| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katarzyna B Leszczynska, Iosifina P Foskolou, Aswin G Abraham, Selvakumar Anbalagan, Céline Tellier, Syed Haider, Paul N Span, Eric E O'Neill, Francesca M Buffa, Ester M Hammon. Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT. The Journal of clinical investigation. vol 125. issue 6. 2015-08-12. PMID:25961455. |
hypoxia-induced p53 modulates both apoptosis and radiosensitivity via akt. |
2015-08-12 |
2023-08-13 |
human |
| Katarzyna B Leszczynska, Iosifina P Foskolou, Aswin G Abraham, Selvakumar Anbalagan, Céline Tellier, Syed Haider, Paul N Span, Eric E O'Neill, Francesca M Buffa, Ester M Hammon. Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT. The Journal of clinical investigation. vol 125. issue 6. 2015-08-12. PMID:25961455. |
induction of p53 targets, phlda3, and a specific inpp5d transcript mediated apoptosis in response to hypoxia through akt inhibition. |
2015-08-12 |
2023-08-13 |
human |
| Katarzyna B Leszczynska, Iosifina P Foskolou, Aswin G Abraham, Selvakumar Anbalagan, Céline Tellier, Syed Haider, Paul N Span, Eric E O'Neill, Francesca M Buffa, Ester M Hammon. Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT. The Journal of clinical investigation. vol 125. issue 6. 2015-08-12. PMID:25961455. |
moreover, pharmacological inhibition of akt led to apoptosis in the hypoxic regions of p53-deficient tumors and consequently increased radiosensitivity. |
2015-08-12 |
2023-08-13 |
human |
| Katarzyna B Leszczynska, Iosifina P Foskolou, Aswin G Abraham, Selvakumar Anbalagan, Céline Tellier, Syed Haider, Paul N Span, Eric E O'Neill, Francesca M Buffa, Ester M Hammon. Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT. The Journal of clinical investigation. vol 125. issue 6. 2015-08-12. PMID:25961455. |
together, these results identify mediators of hypoxia-induced p53-dependent apoptosis and suggest akt inhibition may improve radiotherapy response in p53-deficient tumors. |
2015-08-12 |
2023-08-13 |
human |
| Cundong Fan, Jingjing Chen, Yi Wang, Yum-Shing Wong, Yibo Zhang, Wenjie Zheng, Wenqiang Cao, Tianfeng Che. Selenocystine potentiates cancer cell apoptosis induced by 5-fluorouracil by triggering reactive oxygen species-mediated DNA damage and inactivation of the ERK pathway. Free radical biology & medicine. vol 65. 2015-08-11. PMID:23837948. |
however, pretreatment of the cells with glutathione reversed the apoptosis induced by sec and 5-fu and recovered the expression of erk and akt inactivation, which revealed the important role of reactive oxygen species in cell apoptosis and regulation of erk and akt pathways. |
2015-08-11 |
2023-08-12 |
human |
| John Towe. Mitochondrial maintenance failure in aging and role of sexual dimorphism. Archives of biochemistry and biophysics. vol 576. 2015-08-10. PMID:25447815. |
studies in mammals and invertebrates implicate autophagy, apoptosis, akt, parp, p53 and foxo in mediating sex-specific differences in stress resistance and aging. |
2015-08-10 |
2023-08-13 |
caenorhabditis_elegans |
| Benigno C Valdez, Yang Li, David Murray, Jie Ji, Yan Liu, Uday Popat, Richard E Champlin, Borje S Andersso. Comparison of the cytotoxicity of cladribine and clofarabine when combined with fludarabine and busulfan in AML cells: Enhancement of cytotoxicity with epigenetic modulators. Experimental hematology. vol 43. issue 6. 2015-08-10. PMID:25704054. |
cell exposure to these drug combinations resulted in 60%-80% inhibition of proliferation; activation of the atm pathway; increase in histone modifications; decrease in hdac3, hdac4, hdac5 and sirt7 proteins; decrease in mitochondrial membrane potential; activation of apoptosis and stress signaling pathways; and downregulation of the akt pathway. |
2015-08-10 |
2023-08-13 |
