| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo Liu, Xin Chen, Zhao-Qi Wang, Wei-Min Ton. Nbn gene inactivation in the CNS of mouse inhibits the myelinating ability of the mature cortical oligodendrocytes. Glia. vol 62. issue 1. 2014-07-16. PMID:24272708. |
in this study presented here, we report that nbn-deficiency induces the enhanced apoptosis of the mature oligodendrocytes at postnatal day 7, which further affects the myelination of the nerve fibers of cerebrum and corpus callosum.the distinct regulatory roles of ataxia telangiectasia mutated (atm) signaling and protein kinase b(akt)/the mammalian target of rapamycin (akt/mtor) signaling are responsible for the enhanced apoptosis of the nbn-deficient oligodendrocytes. |
2014-07-16 |
2023-08-12 |
mouse |
| Kathrin Zitzmann, Sandra Andersen, George Vlotides, Gerald Spöttl, Shengwen Zhang, Rakesh Datta, Michael Culler, Burkhard Göke, Christoph J Auernhamme. The novel somatostatin receptor 2/dopamine type 2 receptor chimeric compound BIM-23A758 decreases the viability of human GOT1 midgut carcinoid cells. Neuroendocrinology. vol 98. issue 2. 2014-07-15. PMID:23797089. |
these effects involved apoptosis induction as well as inhibition of mitogen-activated protein kinase and akt signaling. |
2014-07-15 |
2023-08-12 |
human |
| Hong Zheng, Siying Wang, Pingkun Zhou, Wei Liu, Fang N. Effects of Ligustrazine on DNA damage and apoptosis induced by irradiation. Environmental toxicology and pharmacology. vol 36. issue 3. 2014-07-15. PMID:24184571. |
our results suggest that ligustrazine has radioprotective effect through its capabilities as a powerful antioxidant, in reducing reactive oxygen species (ros) level induced by irradiation, minimizing dna damage and apoptosis, and activating survival signal akt pathways. |
2014-07-15 |
2023-08-12 |
mouse |
| Hazel A Rogers, Cerys Mayne, Rebecca J Chapman, John-Paul Kilday, Beth Coyle, Richard G Grund. PI3K pathway activation provides a novel therapeutic target for pediatric ependymoma and is an independent marker of progression-free survival. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 19. issue 23. 2014-07-14. PMID:24077346. |
pi3ks transduce signals from growth factors and cytokines, resulting in the phosphorylation and activation of akt, which in turn induces changes in cell growth, proliferation, and apoptosis. |
2014-07-14 |
2023-08-12 |
Not clear |
| Gali Umschweif, Alexander G Alexandrovich, Victoria Trembovler, Michal Horowitz, Esther Shoham. The role and dynamics of β-catenin in precondition induced neuroprotection after traumatic brain injury. PloS one. vol 8. issue 10. 2014-07-11. PMID:24124534. |
among these changes is akt phosphorylation, which decreases apoptosis and induces hif1α. |
2014-07-11 |
2023-08-12 |
mouse |
| Tetsuya Kurosu, Toshikage Nagao, Nan Wu, Gaku Oshikawa, Osamu Miur. Inhibition of the PI3K/Akt/GSK3 pathway downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD downregulates DNA damage-induced Chk1 activation as well as G2/M arrest and prominently enhances induction of apoptosis. PloS one. vol 8. issue 11. 2014-07-11. PMID:24260231. |
gsk3 inhibitors, including licl and sb216763, restored the sustained chk1 activation and mitigated apoptosis in cells treated with etoposide and the inhibitors for aberrant kinases, pi3k, or akt. |
2014-07-11 |
2023-08-12 |
Not clear |
| Chi Hang Wong, Herbert H Loong, Connie W C Hui, Cecilia P Y Lau, Edwin P Hui, Brigette B Y Ma, Anthony T C Cha. Preclinical evaluation of the PI3K-mTOR dual inhibitor PF-04691502 as a novel therapeutic drug in nasopharyngeal carcinoma. Investigational new drugs. vol 31. issue 6. 2014-07-08. PMID:23975511. |
