| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiye Wang, Yaoming Chen, Wenbin Zhang, Gang Zheng, Shanshan Meng, Honglei Che, Tao Ke, Jingrun Yang, Jingyuan Chen, Wenjing Lu. Akt activation protects liver cells from apoptosis in rats during acute cold exposure. International journal of biological sciences. vol 9. issue 5. 2013-12-09. PMID:23781144. |
akt activation protects liver cells from apoptosis in rats during acute cold exposure. |
2013-12-09 |
2023-08-12 |
rat |
| Jiye Wang, Yaoming Chen, Wenbin Zhang, Gang Zheng, Shanshan Meng, Honglei Che, Tao Ke, Jingrun Yang, Jingyuan Chen, Wenjing Lu. Akt activation protects liver cells from apoptosis in rats during acute cold exposure. International journal of biological sciences. vol 9. issue 5. 2013-12-09. PMID:23781144. |
blockade of akt activation diminished the transient increase of intracellular atp content and exacerbated cell apoptosis during acute cold exposure. |
2013-12-09 |
2023-08-12 |
rat |
| Dinender K Singla, Aisha Ahmed, Reetu Singla, Binbin Ya. Embryonic stem cells improve cardiac function in Doxorubicin-induced cardiomyopathy mediated through multiple mechanisms. Cell transplantation. vol 21. issue 9. 2013-12-06. PMID:22449713. |
therefore, we transplanted es cells or cm in dic to examine apoptosis, fibrosis, cytoplasmic vacuolization, and myofibrillar loss and their associated akt and erk pathway. |
2013-12-06 |
2023-08-12 |
mouse |
| Nidhi Khanna, Yimin Fang, Mee-Sup Yoon, Jie Che. XPLN is an endogenous inhibitor of mTORC2. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 40. 2013-12-03. PMID:24043828. |
consistent with akt promoting cell survival and xpln playing a negative role in this process, xpln knockdown protects cells from starvation-induced apoptosis. |
2013-12-03 |
2023-08-12 |
Not clear |
| Qinqin Wu, Benling Qi, Yun Liu, Bei Cheng, Lihua Liu, Yuanyuan Li, Qian Wan. Mechanisms underlying protective effects of trimetazidine on endothelial progenitor cells biological functions against H2O2-induced injury: involvement of antioxidation and Akt/eNOS signaling pathways. European journal of pharmacology. vol 707. issue 1-3. 2013-11-26. PMID:23528356. |
the results showed that pretreatment of epcs with tmz (10 µm) protected the proliferation, adhesion, migration, and apoptosis of epcs against h2o2, accompanied by an increase in superoxide dismutase (sod) activity, a decrease in malonaldehyde (mda) content, and increases in enos, akt phosphorylation, and no production. |
2013-11-26 |
2023-08-12 |
Not clear |
| Bingbing Dai, Suk-Young Yoo, Geoffrey Bartholomeusz, Ryan A Graham, Mourad Majidi, Shaoyu Yan, Jieru Meng, Lin Ji, Kevin Coombes, John D Minna, Bingliang Fang, Jack A Rot. KEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancer. Cancer research. vol 73. issue 17. 2013-11-26. PMID:23824739. |
we found that simultaneous inhibition of txnrd1 and akt pathways induced robust reactive oxygen species production, which was involved in c-jun-nh2-kinase (jnk; mapk8) activation and cell apoptosis. |
2013-11-26 |
2023-08-12 |
Not clear |
| Hiroyuki Yamada, Kazutoshi Iijima, Osamu Tomita, Tomoko Taguchi, Masashi Miharu, Kenichiro Kobayashi, Hajime Okita, Masahiro Saito, Toshiaki Shimizu, Nobutaka Kiyokaw. Effects of insulin-like growth factor-1 on B-cell precursor acute lymphoblastic leukemia. International journal of hematology. vol 97. issue 1. 2013-11-19. PMID:23250859. |
interestingly, the proliferative effect of igf-1 was partially blocked by inhibitors of mapk and akt, whereas the inhibition of dexamethasone-induced apoptosis was completely blocked by both inhibitors. |
2013-11-19 |
2023-08-12 |
Not clear |
