| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenting Jiang, Yuanting Fu, Fang Yang, Yufeng Yang, Ting Liu, Wenjie Zheng, Lilan Zeng, Tianfeng Che. Gracilaria lemaneiformis polysaccharide as integrin-targeting surface decorator of selenium nanoparticles to achieve enhanced anticancer efficacy. ACS applied materials & interfaces. vol 6. issue 16. 2015-10-27. PMID:25073123. |
therefore, p53, mapks, and akt pathways were activated to advance cell apoptosis. |
2015-10-27 |
2023-08-13 |
Not clear |
| Rong-Jane Chen, Shih-He Siao, Chung-Huei Hsu, Chu-Yung Chang, Louis W Chang, Chih-Hsiung Wu, Pinpin Lin, Ying-Jan Wan. TCDD promotes lung tumors via attenuation of apoptosis through activation of the Akt and ERK1/2 signaling pathways. PloS one. vol 9. issue 6. 2015-10-26. PMID:24927102. |
tcdd promotes lung tumors via attenuation of apoptosis through activation of the akt and erk1/2 signaling pathways. |
2015-10-26 |
2023-08-13 |
mouse |
| Rong-Jane Chen, Shih-He Siao, Chung-Huei Hsu, Chu-Yung Chang, Louis W Chang, Chih-Hsiung Wu, Pinpin Lin, Ying-Jan Wan. TCDD promotes lung tumors via attenuation of apoptosis through activation of the Akt and ERK1/2 signaling pathways. PloS one. vol 9. issue 6. 2015-10-26. PMID:24927102. |
the inhibition of apoptosis is likely mediated by the activation of the akt and erk1/2 pathways, as determined by the effectiveness of pathway-specific inhibitors in abrogating the anti-apoptotic activity of tcdd. |
2015-10-26 |
2023-08-13 |
mouse |
| Rong-Jane Chen, Shih-He Siao, Chung-Huei Hsu, Chu-Yung Chang, Louis W Chang, Chih-Hsiung Wu, Pinpin Lin, Ying-Jan Wan. TCDD promotes lung tumors via attenuation of apoptosis through activation of the Akt and ERK1/2 signaling pathways. PloS one. vol 9. issue 6. 2015-10-26. PMID:24927102. |
in conclusion, we demonstrated that tcdd promoted nnk-induced lung tumorigenesis and revealed that tcdd inhibits staurosporine-induced apoptosis, at least in part, through the akt and erk1/2 signaling pathways. |
2015-10-26 |
2023-08-13 |
mouse |
| Kandasamy Palanivel, Veerasamy Kanimozhi, Balamuthu Kadalmani, Mohammad Abdulkader Akbarsh. Verrucarin A induces apoptosis through ROS-mediated EGFR/MAPK/Akt signaling pathways in MDA-MB-231 breast cancer cells. Journal of cellular biochemistry. vol 115. issue 11. 2015-10-26. PMID:24963595. |
furthermore, va-induced apoptosis was accompanied by the activation of p38mapk and inhibition of phosphorylation of egfr as well as of akt and erk1/2. |
2015-10-26 |
2023-08-13 |
human |
| Shingo Tanaka, Mitsutoshi Nakada, Daisuke Yamada, Ichiro Nakano, Tomoki Todo, Yasushi Ino, Takayuki Hoshii, Yuko Tadokoro, Kumiko Ohta, Mohamed A E Ali, Yutaka Hayashi, Jun-ichiro Hamada, Atsushi Hira. Strong therapeutic potential of γ-secretase inhibitor MRK003 for CD44-high and CD133-low glioblastoma initiating cells. Journal of neuro-oncology. vol 121. issue 2. 2015-10-26. PMID:25293440. |
nine patient-derived gics were treated by mrk003, and its efficacy on cell viability, apoptosis, sphere forming ability and akt expression level which might be related to notch downstream and be greatly important signals in gbm was evaluated. |
2015-10-26 |
2023-08-13 |
Not clear |
| Lei Zhan, Yang Yang, Tao-Tao Ma, Cheng Huang, Xiao-Ming Meng, Lei Zhang, Jun L. Transient receptor potential vanilloid 4 inhibits rat HSC-T6 apoptosis through induction of autophagy. Molecular and cellular biochemistry. vol 402. issue 1-2. 2015-10-26. PMID:25600591. |
these results indicated that trpv4 could inhibit hscs apoptosis partially by regulating autophagy-dependent akt signaling pathway activation. |
