| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshinaga Maeda, Keisuke Takeuchi, Pang Xiaoling, Dimitar P Zankov, Naoyuki Takashima, Akira Fujiyoshi, Takashi Kadowaki, Katsuyuki Miura, Hirotsugu Ueshima, Hisakazu Ogit. Lipoprotein-associated phospholipase A2 regulates macrophage apoptosis via the Akt and caspase-7 pathways. Journal of atherosclerosis and thrombosis. vol 21. issue 8. 2015-05-19. PMID:24717759. |
lipoprotein-associated phospholipase a2 regulates macrophage apoptosis via the akt and caspase-7 pathways. |
2015-05-19 |
2023-08-13 |
Not clear |
| C Fan, W Zheng, X Fu, X Li, Y-S Wong, T Che. Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo. Cell death & disease. vol 5. 2015-05-18. PMID:24763048. |
however, inhibition of ros reversed the apoptosis induced by sec and af, and recovered the inactivation of erk and akt, which revealed the importance of ros in cell apoptosis and regulation of erk and akt pathways. |
2015-05-18 |
2023-08-13 |
mouse |
| Xiao-Feng Liang, Chen Fang, Yi-Ni Ma, Xin Guan, Yang Liu, Chao Han, Jing Liu, Wei Zo. [Relationship between ER-α36 and Akt in PC12 cells exposed to glucose deprivation]. Sheng li xue bao : [Acta physiologica Sinica]. vol 65. issue 4. 2015-05-16. PMID:23963069. |
the results showed that, (1) glucose deprivation induced by mem treatment for 6 h reduced survival rate and increased apoptotic rate in pc12 cells significantly compared to control group (p < 0.01); and it produced a decrease in the expression of glut-4 protein (p < 0.01); (2) the expression level of er-α36 was decreased significantly at 3 h of glucose deprivation, and then increased, while phosphorylation of akt participated in the glucose deprivation was increased at first and then reduced; ly294002 (pi3k inhibitor) contributed to decreased expression of er-α36, and suppressed the activation of akt; (3) the rate of apoptosis was significantly increased in pc12-36l cells after glucose deprivation compared with that in wild type pc12 cells (p < 0.01). |
2015-05-16 |
2023-08-12 |
Not clear |
| Meriam Haoues, Amira Refai, Aude Mallavialle, M Ridha Barbouche, Nizar Laabidi, Marcel Deckert, Makram Essaf. Forkhead box O3 (FOXO3) transcription factor mediates apoptosis in BCG-infected macrophages. Cellular microbiology. vol 16. issue 9. 2015-05-12. PMID:24712562. |
bcg-induced apoptosis was associated with dephosphorylation of the prosurvival activated threonine kinase (akt) and its target foxo3. |
2015-05-12 |
2023-08-13 |
human |
| Hao Liu, Jiang Yin, Chengkun Wang, Yixue Gu, Min Deng, Zhimin H. FOXO3a mediates the cytotoxic effects of cisplatin in lung cancer cells. Anti-cancer drugs. vol 25. issue 8. 2015-05-12. PMID:24814195. |
the results showed that cisplatin inhibited the proliferation of these lung cancer cell lines by inhibiting the pi3k/akt pathway, with evidence of decreasing phosphorylation of pi3k and akt under cisplatin treatment, and constitutively activating akt1 could reduce cisplatin-induced cell apoptosis. |
2015-05-12 |
2023-08-13 |
human |
| Azusa Tanimoto, Tadaaki Yamada, Shigeki Nanjo, Shinji Takeuchi, Hiromichi Ebi, Kenji Kita, Kunio Matsumoto, Seiji Yan. Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells. Oncotarget. vol 5. issue 13. 2015-05-12. PMID:24952482. |
additionally, the heat shock protein 90 (hsp90) inhibitor suppressed protein expression of alk, met, egfr, and akt, and thereby induced apoptosis in eml4-alk nsclc cells, even in the presence of egfr ligands or hgf. |
2015-05-12 |
2023-08-13 |
Not clear |
| Nianli Liu, Chaohui Zuo, Xiaohong Wang, Tianran Chen, Darong Yang, Jing Wang, Haizhen Zh. miR-942 decreases TRAIL-induced apoptosis through ISG12a downregulation and is regulated by AKT. Oncotarget. vol 5. issue 13. 2015-05-12. PMID:24970806. |
