| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Binbin Yan, Dinender K Singl. Transplanted induced pluripotent stem cells mitigate oxidative stress and improve cardiac function through the Akt cell survival pathway in diabetic cardiomyopathy. Molecular pharmaceutics. vol 10. issue 9. 2014-10-29. PMID:23879836. |
animals transplanted with ips cells or cm demonstrated a significant reduction in apoptosis, mediated by akt upregulation and erk1/2 downregulation, and inhibition of interstitial fibrosis via mmp-9 suppression compared with the stz group. |
2014-10-29 |
2023-08-12 |
mouse |
| Feng Pan, Yan-Xiang Cheng, Cheng-Liang Zhu, Feng-Hua Tao, Zhang-Hua Li, Hai-Ying Tao, Bin He, Ling Yu, Peng Ji, Huan Tan. Tacolimus postconditioning alleviates apoptotic cell death in rats after spinal cord ischemia-reperfusion injury via up-regulating protein-serine-threonine kinases phosphorylation. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 33. issue 6. 2014-10-29. PMID:24337847. |
it is concluded that tacrolimus post-conditioning can increase akt activity in spinal cord tissue of rats, inhibit apoptosis of neural cells as well as tissue edema, and thereby alleviate spinal cord ischemia-reperfusion injury. |
2014-10-29 |
2023-08-12 |
rat |
| Maria Teresa Di Martino, Virginia Campani, Gabriella Misso, Maria Eugenia Gallo Cantafio, Annamaria Gullà, Umberto Foresta, Pietro Hiram Guzzi, Maria Castellano, Anna Grimaldi, Vincenzo Gigantino, Renato Franco, Sara Lusa, Mario Cannataro, Pierosandro Tagliaferri, Giuseppe De Rosa, Pierfrancesco Tassone, Michele Caragli. In vivo activity of miR-34a mimics delivered by stable nucleic acid lipid particles (SNALPs) against multiple myeloma. PloS one. vol 9. issue 2. 2014-10-29. PMID:24587182. |
we detected early inactivation of pro-survival and proliferative kinases erk-2 and akt followed at later time points by caspase-6 and -3 activation and apoptosis induction. |
2014-10-29 |
2023-08-12 |
mouse |
| Rebeca Fernandez-Ruiz, Elaine Vieira, Pablo M Garcia-Roves, Ramon Gomi. Protein tyrosine phosphatase-1B modulates pancreatic β-cell mass. PloS one. vol 9. issue 2. 2014-10-28. PMID:24587334. |
furthermore, the ablation of ptp1b is able to regulate key proteins involved in the proliferation and/or apoptosis pathways, such as stat3, akt, erk1/2 and p53 in isolated islets from ptp1b knockout (ptp1b (-)/(-)) mice. |
2014-10-28 |
2023-08-12 |
mouse |
| Joachim Fensterle, Babette Aicher, Irene Seipelt, Michael Teifel, Juergen Enge. Current view on the mechanism of action of perifosine in cancer. Anti-cancer agents in medicinal chemistry. vol 14. issue 4. 2014-10-28. PMID:24628236. |
perifosine treatment exhibits a complex molecular response including the inhibition of akt or the induction of apoptosis via clustering of death receptors in lipid rafts. |
2014-10-28 |
2023-08-12 |
Not clear |
| Guang-rong Ji, Nai-chun Yu, Xiang Xue, Zong-guang L. 4-Hydroxy-2-nonenal induces apoptosis by inhibiting AKT signaling in human osteosarcoma cells. TheScientificWorldJournal. vol 2014. 2014-10-28. PMID:24711740. |
4-hydroxy-2-nonenal induces apoptosis by inhibiting akt signaling in human osteosarcoma cells. |
2014-10-28 |
2023-08-13 |
human |
| Li Yuan, Chun-Li Lu, Ying Wang, Yang Li, Xiao-Ya L. Ang (1-7) protects islet endothelial cells from palmitate-induced apoptosis by AKT, eNOS, p38 MAPK, and JNK pathways. Journal of diabetes research. vol 2014. 2014-10-28. PMID:24804268. |
ang (1-7) protects islet endothelial cells from palmitate-induced apoptosis by akt, enos, p38 mapk, and jnk pathways. |
2014-10-28 |
2023-08-13 |
Not clear |
| Li Yuan, Chun-Li Lu, Ying Wang, Yang Li, Xiao-Ya L. Ang (1-7) protects islet endothelial cells from palmitate-induced apoptosis by AKT, eNOS, p38 MAPK, and JNK pathways. Journal of diabetes research. vol 2014. 2014-10-28. PMID:24804268. |
palmitate decreased the phosphorylation of akt and enos, and ang (1-7) increased the phosphorylation of these kinases (p < 0.05), with a concomitant reduction in ms-1 cells apoptosis. |
2014-10-28 |
2023-08-13 |
Not clear |
| Evren Ozcinar, Esma N Okatan, Erkan Tuncay, Sadik Eryilmaz, Belma Tura. Improvement of functional recovery of donor heart following cold static storage with doxycycline cardioplegia. Cardiovascular toxicology. vol 14. issue 1. 2014-10-27. PMID:24104944. |
biochemical data showed that dox cardioplegia prevented an increase in mmp-2 activity and blocked apoptosis through increased activity of the pro-survival kinase akt in the donor heart homogenates. |
2014-10-27 |
2023-08-12 |
rat |
| Souvik Roy, Satyajit Kumar Metya, Noorjaman Rahaman, Santanu Sannigrahi, Faiqa Ahme. Ferulic acid in the treatment of post-diabetes testicular damage: relevance to the down regulation of apoptosis correlates with antioxidant status via modulation of TGF-β1, IL-1β and Akt signalling. Cell biochemistry and function. vol 32. issue 1. 2014-10-23. PMID:23661600. |
