| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Yang, R Deng, X-J Qian, S-H Chang, X-Q Wu, J Qin, G-K Feng, K Ding, X-F Zh. Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer. Cell death & disease. vol 5. 2014-10-21. PMID:24625973. |
feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel akt inhibitor dc120 in human liver cancer. |
2014-10-21 |
2023-08-12 |
human |
| F Yang, R Deng, X-J Qian, S-H Chang, X-Q Wu, J Qin, G-K Feng, K Ding, X-F Zh. Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer. Cell death & disease. vol 5. 2014-10-21. PMID:24625973. |
in the present study, we found a novel 2-pyrimidyl-5-amidothiazole compound, dc120, as an atp competitive akt kinase inhibitor that suppressed proliferation and induced apoptosis in liver cancer cells both in vitro and in vivo. |
2014-10-21 |
2023-08-12 |
human |
| Christiane Daniela Fichter, Sylvia Timme, Julia Alexandra Braun, Verena Gudernatsch, Anja Schöpflin, Lioudmilla Bogatyreva, Helene Geddert, Gerhard Faller, David Klimstra, Laura Tang, Dieter Hauschke, Martin Werner, Silke Lassman. EGFR, HER2 and HER3 dimerization patterns guide targeted inhibition in two histotypes of esophageal cancer. International journal of cancer. vol 135. issue 7. 2014-10-20. PMID:24510732. |
in vitro escc (oe21) cells displayed a significant response to erlotinib, gefitinib and lapatinib, with loss of akt phosphorylation, g0/g1 cell cycle arrest and induction of apoptosis. |
2014-10-20 |
2023-08-12 |
Not clear |
| b' Lei Wang, Hongbo Hu, Zhe Wang, Hua Xiong, Yan Cheng, Joshua Dezhong Liao, Yibin Deng, Junxuan L\\xc3\\xb. Methylseleninic acid suppresses pancreatic cancer growth involving multiple pathways. Nutrition and cancer. vol 66. issue 2. 2014-10-15. PMID:24447148.' |
a rapid inhibition of akt phosphorylation was followed by reduced mtor signaling and increased autophagy in panc-1 cells attenuating caspase-mediated apoptosis execution. |
2014-10-15 |
2023-08-12 |
mouse |
| Kenneth Maies. Driving neural regeneration through the mammalian target of rapamycin. Neural regeneration research. vol 9. issue 15. 2014-10-15. PMID:25317149. |
mtor through its relationship with phosphoinositide 3-kinase (pi 3-k) and protein kinase b (akt) and multiple downstream signaling pathways such as p70 ribosomal s6 kinase (p70s6k) and proline rich akt substrate 40 kda (pras40) promotes neuronal cell regeneration through stem cell renewal and oversees critical pathways such as apoptosis, autophagy, and necroptosis to foster protection against neurodegenerative disorders. |
2014-10-15 |
2023-08-13 |
Not clear |
| Mi-Sung Kim, Jong-Eun Kim, Do Young Lim, Zunnan Huang, Hanyong Chen, Alyssa Langfald, Ronald A Lubet, Clinton J Grubbs, Zigang Dong, Ann M Bod. Naproxen induces cell-cycle arrest and apoptosis in human urinary bladder cancer cell lines and chemically induced cancers by targeting PI3K. Cancer prevention research (Philadelphia, Pa.). vol 7. issue 2. 2014-10-10. PMID:24327721. |
naproxen also caused apoptosis and inhibited akt phosphorylation in rat urinary bladder cancers induced by n-butyl-n-(4-hydroxybutyl)-nitrosamine. |
2014-10-10 |
2023-08-12 |
human |
| Rafiqa Eachkoti, M V Ramana Reddy, Yen K Lieu, Stephen C Cosenza, E PremKumar Redd. Identification and characterisation of a novel heat shock protein 90 inhibitor ONO4140. European journal of cancer (Oxford, England : 1990). vol 50. issue 11. 2014-10-07. PMID:24835034. |
the study also reveals that apoptosis following hsp90 inhibition with ono4140 occurs via caspase9-caspase3 intrinsic apoptotic pathway, a process that is likely triggered by inactivation of akt. |
2014-10-07 |
2023-08-13 |
Not clear |