2015-10-26 |
2023-08-13 |
rat |
| Jianli Zhang, Yue Hong, Jie She. Combination treatment with perifosine and MEK-162 demonstrates synergism against lung cancer cells in vitro and in vivo. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 7. 2015-10-26. PMID:25697899. |
here, we reported that the akt inhibitor perifosine and the mek\erk inhibitor mek-162 synergistically induced lung cancer cell (a549 and h460 lines) growth inhibition and apoptosis. |
2015-10-26 |
2023-08-13 |
Not clear |
| Jin Muk Kang, Sujin Park, Staci Jakyong Kim, Hyojung Kim, Bona Lee, Junil Kim, Jinah Park, Shin Tae Kim, Han-Kwang Yang, Woo Ho Kim, Seong-Jin Ki. KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78. Cancer research. vol 75. issue 15. 2015-10-26. PMID:26045166. |
kiaa1324 blocked oncogenic activities of grp78 by inhibiting grp78-caspase-7 interaction and suppressing grp78-mediated akt activation, thereby inducing apoptosis. |
2015-10-26 |
2023-08-13 |
Not clear |
| Irina O Zakharova, Tatyana V Sokolova, Liubov V Bayunova, Yulia A Vlasova, Maria P Rychkova, Natalia F Avrov. α-Tocopherol at nanomolar concentration protects PC12 cells from hydrogen peroxide-induced death and modulates protein kinase activities. International journal of molecular sciences. vol 13. issue 9. 2015-10-22. PMID:23109870. |
the protection by 100 nm α-tocopherol against h(2)o(2)-induced pc12 cell death was pronounced if the time of pre-incubation with α-tocopherol was 3-18 h. for the first time, the protective effect of α-tocopherol was shown to depend on its concentration in the nanomolar range (1 nm < 10 nm < 100 nm), if the pre-incubation time was 18 h. nanomolar and micromolar α-tocopherol decreased the number of pc12 cells in late apoptosis induced by h(2)o(2) to the same extent if pre-incubation time was 18 h. immunoblotting data showed that α-tocopherol markedly diminished the time of maximal activation of extracellular signal-regulated kinase 1/2 (erk 1/2) and protein kinase b (akt)-induced in pc12 cells by h(2)o(2). |
2015-10-22 |
2023-08-12 |
Not clear |
| Jingjing Wang, Zhuang Yang, Jiaolin Wen, Feng Ma, Fang Wang, Kun Yu, Minghai Tang, Wenshuang Wu, Yinfeng Dong, Xia Cheng, Chunlai Nie, Lijuan Che. SKLB-M8 induces apoptosis through the AKT/mTOR signaling pathway in melanoma models and inhibits angiogenesis with decrease of ERK1/2 phosphorylation. Journal of pharmacological sciences. vol 126. issue 3. 2015-10-19. PMID:25341684. |
flow cytometory analysis showed that sklb-m8 induced g2/m arrest in three melanoma cell lines, and western blotting demonstrated that sklb-m8 down-regulated the expression of cdc2, up-regulated p53 in a2058 and chl-1 cells, and triggered cell apoptosis through down-regulating akt and phosphorylated mtor (p-mtor). |
2015-10-19 |
2023-08-13 |
mouse |
| Lan Wang, Na Man, Xiao-Jian Sun, Yurong Tan, Marta García-Cao, Marta Garcia Cao, Fan Liu, Megan Hatlen, Haiming Xu, Gang Huang, Meredith Mattlin, Arpit Mehta, Evadnie Rampersaud, Robert Benezra, Stephen D Nime. Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression. Blood. vol 126. issue 5. 2015-10-19. PMID:26084673. |
an id1 inhibitor impaired the in vitro growth of aml cells and, when combined with an akt inhibitor, triggered even greater apoptosis and growth inhibition, whereas normal hematopoietic stem/progenitor cells were largely spared. |
2015-10-19 |
2023-08-13 |
mouse |
