| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Wang, Xu Li, Xiaoliang Wang, Waynebond Lau, Yajing Wang, Yuan Xing, Xing Zhang, Xinliang Ma, Feng Ga. Ginsenoside Rd attenuates myocardial ischemia/reperfusion injury via Akt/GSK-3β signaling and inhibition of the mitochondria-dependent apoptotic pathway. PloS one. vol 8. issue 8. 2014-04-08. PMID:23976968. |
in nrcs, gsrd (10 µm) inhibited si/r-induced ros generation (p<0.01), decreased cellular apoptosis, stabilized the mitochondrial membrane potential (mmp), and attenuated cytosolic translocation of mitochondrial cytochrome c. gsrd inhibited activation of caspase-9 and caspase-3, increased the phosphorylated akt and gsk-3β, and increased the bcl-2/bax ratio. |
2014-04-08 |
2023-08-12 |
rat |
| Jinsheng Hong, Zhenhuan Zhang, Wenlong Lv, Mei Zhang, Chun Chen, Shanmin Yang, Shan Li, Lurong Zhang, Deping Han, Weijian Zhan. Icaritin synergistically enhances the radiosensitivity of 4T1 breast cancer cells. PloS one. vol 8. issue 8. 2014-04-08. PMID:23977023. |
this effect might relate with bioactivities of ict: 1) exert an anti-proliferative effect in a dose- and time-dependent manner, which is different from ir killing effect but likely work together with the ir effect; 2) suppress the ir-induced activation of two survival paths, erk1/2 and akt; 3) induce the g2/m blockage, enhancing ir killing effect; and 4) synergize with ir to enhance cell apoptosis. |
2014-04-08 |
2023-08-12 |
chicken |
| Eric Drago, Michael Bordonaro, Seon Lee, Wafa Atamna, Darina L Lazarov. Propolis augments apoptosis induced by butyrate via targeting cell survival pathways. PloS one. vol 8. issue 9. 2014-04-08. PMID:24023824. |
we established that propolis increases the apoptosis of cc cells exposed to butyrate through suppression of cell survival pathways such as the akt signaling. |
2014-04-08 |
2023-08-12 |
Not clear |
| Eric Drago, Michael Bordonaro, Seon Lee, Wafa Atamna, Darina L Lazarov. Propolis augments apoptosis induced by butyrate via targeting cell survival pathways. PloS one. vol 8. issue 9. 2014-04-08. PMID:24023824. |
thus, our studies ascertained that propolis augments apoptosis of butyrate-sensitive cc cells and re-sensitizes butyrate-resistant cc cells to apoptosis by suppressing akt signaling and downregulating the jak/stat pathway. |
2014-04-08 |
2023-08-12 |
Not clear |
| Yu-Xiu Yang, Xiu-Ling Li, Lei Wang, Shuang-Yin Han, Yan-Rui Zhang, Poyil Pratheeshkumar, Xin Wang, Jian Lu, Yuan-Qin Yin, Li-Juan Sun, Amit Budhraja, Andrew J Hitron, Song-Ze Din. Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells. International journal of oncology. vol 43. issue 3. 2014-04-07. PMID:23828460. |
akt also participates in this process, as its overexpression increases bcl-xl protein expression levels and attenuates nicl2-induced apoptosis. |
2014-04-07 |
2023-08-12 |
human |
| Takayoshi Rokkaku, Ryuichiro Kimura, Chie Ishikawa, Takeshi Yasumoto, Masachika Senba, Fuminori Kanaya, Naoki Mor. Anticancer effects of marine carotenoids, fucoxanthin and its deacetylated product, fucoxanthinol, on osteosarcoma. International journal of oncology. vol 43. issue 4. 2014-04-07. PMID:23857515. |
fucoxanthin and fucoxanthinol inhibit cell growth, migration and invasion and induce apoptosis of osteosarcoma cells at least in part by inhibiting akt and activator protein-1 pathways. |
2014-04-07 |
2023-08-12 |
mouse |
| Ma Fátima G Klingbeil, Flávia C A Xavier, Luiz R Sardinha, Patricia Severino, Monica B Mathor, Rodrigo V Rodrigues, Décio S Pint. Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines. Oncology reports. vol 30. issue 5. 2014-04-07. PMID:24026291. |
