| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanan Guo, Jinyan Du, David J Kwiatkowsk. Molecular dissection of AKT activation in lung cancer cell lines. Molecular cancer research : MCR. vol 11. issue 3. 2013-09-03. PMID:23319332. |
furthermore, a combination of src and mtor inhibition synergistically blocked activation of akt and induced apoptosis. |
2013-09-03 |
2023-08-12 |
human |
| Hu Zhao, Chen Zhu, Chao Qin, Tao Tao, Jie Li, Gong Cheng, Pu Li, Qiang Cao, Xiaoxin Meng, Xiaobing Ju, Pengfei Shao, Lixin Hua, Min Gu, Changjun Yi. Fenofibrate down-regulates the expressions of androgen receptor (AR) and AR target genes and induces oxidative stress in the prostate cancer cell line LNCaP. Biochemical and biophysical research communications. vol 432. issue 2. 2013-09-03. PMID:23399562. |
fenofibrate induces cell cycle arrest in g1 phase and apoptosis in lncap cells, reduces the expressions of androgen receptor (ar) and ar target genes (prostate-specific antigen and tmprss2), and inhibits akt phosphorylation. |
2013-09-03 |
2023-08-12 |
Not clear |
| Jingzhou Hu, Yue He, Ming Yan, Chao Zhu, Weimin Ye, Hanguang Zhu, Wantao Chen, Chenping Zhang, Zhiyuan Zhan. Dose dependent activation of retinoic acid-inducible gene-I promotes both proliferation and apoptosis signals in human head and neck squamous cell carcinoma. PloS one. vol 8. issue 3. 2013-09-03. PMID:23484008. |
in contrast, activation of rig-i by a high dose of 3p-rna induces robust mitochondria-derived apoptosis accompanied by decreased activation of akt, which is independent of the interferon and tnfα receptor, but can be rescued by over-expression of constitutively active akt. |
2013-09-03 |
2023-08-12 |
human |
| Jingzhou Hu, Yue He, Ming Yan, Chao Zhu, Weimin Ye, Hanguang Zhu, Wantao Chen, Chenping Zhang, Zhiyuan Zhan. Dose dependent activation of retinoic acid-inducible gene-I promotes both proliferation and apoptosis signals in human head and neck squamous cell carcinoma. PloS one. vol 8. issue 3. 2013-09-03. PMID:23484008. |
together, our results reveal a dual role of rig-i in hnscc through regulating activation of akt, in which rig-i activation by low-dose viral dsrna increases host cell survival, whereas higher level of rig-i activation leads to apoptosis. |
2013-09-03 |
2023-08-12 |
human |
| Ying Yin, Yue Guan, Jialin Duan, Guo Wei, Yanrong Zhu, Wei Quan, Chao Guo, Dan Zhou, Yanhua Wang, Miaomiao Xi, Aidong We. Cardioprotective effect of Danshensu against myocardial ischemia/reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation. European journal of pharmacology. vol 699. issue 1-3. 2013-09-02. PMID:23200898. |
cardioprotective effect of danshensu against myocardial ischemia/reperfusion injury and inhibits apoptosis of h9c2 cardiomyocytes via akt and erk1/2 phosphorylation. |
2013-09-02 |
2023-08-12 |
rat |
| Yassamine Lazrek, Olivier Dubreuil, Véronique Garambois, Nadège Gaborit, Christel Larbouret, Christophe Le Clorennec, Gaelle Thomas, Wilhem Leconet, Marta Jarlier, Martine Pugnière, Nadia Vié, Bruno Robert, Céline Monnet, Khalil Bouayadi, Hakim Kharrat, Philippe Mondon, André Pèlegrin, Thierry Chardè. Anti-HER3 domain 1 and 3 antibodies reduce tumor growth by hindering HER2/HER3 dimerization and AKT-induced MDM2, XIAP, and FoxO1 phosphorylation. Neoplasia (New York, N.Y.). vol 15. issue 3. 2013-08-30. PMID:23479511. |
anti-her3 abs blocked her2/her3 heterodimerization and her3 phosphorylation at the cell membrane, leading to inhibition of phosphorylation of the downstream akt targets murine double minute 2, x-linked inhibitor of apoptosis, and forkhead box o1. |
2013-08-30 |
2023-08-12 |
mouse |
| Rakeshwar S Guleria, Amar B Singh, Irina T Nizamutdinova, Tatiana Souslova, Amin A Mohammad, Jonathan A Kendall, Kenneth M Baker, Jing Pa. Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats. Journal of molecular and cellular cardiology. vol 57. 2013-08-27. PMID:23395853. |