| Jamie N Anastas, Rima M Kulikauskas, Tigist Tamir, Helen Rizos, Georgina V Long, Erika M von Euw, Pei-Tzu Yang, Hsiao-Wang Chen, Lauren Haydu, Rachel A Toroni, Olivia M Lucero, Andy J Chien, Randall T Moo. WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors. The Journal of clinical investigation. vol 124. issue 7. 2014-10-06. PMID:24865425. |
rnai-mediated reduction of endogenous wnt5a in melanoma decreased cell growth, increased apoptosis in response to brafi challenge, and decreased the activity of prosurvival akt signaling. |
2014-10-06 |
2023-08-13 |
Not clear |
| Mia Kim, Mal Soon Shin, Jae Min Lee, Han Sam Cho, Chang Ju Kim, Young Joon Kim, Hey Ran Choi, Jung Won Jeo. Inhibitory Effects of Isoquinoline Alkaloid Berberine on Ischemia-Induced Apoptosis via Activation of Phosphoinositide 3-Kinase/Protein Kinase B Signaling Pathway. International neurourology journal. vol 18. issue 3. 2014-10-03. PMID:25279238. |
in the present study, we investigated the effects of berberine on global ischemia-induced apoptosis, and focused on the phosphoinositide 3-kinase (pi3k)/protein kinase b (akt) signaling pathway in the hippocampus using gerbils. |
2014-10-03 |
2023-08-13 |
Not clear |
| Tomiteru Togano, Mariko Watanabe, Kinji Itoh, Kazuo Umezawa, Noriyuki Masuda, Masaaki Higashihara, Ryouichi Hori. Activation of Akt involves resistance to NF-κB inhibition and abrogation of both triggers synergistic apoptosis in lung adenocarcinoma cells. Lung cancer (Amsterdam, Netherlands). vol 83. issue 2. 2014-10-01. PMID:24331410. |
activation of akt involves resistance to nf-κb inhibition and abrogation of both triggers synergistic apoptosis in lung adenocarcinoma cells. |
2014-10-01 |
2023-08-12 |
Not clear |
| Takuya Furuta, Mitsutoshi Nakada, Kouichi Misaki, Yasunori Sato, Yutaka Hayashi, Yasuni Nakanuma, Jun-ichiro Hamad. Molecular analysis of a recurrent glioblastoma treated with bevacizumab. Brain tumor pathology. vol 31. issue 1. 2014-09-30. PMID:23504126. |
mib-1 staining index and phosphorylation levels of p44/42-mitogen-activated protein kinase did not change, whereas phosphorylated protein kinase b (akt) was decreased in the autopsy specimen, suggesting compensation and/or amplification of other proliferative signaling pathways such as suppression of apoptosis signaling. |
2014-09-30 |
2023-08-12 |
Not clear |
| Dong Zhou, Roderick J Tan, Lin Lin, Lili Zhou, Youhua Li. Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury. Kidney international. vol 84. issue 3. 2014-09-30. PMID:23715119. |
compared with controls, ksp-met-/- mice displayed higher serum creatinine, more severe morphologic lesions, and increased apoptosis, which was accompanied by an increased expression of bax and fas ligand and decreased phosphorylation/activation of akt. |
2014-09-30 |
2023-08-12 |
mouse |
| Jin Wang, Jianjun Chen, Duane D Miller, Wei L. Synergistic combination of novel tubulin inhibitor ABI-274 and vemurafenib overcome vemurafenib acquired resistance in BRAFV600E melanoma. Molecular cancer therapeutics. vol 13. issue 1. 2014-09-29. PMID:24249714. |
western blot analysis revealed that the combination treatment effectively reduced the level of phosphorylated and total akt, activated the apoptosis cascade, and increased cleaved caspase-3 and cleaved parp, but had no significant influence on the level of extracellular signal-regulated kinase (erk) phosphorylation. |
2014-09-29 |
2023-08-12 |
mouse |
| Rathi N Pillai, Suresh S Ramalinga. Heat shock protein 90 inhibitors in non-small-cell lung cancer. Current opinion in oncology. vol 26. issue 2. 2014-09-29. PMID:24463348. |
many cancers have increased expression of hsp90 to ensure their malignant phenotype of increased proliferation, decreased apoptosis, and metastatic potential by conservation of proteins like epidermal growth factor receptor (egfr), human epidermal growth factor receptor 2, anaplastic lymphoma kinase (alk), v-raf murine sarcoma viral oncogene homologue b1, akt, b-cell lymphoma 2, and cell cycle proteins. |