cne-2, hk1 and hone-1 were selected to further evaluate the effect of pf-04691502 on cell cycle, apoptosis and akt downstream signaling. |
2014-07-08 |
2023-08-12 |
mouse |
| Chi Hang Wong, Herbert H Loong, Connie W C Hui, Cecilia P Y Lau, Edwin P Hui, Brigette B Y Ma, Anthony T C Cha. Preclinical evaluation of the PI3K-mTOR dual inhibitor PF-04691502 as a novel therapeutic drug in nasopharyngeal carcinoma. Investigational new drugs. vol 31. issue 6. 2014-07-08. PMID:23975511. |
pf-04691502 induced g0/g1 cell cycle arrest and apoptosis at 24 h incubation and it significantly abrogated akt and its downstream signaling by suppressing the expression of p-mtor, p-p70s6k, p-akt(s473, t308), p-s6 and p-4e-bp1, suggesting its effectiveness in inhibition of translation and protein synthesis. |
2014-07-08 |
2023-08-12 |
mouse |
| Xin Zheng, Xiaohong Gai, Feihu Ding, Zhongtang Lu, Kangsheng Tu, Yingmin Yao, Qingguang Li. Histone acetyltransferase PCAF up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling. Molecular cancer. vol 12. issue 1. 2014-07-08. PMID:23981651. |
histone acetyltransferase pcaf up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone h4 and inactivating akt signaling. |
2014-07-08 |
2023-08-12 |
Not clear |
| Christian Thomas, Francois Lamoureux, Claire Crafter, Barry R Davies, Eliana Beraldi, Ladan Fazli, Soojin Kim, Daksh Thaper, Martin E Gleave, Amina Zoubeid. Synergistic targeting of PI3K/AKT pathway and androgen receptor axis significantly delays castration-resistant prostate cancer progression in vivo. Molecular cancer therapeutics. vol 12. issue 11. 2014-07-07. PMID:23966621. |
here, we report that the akt inhibitor azd5363 potently inhibits proliferation and induces apoptosis in prostate cancer cell lines expressing the ar and has anticancer activity in vivo in androgen-sensitive and castration-resistant phases of the lncap xenograft model. |
2014-07-07 |
2023-08-12 |
Not clear |
| Akechai Im-aram, Lee Farrand, Seung-Min Bae, Gwonhwa Song, Yong Sang Song, Jae Yong Han, Benjamin K Tsan. The mTORC2 component rictor contributes to cisplatin resistance in human ovarian cancer cells. PloS one. vol 8. issue 9. 2014-07-07. PMID:24086535. |
here, using sensitive wild-type p53 (ov2008 and a2780s), resistant wild-type p53 (c13* and ovcar433), and p53 compromised (a2780cp, occ1, and skov-3) ovarian cancer cells, we have demonstrated that (i) rictor is a determinant of cisplatin resistance in chemosensitive human ovarian cancer cells; (ii) cisplatin down-regulates rictor content by caspase-3 cleavage and proteasomal degradation; (iii) rictor down-regulation sensitizes chemo-resistant ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner; (iv) rictor suppresses cisplatin-induced apoptosis and confers resistance by activating and stabilizing akt. |
2014-07-07 |
2023-08-12 |
human |
| Karin Zins, Trevor Lucas, Patrick Reichl, Dietmar Abraham, Seyedhossein Aharineja. A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice. PloS one. vol 8. issue 9. 2014-07-01. PMID:24040362. |
these data suggest a role of aza1 in blocking rac1/cdc42-dependent cell cycle progression, cancer cell migration and increase of cancer cell apoptosis involving down-regulation of the akt and pak signaling pathway in prostate cancer cells. |
2014-07-01 |
2023-08-12 |
mouse |
| Pengliang Shen, Jiabin Sun, Guiqin Xu, Li Zhang, Zhaojuan Yang, Suhua Xia, Yang Wang, Yongzhong Liu, Guowei Sh. KLF9, a transcription factor induced in flutamide-caused cell apoptosis, inhibits AKT activation and suppresses tumor growth of prostate cancer cells. The Prostate. vol 74. issue 9. 2014-07-01. PMID:24737412. |
klf9, a transcription factor induced in flutamide-caused cell apoptosis, inhibits akt activation and suppresses tumor growth of prostate cancer cells. |
