| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shujun Zhang, Binglin Cheng, Hali Li, Wei Xu, Bo Zhai, Shangha Pan, Lei Wang, Ming Liu, Xueying Su. Matrine inhibits proliferation and induces apoptosis of human colon cancer LoVo cells by inactivating Akt pathway. Molecular biology reports. vol 41. issue 4. 2014-12-03. PMID:24452711. |
matrine inhibits proliferation and induces apoptosis of human colon cancer lovo cells by inactivating akt pathway. |
2014-12-03 |
2023-08-12 |
human |
| Shujun Zhang, Binglin Cheng, Hali Li, Wei Xu, Bo Zhai, Shangha Pan, Lei Wang, Ming Liu, Xueying Su. Matrine inhibits proliferation and induces apoptosis of human colon cancer LoVo cells by inactivating Akt pathway. Molecular biology reports. vol 41. issue 4. 2014-12-03. PMID:24452711. |
specific inhibition of pakt induced cell apoptosis, and synergized with matrine to inhibit the proliferation of lovo cells; whereas activation of akt neutralized the inhibitory effect of matrine on cell proliferation. |
2014-12-03 |
2023-08-12 |
human |
| Shujun Zhang, Binglin Cheng, Hali Li, Wei Xu, Bo Zhai, Shangha Pan, Lei Wang, Ming Liu, Xueying Su. Matrine inhibits proliferation and induces apoptosis of human colon cancer LoVo cells by inactivating Akt pathway. Molecular biology reports. vol 41. issue 4. 2014-12-03. PMID:24452711. |
the present study has demonstrated that matrine inhibits proliferation and induces apoptosis of human colon cancer lovo cells by inactivating akt pathway, indicating matrine may be a potential anti-cancer agent for colon cancer. |
2014-12-03 |
2023-08-12 |
human |
| Paulraj Raja Singh, Ramachandran Arunkumar, Velayutham Sivakamasundari, Govindaraj Sharmila, Perumal Elumalai, Elayapillai Suganthapriya, Amalanathan Brindha Mercy, Kalimuthu Senthilkumar, Jegadeesan Arunakara. Anti-proliferative and apoptosis inducing effect of nimbolide by altering molecules involved in apoptosis and IGF signalling via PI3K/Akt in prostate cancer (PC-3) cell line. Cell biochemistry and function. vol 32. issue 3. 2014-12-01. PMID:23963693. |
the mrna expression of fas ligand, fas-associated death domain receptor (faddr), bcl-2-associated x protein (bax), bcl-2-associated death promoter (bad), phosphatidylinositide 3-kinases (pi3k), akt, igf1, igf1 receptor (igf1r) and igf binding protein 3 were quantified by reverse transcription polymerase chain reaction and protein expression of bax, cytochrome c, x-linked inhibitor of apoptosis protein (xiap), b-cell lymphoma 2 (bcl-2), caspases -8, -9, -10 and -3, poly(adp-ribose) polymerase (parp), cleaved parp, igf1r, pi3k, akt, p-akt was determined by western blot analysis, in nimbolide-treated pc-3 cell line. |
2014-12-01 |
2023-08-12 |
Not clear |
| Danielle S Potter, Paul Kelly, Olive Denneny, Veronique Juvin, Len R Stephens, Caroline Dive, Christopher J Morro. BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737. Neoplasia (New York, N.Y.). vol 16. issue 2. 2014-12-01. PMID:24709422. |
the observation that abt-737-induced apoptosis was unaffected by inhibition of pi3k downstream effectors akt and mtor, implicated a novel pi3k-dependant pathway. |
2014-12-01 |
2023-08-13 |
Not clear |
| Nur Diyana Md Zamri, Mustapha Umar Imam, Siti Aisyah Abd Ghafar, Maznah Ismai. Antioxidative Effects of Germinated Brown Rice-Derived Extracts on H2O2-Induced Oxidative Stress in HepG2 Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-11-28. PMID:25431609. |
in addition, h2o2 produced transcriptional changes in p53, jnk, p38 mapk, akt, bax, and cdk4 that were inclined towards apoptosis, while gbr-extracts showed some transcriptional changes (upregulation of bax and p53) that suggested an inclination for apoptosis although other changes (upregulation of antioxidant genes, akt, jnk, and p38 mapk) suggested that gbr-extracts favored survival of the hepg2 cells. |