mir-942 decreases trail-induced apoptosis through isg12a downregulation and is regulated by akt. |
2015-05-12 |
2023-08-13 |
mouse |
| Gaoya Xu, Weidan Ji, Yinghan Su, Yang Xu, Yan Yan, Shuwen Shen, Xiaoya Li, Bin Sun, Haihua Qian, Lei Chen, Xiaohui Fu, Mengchao Wu, Changqing S. Sulfatase 1 (hSulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model. Oncotarget. vol 5. issue 13. 2015-05-12. PMID:24970807. |
the bfgf-stimulated activation of protein kinase b (akt) and extracellular signal-regulated kinase (erk) pathways was suppressed by hsulf-1, which led to a decreased expression of the target genes cyclin d1 and survivin, then finally induced cell cycle arrest and apoptosis in hcc cells. |
2015-05-12 |
2023-08-13 |
human |
| Lei-Lei Ma, Hong-Wei Ge, Fei-Juan Kong, Ling-Bo Qian, Bang-Chuan Hu, Qian Li, Liang Xu, Jing-Quan Liu, Yun-Xiang Xu, Ren-Hua Su. Ventricular hypertrophy abrogates intralipid-induced cardioprotection by alteration of reperfusion injury salvage kinase/glycogen synthase kinase 3β signal. Shock (Augusta, Ga.). vol 41. issue 5. 2015-05-11. PMID:24430545. |
nonetheless, ilp failed to improve left ventricular hemodynamics and reduced infarct size and apoptosis and increase the phosphorylated akt, erk1/2, gsk3β, and antiapoptotic bcl-2 in hypertrophied myocardium. |
2015-05-11 |
2023-08-12 |
rat |
| Shigeru Tanaka, Tatsuhiro Miyagi, Eisuke Dohi, Takahiro Seki, Izumi Hide, Yusuke Sotomaru, Yoshinaga Saeki, E Antonio Chiocca, Masayasu Matsumoto, Norio Saka. Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli. Neurobiology of disease. vol 68. 2015-05-11. PMID:24769160. |
collectively, these in vitro and in vivo results suggest that the developmental expression of constitutively active gs-coupled gpr3 activates the erk and akt signaling pathways at the basal level, thereby protecting neurons from apoptosis that is induced by various stimuli. |
2015-05-11 |
2023-08-13 |
mouse |
| b' Desanka Milanovi\\xc4\\x87, Vesna Pe\\xc5\\xa1i\\xc4\\x87, Jelena Popi\\xc4\\x87, Nikola Tani\\xc4\\x87, Selma Kanazir, Vesna Jevtovi\\xc4\\x87-Todorovi\\xc4\\x87, Sabera Ru\\xc5\\xbediji\\xc4\\x8. Propofol anesthesia induces proapoptotic tumor necrosis factor-\\xce\\xb1 and pro-nerve growth factor signaling and prosurvival Akt and XIAP expression in neonatal rat brain. Journal of neuroscience research. vol 92. issue 10. 2015-05-11. PMID:24827783.' |
we also investigated how propofol influences the expression of akt and x-linked inhibitor of apoptosis (xiap) expression, proteins that promote prosurvival pathways. |
2015-05-11 |
2023-08-13 |
rat |
| Ye Song, Zheng Hu, Hao Long, Yuping Peng, Xi'an Zhang, Tianshi Que, Shihao Zheng, Zhiyong Li, Gang Wang, Liu Yi, Zhen Liu, Weiyi Fang, Songtao Q. A complex mechanism for HDGF-mediated cell growth, migration, invasion, and TMZ chemosensitivity in glioma. Journal of neuro-oncology. vol 119. issue 2. 2015-05-11. PMID:24986090. |
together, our data suggested that hdgf regulates glioma cell growth, apoptosis and epithelial-mesenchymal transition (emt) probably through the akt and the tgf-β signaling pathways. |
2015-05-11 |
2023-08-13 |
Not clear |
| Gagan Deep, Rahul Kumar, Anil K Jain, Chapla Agarwal, Rajesh Agarwa. Silibinin inhibits fibronectin induced motility, invasiveness and survival in human prostate carcinoma PC3 cells via targeting integrin signaling. Mutation research. vol 768. 2015-05-11. PMID:25285031. |
molecular analyses revealed that silibinin treatment modulated the fibronectin-induced expression of integrins (α5, αv, β1 and β3), actin-remodeling (fak, src, gtpases, arp2 and cortactin), apoptosis (cparp and cleaved caspase 3), emt (e-cadherin and β-catenin), and cell survival (survivin and akt) related signaling molecules in pc3 cells. |
2015-05-11 |
2023-08-13 |
mouse |