a concentration of 0.3 mg/ml (ic50) of the drugs induced apoptosis, affecting gene expression and protein levels of akt, pten and cyclin d1. |
2014-04-07 |
2023-08-12 |
Not clear |
| Rajesh Mukthavaram, Pengfei Jiang, Rohit Saklecha, Dmitri Simberg, Ila Sri Bharati, Natsuko Nomura, Ying Chao, Sandra Pastorino, Sandeep C Pingle, Valentina Fogal, Wolf Wrasidlo, Milan Makale, Santosh Kesar. High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile. International journal of nanomedicine. vol 8. 2014-04-04. PMID:24174874. |
in vitro experiments revealed that liposomal sts blocked akt phosphorylation, induced poly(adp-ribose) polymerase cleavage, and produced cell death via apoptosis. |
2014-04-04 |
2023-08-12 |
Not clear |
| Francois Lamoureux, Amina Zoubeid. Dual inhibition of autophagy and the AKT pathway in prostate cancer. Autophagy. vol 9. issue 7. 2014-04-03. PMID:23670050. |
taken together, these data demonstrate that akt inhibitor azd5363, synergizes with the lysosomotropic inhibitor of autophagy, chloroquine, to induce apoptosis and delay tumor progression in prostate cancer models that are resistant to monotherapy, with azd5363 providing a new therapeutic approach potentially translatable to patients. |
2014-04-03 |
2023-08-12 |
Not clear |
| Xiao M Pei, Benjamin Y Yung, Shea Ping Yip, Michael Ying, Iris F Benzie, Parco M Si. Desacyl ghrelin prevents doxorubicin-induced myocardial fibrosis and apoptosis via the GHSR-independent pathway. American journal of physiology. Endocrinology and metabolism. vol 306. issue 3. 2014-03-31. PMID:24326424. |
doxorubicin induced fibrosis (accumulated collagen deposition and increased ctgf), activated apoptosis (increased tunel index, apoptotic dna fragmentation, and caspase-3 activity and decreased bcl-2/bax ratio), and suppressed phosphorylation status of prosurvival signals (erk1/2 and akt) in ventricular muscles. |
2014-03-31 |
2023-08-12 |
mouse |
| Xiao M Pei, Benjamin Y Yung, Shea Ping Yip, Michael Ying, Iris F Benzie, Parco M Si. Desacyl ghrelin prevents doxorubicin-induced myocardial fibrosis and apoptosis via the GHSR-independent pathway. American journal of physiology. Endocrinology and metabolism. vol 306. issue 3. 2014-03-31. PMID:24326424. |
notably, the changes in the major markers of apoptosis, fibrosis, and akt phosphorylation were found to be similar in the animals following the treatment of desacyl ghrelin with and without ghsr antagonist [d-lys3]-ghrp-6. |
2014-03-31 |
2023-08-12 |
mouse |
| Houda Zrelli, Mieko Matsuka, Masahiro Araki, Mokhtar Zarrouk, Hitoshi Miyazak. Hydroxytyrosol induces vascular smooth muscle cells apoptosis through NO production and PP2A activation with subsequent inactivation of Akt. Planta medica. vol 77. issue 15. 2014-03-28. PMID:21590650. |
hydroxytyrosol induces vascular smooth muscle cells apoptosis through no production and pp2a activation with subsequent inactivation of akt. |
2014-03-28 |
2023-08-12 |
Not clear |
| Houda Zrelli, Mieko Matsuka, Masahiro Araki, Mokhtar Zarrouk, Hitoshi Miyazak. Hydroxytyrosol induces vascular smooth muscle cells apoptosis through NO production and PP2A activation with subsequent inactivation of Akt. Planta medica. vol 77. issue 15. 2014-03-28. PMID:21590650. |
ht as well as the no donor snap reduced the phosphorylation levels of akt, suggesting that ht inactivates akt via no production with subsequent apoptosis of vsmcs. |
2014-03-28 |
2023-08-12 |
Not clear |
