| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea Cuconati, Courtney Mills, Cally Goddard, Xianchao Zhang, Wenquan Yu, Haitao Guo, Xiaodong Xu, Timothy M Bloc. Suppression of AKT anti-apoptotic signaling by a novel drug candidate results in growth arrest and apoptosis of hepatocellular carcinoma cells. PloS one. vol 8. issue 1. 2013-06-24. PMID:23355882. |
suppression of akt anti-apoptotic signaling by a novel drug candidate results in growth arrest and apoptosis of hepatocellular carcinoma cells. |
2013-06-24 |
2023-08-12 |
Not clear |
| Changxin Xu, Ethan C Reichert, Tomoyuki Nakano, Mariah Lohse, Alison A Gardner, Mónica P Revelo, Matthew K Topham, Diana M Stafforin. Deficiency of phospholipase A2 group 7 decreases intestinal polyposis and colon tumorigenesis in Apc(Min/+) mice. Cancer research. vol 73. issue 9. 2013-06-24. PMID:23361301. |
in colonic epithelial cells, exposure to a paf analog led to dephosphorylation of akt at serine-473 and induction of apoptosis. |
2013-06-24 |
2023-08-12 |
mouse |
| Changxin Xu, Ethan C Reichert, Tomoyuki Nakano, Mariah Lohse, Alison A Gardner, Mónica P Revelo, Matthew K Topham, Diana M Stafforin. Deficiency of phospholipase A2 group 7 decreases intestinal polyposis and colon tumorigenesis in Apc(Min/+) mice. Cancer research. vol 73. issue 9. 2013-06-24. PMID:23361301. |
the mechanism of this response involved formation of a complex between β-arrestin 1 and the akt phosphatase phlpp2, and activation of the intrinsic pathway of apoptosis. |
2013-06-24 |
2023-08-12 |
mouse |
| Mingshan Niu, Yan Sun, Xuejiao Liu, Li Tang, Rongguo Qi. Tautomycetin induces apoptosis by inactivating Akt through a PP1-independent signaling pathway in human breast cancer cells. Journal of pharmacological sciences. vol 121. issue 1. 2013-06-21. PMID:23269238. |
tautomycetin induces apoptosis by inactivating akt through a pp1-independent signaling pathway in human breast cancer cells. |
2013-06-21 |
2023-08-12 |
human |
| Mingshan Niu, Yan Sun, Xuejiao Liu, Li Tang, Rongguo Qi. Tautomycetin induces apoptosis by inactivating Akt through a PP1-independent signaling pathway in human breast cancer cells. Journal of pharmacological sciences. vol 121. issue 1. 2013-06-21. PMID:23269238. |
furthermore, we identified that tmc induced apoptosis by suppressing akt signaling pathway activation, which is independent of protein phosphatase pp1 inhibition. |
2013-06-21 |
2023-08-12 |
human |
| Chuan Dong Wei, Yan Li, Hong Yun Zheng, Kai Sheng Sun, Yong Qing Tong, Wen Dai, Wei Wu, An Yu Ba. Globular adiponectin protects H9c2 cells from palmitate-induced apoptosis via Akt and ERK1/2 signaling pathways. Lipids in health and disease. vol 11. 2013-06-19. PMID:23050488. |
globular adiponectin protects h9c2 cells from palmitate-induced apoptosis via akt and erk1/2 signaling pathways. |
2013-06-19 |
2023-08-12 |
Not clear |
| Ping He, Hanako Kuhara, Isao Tachibana, Yingji Jin, Yoshito Takeda, Satoshi Tetsumoto, Toshiyuki Minami, Satoshi Kohmo, Haruhiko Hirata, Ryo Takahashi, Koji Inoue, Izumi Nagatomo, Hiroshi Kida, Takashi Kijima, Tetsuji Naka, Eiichi Morii, Ichiro Kawase, Atsushi Kumanogo. Calretinin mediates apoptosis in small cell lung cancer cells expressing tetraspanin CD9. FEBS open bio. vol 3. 2013-06-18. PMID:23772398. |
when calretinin was knocked down, cd9-positive sclc cells revealed increased akt phosphorylation and decreased apoptosis. |
2013-06-18 |
2023-08-12 |
Not clear |