| T J Wright, C McKee, M A Birch-Machin, R Ellis, J L Armstrong, P E Lova. Increasing the therapeutic efficacy of docetaxel for cutaneous squamous cell carcinoma through the combined inhibition of phosphatidylinositol 3-kinase/AKT signalling and autophagy. Clinical and experimental dermatology. vol 38. issue 4. 2013-11-18. PMID:23530461. |
the aim of the current study was to test the hypothesis that combined inhibition of akt signalling and autophagy by the lysosomal inhibitor chloroquine increases the susceptibility to docetaxel-induced apoptosis of cscc cells isolated from a lymph-node metastasis. |
2013-11-18 |
2023-08-12 |
Not clear |
| T J Wright, C McKee, M A Birch-Machin, R Ellis, J L Armstrong, P E Lova. Increasing the therapeutic efficacy of docetaxel for cutaneous squamous cell carcinoma through the combined inhibition of phosphatidylinositol 3-kinase/AKT signalling and autophagy. Clinical and experimental dermatology. vol 38. issue 4. 2013-11-18. PMID:23530461. |
combined akt inhibition and chloroquine treatment of met 4 cscc cells resulted in significantly enhanced inhibition of cell viability and apoptosis induced by clinically achievable concentrations of docetaxel (p < 0.001). |
2013-11-18 |
2023-08-12 |
Not clear |
| L Wang, L-S You, W-M Ni, Q-L Ma, Y Tong, L-P Mao, J-J Qian, J Ji. β-Catenin and AKT are promising targets for combination therapy in acute myeloid leukemia. Leukemia research. vol 37. issue 10. 2013-11-15. PMID:23867056. |
significant increases in growth inhibition and apoptosis were induced by an akt inhibitor when the wnt3a gene of thp-1 cells was silenced. |
2013-11-15 |
2023-08-12 |
Not clear |
| Ying Tan, Kenzo Uchida, Hideaki Nakajima, Alexander R Guerrero, Shuji Watanabe, Takayuki Hirai, Naoto Takeura, Shao-Yu Liu, William E B Johnson, Hisatoshi Bab. Blockade of interleukin 6 signaling improves the survival rate of transplanted bone marrow stromal cells and increases locomotor function in mice with spinal cord injury. Journal of neuropathology and experimental neurology. vol 72. issue 10. 2013-11-15. PMID:24042200. |
transplantation of bmsc with cotreatment of mr16-1 was associated with a decrease of some proinflammatory cytokines, an increase of neurotrophic factors, decreased apoptosis rates of transplanted bmscs, and enhanced expression of survival factors akt and extracellular signal-regulated protein kinases 1/2. |
2013-11-15 |
2023-08-12 |
mouse |
| Rui Wang, Fangyuan Shao, Zhong Liu, Jiaxuan Zhang, Shaoxiang Wang, Jinyun Liu, Hui Liu, Hongyuan Chen, Kaisheng Liu, Min Xia, Yifei Wan. The Hsp90 inhibitor SNX-2112, induces apoptosis in multidrug resistant K562/ADR cells through suppression of Akt/NF-κB and disruption of mitochondria-dependent pathways. Chemico-biological interactions. vol 205. issue 1. 2013-11-13. PMID:23777986. |
moreover, the inactivation of the akt and nf-κb signaling pathways may be involved in snx-2112-induced apoptosis. |
2013-11-13 |
2023-08-12 |
human |
| Azhar Rasul, Chuan Ding, Xiaomeng Li, Muhammad Khan, Fei Yi, Muhammad Ali, Tonghui M. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis. Apoptosis : an international journal on programmed cell death. vol 17. issue 10. 2013-11-12. PMID:22711363. |
interestingly, we also found that dracorhodin perchlorate significantly suppressed the igf-1-induced phosphorylation of akt in the stably expressing egfp-akt recombinant cho-hir cells and inhibited tnf-induced nf-κb transcriptional activity in the nf-κbp65-egfp recombinant u2os cells, indicating that inhibition of pi3k/akt and nf-κb may provide a molecular basis for the ability of dracorhodin perchlorate to induce apoptosis. |
2013-11-12 |
2023-08-12 |
human |