| Houda Zrelli, Mieko Matsuka, Masahiro Araki, Mokhtar Zarrouk, Hitoshi Miyazak. Hydroxytyrosol induces vascular smooth muscle cells apoptosis through NO production and PP2A activation with subsequent inactivation of Akt. Planta medica. vol 77. issue 15. 2014-03-28. PMID:21590650. |
moreover, ht-dependent apoptosis and reduction in the phosphorylation level of akt were suppressed by okadaic acid, an inhibitor of protein phosphatase 2a (pp2a) that dephosphorylates akt. |
2014-03-28 |
2023-08-12 |
Not clear |
| Houda Zrelli, Mieko Matsuka, Masahiro Araki, Mokhtar Zarrouk, Hitoshi Miyazak. Hydroxytyrosol induces vascular smooth muscle cells apoptosis through NO production and PP2A activation with subsequent inactivation of Akt. Planta medica. vol 77. issue 15. 2014-03-28. PMID:21590650. |
together, these findings indicate that ht could induce vsmcs apoptosis through no production and pp2a activation followed by inactivation of akt signaling pathway. |
2014-03-28 |
2023-08-12 |
Not clear |
| Li Yuan, Yutang Wang, Jing Wang, Haifang Xiao, Xuebo Li. Additive effect of zinc oxide nanoparticles and isoorientin on apoptosis in human hepatoma cell line. Toxicology letters. vol 225. issue 2. 2014-03-28. PMID:24374571. |
zno nps could synergistically potentiate iso to induce apoptosis through resulting in mitochondrial dysfunction, inhibiting the phosphorylation of akt and erk1/2, and enhancing the phosphorylation of jnk and p38. |
2014-03-28 |
2023-08-12 |
human |
| Vinodkumar B Pillai, Nagalingam R Sundaresan, Mahesh P Gupt. Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging. Circulation research. vol 114. issue 2. 2014-03-28. PMID:24436432. |
in the latter part of the review, we summarize the implications of sirtuin-dependent regulation of akt signaling in the control of major cellular processes such as cellular growth, angiogenesis, apoptosis, autophagy, and aging, which are involved in the initiation and progression of several diseases. |
2014-03-28 |
2023-08-12 |
Not clear |
| Alessandro Cannavo, Giuseppe Rengo, Daniela Liccardo, Gianluigi Pironti, Maria Cecilia Scimia, Laura Scudiero, Claudio De Lucia, Marco Ferrone, Dario Leosco, Nicola Zambrano, Walter J Koch, Bruno Trimarco, Giovanni Esposit. Prothymosin alpha protects cardiomyocytes against ischemia-induced apoptosis via preservation of Akt activation. Apoptosis : an international journal on programmed cell death. vol 18. issue 10. 2014-03-26. PMID:23857453. |
prothymosin alpha protects cardiomyocytes against ischemia-induced apoptosis via preservation of akt activation. |
2014-03-26 |
2023-08-12 |
mouse |
| Xuesen Yang, Aimin Wei, Yong Liu, Genlin He, Zhou Zhou, Zhengping Y. IGF-1 protects retinal ganglion cells from hypoxia-induced apoptosis by activating the Erk-1/2 and Akt pathways. Molecular vision. vol 19. 2014-03-25. PMID:24049436. |
igf-1 protects retinal ganglion cells from hypoxia-induced apoptosis by activating the erk-1/2 and akt pathways. |
2014-03-25 |
2023-08-12 |
Not clear |
| Huan-Yong Che, Hang-Yuan Guo, Xu-Wei Si, Qiao-Ying You, Wei-Ying Lo. Additive effect by combination of Akt inhibitor, MK-2206, and PDGFR inhibitor, tyrphostin AG 1296, in suppressing anaplastic thyroid carcinoma cell viability and motility. OncoTargets and therapy. vol 7. 2014-03-25. PMID:24665203. |
the combination of mk-2206 and tyrphostin ag 1296 induces additive apoptosis, additive suppression of the akt signaling pathway, as well as additive inhibition of cell migration and invasion of atc cells. |
2014-03-25 |
2023-08-12 |
Not clear |