| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Supak Yothaisong, Hasaya Dokduang, Anchalee Techasen, Nisana Namwat, Puangrat Yongvanit, Vajarabhongsa Bhudhisawasdi, Anucha Puapairoj, Gregory J Riggins, Watcharin Loilom. Increased activation of PI3K/AKT signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 6. 2014-02-21. PMID:23832540. |
furthermore, nvp-bez235 effectively inhibited cca cell growth and migration through reduced akt and mtor phosphorylation and significantly induced g1 arrest without apoptosis induction, although increase autophagy response was observed. |
2014-02-21 |
2023-08-12 |
Not clear |
| Eun Jeong Lee, Un-Jung Yun, Kyung Hee Koo, Jee Young Sung, Jaegal Shim, Sang-Kyu Ye, Kyeong-Man Hong, Yong-Nyun Ki. Down-regulation of lipid raft-associated onco-proteins via cholesterol-dependent lipid raft internalization in docosahexaenoic acid-induced apoptosis. Biochimica et biophysica acta. vol 1841. issue 1. 2014-02-21. PMID:24120917. |
in addition, overexpression of akt or constitutively active akt attenuated dha-induced apoptosis. |
2014-02-21 |
2023-08-12 |
human |
| Narmadha Reddy Gangula, Subbareddy Maddik. WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). The Journal of biological chemistry. vol 288. issue 48. 2014-02-21. PMID:24145035. |
similar to phlpp1 function, wdr48 and usp12 negatively regulate akt activation and thus promote cellular apoptosis. |
2014-02-21 |
2023-08-12 |
Not clear |
| Brigette B Y Ma, Vivian W Y Lui, Connie W C Hui, Cecilia P Y Lau, Chi H Wong, Edwin P Hui, Margaret H L Ng, Suk H Cheng, Sai W Tsao, Chi-Man Tsang, Crystal S F Cheung, Kakiu Ho, Anthony T C Cha. Preclinical evaluation of the mTOR-PI3K inhibitor BEZ235 in nasopharyngeal cancer models. Cancer letters. vol 343. issue 1. 2014-02-20. PMID:24041865. |
the ic50 value of bez235 for growth was in the nanomolar range in vitro, induce g1 cycle arrest and apoptosis, and inhibited akt and mtor signaling in most npc cell lines. |
2014-02-20 |
2023-08-12 |
Not clear |
| Theophilus I Emeto, Joseph V Moxon, Erik Biros, Catherine M Rush, Paula Clancy, Lynn Woodward, Corey S Moran, Roby J Jose, Tam Nguyen, Philip J Walker, Jonathan Golledg. Urocortin 2 is associated with abdominal aortic aneurysm and mediates anti-proliferative effects on vascular smooth muscle cells via corticotrophin releasing factor receptor 2. Clinical science (London, England : 1979). vol 126. issue 7. 2014-02-19. PMID:24107226. |
we assessed the relative expression of ucn1-3 in aaa by qrt-pcr (quantitative reverse transcription-pcr) and elisa, and examined in vitro how ucn2 affects human aortic vsmc (vascular smooth muscle cell) akt phosphorylation, pro-inflammatory cytokine il (interleukin)-6 secretion, proliferation, cell cycle and apoptosis. |
2014-02-19 |
2023-08-12 |
human |
| Chi Yang, Jue Fan, Zhenhong Zhuang, Yi Fang, Yanfeng Zhang, Shihua Wan. The role of NAD(+)-dependent isocitrate dehydrogenase 3 subunit α in AFB1 induced liver lesion. Toxicology letters. vol 224. issue 3. 2014-02-18. PMID:24211421. |
over-expression of idh3α increased the phosphorylation level of akt (protein kinase b) and neutralized the cellular toxicity induced by afb1 or h2o2 and apoptosis induced by afb1, while the reduced expression of idh3α by sirna decreased the phosphorylation, indicating that idh3α played important roles in oxidative stress-induced pi3k/akt pathway. |
2014-02-18 |
2023-08-12 |
Not clear |
| In Seok Song, Soon-Suk Kang, Eun-Soon Kim, Hyun-Min Park, Chul Young Choi, Hungwon Tchah, Jae Yong Ki. Heat shock protein 27 phosphorylation is involved in epithelial cell apoptosis as well as epithelial migration during corneal epithelial wound healing. Experimental eye research. vol 118. 2014-02-18. PMID:24239511. |
