| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Murali M Yallapu, Sheema Khan, Diane M Maher, Mara C Ebeling, Vasudha Sundram, Neeraj Chauhan, Aditya Ganju, Swathi Balakrishna, Brij K Gupta, Nadeem Zafar, Meena Jaggi, Subhash C Chauha. Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer. Biomaterials. vol 35. issue 30. 2015-03-30. PMID:25028336. |
it also suppresses stat3 and akt phosphorylation and leads to apoptosis via inhibition of key anti-apoptotic proteins, mcl-1, bcl-xl and caused induction of parp cleavage. |
2015-03-30 |
2023-08-13 |
mouse |
| Fang Tian, Lijie Dong, Yu Zhou, Yan Shao, Wenbo Li, Hong Zhang, Fei Wan. Rapamycin-Induced apoptosis in HGF-stimulated lens epithelial cells by AKT/mTOR, ERK and JAK2/STAT3 pathways. International journal of molecular sciences. vol 15. issue 8. 2015-03-30. PMID:25116684. |
moreover, the forced expression of akt, erk and stat3 could induce a significant suppression of apoptosis in these cells after treatment of rapamycin. |
2015-03-30 |
2023-08-13 |
Not clear |
| Juhyun Song, So Mang Kang, Won Taek Lee, Kyung Ah Park, Kyoung Min Lee, Jong Eun Le. The beneficial effect of melatonin in brain endothelial cells against oxygen-glucose deprivation followed by reperfusion-induced injury. Oxidative medicine and cellular longevity. vol 2014. 2015-03-30. PMID:25126203. |
in response to ogd/r injury of bend.3 cells, melatonin activates akt, which promotes cell survival, and attenuates phosphorylation of jnk, which triggers apoptosis. |
2015-03-30 |
2023-08-13 |
Not clear |
| Ellen Weisberg, Atsushi Nonami, Zhao Chen, Feiyang Liu, Jianming Zhang, Martin Sattler, Erik Nelson, Kristen Cowens, Amanda L Christie, Constantine Mitsiades, Kwok-Kin Wong, Qingsong Liu, Nathanael Gray, James D Griffi. Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies. Leukemia. vol 29. issue 1. 2015-03-24. PMID:24791855. |
the observed synergy enhanced dephosphorylation of akt, 4e-binding protein 1 and s6 kinase, and correlated with increased apoptosis. |
2015-03-24 |
2023-08-13 |
human |
| Arman Ghorbani, Mahmood Jeddi-Tehrani, Atoosa Saidpour, Majid Safa, Ahmad Ali Bayat, Hamid Zan. PI3K/AKT and Mdm2 activation are associated with inhibitory effect of cAMP increasing agents on DNA damage-induced cell death in human pre-B NALM-6 cells. Archives of biochemistry and biophysics. vol 566. 2015-03-19. PMID:25524737. |
akt signaling inhibits p53-mediated transcription and apoptosis. |
2015-03-19 |
2023-08-13 |
human |
| Arman Ghorbani, Mahmood Jeddi-Tehrani, Atoosa Saidpour, Majid Safa, Ahmad Ali Bayat, Hamid Zan. PI3K/AKT and Mdm2 activation are associated with inhibitory effect of cAMP increasing agents on DNA damage-induced cell death in human pre-B NALM-6 cells. Archives of biochemistry and biophysics. vol 566. 2015-03-19. PMID:25524737. |
the results of present study showed that camp disrupted dna damage/p53-mediated apoptosis through akt and subsequent nf-κb activation. |
2015-03-19 |
2023-08-13 |
human |
| Yahong Wang, Ziying Lin, Haili Huang, Huijuan He, Lawei Yang, Ting Chen, Teng Yang, Nina Ren, Yun Jiang, Wenya Xu, David W Kamp, Tie Liu, Gang Li. AMPK is required for PM2.5-induced autophagy in human lung epithelial A549 cells. International journal of clinical and experimental medicine. vol 8. issue 1. 2015-03-18. PMID:25784975. |