ferulic acid in the treatment of post-diabetes testicular damage: relevance to the down regulation of apoptosis correlates with antioxidant status via modulation of tgf-β1, il-1β and akt signalling. |
2014-10-23 |
2023-08-12 |
rat |
| Yan-Na Liu, Ren-Zhong Wan, Zhao-Peng Li. Recent developments of small molecule PI3K/mTOR dual inhibitors. Mini reviews in medicinal chemistry. vol 13. issue 14. 2014-10-22. PMID:24195664. |
an interest in targeting two important points along this critical signaling pathway has spurred the development of dual pi3k/mtor inhibitors that could both prevent cancer cell proliferation and induce programmed cell death (apoptosis) by fully suppressing akt activation. |
2014-10-22 |
2023-08-12 |
Not clear |
| X C Xu, X Abuduhadeer, W B Zhang, T Li, H Gao, Y H Wan. Knockdown of RAGE inhibits growth and invasion of gastric cancer cells. European journal of histochemistry : EJH. vol 57. issue 4. 2014-10-22. PMID:24441189. |
knockdown of rage reduced cell proliferation and invasion of gastric cancer with decreased expression of akt, pcna and mmp-2, and induced cell apoptosis and cycle arrest. |
2014-10-22 |
2023-08-12 |
human |
| Bo-Min Kim, Do-Hee Kim, Jeong-Hill Park, Young-Joon Surh, Hye-Kyung N. Ginsenoside Rg3 Inhibits Constitutive Activation of NF-κB Signaling in Human Breast Cancer (MDA-MB-231) Cells: ERK and Akt as Potential Upstream Targets. Journal of cancer prevention. vol 19. issue 1. 2014-10-22. PMID:25337569. |
these findings suggest that rg3 induced apoptosis in mda-mb-231 cells, which is mediated by blocking nf-κb signaling via inactivation of erk and akt as well as destabilization of mutant p53. |
2014-10-22 |
2023-08-13 |
human |
| Li Yue, Sonia Haroun, Jean-Luc Parent, Artur J de Brum-Fernande. Prostaglandin D(2) induces apoptosis of human osteoclasts through ERK1/2 and Akt signaling pathways. Bone. vol 60. 2014-10-21. PMID:24345643. |
prostaglandin d(2) induces apoptosis of human osteoclasts through erk1/2 and akt signaling pathways. |
2014-10-21 |
2023-08-12 |
human |
| Li Yue, Sonia Haroun, Jean-Luc Parent, Artur J de Brum-Fernande. Prostaglandin D(2) induces apoptosis of human osteoclasts through ERK1/2 and Akt signaling pathways. Bone. vol 60. 2014-10-21. PMID:24345643. |
in conclusion, endogenous or exogenous pgd2 induces crth2-dependent apoptosis in human differentiated ocs; β-arrestin-1, erk1/2, and akt, but not ikk2/nf-κb are probably implicated in the signaling pathways of this receptor in the model studied. |
2014-10-21 |
2023-08-12 |
human |
| Chenxi Zhou, Jun Ding, Yuanwen W. Resveratrol induces apoptosis of bladder cancer cells via miR‑21 regulation of the Akt/Bcl‑2 signaling pathway. Molecular medicine reports. vol 9. issue 4. 2014-10-21. PMID:24535223. |
notably, overexpression of mir‑21 expression was able to restore the inhibition of akt activity, downregulation of bcl‑2 expression and apoptosis induced by resveratrol. |
2014-10-21 |
2023-08-12 |
human |
| K-j Min, B R Seo, Y C Bae, Y H Yoo, T K Kwo. Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L). Cell death & disease. vol 5. 2014-10-21. PMID:24556678. |
antipsychotic agent thioridazine sensitizes renal carcinoma caki cells to trail-induced apoptosis through reactive oxygen species-mediated inhibition of akt signaling and downregulation of mcl-1 and c-flip(l). |
2014-10-21 |
2023-08-12 |
mouse |
| K-j Min, B R Seo, Y C Bae, Y H Yoo, T K Kwo. Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L). Cell death & disease. vol 5. 2014-10-21. PMID:24556678. |
furthermore, thioridazine increased the production of reactive oxygen species (ros) in caki cells, and ros scavengers (n-acetylcysteine, glutathione ethyl ester, and trolox) inhibited thioridazine plus trail-induced apoptosis, as well as akt inhibition and the downregulation of c-flip(l) and mcl-1. |
2014-10-21 |
2023-08-12 |
mouse |
| K-j Min, B R Seo, Y C Bae, Y H Yoo, T K Kwo. Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L). Cell death & disease. vol 5. 2014-10-21. PMID:24556678. |
collectively, our study demonstrates that thioridazine enhances trail-mediated apoptosis via the ros-mediated inhibition of akt signaling and the downregulation of c-flip(l) and mcl-1 at the post-translational level. |
2014-10-21 |
2023-08-12 |
mouse |
| K Liu, Y Shi, X H Guo, Y B Ouyang, S S Wang, D J Liu, A N Wang, N Li, D X Che. Phosphorylated AKT inhibits the apoptosis induced by DRAM-mediated mitophagy in hepatocellular carcinoma by preventing the translocation of DRAM to mitochondria. Cell death & disease. vol 5. 2014-10-21. PMID:24556693. |
phosphorylated akt inhibits the apoptosis induced by dram-mediated mitophagy in hepatocellular carcinoma by preventing the translocation of dram to mitochondria. |
2014-10-21 |
2023-08-12 |
Not clear |