Not clear |
| Wenqiang Cao, Xiaoling Li, Shanyuan Zheng, Wenjie Zheng, Yum-Shing Wong, Tianfeng Che. Selenocysteine derivative overcomes TRAIL resistance in melanoma cells: evidence for ROS-dependent synergism and signaling crosstalk. Oncotarget. vol 5. issue 17. 2015-08-06. PMID:25277183. |
herein, we reported that 3,3'-diselenodipropionic acid (dsea), a selenocysteine derivative, could synergistically enhance the growth inhibitory effect of trail on a375 melanoma cells though induction of ros-dependent apoptosis with involvement of pten-mediated akt inactivation and dna damage-mediated p53 phosphorylation, which subsequently activated mitochondrial and death receptor apoptotic pathways. |
2015-08-06 |
2023-08-13 |
Not clear |
| Wenqiang Cao, Xiaoling Li, Shanyuan Zheng, Wenjie Zheng, Yum-Shing Wong, Tianfeng Che. Selenocysteine derivative overcomes TRAIL resistance in melanoma cells: evidence for ROS-dependent synergism and signaling crosstalk. Oncotarget. vol 5. issue 17. 2015-08-06. PMID:25277183. |
in contrast, antioxidants effectively reversed the cell apoptosis through regulation of akt and p53 signaling pathways. |
2015-08-06 |
2023-08-13 |
Not clear |
| Komal Jhaveri, Shanu Mod. Ganetespib: research and clinical development. OncoTargets and therapy. vol 8. 2015-08-05. PMID:26244021. |
hsp90 expression is upregulated in cancers, and this contributes to the malignant phenotype of increased proliferation and decreased apoptosis and maintenance of metastatic potential via conservation of its client proteins, including human epidermal growth factor receptor 2, anaplastic lymphoma kinase, androgen receptor, estrogen receptor, akt, raf-1, cell cycle proteins, and b-cell lymphoma 2 among others. |
2015-08-05 |
2023-08-13 |
human |
| Lykke Blaabjerg, Gitte L Christensen, Masahito Matsumoto, Talitha van der Meulen, Mark O Huising, Nils Billestrup, Wylie W Val. CRFR1 activation protects against cytokine-induced β-cell death. Journal of molecular endocrinology. vol 53. issue 3. 2015-07-31. PMID:25324488. |
crfr1/crfr2 ligands activated akt and crfr1 signaling and reduced apoptosis in human islets. |
2015-07-31 |
2023-08-13 |
mouse |
| Lykke Blaabjerg, Gitte L Christensen, Masahito Matsumoto, Talitha van der Meulen, Mark O Huising, Nils Billestrup, Wylie W Val. CRFR1 activation protects against cytokine-induced β-cell death. Journal of molecular endocrinology. vol 53. issue 3. 2015-07-31. PMID:25324488. |
in rat and mouse insulin-secreting cell lines (ins-1 and min6), crfr1 agonists upregulated insulin receptor substrate 2 (irs2) expression, increased akt activation, counteracted the cytokine-mediated decrease in bad phosphorylation, and inhibited apoptosis. |
2015-07-31 |
2023-08-13 |
mouse |
| Wenjing Zheng, Chengwen Cao, Yanan Liu, Qianqian Yu, Chuping Zheng, Dongdong Sun, Xiaofan Ren, Jie Li. Multifunctional polyamidoamine-modified selenium nanoparticles dual-delivering siRNA and cisplatin to A549/DDP cells for reversal multidrug resistance. Acta biomaterialia. vol 11. 2015-07-30. PMID:25204523. |
when the mdr1 sirna was conjugated with g5@se np via electrostatic interaction, a significant down-regulation of p-glycoprotein and multidrug resistance-associated protein expression was observed; g5@se-ddp-sirna arrested a549/ddp cells at g1 phase and led to enhanced cytotoxicity in a549/ddp cells through induction of apoptosis involving the akt and erk signaling pathways. |
2015-07-30 |
2023-08-13 |
mouse |
| Xiao-Yun Liu, Maria E Gonzalez-Toledo, Austin Fagan, Wei-Ming Duan, Yanying Liu, Siyuan Zhang, Bin Li, Chun-Shu Piao, Lila Nelson, Li-Ru Zha. Stem cell factor and granulocyte colony-stimulating factor exhibit therapeutic effects in a mouse model of CADASIL. Neurobiology of disease. vol 73. 2015-07-29. PMID:25251607. |
