| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiang Li, Xiang-Yu Ma, Ya-Fei Feng, Zhen-Sheng Ma, Jian Wang, Tian-Cheng Ma, Wei Qi, Wei Lei, Lin Wan. Osseointegration of chitosan coated porous titanium alloy implant by reactive oxygen species-mediated activation of the PI3K/AKT pathway under diabetic conditions. Biomaterials. vol 36. 2015-07-16. PMID:25308520. |
results showed that diabetes-induced ros overproduction led to osteoblast dysfunction and apoptosis, concomitant with the inhibition of akt in osteoblasts on the ti substrate. |
2015-07-16 |
2023-08-13 |
rat |
| Y Zhen, L Guanghui, Z Xief. Knockdown of EGFR inhibits growth and invasion of gastric cancer cells. Cancer gene therapy. vol 21. issue 11. 2015-07-15. PMID:25394504. |
knockdown of egfr reduced cell proliferation and invasion of gc with decreased expression of akt, pcna and mmp-9 and induced cell apoptosis and cycle arrest. |
2015-07-15 |
2023-08-13 |
human |
| Florian Ewald, Dominik Nörz, Astrid Grottke, Bianca T Hofmann, Björn Nashan, Manfred Jücke. Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors. Investigational new drugs. vol 32. issue 6. 2015-07-13. PMID:25152244. |
to provide a rationale for treatment of cca with inhibitors of these respective pathways, we analyzed the effects of akt inhibitor mk-2206, mek inhibitor azd6244 (arry-142886) and mtor kinase inhibitor azd8055 on three cca cell lines in vitro, concerning proliferation, cell signaling and apoptosis. |
2015-07-13 |
2023-08-13 |
Not clear |
| M Puglisi, P Thavasu, A Stewart, J S de Bono, M E R O'Brien, S Popat, J Bhosle, U Banerj. AKT inhibition synergistically enhances growth-inhibitory effects of gefitinib and increases apoptosis in non-small cell lung cancer cell lines. Lung cancer (Amsterdam, Netherlands). vol 85. issue 2. 2015-07-09. PMID:24957682. |
akt inhibition synergistically enhances growth-inhibitory effects of gefitinib and increases apoptosis in non-small cell lung cancer cell lines. |
2015-07-09 |
2023-08-13 |
Not clear |
| Bo Zhai, Xian Jiang, Changjun He, Dali Zhao, Lixin Ma, Lishan Xu, Hongchi Jiang, Xueying Su. Arsenic trioxide potentiates the anti-cancer activities of sorafenib against hepatocellular carcinoma by inhibiting Akt activation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 4. 2015-07-09. PMID:25416439. |
the results have demonstrated that ato synergized with sorafenib to inhibit the proliferation and promote the apoptosis of hcc cells by diminishing the increased activation of akt by sorafenib. |
2015-07-09 |
2023-08-13 |
mouse |
| Bo Zhai, Xian Jiang, Changjun He, Dali Zhao, Lixin Ma, Lishan Xu, Hongchi Jiang, Xueying Su. Arsenic trioxide potentiates the anti-cancer activities of sorafenib against hepatocellular carcinoma by inhibiting Akt activation. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 4. 2015-07-09. PMID:25416439. |
ato was shown to inhibit the expression or activation of akt downstream factors, including glycogen synthase kinase (gsk)-3β, mammalian target of rapamycin (mtor), ribosomal protein s6 kinase (s6k), and eukaryotic translation initiation factor 4e-binding protein 1 (4ebp1), which regulate cell apoptosis and were upregulated or activated by sorafenib. |
2015-07-09 |
2023-08-13 |
mouse |
| Li-Juan Deng, Li-Ping Hu, Qun-Long Peng, Xiao-Lin Yang, Liang-Liang Bai, Anita Yiu, Yong Li, Hai-Yan Tian, Wen-Cai Ye, Dong-Mei Zhan. Hellebrigenin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Chemico-biological interactions. vol 219. 2015-07-08. PMID:24954031. |