diabetic cardiomyopathy was characterized in zdf rats by increased oxidative stress, apoptosis, fibrosis, inflammation, activation of map kinases and nf-κb signaling and diminished akt phosphorylation, along with decreased glucose transport and increased cardiac lipid accumulation, and ultimately diastolic dysfunction. |
2013-08-27 |
2023-08-12 |
rat |
| Cheng-Hsing Kao, Chih-Zen Chang, Yu-Feng Su, Yee-Jean Tsai, Kao-Ping Chang, Tzu-Kang Lin, Shiuh-Lin Hwang, Chih-Lung Li. 17β-Estradiol attenuates secondary injury through activation of Akt signaling via estrogen receptor alpha in rat brain following subarachnoid hemorrhage. The Journal of surgical research. vol 183. issue 1. 2013-08-27. PMID:23465388. |
this study tested the hypothesis that attenuation of sah-induced apoptosis after 17β-estradiol (e2) treatment is associated with an increase in phosphorylation of akt via estrogen receptor-α (er-α) in rats. |
2013-08-27 |
2023-08-12 |
rat |
| Reshma Bhowmick, Albert W Girott. Cytoprotective signaling associated with nitric oxide upregulation in tumor cells subjected to photodynamic therapy-like oxidative stress. Free radical biology & medicine. vol 57. 2013-08-23. PMID:23261943. |
regarding pro-survival stress signaling, rapid activation of akt was unaffected by 1400 w, but prevented by wortmannin, which also enhanced apoptosis. |
2013-08-23 |
2023-08-12 |
Not clear |
| T W Son, S P Yun, M S Yong, B N Seo, J M Ryu, H Y Youn, Y M Oh, H J Ha. Netrin-1 protects hypoxia-induced mitochondrial apoptosis through HSP27 expression via DCC- and integrin α6β4-dependent Akt, GSK-3β, and HSF-1 in mesenchymal stem cells. Cell death & disease. vol 4. 2013-08-23. PMID:23538444. |
netrin-1 protects hypoxia-induced mitochondrial apoptosis through hsp27 expression via dcc- and integrin α6β4-dependent akt, gsk-3β, and hsf-1 in mesenchymal stem cells. |
2013-08-23 |
2023-08-12 |
Not clear |
| T W Son, S P Yun, M S Yong, B N Seo, J M Ryu, H Y Youn, Y M Oh, H J Ha. Netrin-1 protects hypoxia-induced mitochondrial apoptosis through HSP27 expression via DCC- and integrin α6β4-dependent Akt, GSK-3β, and HSF-1 in mesenchymal stem cells. Cell death & disease. vol 4. 2013-08-23. PMID:23538444. |
in conclusion, ntn-1-induced hsp27 protected hypoxic injury-related ucb-msc apoptosis through dcc- and in α6β4-dependent akt, gsk-3β, and hsf-1 signaling pathways. |
2013-08-23 |
2023-08-12 |
Not clear |
| Yuyu Yao, Zulong Sheng, YeFei Li, Cong Fu, Genshan Ma, Naifeng Liu, Julie Chao, Lee Cha. Tissue kallikrein-modified human endothelial progenitor cell implantation improves cardiac function via enhanced activation of akt and increased angiogenesis. Laboratory investigation; a journal of technical methods and pathology. vol 93. issue 5. 2013-08-20. PMID:23508045. |
tk protects hepcs from oxidative stress-induced apoptosis via inhibition of activation of caspase-3 and -9, induction of akt phosphorylation, and secretion of vascular endothelial growth factor. |
2013-08-20 |
2023-08-12 |
mouse |
| Hany M Ibrahim, Ibrahim A El-Elaimy, Heba M Saad Eldien, Badr Mohamed Badr, Danny M Rabah, Gamal Bad. Blocking type I interferon signaling rescues lymphocytes from oxidative stress, exhaustion, and apoptosis in a streptozotocin-induced mouse model of type I diabetes. Oxidative medicine and cellular longevity. vol 2013. 2013-08-20. PMID:23533683. |
in addition, lymphocytes from diabetic mice exhibited a marked reduction in their proliferative capacity, increased apoptosis, upregulation of the exhaustion marker pd-1, and aberrant phosphorylation of stat1, stat2, akt and i κ b- α. |
2013-08-20 |
2023-08-12 |
mouse |