2014-07-01 |
2023-08-13 |
Not clear |
| Lijun Duan, Xiaofang Hao, Zhiyong Liu, Yang Zhang, Guangling Zhan. MiR-129-5p is down-regulated and involved in the growth, apoptosis and migration of medullary thyroid carcinoma cells through targeting RET. FEBS letters. vol 588. issue 9. 2014-06-27. PMID:24631532. |
ectopic expression of mir-129-5p significantly decreases cell growth, induces apoptosis and suppresses migration ability in mtc cells through decreasing the phosphorylated akt, thus functioning as a tumor suppressor. |
2014-06-27 |
2023-08-12 |
Not clear |
| Shanshan Zhou, Xia Yin, Yang Zheng, Xiao Miao, Wenke Feng, Jun Cai, Lu Ca. Metallothionein prevents intermittent hypoxia-induced cardiac endoplasmic reticulum stress and cell death likely via activation of Akt signaling pathway in mice. Toxicology letters. vol 227. issue 2. 2014-06-27. PMID:24680926. |
in vitro mechanistic study with h9c2 cardiac and primary neonatal cardiomyocytes showed that mt protection from er stress-induced apoptosis was mediated by up-regulating akt phosphorylation since inhibition of akt phosphorylation abolished mt's protection mt from er stress and apoptosis. |
2014-06-27 |
2023-08-12 |
mouse |
| Eva Pozsgai, Szabolcs Bellyei, Anna Cseh, Arpad Boronkai, Boglarka Racz, Aliz Szabo, Balazs Sumegi, Eniko Hocsa. Quercetin increases the efficacy of glioblastoma treatment compared to standard chemoradiotherapy by the suppression of PI-3-kinase-Akt pathway. Nutrition and cancer. vol 65. issue 7. 2014-06-26. PMID:24032376. |
our data indicate that the supplementation of standard therapy with quercetin increases efficacy of treatment of experimental glioblastoma through synergism in the induction of apoptosis via the cleavage of caspase-3 and parp-1 and by the suppression of the actitivation of akt pathway. |
2014-06-26 |
2023-08-12 |
Not clear |
| Haiyan Chen, Zhengqing Zhao, Jiaoyang Zheng, Xiangfang Chen, Junjie Zou, Yongquan Shi, Zhimin Li. The effect of IGF-1 on symptoms of sleep deprivation in a rat model of inflammatory heart disease and metabolic syndrome. Biochemical and biophysical research communications. vol 446. issue 4. 2014-06-24. PMID:24613383. |
igf-1 administration also reduced the phosphorylation of akt and expression of bax, a promoter of apoptosis. |
2014-06-24 |
2023-08-12 |
rat |
| Jin-Ning Song, Ji-Yang An, Guang-Shan Hao, Dan-Dong Li, Peng Sun, Yu Li, Jun-Gang Xu. Role of Akt signaling pathway in delayed cerebral vasospasm after subarachnoid hemorrhage in rats. Acta neurochirurgica. vol 155. issue 11. 2014-06-20. PMID:23873121. |
akt plays an important role in cell survival, proliferation, apoptosis and other activities. |
2014-06-20 |
2023-08-12 |
rat |
| Jin-Ning Song, Ji-Yang An, Guang-Shan Hao, Dan-Dong Li, Peng Sun, Yu Li, Jun-Gang Xu. Role of Akt signaling pathway in delayed cerebral vasospasm after subarachnoid hemorrhage in rats. Acta neurochirurgica. vol 155. issue 11. 2014-06-20. PMID:23873121. |
recent studies have focused on the inhibition of akt in acute vasospasm and neuronal apoptosis after subarachnoid hemorrhage (sah). |
2014-06-20 |
2023-08-12 |
rat |
| Subrata Chowdhury, Xiao Wang, Coimbatore B Srikant, Qing Li, Min Fu, Ying Jia Gong, Guang Ning, Jun-Li Li. IGF-I stimulates CCN5/WISP2 gene expression in pancreatic β-cells, which promotes cell proliferation and survival against streptozotocin. Endocrinology. vol 155. issue 5. 2014-06-16. PMID:24552398. |
ccn5 overexpression stimulates the proliferation of insulinoma cells, activates akt kinase, and inhibits streptozotocin-induced apoptosis, suggesting that increased ccn5 expression contributes to igf-i-stimulated islet cell growth and/or survival. |
2014-06-16 |
2023-08-12 |
mouse |