2014-09-29 |
2023-08-12 |
human |
| G Ma, K Kawamura, Y Shan, S Okamoto, Q Li, M Namba, M Shingyoji, Y Tada, K Tatsumi, K Hiroshima, H Shimada, M Tagaw. Combination of adenoviruses expressing melanoma differentiation-associated gene-7 and chemotherapeutic agents produces enhanced cytotoxicity on esophageal carcinoma. Cancer gene therapy. vol 21. issue 1. 2014-09-24. PMID:24434574. |
these data collectively suggest that ad-mda-7 induced apoptosis despite akt activation and that the combinatory antitumor effects with 5-fu were produced partly by downregulating the ad-mda-7-induced akt activation. |
2014-09-24 |
2023-08-12 |
human |
| Wei Ding, Tait D Shanafelt, Connie E Lesnick, Charles Erlichman, Jose F Leis, Charla Secreto, Traci R Sassoon, Timothy G Call, Deborah A Bowen, Michael Conte, Shaji Kumar, Neil E Ka. Akt inhibitor MK2206 selectively targets CLL B-cell receptor induced cytokines, mobilizes lymphocytes and synergizes with bendamustine to induce CLL apoptosis. British journal of haematology. vol 164. issue 1. 2014-09-23. PMID:24111951. |
akt inhibitor mk2206 selectively targets cll b-cell receptor induced cytokines, mobilizes lymphocytes and synergizes with bendamustine to induce cll apoptosis. |
2014-09-23 |
2023-08-12 |
Not clear |
| Hye Ri Kim, Chan Gi Park, Ji Youn Jun. Acacetin (5,7-dihydroxy-4'-methoxyflavone) exhibits in vitro and in vivo anticancer activity through the suppression of NF-κB/Akt signaling in prostate cancer cells. International journal of molecular medicine. vol 33. issue 2. 2014-09-18. PMID:24285354. |
consistent with its ability to induce apoptosis, the acacetin-mediated inhibition of the pro-survival pathway, akt, and of the nf-κb pathway was accompanied by a marked reduction in the levels of the nf-κb‑regulated anti-apoptotic proteins, bcl-2 and x-linked inhibitor of apoptosis protein (xiap), as well as of the proliferative protein, cyclooxygenase (cox)-2. |
2014-09-18 |
2023-08-12 |
mouse |
| Weiwei Guo, Lichong Yan, Ling Yang, Xiaoyu Liu, Qiukai E, Peiye Gao, Xiaofei Ye, Wen Liu, Ji Zu. Targeting GRP75 improves HSP90 inhibitor efficacy by enhancing p53-mediated apoptosis in hepatocellular carcinoma. PloS one. vol 9. issue 1. 2014-09-18. PMID:24465691. |
the inhibition of hsp90 on cancer cell growth largely through degrading client proteins, like akt and p53, therefore, triggering cancer cell apoptosis. |
2014-09-18 |
2023-08-12 |
Not clear |
| Xiangyi Ma, Danfeng Luo, Kezhen Li, Ronghua Liu, Yan Liu, Tao Zhu, Dongrui Deng, Jianfeng Zhou, Li Meng, Shixuan Wang, Ding M. Suppression of EphB4 improves the inhibitory effect of mTOR shRNA on the biological behaviors of ovarian cancer cells by down-regulating Akt phosphorylation. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 32. issue 3. 2014-09-11. PMID:22684558. |
the effects of the antisense ephb4 vectors and the shrna vectors on the proliferation, apoptosis and invasion of ovarian cancer cells were measured, and the expression of ephb4, mtor and akt detected. |
2014-09-11 |
2023-08-12 |
Not clear |
| Xiangyi Ma, Danfeng Luo, Kezhen Li, Ronghua Liu, Yan Liu, Tao Zhu, Dongrui Deng, Jianfeng Zhou, Li Meng, Shixuan Wang, Ding M. Suppression of EphB4 improves the inhibitory effect of mTOR shRNA on the biological behaviors of ovarian cancer cells by down-regulating Akt phosphorylation. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 32. issue 3. 2014-09-11. PMID:22684558. |
the results showed that transfection with mtor shrna could inhibit growth, induce apoptosis, and reduce invasive ability of ovarian cancer cells, which was accompanied by downregulation of ephb4, mtor and akt. |
2014-09-11 |
2023-08-12 |
Not clear |