| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guo-Wei Wang, Chao Lv, Zhi-Ran Shi, Ren-Tao Zeng, Xue-Yun Dong, Wei-Dong Zhang, Run-Hui Liu, Lei Shan, Yun-Heng She. Abieslactone induces cell cycle arrest and apoptosis in human hepatocellular carcinomas through the mitochondrial pathway and the generation of reactive oxygen species. PloS one. vol 9. issue 12. 2015-12-21. PMID:25502685. |
recent studies have shown that ros is upstream of akt signal in mitochondria-mediated hepatoma cell apoptosis. |
2015-12-21 |
2023-08-13 |
human |
| Guo-Wei Wang, Chao Lv, Zhi-Ran Shi, Ren-Tao Zeng, Xue-Yun Dong, Wei-Dong Zhang, Run-Hui Liu, Lei Shan, Yun-Heng She. Abieslactone induces cell cycle arrest and apoptosis in human hepatocellular carcinomas through the mitochondrial pathway and the generation of reactive oxygen species. PloS one. vol 9. issue 12. 2015-12-21. PMID:25502685. |
in addition, inactivation of total and phosphorylated akt activities was found to be involved in abieslactone-induced hepg2 cell apoptosis. |
2015-12-21 |
2023-08-13 |
human |
| Baohua Sun, Bhavin Shah, Warren Fiskus, Jun Qi, Kimal Rajapakshe, Cristian Coarfa, Li Li, Santhana G T Devaraj, Sunil Sharma, Liang Zhang, Michael L Wang, Dyana T Saenz, Stephanie Krieger, James E Bradner, Kapil N Bhall. Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib. Blood. vol 126. issue 13. 2015-12-21. PMID:26254443. |
ba treatment also induced apoptosis of the in vitro isolated, ibrutinib-resistant mcl cells, which overexpress cdk6, bcl2, bcl-xl, xiap, and akt, but lack ibrutinib resistance-conferring btk mutation. |
2015-12-21 |
2023-08-13 |
mouse |
| Peter P Ruvolo, YiHua Qiu, Kevin R Coombes, Nianxiang Zhang, E Shannon Neeley, Vivian R Ruvolo, Numsen Hail, Gautam Borthakur, Marina Konopleva, Michael Andreeff, Steven M Kornbla. Phosphorylation of GSK3α/β correlates with activation of AKT and is prognostic for poor overall survival in acute myeloid leukemia patients. BBA clinical. vol 4. 2015-12-17. PMID:26674329. |
cell cycle arrest and apoptosis are tightly regulated by akt via phosphorylation of gsk3α and β isoforms which inactivates these kinases. |
2015-12-17 |
2023-08-13 |
Not clear |
| Gangarao Davuluri, Katarzyna Augoff, William P Schiemann, Edward F Plow, Khalid Sossey-Alaou. WAVE3-NFκB interplay is essential for the survival and invasion of cancer cells. PloS one. vol 9. issue 10. 2015-12-16. PMID:25329315. |
loss of wave3 also sensitized cancer cells to apoptosis and cell death driven by tnfα, through the inhibition of the akt pro-survival pathway. |
2015-12-16 |
2023-08-13 |
Not clear |
| Sara Zanini, Francesco Giovinazzo, Daniele Alaimo, Ben Lawrence, Roswitha Pfragner, Claudio Bassi, Irvin Modlin, Mark Kid. GNA15 expression in small intestinal neuroendocrine neoplasia: functional and signalling pathway analyses. Cellular signalling. vol 27. issue 5. 2015-12-15. PMID:25701539. |
in krj-i cells, decreased expression of gna15 was associated with inhibition of proliferation, activation of apoptosis and differential effects on pro-proliferative erk, nfκb and akt pathway signalling. |
2015-12-15 |
2023-08-13 |
Not clear |
| Wenru Su, Zuohong Li, Yu Jia, Yehong Zhu. Rapamycin is neuroprotective in a rat chronic hypertensive glaucoma model. PloS one. vol 9. issue 6. 2015-12-14. PMID:24923557. |
mechanistically, rapamycin-mediated suppression of rgcs apoptosis is by sparing phosphorylation of akt at a site critical for maintenance of its survival-promoting activity in cell and animal model. |
