| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laurel A Grisanti, Jennifer A Talarico, Rhonda L Carter, Justine E Yu, Ashley A Repas, Scott W Radcliffe, Hoang-Ai Tang, Catherine A Makarewich, Steven R Houser, Douglas G Tille. β-Adrenergic receptor-mediated transactivation of epidermal growth factor receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1/2 and Akt. Journal of molecular and cellular cardiology. vol 72. 2015-01-13. PMID:24566221. |
β-adrenergic receptor-mediated transactivation of epidermal growth factor receptor decreases cardiomyocyte apoptosis through differential subcellular activation of erk1/2 and akt. |
2015-01-13 |
2023-08-12 |
mouse |
| Laurel A Grisanti, Jennifer A Talarico, Rhonda L Carter, Justine E Yu, Ashley A Repas, Scott W Radcliffe, Hoang-Ai Tang, Catherine A Makarewich, Steven R Houser, Douglas G Tille. β-Adrenergic receptor-mediated transactivation of epidermal growth factor receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1/2 and Akt. Journal of molecular and cellular cardiology. vol 72. 2015-01-13. PMID:24566221. |
we hypothesized that acute βar-mediated egfr transactivation in the heart promotes differential subcellular activation of erk1/2 and akt, promoting cell survival through modulation of apoptosis. |
2015-01-13 |
2023-08-12 |
mouse |
| Laurel A Grisanti, Jennifer A Talarico, Rhonda L Carter, Justine E Yu, Ashley A Repas, Scott W Radcliffe, Hoang-Ai Tang, Catherine A Makarewich, Steven R Houser, Douglas G Tille. β-Adrenergic receptor-mediated transactivation of epidermal growth factor receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1/2 and Akt. Journal of molecular and cellular cardiology. vol 72. 2015-01-13. PMID:24566221. |
βar-mediated egfr-transactivation also decreased apoptosis in serum-depleted rncm, as measured via tunel as well as caspase 3 activity/cleavage, which were sensitive to the inhibition of either erk1/2 (pd184352) or akt (ly-294002) signaling. |
2015-01-13 |
2023-08-12 |
mouse |
| Meiling Li, Yanna Liu, Fei Xia, Zhimeng Wu, Li Deng, Rong Jiang, Feng-Jin Gu. Progranulin is required for proper ER stress response and inhibits ER stress-mediated apoptosis through TNFR2. Cellular signalling. vol 26. issue 7. 2015-01-10. PMID:24703938. |
here we present evidences demonstrating that pgrn is also an endoplasmic reticulum (er) stress responsive factor: pgrn expression was induced and its activation of erk1/2 and akt signaling enhanced in response to er stress; normal er stress response was lost in pgrn deficient cells and pgrn deficient cells became hypersusceptible to er stress-induced apoptosis; additionally, recombinant pgrn could rescue the defects in er-stress responses seen in pgrn deficient cells. |
2015-01-10 |
2023-08-13 |
Not clear |
| Meiling Li, Yanna Liu, Fei Xia, Zhimeng Wu, Li Deng, Rong Jiang, Feng-Jin Gu. Progranulin is required for proper ER stress response and inhibits ER stress-mediated apoptosis through TNFR2. Cellular signalling. vol 26. issue 7. 2015-01-10. PMID:24703938. |
in addition, the 2nd and 3rd cysteine-rich domains (crd) in the extracellular portion of tnfr2 (crd2crd3), known to directly bind to pgrn, disturbed the interaction of pgrn with tnfr2, and in turn abolished pgrn-mediated activation of erk1/2 and akt signaling and protection against apoptosis in response to er-stress. |
2015-01-10 |
2023-08-13 |
Not clear |
| Wei Huang, Shunan Tang, Xue Qiao, Wanwan Ma, Shuai Ji, Kui Wang, Min Ye, Siwang Y. Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions. Fitoterapia. vol 94. 2015-01-09. PMID:24486984. |
iaa strongly inhibited akt phosphorylation within 5 min; however, overexpression of constitutively activated akt could not rescue iaa-mediated inhibition, indicating that inhibition of akt was not involved in iaa-induced apoptosis. |
2015-01-09 |