| Hany M Ibrahim, Ibrahim A El-Elaimy, Heba M Saad Eldien, Badr Mohamed Badr, Danny M Rabah, Gamal Bad. Blocking type I interferon signaling rescues lymphocytes from oxidative stress, exhaustion, and apoptosis in a streptozotocin-induced mouse model of type I diabetes. Oxidative medicine and cellular longevity. vol 2013. 2013-08-20. PMID:23533683. |
interestingly, following the blocking of type i ifn signaling in diabetic mice, the lymphocytes exhibited restored proliferative capacity, decreased apoptosis, normal expression of pd-1, and normal phosphorylation of stat1, stat2, akt and i κ b- α. |
2013-08-20 |
2023-08-12 |
mouse |
| Zhongchan Sun, Guang Tong, Nan Ma, Jianying Li, Xiujuan Li, Shuang Li, Jingyu Zhou, Lize Xiong, Feng Cao, Libo Yao, Haichang Wang, Lan She. NDRG2: a newly identified mediator of insulin cardioprotection against myocardial ischemia-reperfusion injury. Basic research in cardiology. vol 108. issue 3. 2013-08-16. PMID:23463182. |
reperfusion with insulin inhibited myocardial apoptosis and reduced infarct size, as well as significantly up-regulated myocardial akt and ndrg2 phosphorylation levels compared with the i/r group. |
2013-08-16 |
2023-08-12 |
rat |
| Shukuan Ling, Yochai Birnbaum, Manjyot K Nanhwan, Bejoy Thomas, Mandeep Bajaj, Yu Li, Yinghui Li, Yumei Y. Dickkopf-1 (DKK1) phosphatase and tensin homolog on chromosome 10 (PTEN) crosstalk via microRNA interference in the diabetic heart. Basic research in cardiology. vol 108. issue 3. 2013-08-16. PMID:23636253. |
the attenuation of dkk1 increased akt phosphorylation, improved glucose uptake and decreased apoptosis in hcms exposed to hyperglycemia. |
2013-08-16 |
2023-08-12 |
mouse |
| Xuanchun Wang, Ye Gong, Mingzhe Zheng, Qing Xie, Hailiang Tang, Daijun Wang, Xiancheng Che. Early changes in GMRP1 after intracerebral hemorrhage: involvement in brain damage and cell apoptosis. Acta neurochirurgica. Supplement. vol 118. 2013-08-13. PMID:23564125. |
glucose metabolism-related protein 1 (gmrp1), also known as btbd10, has been reported to inhibit apoptosis of neuronal and islet beta cells via the akt pathway. |
2013-08-13 |
2023-08-12 |
rat |
| Xuanchun Wang, Ye Gong, Mingzhe Zheng, Qing Xie, Hailiang Tang, Daijun Wang, Xiancheng Che. Early changes in GMRP1 after intracerebral hemorrhage: involvement in brain damage and cell apoptosis. Acta neurochirurgica. Supplement. vol 118. 2013-08-13. PMID:23564125. |
we presented here evidence that a decreased gmrp1-mediated akt pathway contributed to cell apoptosis on the hemorrhagic side, suggesting that gmrp1 plays an important role in brain damage after ich. |
2013-08-13 |
2023-08-12 |
rat |
| Jing Zhou, Gang Li, Zhi-Hua Wang, Li-Ping Wang, Pu-Jiang Don. Effects of low-dose hydroxychloroquine on expression of phosphorylated Akt and p53 proteins and cardiomyocyte apoptosis in peri-infarct myocardium in rats. Experimental and clinical cardiology. vol 18. issue 2. 2013-08-13. PMID:23940455. |
effects of low-dose hydroxychloroquine on expression of phosphorylated akt and p53 proteins and cardiomyocyte apoptosis in peri-infarct myocardium in rats. |
2013-08-13 |
2023-08-12 |
rat |
| Jing Zhou, Gang Li, Zhi-Hua Wang, Li-Ping Wang, Pu-Jiang Don. Effects of low-dose hydroxychloroquine on expression of phosphorylated Akt and p53 proteins and cardiomyocyte apoptosis in peri-infarct myocardium in rats. Experimental and clinical cardiology. vol 18. issue 2. 2013-08-13. PMID:23940455. |
low-dose hydroxychloroquine (hcq) and ataxia-telangiectasia-mutated (atm) protein kinase have recently been postulated to be beneficial for the prevention of the age-associated metabolic syndrome including hypertension, hypercholesterolemia and glucose intolerance; however, the effects of low-dose hcq on the expression of atm downstream phosphorylated akt (protein kinase b) and p53 proteins and cardiomyocyte apoptosis in the peri-infarct myocardium remain unclear. |
2013-08-13 |
2023-08-12 |
rat |