in an in vitro model of apoptosis, scf+g-csf prevented apoptotic cell death in vsmcs through akt signaling and by inhibiting caspase-3 activity. |
2015-07-29 |
2023-08-13 |
mouse |
| Min Zeng, Wilfred A van der Donk, Jie Che. Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt. Molecular biology of the cell. vol 25. issue 24. 2015-07-28. PMID:25273559. |
finally, consistent with a function of akt in regulating cell survival, lancl2 knockdown increases the rate of apoptosis, which is reversed by the expression of a constitutively active akt. |
2015-07-28 |
2023-08-13 |
human |
| Christopher S Hackett, David A Quigley, Robyn A Wong, Justin Chen, Christine Cheng, Young K Song, Jun S Wei, Ludmila Pawlikowska, Yun Bao, David D Goldenberg, Kim Nguyen, W Clay Gustafson, Sundari K Rallapalli, Yoon-Jae Cho, James M Cook, Serguei Kozlov, Jian-Hua Mao, Terry Van Dyke, Pui-Yan Kwok, Javed Khan, Allan Balmain, QiWen Fan, William A Weis. Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma. Cell reports. vol 9. issue 3. 2015-07-23. PMID:25437558. |
in human neuroblastoma cells, either blockade of arg1 or benzodiazepine-mediated activation of gaba-a receptors induced apoptosis and inhibited mitogenic signaling through akt and mapk. |
2015-07-23 |
2023-08-13 |
human |
| Güliz Vanli, Nieves Peltzer, Gilles Dubuis, Christian Widman. The activity of the anti-apoptotic fragment generated by the caspase-3/p120 RasGAP stress-sensing module displays strict Akt isoform specificity. Cellular signalling. vol 26. issue 12. 2015-07-21. PMID:25246356. |
akt family members regulate many cellular processes including proliferation, inhibition of apoptosis and metabolism. |
2015-07-21 |
2023-08-13 |
Not clear |
| Piergiorgio Pettazzoni, Andrea Viale, Parantu Shah, Alessandro Carugo, Haoqiang Ying, Huamin Wang, Giannicola Genovese, Sahil Seth, Rosalba Minelli, Tessa Green, Emmet Huang-Hobbs, Denise Corti, Nora Sanchez, Luigi Nezi, Matteo Marchesini, Avnish Kapoor, Wantong Yao, Maria E Di Francesco, Alessia Petrocchi, Angela K Deem, Kenneth Scott, Simona Colla, Gordon B Mills, Jason B Fleming, Timothy P Heffernan, Philip Jones, Carlo Toniatti, Ronald A DePinho, Giulio F Draett. Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer. Cancer research. vol 75. issue 6. 2015-07-21. PMID:25736685. |
importantly, constitutive akt activation, which may mimic the fraction of akt2-amplified pdac, was able to bypass the induction of apoptosis caused by kras* ablation, highlighting a potential inherent resistance mechanism that may inform the clinical application of mek inhibitor therapy. |
2015-07-21 |
2023-08-13 |
mouse |
| Hong Yao, Xiangyang Han, Xiuzhen Ha. The cardioprotection of the insulin-mediated PI3K/Akt/mTOR signaling pathway. American journal of cardiovascular drugs : drugs, devices, and other interventions. vol 14. issue 6. 2015-07-17. PMID:25160498. |
insulin can protect cardiomyocytes from apoptosis by regulating a number of signaling molecules, such as enos, foxos, bad, gsk-3β, mtor, ndrg2, and nrf2, through activating pi3k and akt. |
2015-07-17 |
2023-08-13 |
Not clear |
| Wenbin Yin, Baoying Li, Xiaoli Li, Fei Yu, Qian Cai, Zhen Zhang, Junfu Wang, Jianhua Zhang, Ruihai Zhou, Mei Cheng, Haiqing Ga. Critical role of prohibitin in endothelial cell apoptosis caused by glycated low-density lipoproteins and protective effects of grape seed procyanidin B2. Journal of cardiovascular pharmacology. vol 65. issue 1. 2015-07-17. PMID:25343566. |
moreover, phb sirna increased huvec apoptosis, along with defective mitochondria and increased levels of cytosol cytochrome c concentration, caspase-3 activity, bax/bcl-2 ratio, and phosphorylated akt, whereas phb overexpression or gspb2 restored these changes. |
2015-07-17 |
2023-08-13 |
human |