hellebrigenin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma hepg2 cells through inhibition of akt. |
2015-07-08 |
2023-08-13 |
human |
| Li-Juan Deng, Li-Ping Hu, Qun-Long Peng, Xiao-Lin Yang, Liang-Liang Bai, Anita Yiu, Yong Li, Hai-Yan Tian, Wen-Cai Ye, Dong-Mei Zhan. Hellebrigenin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Chemico-biological interactions. vol 219. 2015-07-08. PMID:24954031. |
in addition, akt expression and phosphorylation were inhibited by hellebrigenin, whereas akt silencing with sirna significantly blocked cell cycle arrest but enhanced apoptosis induced by hellebrigenin. |
2015-07-08 |
2023-08-13 |
human |
| Zi-Miao Liu, Hong-Yu Tseng, Ya-Ling Cheng, Bi-Wen Yeh, Wen-Jeng Wu, Huei-Sheng Huan. TG-interacting factor transcriptionally induced by AKT/FOXO3A is a negative regulator that antagonizes arsenic trioxide-induced cancer cell apoptosis. Toxicology and applied pharmacology. vol 285. issue 1. 2015-07-03. PMID:25791921. |
furthermore, blockage of the akt pathway enhanced ato-induced cdkn1a expression and resultant apoptosis in cancer cells, but overexpression of akt1 inhibited cdkn1a expression. |
2015-07-03 |
2023-08-13 |
Not clear |
| Do-Hyung Lee, Soyoung Kim, Kyung-Soo Na. Protective effects of deep sea water against doxorubicin‑induced cardiotoxicity in H9c2 cardiac muscle cells. International journal of oncology. vol 45. issue 6. 2015-07-02. PMID:25270851. |
moreover, dsw treatment rescued the activation of protein kinase b (akt) to protect cells from dox-triggered apoptosis. |
2015-07-02 |
2023-08-13 |
rat |
| Chen Shao, Jianqiu Gu, Xin Meng, Hongzhi Zheng, Difei Wan. Systematic investigation into the role of intermittent high glucose in pancreatic beta-cells. International journal of clinical and experimental medicine. vol 8. issue 4. 2015-07-01. PMID:26131124. |
to determine how it induces beta-cell dysfunction, we systematically evaluated the effects of intermittent high glucose (ihg) in ins-1 rat pancreatic beta-cells on their proliferation activity, apoptosis, insulin secretion, reactive oxygen species (ros), intracellular concentration of ca(2+) ([ca(2+)]i), and the pten expression as well as akt phosphorylation. |
2015-07-01 |
2023-08-13 |
rat |
| Boon Yin Khoo, Siang Ling Chua, Prabha Balara. Apoptotic effects of chrysin in human cancer cell lines. International journal of molecular sciences. vol 11. issue 5. 2015-06-29. PMID:20559509. |
in most of the cancer cells tested, chrysin has shown to inhibit proliferation and induce apoptosis, and is more potent than other tested flavonoids in leukemia cells, where chrysin is likely to act via activation of caspases and inactivation of akt signaling in the cells. |
2015-06-29 |
2023-08-12 |
human |
| Xiang Li, Shu-Juan Zhao, Hai-Lian Shi, Shui-Ping Qiu, Jian-Qun Xie, Hui Wu, Bei-Bei Zhang, Zheng-Tao Wang, Jian-Ye Yuan, Xiao-Jun W. Berberine hydrochloride IL-8 dependently inhibits invasion and IL-8-independently promotes cell apoptosis in MDA-MB-231 cells. Oncology reports. vol 32. issue 6. 2015-06-29. PMID:25335112. |
ber modulated multiple signaling pathway molecules involved in the regulation of cell apoptosis, including activation of p38 mapk and jnk and deactivation of jak2, p85 pi3k, akt and nf-κb. |
2015-06-29 |
2023-08-13 |
Not clear |