the scratch-induced directional wounding assay, western blotting, using antibodies against non-phosphorylated and phosphorylated hsp27, non-phosphorylated and phosphorylated akt, and bcl-2-associated x protein (bax), immunofluorescence staining to determine the filament actin, flow cytometry to measure apoptosis, and proliferation assay were performed to determine the role of hsp27. |
2014-02-18 |
2023-08-12 |
human |
| Ellen Preuss, Manuela Hugle, Romy Reimann, Marcel Schlecht, Simone Fuld. Pan-mammalian target of rapamycin (mTOR) inhibitor AZD8055 primes rhabdomyosarcoma cells for ABT-737-induced apoptosis by down-regulating Mcl-1 protein. The Journal of biological chemistry. vol 288. issue 49. 2014-02-13. PMID:24133218. |
similar to azd8055, the pi3k/mtor inhibitor nvp-bez235, the pi3k inhibitor nvp-bkm120 and akt inhibitor synergize with abt-737 to trigger apoptosis, whereas no cooperativity is found for the mtor complex 1 inhibitor rad001. |
2014-02-13 |
2023-08-12 |
Not clear |
| Jun She, Arnaud Goolaerts, Jun Shen, Jing Bi, Lin Tong, Lei Gao, Yuanlin Song, Chunxue Ba. KGF-2 targets alveolar epithelia and capillary endothelia to reduce high altitude pulmonary oedema in rats. Journal of cellular and molecular medicine. vol 16. issue 12. 2014-02-11. PMID:22568566. |
in addition, kgf-2 significantly inhibited decrease of transendothelial permeability after exposure to hypoxia, accompanied by a 10-fold increase of akt activity and inhibited apoptosis in human pulmonary microvascular endothelial cells, demonstrating attenuated endothelial apoptosis might contribute to reduction of endothelial permeability. |
2014-02-11 |
2023-08-12 |
human |
| Isabel Cordero-Herrera, María Angeles Martín, Laura Bravo, Luis Goya, Sonia Ramo. Epicatechin gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon cancer SW480 cells. Nutrition and cancer. vol 65. issue 5. 2014-02-11. PMID:23859040. |
exposure of sw480 cells to ecg also led to apoptosis as determined by time-dependent changes in caspase-3 activity, mapks [extracellular regulated kinase (erk), p38, and c-jun amino-terminal kinase (jnk)], p21 and p53 activation, and akt inhibition. |
2014-02-11 |
2023-08-12 |
human |
| Bidur Parajuli, Hyun-Gyo Lee, Sang-Hoon Kwon, Soon-Do Cha, So-Jin Shin, Gun-Ho Lee, Insoo Bae, Chi-Heum Ch. Salinomycin inhibits Akt/NF-κB and induces apoptosis in cisplatin resistant ovarian cancer cells. Cancer epidemiology. vol 37. issue 4. 2014-02-03. PMID:23545383. |
the present study focused on investigating important cell signaling molecules such as akt and nf-κb during salinomycin-induced apoptosis in cisplatin resistant ovarian cancer cells (a2780cis). |
2014-02-03 |
2023-08-12 |
Not clear |
| D Drakulić, N Veličković, M Stanojlović, I Grković, N Mitrović, I Lavrnja, A Horva. Low-dose dexamethasone treatment promotes the pro-survival signalling pathway in the adult rat prefrontal cortex. Journal of neuroendocrinology. vol 25. issue 7. 2014-01-28. PMID:23551329. |
the present study aimed to determine whether low-dose subchronic dex treatment (100 μg/kg for eight consecutive days) exerts long-term effects on apoptosis in the adult rat prefrontal cortex (pfc) by examining the expression of cell death-promoting molecules [poly(adp-ribose) polymerase (parp), p53, procaspase 3, cleaved caspase 3, bax] and cell-survival molecules (akt, bcl-2). |
2014-01-28 |
2023-08-12 |
rat |
| Ming-Yao Chang, Yu-Jen Yang, Chih-Han Chang, Alan C L Tang, Wei-Yin Liao, Fong-Yu Cheng, Chen-Sheng Yeh, James J Lai, Patrick S Stayton, Patrick C H Hsie. Functionalized nanoparticles provide early cardioprotection after acute myocardial infarction. Journal of controlled release : official journal of the Controlled Release Society. vol 170. issue 2. 2014-01-28. PMID:23665256. |
plga-igf-1 nps also prolonged akt activation in cardiomyocytes up to 24h and prevented cardiomyocyte apoptosis induced by doxorubicin in a dose-dependent manner. |
