| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin-xi Wang, Yan-ping Wang, Xiao-ying Liu, Liang Liu, Li-jing Wang, Wen-jia Chen, Xiao-hong Liu, Li-bin Li. [Dexamethasone-induced apoptosis of murine MIN6 pancreatic beta-cells and its effect on AKT phosphorylation]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 44. issue 11. 2013-09-26. PMID:21355321. |
the results indicated that after exposure to dexamethasone at a concentration ranging from 50-800 nmol x l(-1) for 48 h, the percentage of cell apoptosis was significantly increased with the concentration over 100 nmol x l(-1) of dexamethasone; after exposure to dexamethasone (100 nmol x l(-1)) for 72 h, the activity of caspase-3 increased significantly; after exposure to dexamethasone at a concentration ranging from 50-800 nmol x l(-1) for 48 h, the expression of cyt-c increased, bcl-2 and akt phosphorylation decreased while bax and t-akt remained unchanged. |
2013-09-26 |
2023-08-12 |
Not clear |
| Lin-xi Wang, Yan-ping Wang, Xiao-ying Liu, Liang Liu, Li-jing Wang, Wen-jia Chen, Xiao-hong Liu, Li-bin Li. [Dexamethasone-induced apoptosis of murine MIN6 pancreatic beta-cells and its effect on AKT phosphorylation]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 44. issue 11. 2013-09-26. PMID:21355321. |
the mechanism of dexamethasone-dependent cell apoptosis is probably related to down regulation of the bcl-2 expression and reduction of akt phosphorylation. |
2013-09-26 |
2023-08-12 |
Not clear |
| Reecha D Shah, Jayashree C Jagtap, S Mruthyunjaya, Ganesh V Shelke, Radha Pujari, Gowry Das, Padma Shastr. Sodium valproate potentiates staurosporine-induced apoptosis in neuroblastoma cells via Akt/survivin independently of HDAC inhibition. Journal of cellular biochemistry. vol 114. issue 4. 2013-09-25. PMID:23097134. |
moreover, ms-275, a structurally distinct class i hdac inhibitor did not affect sts-mediated apoptosis, nor decrease the levels of survivin and akt. |
2013-09-25 |
2023-08-12 |
human |
| Reecha D Shah, Jayashree C Jagtap, S Mruthyunjaya, Ganesh V Shelke, Radha Pujari, Gowry Das, Padma Shastr. Sodium valproate potentiates staurosporine-induced apoptosis in neuroblastoma cells via Akt/survivin independently of HDAC inhibition. Journal of cellular biochemistry. vol 114. issue 4. 2013-09-25. PMID:23097134. |
valpromide (vpm), an amide analog of vpa that does not inhibit hdac also potentiated cell death in nb cells associated with decreased survivin and akt levels suggesting that hdac inhibition might not be crucial for sts-induced apoptosis. |
2013-09-25 |
2023-08-12 |
human |
| Qiu Zhang, Shumei Zhai, Liwen Li, Xiue Li, Hongyu Zhou, Aifeng Liu, Gaoxing Su, Qingxin Mu, Yuhong Du, Bing Ya. Anti-tumor selectivity of a novel tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models. Biochemical pharmacology. vol 86. issue 3. 2013-09-24. PMID:23743233. |
cdbt blocks microtubule formation, decreases cancer-essential proteins craf-1, erbb2 and phosphorylated akt, and causes g2/m arrest and apoptosis. |
2013-09-24 |
2023-08-12 |
mouse |
| M-S Mo, H-B Li, B-Y Wang, S-L Wang, Z-L Zhu, X-R Y. PI3K/Akt and NF-κB activation following intravitreal administration of 17β-estradiol: neuroprotection of the rat retina from light-induced apoptosis. Neuroscience. vol 228. 2013-09-23. PMID:23069760. |
moreover, the inhibition of akt activation by ly294002 increased retinal neuronal apoptosis, demonstrating that the pi3k/akt signaling pathway is involved. |
2013-09-23 |
2023-08-12 |
rat |