| Kaijun Di, Stephen T Keir, Daniela Alexandru-Abrams, Xing Gong, Howard Nguyen, Henry S Friedman, Daniela A Bot. Profiling Hsp90 differential expression and the molecular effects of the Hsp90 inhibitor IPI-504 in high-grade glioma models. Journal of neuro-oncology. vol 120. issue 3. 2015-10-15. PMID:25115740. |
hsp90 inhibition by ipi-504 induced apoptosis, blocked migration and invasion, and significantly decreased epidermal growth factor receptor levels, mitogen-activated protein kinase and/or akt activities, and secretion of vascular endothelial growth factor in glioma cell lines. |
2015-10-15 |
2023-08-13 |
mouse |
| Chunyang Li, Jie Chen, Bangmin Lu, Zheng Shi, Hailian Wang, Bin Zhang, Kailiang Zhao, Wei Qi, Jinku Bao, Yi Wan. Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells. PloS one. vol 9. issue 7. 2015-10-14. PMID:24992302. |
molecular switch role of akt in polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer a549 cells. |
2015-10-14 |
2023-08-13 |
human |
| Chunyang Li, Jie Chen, Bangmin Lu, Zheng Shi, Hailian Wang, Bin Zhang, Kailiang Zhao, Wei Qi, Jinku Bao, Yi Wan. Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells. PloS one. vol 9. issue 7. 2015-10-14. PMID:24992302. |
pol initiated apoptosis through inhibiting akt-nf-κb pathway, while pol triggered autophagy via suppressing akt-mtor pathway, suggesting the molecular switch role of akt in regulating between pol-induced apoptosis and autophagy. |
2015-10-14 |
2023-08-13 |
human |
| Chunyang Li, Jie Chen, Bangmin Lu, Zheng Shi, Hailian Wang, Bin Zhang, Kailiang Zhao, Wei Qi, Jinku Bao, Yi Wan. Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells. PloS one. vol 9. issue 7. 2015-10-14. PMID:24992302. |
moreover, ros was involved in pol-induced inhibition of akt expression, and might therefore mediate both apoptosis and autophagy in a549 cells. |
2015-10-14 |
2023-08-13 |
human |
| Qisen Xiang, Yunfang Ma, Jilin Dong, Ruiling She. Carnosic acid induces apoptosis associated with mitochondrial dysfunction and Akt inactivation in HepG2 cells. International journal of food sciences and nutrition. vol 66. issue 1. 2015-10-06. PMID:25265205. |
carnosic acid induces apoptosis associated with mitochondrial dysfunction and akt inactivation in hepg2 cells. |
2015-10-06 |
2023-08-13 |
human |
| Sijun Deng, Shusheng Tang, Shen Zhang, Chaoming Zhang, Congcong Wang, Yan Zhou, Chongshan Dai, Xilong Xia. Furazolidone induces apoptosis through activating reactive oxygen species-dependent mitochondrial signaling pathway and suppressing PI3K/Akt signaling pathway in HepG2 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 75. 2015-10-05. PMID:25434308. |
meanwhile, fzd treatment inhibited both the activation and expression of akt, and pi3k/akt inhibitor ly294002 promoted fzd-induced apoptosis. |
2015-10-05 |
2023-08-13 |
Not clear |
| Young-Ah Suh, Se-Young Jo, Hwa-Young Lee, Chuhee Le. Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells. International journal of oncology. vol 46. issue 3. 2015-10-05. PMID:25544427. |
we further found that apigenin decreased akt phosphorylation and the level of b-cell lymphoma-extra large (bcl-xl or bcl2-like 1 isoform 1), an inhibitor of apoptosis. |
2015-10-05 |
2023-08-13 |
Not clear |
| Keizo Yuasa, Reina Ota, Shinya Matsuda, Kinuka Isshiki, Masahiro Inoue, Akihiko Tsuj. Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins. Biochemical and biophysical research communications. vol 464. issue 1. 2015-09-30. PMID:26047703. |
our findings suggest that dapk2-induced apoptosis is negatively regulated by akt and 14-3-3 proteins. |
2015-09-30 |
2023-08-13 |
Not clear |