| Ni Xia, Jiao Jiao, Ting-Ting Tang, Bing-Jie Lv, Yu-Zhi Lu, Ke-Jing Wang, Zheng-Feng Zhu, Xiao-Bo Mao, Shao-Fang Nie, Qing Wang, Xin Tu, Hong Xiao, Yu-Hua Liao, Guo-Ping Shi, Xiang Chen. Activated regulatory T-cells attenuate myocardial ischaemia/reperfusion injury through a CD39-dependent mechanism. Clinical science (London, England : 1979). vol 128. issue 10. 2015-05-09. PMID:25558978. |
moreover, adoptive transfer of in vitro-activated tregs attenuated cardiomyocyte apoptosis, activated a pro-survival pathway involving akt and extracellular-signal-regulated kinase (erk) and inhibited neutrophil infiltration, which was compromised by cd39 deficiency. |
2015-05-09 |
2023-08-13 |
mouse |
| Nan Wu, Xiaowen Zhang, Pengyu Jia, Dalin Ji. Hypercholesterolemia abrogates the protective effect of ischemic postconditioning by induction of apoptosis and impairment of activation of reperfusion injury salvage kinase pathway. Biochemical and biophysical research communications. vol 458. issue 1. 2015-05-06. PMID:25637532. |
moreover, we also found that hc inhibited the phosphorylation of akt and erk1/2 which usually activated by ipoc in normal heart, induced excessive apoptosis by down-regulating bcl-2 and up-regulating bax, cytochrome c, caspase 9 and caspase 3 when compared with that in normal heart. |
2015-05-06 |
2023-08-13 |
Not clear |
| Dandan Zhu, Jianxin Wang, Xiaolei Sun, Jinling Chen, Yinong Duan, Jing Pan, Tianhua Xu, Yongwei Qin, Xingxin He, Caiqun Huan. Septin4_i1 regulates apoptosis in hepatic stellate cells through peroxisome proliferator-activated receptor-γ/Akt/B-cell lymphoma 2 pathway. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 63. issue 3. 2015-04-29. PMID:25527525. |
in conclusion, our data suggest that sept4_i1 induces hsc apoptosis by inhibiting akt and bcl-2 expression and up-regulating ppar-γ expression. |
2015-04-29 |
2023-08-13 |
Not clear |
| Ferhan S Siddiqi, Li-Hao Chen, Suzanne L Advani, Kerri Thai, Sri N Batchu, Tamadher A Alghamdi, Kathryn E White, Manish M Sood, Ian W Gibson, Kim A Connelly, Philip A Marsden, Andrew Advan. CXCR4 promotes renal tubular cell survival in male diabetic rats: implications for ligand inactivation in the human kidney. Endocrinology. vol 156. issue 3. 2015-04-29. PMID:25549045. |
in cultured cells, cxcr4 blockade promoted tubular cell apoptosis, up-regulated bcl-2-associated death promoter, and prevented high glucose/sdf-1-augmented phosphorylation of the pro-survival kinase, akt. |
2015-04-29 |
2023-08-13 |
human |
| Xin Jiang, Jun Chen, Chi Zhang, Zhiguo Zhang, Yi Tan, Wenke Feng, Melissa Skibba, Ying Xin, Lu Ca. The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/Sirt1/PGC-1α signaling. Endocrinology. vol 156. issue 3. 2015-04-29. PMID:25560828. |
the protective effect of fgf21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular akt and ampk/sirt1/pgc-1α signaling. |
2015-04-29 |
2023-08-13 |
mouse |
| Gregory B Carey, Sanjit K Roy, Hanako Dain. The natural tumorcide Manumycin-A targets protein phosphatase 1α and reduces hydrogen peroxide to induce lymphoma apoptosis. Experimental cell research. vol 332. issue 1. 2015-04-24. PMID:25556058. |
we recently showed that man-a stimulated reactive oxygen species (ros) which were upstream of serine/threonine (ser/thr) dephosphorylation and caspase-dependent cleavage of mek and akt in lymphoma apoptosis. |
2015-04-24 |
2023-08-13 |
human |
| Zhi Shi, Hae Ryon Park, Yuhong Du, Zijian Li, Kejun Cheng, Shi-Yong Sun, Zenggang Li, Haian Fu, Fadlo R Khur. Cables1 complex couples survival signaling to the cell death machinery. Cancer research. vol 75. issue 1. 2015-04-23. PMID:25361894. |
ectopic expression of activated akt (akt1) prevented cables1-induced apoptosis. |
2015-04-23 |
2023-08-13 |
human |