2014-01-28 |
2023-08-12 |
mouse |
| Qinghong Yu, Binhai Chen, Xiang Zhang, WenBin Qian, Baodong Ye, Yuhong Zho. Arsenic trioxide-enhanced, matrine-induced apoptosis in multiple myeloma cell lines. Planta medica. vol 79. issue 9. 2014-01-27. PMID:23700110. |
activation of caspase-3 and poly (adp-ribose) polymerase, upregulation of bim expression, downregulation of bcl-2, survivin expression, as well as inhibition of phosphorylated akt related to matrine (0, 0.25, 0.5, 1.0, and 2.0 g/l)-mediated apoptosis, and the effects were enhanced when arsenic trioxide (8 ug/ml) was combined with matrine (1.0 g/l). |
2014-01-27 |
2023-08-12 |
Not clear |
| Ruchi Ghildiyal, Deobrat Dixit, Ellora Se. EGFR inhibitor BIBU induces apoptosis and defective autophagy in glioma cells. Molecular carcinogenesis. vol 52. issue 12. 2014-01-23. PMID:22753156. |
the ability of bibu to abrogate akt and stat3 activation, induce apoptosis and prevent execution of autophagy warrants its investigation as a potent anti-glioma target. |
2014-01-23 |
2023-08-12 |
Not clear |
| Norman Y Liaw, Louise See Hoe, Freya L Sheeran, Jason N Peart, John P Headrick, Michael M H Cheung, Salvatore Pep. Postnatal shifts in ischemic tolerance and cell survival signaling in murine myocardium. American journal of physiology. Regulatory, integrative and comparative physiology. vol 305. issue 10. 2014-01-23. PMID:24068046. |
hearts from male c57bl/6 mice (neonates, 2, 4, 8, and 12 wk of age, n = 6/group) were assayed for survival signaling/effectors [akt, p38mapk, glycogen synthase kinase-3β (gsk-3β), heat shock protein 27 (hsp27), connexin-43, hypoxia-inducible factor-1α (hif-1α), and caveolin-3] and regulators of apoptosis (bax and bcl-2) and autophagy (lc3b, parkin, and beclin1). |
2014-01-23 |
2023-08-12 |
mouse |
| Ramesh B Batchu, Oksana V Gruzdyn, Christopher S Bryant, Aamer M Qazi, Sanjeev Kumar, Sreedhar Chamala, Shu T Kung, Ramana S Sanka, Udaya S Puttagunta, Donald W Weaver, Scott A Grube. Ritonavir-Mediated Induction of Apoptosis in Pancreatic Cancer Occurs via the RB/E2F-1 and AKT Pathways. Pharmaceuticals (Basel, Switzerland). vol 7. issue 1. 2014-01-23. PMID:24451403. |
ritonavir-mediated induction of apoptosis in pancreatic cancer occurs via the rb/e2f-1 and akt pathways. |
2014-01-23 |
2023-08-12 |
human |
| Qingqing Cai, Huiqiang Huang, Dong Qian, Kailin Chen, Junhua Luo, Ying Tian, Tianxin Lin, Tongyu Li. 13-methyltetradecanoic acid exhibits anti-tumor activity on T-cell lymphomas in vitro and in vivo by down-regulating p-AKT and activating caspase-3. PloS one. vol 8. issue 6. 2014-01-22. PMID:23762338. |
these data indicate that 13-mtd inhibits proliferation and induces apoptosis through the down-regulation of akt phosphorylation followed by caspase activation, which may provide a new approach for treating t-cell lymphomas. |
2014-01-22 |
2023-08-12 |
human |
| Shi-feng Chen, Jian-Zhong Che. Development for anticancer therapy: small-molecule inhibitors targeting protein kinase B. Mini reviews in medicinal chemistry. vol 13. issue 9. 2014-01-21. PMID:22512570. |
protein kinase b (pkb, also known as akt) plays a critical role in the multiple cellular processes including glucose metabolism, cell growth, survival, apoptosis, transcription, and cell migration. |
2014-01-21 |
2023-08-12 |
human |
| Caroline Morin, Samuel Fortin, André M Cantin, Marco Sirois, Chantal Sirois, Edmond Rizcallah, Éric Roussea. Anti-cancer effects of a new docosahexaenoic acid monoacylglyceride in lung adenocarcinoma. Recent patents on anti-cancer drug discovery. vol 8. issue 3. 2014-01-21. PMID:23092161. |
furthermore, mag-dha treatment increased pten expression and activation concomitant with a decrease in akt phosphorylation levels and enhanced apoptosis. |
2014-01-21 |
2023-08-12 |
mouse |