2023-08-12 |
human |
| Chueh-Chuan Yen, Chung-Der Hsiao, Wei-Ming Chen, Yao-Shan Wen, Yung-Chan Lin, Ting-Wei Chang, Fang-Yi Yao, Shih-Chieh Hung, Jir-You Wang, Jen-Hwey Chiu, Hsei-Wei Wang, Chi-Hung Lin, Tain-Hsiung Chen, Paul Chih-Hsueh Chen, Chien-Lin Liu, Cheng-Hwai Tzeng, Jonathan A Fletche. Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition. Oncotarget. vol 5. issue 3. 2015-01-09. PMID:24566468. |
15-deoxy-Δ12, 14-prostaglandin j2 (15d-pgj2), a prostaglandin derivative, has shown its anti-tumor activity by inducing apoptosis through reactive oxygen species (ros)-mediated inactivation of v-akt, a murine thymoma viral oncogene homolog, (akt) in cancer cells. |
2015-01-09 |
2023-08-12 |
Not clear |
| Chueh-Chuan Yen, Chung-Der Hsiao, Wei-Ming Chen, Yao-Shan Wen, Yung-Chan Lin, Ting-Wei Chang, Fang-Yi Yao, Shih-Chieh Hung, Jir-You Wang, Jen-Hwey Chiu, Hsei-Wei Wang, Chi-Hung Lin, Tain-Hsiung Chen, Paul Chih-Hsueh Chen, Chien-Lin Liu, Cheng-Hwai Tzeng, Jonathan A Fletche. Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition. Oncotarget. vol 5. issue 3. 2015-01-09. PMID:24566468. |
in addition, transfection of constitutively active akt or plk1 partially rescued cells from 15d-pgj2-induced apoptosis, suggesting crucial roles for both pathways in the anti-cancer effects of 15d-pgj2. |
2015-01-09 |
2023-08-12 |
Not clear |
| William S Kim, Yuhua Zhu, Qiming Deng, Chee Jia Chin, Chong Bin He, Amanda J Grieco, Gautam G Dravid, Chintan Parekh, Roger P Hollis, Timothy F Lane, Eric E Bouhassira, Donald B Kohn, Gay M Crook. Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling. Stem cells (Dayton, Ohio). vol 32. issue 6. 2015-01-07. PMID:24677652. |
akt activation upregulates gata-1 and foxo3 transcriptional pathways with resulting inhibition of apoptosis, modulation of cell cycle, and enhanced maturation of erythroid cells. |
2015-01-07 |
2023-08-12 |
human |
| L Wei, W Qu, J Sun, X Wang, L Lv, L Xie, X Son. Knockdown of cancerous inhibitor of protein phosphatase 2A may sensitize NSCLC cells to cisplatin. Cancer gene therapy. vol 21. issue 5. 2015-01-07. PMID:24874844. |
the data demonstrated that cip2a silencing led to decreased proliferation, impaired clonogenicity and enhanced chemosensitivity and apoptosis to cisplatin in human nsclc cells, as well as reduced akt phosphorylation. |
2015-01-07 |
2023-08-13 |
human |
| Qiong Yang, Kan Yang, Anying L. microRNA-21 protects against ischemia-reperfusion and hypoxia-reperfusion-induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt-dependent mechanism. Molecular medicine reports. vol 9. issue 6. 2015-01-05. PMID:24676391. |
during i/r and h/r, forced expression of mir-21 upregulated the akt signaling activity via suppressing the expression of phosphatase and tensin homolog (pten) and the increased activity of akt signaling further inhibited apoptosis partially by increasing the ratio of b-cell lymphoma 2(bcl-2)/bcl-2-associated x protein, which further suppressed the expression of caspase-3. |
2015-01-05 |
2023-08-12 |
Not clear |
| Lin Yang, Guangchao Li, Likun Zhao, Fei Pan, Jiankun Qiang, Siqi Ha. Blocking the PI3K pathway enhances the efficacy of ALK-targeted therapy in EML4-ALK-positive nonsmall-cell lung cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 10. 2015-01-05. PMID:24972969. |
we found that genetic or pharmacological inhibition of alk markedly abrogated phosphorylated stat3 and erk, but it failed to suppress akt activity or induce apoptosis, in eml4-alk-positive h2228 cells. |
2015-01-05 |
2023-08-13 |
Not clear |
| Praveen Bhoopathi, Bridget A Quinn, Qin Gui, Xue-Ning Shen, Steven R Grossman, Swadesh K Das, Devanand Sarkar, Paul B Fisher, Luni Emda. Pancreatic cancer-specific cell death induced in vivo by cytoplasmic-delivered polyinosine-polycytidylic acid. Cancer research. vol 74. issue 21. 2015-01-05. PMID:25205107. |