the effects of phosphorylation of ampk, mtor, akt, erk, jnk, and p53 on lc3ii in a549 were observed following pm2.5 exposure; the role of autophagy in pm2.5-induced apoptosis was examined using 3-methyladenine and rapamycin. |
2015-03-18 |
2023-08-13 |
human |
| Yue Xing, Di Yang, Jing Lu, De-Li Don. Insulin prevents bone morphogenetic protein-4 induced cardiomyocyte apoptosis through activating Akt. Biochemical and biophysical research communications. vol 456. issue 2. 2015-03-13. PMID:25490386. |
insulin prevents bone morphogenetic protein-4 induced cardiomyocyte apoptosis through activating akt. |
2015-03-13 |
2023-08-13 |
Not clear |
| Yue Xing, Di Yang, Jing Lu, De-Li Don. Insulin prevents bone morphogenetic protein-4 induced cardiomyocyte apoptosis through activating Akt. Biochemical and biophysical research communications. vol 456. issue 2. 2015-03-13. PMID:25490386. |
in conclusion, insulin prevents bmp4-induced cardiomyocyte apoptosis and the underlying mechanisms include activation of akt. |
2015-03-13 |
2023-08-13 |
Not clear |
| Zhihong Chen, Yaqiang He, Chengjun Song, Zhijun Dong, Zhejun Su, Jingfeng Xu. Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus. Neural regeneration research. vol 7. issue 3. 2015-03-13. PMID:25767499. |
sericin can reduce hippocampal neuronal apoptosis by activating the akt signal transduction pathway in a rat model of diabetes mellitus. |
2015-03-13 |
2023-08-13 |
rat |
| Zhihong Chen, Yaqiang He, Chengjun Song, Zhijun Dong, Zhejun Su, Jingfeng Xu. Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus. Neural regeneration research. vol 7. issue 3. 2015-03-13. PMID:25767499. |
following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal ca1 region decreased, hippocampal phosphorylated akt and nuclear factor kappa b expression were enhanced, but bcl-xl/bcl-2 associated death promoter expression decreased. |
2015-03-13 |
2023-08-13 |
rat |
| Zhihong Chen, Yaqiang He, Chengjun Song, Zhijun Dong, Zhejun Su, Jingfeng Xu. Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus. Neural regeneration research. vol 7. issue 3. 2015-03-13. PMID:25767499. |
results demonstrated that sericin can reduce hippocampal neuronal apoptosis in a rat model of diabetes mellitus by regulating abnormal changes in the akt signal transduction pathway. |
2015-03-13 |
2023-08-13 |
rat |
| Ta-Ming Liu, Yonghua Ling, Jennifer A Woyach, Kyle Beckwith, Yuh-Ying Yeh, Erin Hertlein, Xiaoli Zhang, Amy Lehman, Farrukh Awan, Jeffrey A Jones, Leslie A Andritsos, Kami Maddocks, Jessica MacMurray, Santosh B Salunke, Ching-Shih Chen, Mitch A Phelps, John C Byrd, Amy J Johnso. OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells. Blood. vol 125. issue 2. 2015-03-11. PMID:25293770. |
through this mechanism, the agent triggers caspase-dependent apoptosis in cll by suppressing bcr, cd49d, cd40, and toll-like receptor 9-mediated akt activation in an integrin-linked kinase-independent manner. |
2015-03-11 |
2023-08-13 |
mouse |
| Chul-Ho Jeong, Kyung-Soo Chun, Juthika Kundu, Byoungduck Par. Phosphorylation of Smac by Akt promotes the caspase-3 activation during etoposide-induced apoptosis in HeLa cells. Molecular carcinogenesis. vol 54. issue 2. 2015-03-10. PMID:24038446. |
phosphorylation of smac by akt promotes the caspase-3 activation during etoposide-induced apoptosis in hela cells. |