| C Meyer, Y Liu, A Kaul, I Peipe, S Doole. Caveolin-1 abrogates TGF-β mediated hepatocyte apoptosis. Cell death & disease. vol 4. 2013-06-17. PMID:23328673. |
restoration of akt activity in caveolin-1 knockdown cells via expression of a constitutive active akt mutant did not completely blunt the apoptotic response to tgf-β, indicating an additional mechanism how caveolin-1 primes hepatocytes for resistance to tgf-β triggered apoptosis. |
2013-06-17 |
2023-08-12 |
Not clear |
| Si Gao, Tianfeng Chen, Mei-Yuk Choi, Yuanwei Liang, Junyi Xue, Yum-Shing Won. Cyanidin reverses cisplatin-induced apoptosis in HK-2 proximal tubular cells through inhibition of ROS-mediated DNA damage and modulation of the ERK and AKT pathways. Cancer letters. vol 333. issue 1. 2013-06-17. PMID:23360684. |
cyanidin reverses cisplatin-induced apoptosis in hk-2 proximal tubular cells through inhibition of ros-mediated dna damage and modulation of the erk and akt pathways. |
2013-06-17 |
2023-08-12 |
Not clear |
| X-F Qi, L Zheng, K-J Lee, D-H Kim, C-S Kim, D-Q Cai, Z Wu, J-W Qin, Y-H Yu, S-K Ki. HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway. Cell death & disease. vol 4. 2013-06-17. PMID:23449454. |
hmg-coa reductase inhibitors induce apoptosis of lymphoma cells by promoting ros generation and regulating akt, erk and p38 signals via suppression of mevalonate pathway. |
2013-06-17 |
2023-08-12 |
Not clear |
| X-F Qi, L Zheng, K-J Lee, D-H Kim, C-S Kim, D-Q Cai, Z Wu, J-W Qin, Y-H Yu, S-K Ki. HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway. Cell death & disease. vol 4. 2013-06-17. PMID:23449454. |
these results suggests that hmg-coa reductase inhibitors induce lymphoma cells apoptosis by increasing intracellular ros generation and p38 activation and suppressing activation of akt and erk pathways, through inhibition of metabolic products of the hmg-coa reductase reaction including mevalonate, fpp and ggpp. |
2013-06-17 |
2023-08-12 |
Not clear |
| Renee D Read, Tim R Fenton, German G Gomez, Jill Wykosky, Scott R Vandenberg, Ivan Babic, Akio Iwanami, Huijun Yang, Webster K Cavenee, Paul S Mischel, Frank B Furnari, John B Thoma. A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma. PLoS genetics. vol 9. issue 2. 2013-06-13. PMID:23459592. |
conversely, reduced expression of riok1 or riok2 disrupted akt signaling and caused cell cycle exit, apoptosis, and chemosensitivity in glioblastoma cells by inducing p53 activity through the rpl11-dependent ribosomal stress checkpoint. |
2013-06-13 |
2023-08-12 |
human |
| Mark Dunleavy, Giovanni Provenzano, David C Henshall, Yuri Bozz. Kainic acid-induced seizures modulate Akt (SER473) phosphorylation in the hippocampus of dopamine D2 receptor knockout mice. Journal of molecular neuroscience : MN. vol 49. issue 1. 2013-06-12. PMID:23188702. |
thus, we propose that gsk-3β phosphorylation-mediated hippocampal cell survival may depend on akt (ser473) phosphorylation; loss of d2r-mediated signalling in the ca3 region of d2r-/- mice leads to reduced akt (ser473) phosphorylation rendering neurons more vulnerable to apoptosis. |
2013-06-12 |
2023-08-12 |
mouse |
| Sebastian Michels, Marcel Trautmann, Elisabeth Sievers, Dagmar Kindler, Sebastian Huss, Marcus Renner, Nicolaus Friedrichs, Jutta Kirfel, Susanne Steiner, Elmar Endl, Peter Wurst, Lukas Heukamp, Roland Penzel, Olle Larsson, Akira Kawai, Shinya Tanaka, Hiroshi Sonobe, Peter Schirmacher, Gunhild Mechtersheimer, Eva Wardelmann, Reinhard Büttner, Wolfgang Hartman. SRC signaling is crucial in the growth of synovial sarcoma cells. Cancer research. vol 73. issue 8. 2013-06-12. PMID:23580575. |
