2013-05-07 |
2023-08-12 |
mouse |
| Kristin K Ambacher, Kristen B Pitzul, Meera Karajgikar, Alison Hamilton, Stephen S Ferguson, Sean P Crega. The JNK- and AKT/GSK3β- signaling pathways converge to regulate Puma induction and neuronal apoptosis induced by trophic factor deprivation. PloS one. vol 7. issue 10. 2013-05-07. PMID:23056511. |
the akt, gsk3 and jnk family kinases have been implicated in neuronal apoptosis associated with neuronal development and several neurodegenerative conditions. |
2013-05-07 |
2023-08-12 |
Not clear |
| Kristin K Ambacher, Kristen B Pitzul, Meera Karajgikar, Alison Hamilton, Stephen S Ferguson, Sean P Crega. The JNK- and AKT/GSK3β- signaling pathways converge to regulate Puma induction and neuronal apoptosis induced by trophic factor deprivation. PloS one. vol 7. issue 10. 2013-05-07. PMID:23056511. |
in summary we have identified a novel and critical link between the akt, gsk3β and jnk kinases and the regulation of puma induction and suggest that this may be pivotal to the regulation of neuronal apoptosis in neurodegenerative conditions. |
2013-05-07 |
2023-08-12 |
Not clear |
| Nicholas C K Valerie, Barbara Dziegielewska, Amol S Hosing, Ewa Augustin, Lloyd S Gray, David L Brautigan, James M Larner, Jaroslaw Dziegielewsk. Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells. Biochemical pharmacology. vol 85. issue 7. 2013-05-07. PMID:23287412. |
inhibition of t-type calcium channels disrupts akt signaling and promotes apoptosis in glioblastoma cells. |
2013-05-07 |
2023-08-12 |
Not clear |