2015-03-10 |
2023-08-12 |
Not clear |
| Chul-Ho Jeong, Kyung-Soo Chun, Juthika Kundu, Byoungduck Par. Phosphorylation of Smac by Akt promotes the caspase-3 activation during etoposide-induced apoptosis in HeLa cells. Molecular carcinogenesis. vol 54. issue 2. 2015-03-10. PMID:24038446. |
the cellular interaction of wild-type smac with xiap was enhanced with similar activation kinetics of akt activity, while this interaction was markedly attenuated in cells expressing the phosphorylation-defective mutant s67a-smac during etoposide-induced apoptosis. |
2015-03-10 |
2023-08-12 |
Not clear |
| Chul-Ho Jeong, Kyung-Soo Chun, Juthika Kundu, Byoungduck Par. Phosphorylation of Smac by Akt promotes the caspase-3 activation during etoposide-induced apoptosis in HeLa cells. Molecular carcinogenesis. vol 54. issue 2. 2015-03-10. PMID:24038446. |
taken together, we propose that the phosphorylation of smac by akt might be a novel mechanism that involves in amplification of caspase cascade pathway during etoposide-induced apoptosis in hela cells. |
2015-03-10 |
2023-08-12 |
Not clear |
| Lei Wu, Liang Yang, Yu Xiong, Hua Guo, Xiaoli Shen, Zujue Cheng, Yan Zhang, Ziyun Gao, Xingen Zh. Annexin A5 promotes invasion and chemoresistance to temozolomide in glioblastoma multiforme cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 12. 2015-03-10. PMID:25245332. |
overexpression of annexin a5 in both cell lines significantly increased cell invasion, matrix metalloproteinase-2 (mmp-2) expression/activity, akt phosphorylation at serine 473, and the half maximal inhibitory concentration (ic50) values of temozolomide and markedly decreased temozolomide-induced apoptosis, all of which were abolished by selective pi3k inhibitor bkm120. |
2015-03-10 |
2023-08-13 |
human |
| Lei Wu, Liang Yang, Yu Xiong, Hua Guo, Xiaoli Shen, Zujue Cheng, Yan Zhang, Ziyun Gao, Xingen Zh. Annexin A5 promotes invasion and chemoresistance to temozolomide in glioblastoma multiforme cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 12. 2015-03-10. PMID:25245332. |
on the other hand, knockdown of annexin a5 markedly decreased cell invasion, mmp-2 expression/activity, akt phosphorylation at serine 473, and the ic50 values of temozolomide and significantly increased temozolomide-induced apoptosis. |
2015-03-10 |
2023-08-13 |
human |
| Huae Xu, Xiaolin Li, Wenqiu Ding, Xiaoning Zeng, Hui Kong, Hong Wang, Weiping Xi. Deguelin induces the apoptosis of lung cancer cells through regulating a ROS driven Akt pathway. Cancer cell international. vol 15. 2015-03-05. PMID:25741219. |
deguelin induces the apoptosis of lung cancer cells through regulating a ros driven akt pathway. |
2015-03-05 |
2023-08-13 |
Not clear |
| Mao-Bin Meng, Huan-Huan Wang, Wen-Hao Guo, Zhi-Qiang Wu, Xian-Liang Zeng, Nicholas G Zaorsky, Hua-Shan Shi, Dong Qian, Zhi-Min Niu, Bo Jiang, Lu-Jun Zhao, Zhi-Yong Yuan, Ping Wan. Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo. Cancer letters. vol 356. issue 2 Pt B. 2015-03-03. PMID:25444918. |
silencing of pkm2 expression enhanced ionizing radiation (ir)-induced apoptosis and autophagy in vitro and in vivo, accompanied by inhibiting akt and pdk1 phosphorylation, but enhanced erk and gsk3β phosphorylation. |
2015-03-03 |
2023-08-13 |
Not clear |