phosphorylation of akt was inhibited by [pic](pei) in pdac, and this event was critical for stimulating apoptosis through xiap and survivin degradation. |
2015-01-05 |
2023-08-13 |
Not clear |
| Richard Justin Garling, Lora Talley Watts, Shane Sprague, Lauren Fletcher, David F Jimenez, Murat Digicayliogl. Does progesterone show neuroprotective effects on traumatic brain injury through increasing phosphorylation of Akt in the hippocampus? Neural regeneration research. vol 9. issue 21. 2015-01-05. PMID:25558238. |
akt is a protein kinase known to play a role in cell signaling pathways that reduce edema, inflammation, apoptosis, and promote cell growth in the brain. |
2015-01-05 |
2023-08-13 |
mouse |
| Kenneth Maies. Cutting through the complexities of mTOR for the treatment of stroke. Current neurovascular research. vol 11. issue 2. 2014-12-31. PMID:24712647. |
as part of the phosphoinositide 3-kinase (pi 3-k) and protein kinase b (akt) cascade, mtor is an essential component of mtor complex 1 (mtorc1) and mtor complex 2 (mtorc2) to govern cell death involving apoptosis, autophagy, and necroptosis, cellular metabolism, and gene transcription. |
2014-12-31 |
2023-08-13 |
Not clear |
| Daniéli Gerhardt, Gabriela Bertola, Fabrícia Dietrich, Fabrício Figueiró, Alfeu Zanotto-Filho, José Cláudio Moreira Fonseca, Fernanda Bueno Morrone, Carlos Henrique Barrios, Ana Maria O Battastini, Christianne G Salbeg. Boldine induces cell cycle arrest and apoptosis in T24 human bladder cancer cell line via regulation of ERK, AKT, and GSK-3β. Urologic oncology. vol 32. issue 1. 2014-12-29. PMID:24239461. |
boldine induces cell cycle arrest and apoptosis in t24 human bladder cancer cell line via regulation of erk, akt, and gsk-3β. |
2014-12-29 |
2023-08-12 |
human |
| Lulu Sun, Chao Chen, Beibei Jiang, Yanli Li, Qiuping Deng, Min Sun, Xiangbo An, Xiao Yang, Ying Yang, Rongli Zhang, Yao Lu, De-Sheng Zhu, Yingqing Huo, Gen-Sheng Feng, Youyi Zhang, Jincai Lu. Grb2-associated binder 1 is essential for cardioprotection against ischemia/reperfusion injury. Basic research in cardiology. vol 109. issue 4. 2014-12-29. PMID:24951957. |
consistently, in hearts of cgko mice subjected to i/r, the activation of caspase 3 and myocardial apoptosis was markedly enhanced whereas the activation of protein kinase b (akt) and mitogen-activated protein kinase (mapk), which are critical for cardiomyocyte survival, was attenuated. |
2014-12-29 |
2023-08-13 |
mouse |
| Kuntal Halder, Sayantan Banerjee, Anamika Bose, Saikat Majumder, Subrata Majumda. Overexpressed PKCδ downregulates the expression of PKCα in B16F10 melanoma: induction of apoptosis by PKCδ via ceramide generation. PloS one. vol 9. issue 3. 2014-12-28. PMID:24632809. |
this in turn promoted cellular proliferation by activating pld1 expression and subsequent akt phosphorylation, which eventually resulted in suppressed ceramide generation and apoptosis. |
2014-12-28 |
2023-08-12 |
Not clear |
| Rachakatla Anuradha, Mudigonda Saraswati, Kishore G Kumar, Surekha H Ran. Apoptosis of beta cells in diabetes mellitus. DNA and cell biology. vol 33. issue 11. 2014-12-18. PMID:25093391. |
the genetic alterations in apoptosis signaling machinery and the pathogenesis of diabetes include fas, fasl, akt, caspases, calpain-10, and phosphatase and tensin homolog (pten). |
2014-12-18 |
2023-08-13 |
Not clear |
| Anna Markowska, Monika Pawałowska, Jolanta Lubin, Janina Markowsk. Signalling pathways in endometrial cancer. Contemporary oncology (Poznan, Poland). vol 18. issue 3. 2014-12-18. PMID:25520571. |
pten inactivation, mutations in the pik3ca or akt result in increased transmission in the pi3k/akt pathway, apoptosis inhibition, intensive cell division, mtor excitation. |
2014-12-18 |
2023-08-13 |
Not clear |