2014-11-28 |
2023-08-13 |
Not clear |
| Anyu Bao, Yan Li, Yongqing Tong, Hongyun Zheng, Wei Wu, Chuandong We. 1,25-Dihydroxyvitamin D₃ and cisplatin synergistically induce apoptosis and cell cycle arrest in gastric cancer cells. International journal of molecular medicine. vol 33. issue 5. 2014-11-26. PMID:24573222. |
the results of this study suggest that 1,25(oh)2d3 potentiates cisplatin-mediated cell growth inhibition and cell apoptosis, which involves the upregulation of bax, a decrease in erk and akt phosphorylation levels, and increased p21 and p27 levels. |
2014-11-26 |
2023-08-12 |
human |
| Van Anh Vo, Jae-Won Lee, Hee Jae Lee, Wanjoo Chun, So Young Lim, Sung-Soo Ki. Inhibition of JNK potentiates temozolomide-induced cytotoxicity in U87MG glioblastoma cells via suppression of Akt phosphorylation. Anticancer research. vol 34. issue 10. 2014-11-26. PMID:25275048. |
on the other hand, akt is a key regulator of cellular survival and has direct effects on the apoptosis machinery. |
2014-11-26 |
2023-08-13 |
Not clear |
| Van Anh Vo, Jae-Won Lee, Hee Jae Lee, Wanjoo Chun, So Young Lim, Sung-Soo Ki. Inhibition of JNK potentiates temozolomide-induced cytotoxicity in U87MG glioblastoma cells via suppression of Akt phosphorylation. Anticancer research. vol 34. issue 10. 2014-11-26. PMID:25275048. |
we, therefore, examined whether inhibition of jnk or p38 potentiates tmz-induced apoptosis in u87mg cells via inhibition of akt activation. |
2014-11-26 |
2023-08-13 |
Not clear |
| Zhihui Zhu, Georg Reise. PAR-1 activation rescues astrocytes through the PI3K/Akt signaling pathway from chemically induced apoptosis that is exacerbated by gene silencing of β-arrestin 1. Neurochemistry international. vol 67. 2014-11-25. PMID:24378649. |
furthermore, application of thrombin rescues β-arrestin 1-lacking astrocytes from apoptosis by enhanced akt (ser 473) phosphorylation. |
2014-11-25 |
2023-08-12 |
Not clear |
| Praveen Kumar Sugumaran, Shuang Wang, Shasha Song, Xiaowei Nie, Lei Zhang, Ye Feng, Wenchao Ma, Daling Zh. 15-oxo-Eicosatetraenoic acid prevents serum deprivation-induced apoptosis of pulmonary arterial smooth muscle cells by activating pro-survival pathway. Prostaglandins, leukotrienes, and essential fatty acids. vol 90. issue 4. 2014-11-25. PMID:24534136. |
taken together, we have established that 15-oxo-ete protects pasmcs against apoptosis through the akt pathway. |
2014-11-25 |
2023-08-12 |
human |
| Xiaoran Liu, Xiaodong Tian, Feng Wang, Yongsu Ma, Marko Kornmann, Yinmo Yan. BRG1 promotes chemoresistance of pancreatic cancer cells through crosstalking with Akt signalling. European journal of cancer (Oxford, England : 1990). vol 50. issue 13. 2014-11-25. PMID:24953335. |
brg1 knockdown inhibited panc-1 and mia paca-2 cell growth in vitro and in vivo, reduced the phosphorylation/activation of akt and p21(cip/waf), enhanced intrinsic and gemcitabine induced apoptosis and attenuated gemcitabine-induced downregulation of e-cadherin. |
2014-11-25 |
2023-08-13 |
human |
| Nan Wu, Wenna Li, Wenqi Shu, Dalin Ji. Protective effect of picroside II on myocardial ischemia reperfusion injury in rats. Drug design, development and therapy. vol 8. 2014-11-24. PMID:24868147. |
treatment with 10 μm and 100 μm picroside ii significantly improved postischemic myocardial function, reduced myocardial infarct size, inhibited apoptosis, increased myocardial no content, upregulated bcl-2, downregulated bax, and increased the phosphorylation of akt and endothelial nos, but cardioprotection was not shown in the 1 μm picroside ii treatment group and was abrogated by wortmannin and l-n(g)-nitroarginine methyl ester. |
2014-11-24 |
2023-08-13 |
rat |
| Jessica Bullenkamp, Mahvash Tavassol. Signalling of Apoptin. Advances in experimental medicine and biology. vol 818. 2014-11-21. PMID:25001530. |