| Adam A Sabile, Matthias J E Arlt, Roman Muff, Knut Husmann, Daniel Hess, Josefine Bertz, Bettina Langsam, Caroline Aemisegger, Urs Ziegler, Walter Born, Bruno Fuch. Caprin-1, a novel Cyr61-interacting protein, promotes osteosarcoma tumor growth and lung metastasis in mice. Biochimica et biophysica acta. vol 1832. issue 8. 2013-09-19. PMID:23528710. |
here we report that cyr61 associates with caprin-1, and confocal microscopy showed that stable ectopic expression of caprin-1 leads to the formation of stress granules containing caprin-1 and cyr61, confers resistance to cisplatin-induced apoptosis, and resulted in constitutive phosphorylation of akt and erk1/2. |
2013-09-19 |
2023-08-12 |
mouse |
| Adam A Sabile, Matthias J E Arlt, Roman Muff, Knut Husmann, Daniel Hess, Josefine Bertz, Bettina Langsam, Caroline Aemisegger, Urs Ziegler, Walter Born, Bruno Fuch. Caprin-1, a novel Cyr61-interacting protein, promotes osteosarcoma tumor growth and lung metastasis in mice. Biochimica et biophysica acta. vol 1832. issue 8. 2013-09-19. PMID:23528710. |
the findings imply that caprin-1 may have a metastasis promoting role in os and show that through resistance to apoptosis and via the activation of akt and erk1/2 pathways, caprin-1 is significantly involved in the development of os metastasis. |
2013-09-19 |
2023-08-12 |
mouse |
| Peter Haslinger, Sandra Haider, Stefan Sonderegger, Jan Velten Otten, Jürgen Pollheimer, Guy Whitley, Martin Knöfle. AKT isoforms 1 and 3 regulate basal and epidermal growth factor-stimulated SGHPL-5 trophoblast cell migration in humans. Biology of reproduction. vol 88. issue 3. 2013-09-17. PMID:23303682. |
compared with shrnamir controls, proliferation and camptothecin-induced apoptosis were not affected in the different akt knockdown cells. |
2013-09-17 |
2023-08-12 |
human |
| Annabelle Veillette, Kathy Grenier, Kevin Brasseur, Guylaine Fréchette-Frigon, Valérie Leblanc, Sophie Parent, Eric Asseli. Regulation of the PI3-K/Akt survival pathway in the rat endometrium. Biology of reproduction. vol 88. issue 3. 2013-09-17. PMID:23390163. |
these results suggest that akt and xiap may be important surviving signaling molecules by which apoptosis is regulated in the rat endometrium during pregnancy and that tgf-beta could be linked to this process. |
2013-09-17 |
2023-08-12 |
rat |
| Graziela Rosa Ravacci, Maria Mitzi Brentani, Tharcisio Tortelli, Raquel Suzana M M Torrinhas, Tatiana Saldanha, Elizabeth Aparecida F S Torres, Dan Linetzky Waitzber. Lipid raft disruption by docosahexaenoic acid induces apoptosis in transformed human mammary luminal epithelial cells harboring HER-2 overexpression. The Journal of nutritional biochemistry. vol 24. issue 3. 2013-09-16. PMID:22749134. |
in hb4ac5.2 cells, but not hb4a cells, we found that dha treatment disrupted lipid raft; inhibited her-2 signaling by decreasing activation of akt, erk1/2 and fasn proteins; and induced apoptosis. |
2013-09-16 |
2023-08-12 |
human |
| Zengguang Wang, Jikui Sun, Xue Li, Shuyuan Yang, Shuyuan Yue, Jianning Zhang, Xuejun Yang, Tao Zhu, Rongcai Jiang, Weidong Yan. Downregulation of Src enhances the cytotoxic effect of temozolomide through AKT in glioma. Oncology reports. vol 29. issue 4. 2013-09-12. PMID:23338526. |
thus, the present study demonstrated that src plays a biologically significant role in tumor proliferation and apoptosis and enhances the cytotoxic effect of temozolomide through akt supression in glioma. |
2013-09-12 |
2023-08-12 |
Not clear |
| I Ben-Sahra, B Dirat, K Laurent, A Puissant, P Auberger, A Budanov, J-F Tanti, F Bos. Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death. Cell death and differentiation. vol 20. issue 4. 2013-09-11. PMID:23238567. |
inhibition of akt, as well as loss of sesn2, sensitizes cells to 2-dg-induced apoptosis. |
2013-09-11 |