treatment of synovial sarcoma cells with dasatinib led to apoptosis and inhibition of cellular proliferation, associated with reduced phosphorylation of fak (ptk2), stat3, igf-ir, and akt. |
2013-06-12 |
2023-08-12 |
mouse |
| Hsing-Yu Weng, Ming-Jen Hsu, Chien-Chih Chen, Bing-Chang Chen, Chuang-Ye Hong, Che-Ming Teng, Shiow-Lin Pan, Wen-Ta Chiu, Chien-Huang Li. Denbinobin induces human glioblastoma multiforme cell apoptosis through the IKKα-Akt-FKHR signaling cascade. European journal of pharmacology. vol 698. issue 1-3. 2013-06-10. PMID:23123054. |
these results suggest that ikkα inactivation, followed by akt and fkhr dephosphorylation and caspase-3 activation, contributes to denbinobin-induced gbm cell apoptosis. |
2013-06-10 |
2023-08-12 |
human |
| Shin Kim, Jinho Lee, Byeong-Churl Jang, Taeg Kyu Kwon, Jong-Wook Par. BAI, a novel cyclin-dependent kinase inhibitor induces apoptosis in A549 cells through activation of caspases and inactivation of Akt. Journal of cellular biochemistry. vol 114. issue 2. 2013-06-04. PMID:22887215. |
bai, a novel cyclin-dependent kinase inhibitor induces apoptosis in a549 cells through activation of caspases and inactivation of akt. |
2013-06-04 |
2023-08-12 |
human |
| Shin Kim, Jinho Lee, Byeong-Churl Jang, Taeg Kyu Kwon, Jong-Wook Par. BAI, a novel cyclin-dependent kinase inhibitor induces apoptosis in A549 cells through activation of caspases and inactivation of Akt. Journal of cellular biochemistry. vol 114. issue 2. 2013-06-04. PMID:22887215. |
interestingly, further biochemical analysis showed that treatment with bai at 20 nm induced apoptosis in a549 cells in association with activation of caspases, cleavage of phospholipase c-γ1 (plc-γ1), and inhibition of akt in a549 cells. |
2013-06-04 |
2023-08-12 |
human |
| Shin Kim, Jinho Lee, Byeong-Churl Jang, Taeg Kyu Kwon, Jong-Wook Par. BAI, a novel cyclin-dependent kinase inhibitor induces apoptosis in A549 cells through activation of caspases and inactivation of Akt. Journal of cellular biochemistry. vol 114. issue 2. 2013-06-04. PMID:22887215. |
transfection analysis with akt cdna encoding constitutively active akt further addressed the significance of akt inhibition in the bai-induced apoptosis in a549 cells. |
2013-06-04 |
2023-08-12 |
human |
| Shin Kim, Jinho Lee, Byeong-Churl Jang, Taeg Kyu Kwon, Jong-Wook Par. BAI, a novel cyclin-dependent kinase inhibitor induces apoptosis in A549 cells through activation of caspases and inactivation of Akt. Journal of cellular biochemistry. vol 114. issue 2. 2013-06-04. PMID:22887215. |
these findings collectively suggest that bai potently inhibits growth of a549, hct116, and caki cells, and that the bai-induced apoptosis in a549 cells is associated with activation of caspases, and inhibition of akt. |
2013-06-04 |
2023-08-12 |
human |
| Lu Sun, Chia-Wen Huang, Jun Wu, Ko-Jie Chen, Shu-Hong Li, Richard D Weisel, Harry Rakowski, Hsing-Wen Sung, Ren-Ke L. The use of cationic microbubbles to improve ultrasound-targeted gene delivery to the ischemic myocardium. Biomaterials. vol 34. issue 8. 2013-06-04. PMID:23245332. |
in vivo studies assessed the ability of the cmb to deliver the therapeutic akt gene to the ischemic rat myocardium and evaluated the effects on apoptosis, angiogenesis, and cardiac function. |
2013-06-04 |
2023-08-12 |
rat |