| Ying Li, Haixia Zhao, Yuzhong Wang, Hao Zheng, Wei Yu, Hongyan Chai, Jing Zhang, John R Falck, Austin M Guo, Jiang Yue, Renxiu Peng, Jing Yan. Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. Toxicology and applied pharmacology. vol 272. issue 1. 2013-11-12. PMID:23747687. |
conversely, the addition of exogenous eicosanoids, including pge2, ltb4 and a 20-hete analog (wit003), and caspase inhibitors, or overexpression of constitutively active akt reversed isoliquiritigenin-induced apoptosis. |
2013-11-12 |
2023-08-12 |
mouse |
| Shashi Rajput, B N Prashanth Kumar, Siddik Sarkar, Subhasis Das, Belal Azab, Prasanna K Santhekadur, Swadesh K Das, Luni Emdad, Devanand Sarkar, Paul B Fisher, Mahitosh Manda. Targeted apoptotic effects of thymoquinone and tamoxifen on XIAP mediated Akt regulation in breast cancer. PloS one. vol 8. issue 4. 2013-11-11. PMID:23613836. |
consistent with these results, overexpression studies further confirmed the involvement of xiap and its regulatory action on akt phosphorylation along with procaspase-9 and parp cleavage in tq-tam coadministrated induced apoptosis. |
2013-11-11 |
2023-08-12 |
Not clear |
| Huizhen Nie, Qingzhen Cao, Lei Zhu, Yuehua Gong, Jianren Gu, Zuping H. Acetylcholine acts on androgen receptor to promote the migration and invasion but inhibit the apoptosis of human hepatocarcinoma. PloS one. vol 8. issue 4. 2013-11-11. PMID:23620780. |
collectively, these data suggest that ach activates stat3 and akt pathways and acts on ar to promote the migration and invasion but inhibit the apoptosis of hcc cells. |
2013-11-11 |
2023-08-12 |
human |
| F M Berglund, N R Weerasinghe, L Davidson, J C Lim, B J Eickholt, N R Lesli. Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1. Oncogene. vol 32. issue 37. 2013-11-08. PMID:23085752. |
changes in her2, pten, pik3ca and akt have all been reported to lead to both enhanced proliferation and failures in hollow lumen formation in three dimensional epithelial culture models, but it is not clear whether these failures in lumen formation are caused by any failure in the spatial coordination of lumen formation (hollowing) or purely a failure in the apoptosis and clearance of luminal cells (cavitation). |
2013-11-08 |
2023-08-12 |
Not clear |
| M Scotece, R Gómez, J Conde, V Lopez, J J Gómez-Reino, F Lago, A B Smith, O Gualill. Oleocanthal inhibits proliferation and MIP-1α expression in human multiple myeloma cells. Current medicinal chemistry. vol 20. issue 19. 2013-11-08. PMID:23521677. |
in addition, we also demonstrated that oleocanthal inhibits mm cells proliferation by inducing the activation of apoptosis mechanisms and by down-regulating erk1/2 and akt signal transduction pathways. |
2013-11-08 |
2023-08-12 |
human |
| M Hemshekhar, K Sunitha, R M Thushara, M Sebastin Santhosh, M Shanmuga Sundaram, K Kemparaju, K S Giris. Antiarthritic and antiinflammatory propensity of 4-methylesculetin, a coumarin derivative. Biochimie. vol 95. issue 6. 2013-11-07. PMID:23485680. |
recently they have also shown to down regulate nuclear factor-kappa b (nf-κb) and protein kinase b (akt) that play a vital role in inflammation and apoptosis. |
2013-11-07 |
2023-08-12 |
Not clear |
| Yazhen Huo, Lihong Fan, Shutao Yin, Yinhui Dong, Xiao Guo, Hanchun Yang, Hongbo H. Involvement of unfolded protein response, p53 and Akt in modulation of porcine reproductive and respiratory syndrome virus-mediated JNK activation. Virology. vol 444. issue 1-2. 2013-11-06. PMID:23850458. |
we also found that p53 and akt were activated at the early stage of infection and functioned as negative regulator of jnk activation to counteract the prrsv-mediated apoptosis. |
2013-11-06 |
2023-08-12 |
Not clear |