| Qin Gu, Lijing Zhai, Xing Feng, Jing Chen, Zhigang Miao, Liyan Ren, Xuanchen Qian, Jian Yu, Yan Li, Xingshun Xu, Chun-Feng Li. Apelin-36, a potent peptide, protects against ischemic brain injury by activating the PI3K/Akt pathway. Neurochemistry international. vol 63. issue 6. 2015-06-26. PMID:24083989. |
we found that ly294002 decreased the phosphorylated akt level and attenuated protective effects of apelin-36 on apoptosis. |
2015-06-26 |
2023-08-12 |
Not clear |
| Jinlin Hou, Anguo Cui, Peiying Song, Hui Hua, Ting Luo, Yangfu Jian. Reactive oxygen species-mediated activation of the Src-epidermal growth factor receptor-Akt signaling cascade prevents bortezomib-induced apoptosis in hepatocellular carcinoma cells. Molecular medicine reports. vol 11. issue 1. 2015-06-24. PMID:25338626. |
the activation of akt represents an adaptive response that prevents bortezomib-induced cell apoptosis. |
2015-06-24 |
2023-08-13 |
Not clear |
| Qi-Yan Zeng, Yu Huang, Lin-Jie Zeng, Min Huang, Yong-Qi Huang, Qi-Fang Zh. Sensitization of cervical carcinoma cells to paclitaxel by an IPP5 active mutant. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 19. 2015-06-23. PMID:25339026. |
furthermore, our results revealed that 8-60hipp5m enhances paclitaxel- induced g2/m arrest and apoptosis, and augments paclitaxel-induced activation of caspases and release of cytochrome c. evaluation of signaling pathways indicated that this synergism was in part related to down- regulation of nf-?b activation and serine/threonine kinase akt pathways. |
2015-06-23 |
2023-08-13 |
human |
| Parvana Hajieva, Nadhim Bayatti, Matthias Granold, Christian Behl, Bernd Moosman. Membrane protein oxidation determines neuronal degeneration. Journal of neurochemistry. vol 133. issue 3. 2015-06-22. PMID:25393523. |
investigating the aminoacyllipids in primary neuronal culture, we found that the targeted protection of transmembrane tyrosine and tryptophan residues was sufficient to prevent neurotoxicity evoked by hydroperoxides, kainic acid, glutathione-depleting drugs, and certain amyloidogenic peptides, but ineffective against non-oxidative inducers of apoptosis such as sphingosine or akt kinase inhibitors. |
2015-06-22 |
2023-08-13 |
Not clear |
| M Shen, Z Liu, B Li, Y Teng, J Zhang, Y Tang, S-C Sun, H Li. Involvement of FoxO1 in the effects of follicle-stimulating hormone on inhibition of apoptosis in mouse granulosa cells. Cell death & disease. vol 5. 2015-06-18. PMID:25321482. |
correspondingly, constitutive activation of foxo1 (all three akt sites were replaced by alanines) also promoted mgc apoptosis despite fsh administration. |
2015-06-18 |
2023-08-13 |
mouse |
| Jun Han, Jia-Li Xuan, Hao-Ran Hu, Zhi-Wu Che. [Protective effect against myocardial ischemia reperfusion injuries induced by hyperoside preconditioning and its relationship with PI3K/Akt signaling pathway in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 40. issue 1. 2015-06-18. PMID:25993800. |
hyp pretreatment apparently restrained myocardial apoptosis as evidenced by decreasing the level of bax expression, increasing the levels of phosphorylation of akt and bcl-2 expression. |
2015-06-18 |
2023-08-13 |
rat |
| Jui-Ling Hsu, Shih-Ping Liu, Chia-Chung Lee, Lih-Ching Hsu, Yunn-Fang Ho, Hsu-Shan Huang, Jih-Hwa Gu. A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 10. 2015-06-15. PMID:25005758. |
the combination treatment of mk2206 (a specific akt inhibitor) with cc-36 showed a synergistic apoptosis in pc-3 cells indicating a potential combination strategy for lkb1 activators. |
2015-06-15 |
2023-08-13 |
human |