2023-08-12 |
Not clear |
| I Ben-Sahra, B Dirat, K Laurent, A Puissant, P Auberger, A Budanov, J-F Tanti, F Bos. Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death. Cell death and differentiation. vol 20. issue 4. 2013-09-11. PMID:23238567. |
in conclusion, we identify sesn2 as a new energetic stress sensor, which appears to be protective against energetic stress-induced apoptosis that integrates the pro-survival function of akt and the negative regulation of mtor. |
2013-09-11 |
2023-08-12 |
Not clear |
| Y Zhang, Y-J Tang, Y Man, F Pan, Z-H Li, L-S Ji. Knockdown of AXL receptor tyrosine kinase in osteosarcoma cells leads to decreased proliferation and increased apoptosis. International journal of immunopathology and pharmacology. vol 26. issue 1. 2013-09-10. PMID:23527720. |
in conclusion, our findings suggest that axl is highly expressed in most of the os tissues compared with the anct, and knockdown of axl inhibits proliferation and induces apoptosis of os cells possibly through downregulation of the akt pathway, suggesting that our findings may provide new insights into the potential therapeutic target for cancer. |
2013-09-10 |
2023-08-12 |
human |
| Petra Waskova-Arnostova, Barbara Elsnicova, Dita Kasparova, Ondrej Sebesta, Jiri Novotny, Jan Neckar, Frantisek Kolar, Jitka Zurmanov. Right-to-left ventricular differences in the expression of mitochondrial hexokinase and phosphorylation of Akt. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 31. issue 1. 2013-09-05. PMID:23343752. |
hk2 isoform is under physiological conditions predominantly localized in the cytosol and upon stimulation of pi3k/ akt pathway associates with mitochondria and thus can prevent apoptosis. |
2013-09-05 |
2023-08-12 |
rat |
| Xin Yan, Hua Shen, Hongjian Jiang, Dan Hu, Jun Wang, Xinqi W. External Qi of Yan Xin Qigong inhibits activation of Akt, Erk1/2 and NF-ĸB and induces cell cycle arrest and apoptosis in colorectal cancer cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 31. issue 1. 2013-09-05. PMID:23363659. |
external qi of yan xin qigong inhibits activation of akt, erk1/2 and nf-ĸb and induces cell cycle arrest and apoptosis in colorectal cancer cells. |
2013-09-05 |
2023-08-12 |
human |
| Huailei Liu, Dayong Han, Yaohua Liu, Xu Hou, Jianing Wu, Huadong Li, Jie Yang, Chen Shen, Guang Yang, Changyu Fu, Xianfeng Li, Hui Che, Jing Ai, Shiguang Zha. Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma. Journal of neuro-oncology. vol 112. issue 1. 2013-09-05. PMID:23392846. |
in this study, we found that har-hc clearly decreased cell viability, induced apoptosis and inhibited akt phosphorylation in glioblastoma cell lines. |
2013-09-05 |
2023-08-12 |
human |
| Fengju OuYang, Guibin Wang, Wei Guo, Yuanyuan Zhang, Wenhua Xiang, Min Zha. AKT signalling and mitochondrial pathways are involved in mushroom polysaccharide-induced apoptosis and G1 or S phase arrest in human hepatoma cells. Food chemistry. vol 138. issue 4. 2013-09-04. PMID:23497867. |
akt signalling and mitochondrial pathways are involved in mushroom polysaccharide-induced apoptosis and g1 or s phase arrest in human hepatoma cells. |
2013-09-04 |
2023-08-12 |
human |
| Yanan Guo, Jinyan Du, David J Kwiatkowsk. Molecular dissection of AKT activation in lung cancer cell lines. Molecular cancer research : MCR. vol 11. issue 3. 2013-09-03. PMID:23319332. |
despite the activation of notch, akt activation and cell survival were not affected by notch inhibitors dapt or compound e. in contrast, src inhibitors pp2 and dasatinib both significantly decreased pakt(ser473) levels and reduced cell survival by inducing apoptosis. |
2013-09-03 |
2023-08-12 |
human |