apoptin has been shown to interact with several cellular proteins including akt and the anaphase-promoting complex that regulate its activity and promote caspase-dependent apoptosis. |
2014-11-21 |
2023-08-13 |
human |
| Elena Grossini, Piero Pollesello, Kevin Bellofatto, Lorenzo Sigaudo, Serena Farruggio, Veronica Origlia, Cristina Mombello, David A S G Mary, Guido Valente, Giovanni Vacc. Protective effects elicited by levosimendan against liver ischemia/reperfusion injury in anesthetized rats. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. vol 20. issue 3. 2014-11-18. PMID:24273004. |
levosimendan administration was able to counteract oxidative damage and apoptosis in a dose-dependent way and to increase gsh, akt, and enos activation. |
2014-11-18 |
2023-08-12 |
rat |
| Dorrah Deeb, Xiaohua Gao, Yong Bo Liu, Kirit Pindolia, Subhash C Gauta. Pristimerin, a quinonemethide triterpenoid, induces apoptosis in pancreatic cancer cells through the inhibition of pro-survival Akt/NF-κB/mTOR signaling proteins and anti-apoptotic Bcl-2. International journal of oncology. vol 44. issue 5. 2014-11-13. PMID:24603988. |
the induction of apoptosis by pm was associated with the inhibition of the pro-survival akt, nf-κb and mtor signaling proteins and their downstream intermediaries such as foxo-3α and cyclin d1 (akt); cox-2 and vegf (nf-κb); p-s6k1 and p-4e-bp1 (mtor) as well as pkcε. |
2014-11-13 |
2023-08-12 |
Not clear |
| Seiichi Okabe, Tetsuzo Tauchi, Yuko Tanaka, Toshihiko Kitahara, Shinya Kimura, Taira Maekawa, Kazuma Ohyashik. Efficacy of the dual PI3K and mTOR inhibitor NVP-BEZ235 in combination with nilotinib against BCR-ABL-positive leukemia cells involves the ABL kinase domain mutation. Cancer biology & therapy. vol 15. issue 2. 2014-11-12. PMID:24100660. |
the combination of nvp-bez235 with a bcr-abl kinase inhibitor, imatinib, or nilotinib, induced a more pronounced colony growth inhibition, whereas the combination of nvp-bez235 and nilotinib was more effective in inducing apoptosis and reducing the phosphorylation of akt, 4e-bp1, and s6 kinase. |
2014-11-12 |
2023-08-12 |
Not clear |
| Julius Semenas, Andreas Hedblom, Regina R Miftakhova, Martuza Sarwar, Rikard Larsson, Liliya Shcherbina, Martin E Johansson, Pirkko Härkönen, Olov Sterner, Jenny L Persso. The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 35. 2014-11-12. PMID:25071204. |
further, sirna-mediated knockdown of pip5k1α exerts similar effects on pc3 cells as isa-2011b treatment, significantly inhibiting akt activity, increasing apoptosis and reducing invasion. |
2014-11-12 |
2023-08-13 |
mouse |
| Dali Zhao, Bo Zhai, Changjun He, Gang Tan, Xian Jiang, Shangha Pan, Xuesong Dong, Zheng Wei, Lixin Ma, Haiquan Qiao, Hongchi Jiang, Xueying Su. Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells. Cellular signalling. vol 26. issue 5. 2014-11-04. PMID:24486412. |
blocking the tgf-α/egfr pathway by gefitinib, a specific egfr inhibitor, reduced the activation of stat (signal transducer and activator of transcription) 3, akt and erk (extracellular signal-regulated kinase), and synergized with sorafenib to inhibit proliferation and induce apoptosis of hypoxic hcc cells. |
2014-11-04 |
2023-08-12 |
Not clear |
| Minzhao Huang, Su-Ni Tang, Ghanshyam Upadhyay, Justin L Marsh, Christopher P Jackman, Rakesh K Srivastava, Sharmila Shanka. Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from Kras(G12D) mice. Cancer letters. vol 353. issue 1. 2014-11-04. PMID:25050737. |
taken together, our data show that the rottlerin induces apoptosis and inhibits pancreatic cancer growth by targeting akt, notch and shh signaling pathways, and provide a new therapeutic approach with translational potential for humans. |
2014-11-04 |
2023-08-13 |
mouse |