2015-12-14 |
2023-08-13 |
rat |
| Raúl Rincón, Ion Cristóbal, Sandra Zazo, Oriol Arpí, Silvia Menéndez, Rebeca Manso, Ana Lluch, Pilar Eroles, Ana Rovira, Joan Albanell, Jesús García-Foncillas, Juan Madoz-Gúrpide, Federico Roj. PP2A inhibition determines poor outcome and doxorubicin resistance in early breast cancer and its activation shows promising therapeutic effects. Oncotarget. vol 6. issue 6. 2015-12-14. PMID:25726524. |
interestingly, restoration of pp2a activity after fty720 treatment reduced cell growth, induced apoptosis and decreased akt and erk activation. |
2015-12-14 |
2023-08-13 |
human |
| Jianxin Wang, Feifan Xu, Dandan Zhu, Yinong Duan, Jinling Chen, Xiaolei Sun, Xue He, Pan Li, Wei Sun, Jinrong Fen. Schistosoma japonicum soluble egg antigens facilitate hepatic stellate cell apoptosis by downregulating Akt expression and upregulating p53 and DR5 expression. PLoS neglected tropical diseases. vol 8. issue 8. 2015-12-08. PMID:25144704. |
schistosoma japonicum soluble egg antigens facilitate hepatic stellate cell apoptosis by downregulating akt expression and upregulating p53 and dr5 expression. |
2015-12-08 |
2023-08-13 |
Not clear |
| Dong-Ming Wu, Peng Zhang, Guang-Chao Xu, Ai-Ping Tong, Cong Zhou, Jin-Yi Lang, Chun-Ting Wan. Pemetrexed induces G1 phase arrest and apoptosis through inhibiting Akt activation in human non small lung cancer cell line A549. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 4. 2015-12-08. PMID:25743822. |
pemetrexed induces g1 phase arrest and apoptosis through inhibiting akt activation in human non small lung cancer cell line a549. |
2015-12-08 |
2023-08-13 |
human |
| Dong-Ming Wu, Peng Zhang, Guang-Chao Xu, Ai-Ping Tong, Cong Zhou, Jin-Yi Lang, Chun-Ting Wan. Pemetrexed induces G1 phase arrest and apoptosis through inhibiting Akt activation in human non small lung cancer cell line A549. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 4. 2015-12-08. PMID:25743822. |
accumulation of gapdh and decrease of hspb1 and eif4e which induce apoptosis through inhibiting phosphorylation of akt were noted. |
2015-12-08 |
2023-08-13 |
human |
| Dong-Ming Wu, Peng Zhang, Guang-Chao Xu, Ai-Ping Tong, Cong Zhou, Jin-Yi Lang, Chun-Ting Wan. Pemetrexed induces G1 phase arrest and apoptosis through inhibiting Akt activation in human non small lung cancer cell line A549. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 4. 2015-12-08. PMID:25743822. |
thus, pemetrexed induced apoptosis in a549 cells through inhibiting the akt pathway. |
2015-12-08 |
2023-08-13 |
human |
| Khadka Sachita, Yongsoo Kim, Hyun-Ju Yu, Sung-Dae Cho, Jeong-Sang Le. In Vitro Assessment of the Anticancer Potential of Evodiamine in Human Oral Cancer Cell Lines. Phytotherapy research : PTR. vol 29. issue 8. 2015-12-03. PMID:25903972. |
evodiamine reduced expression of phosphorylated akt, and ly294002 potentiated evodiamine-induced apoptosis by regulating mcl-1 protein. |
2015-12-03 |
2023-08-13 |
human |
| Khadka Sachita, Yongsoo Kim, Hyun-Ju Yu, Sung-Dae Cho, Jeong-Sang Le. In Vitro Assessment of the Anticancer Potential of Evodiamine in Human Oral Cancer Cell Lines. Phytotherapy research : PTR. vol 29. issue 8. 2015-12-03. PMID:25903972. |
our results suggest that evodiamine induces apoptosis in human oral cancer cells through the akt pathway. |
2015-12-03 |
2023-08-13 |
human |
| Lei Zhang, Linfang Cheng, Qiqi Wang, Dongchen Zhou, Zhigang Wu, Ling Shen, Li Zhang, Jianhua Zh. Atorvastatin protects cardiomyocytes from oxidative stress by inhibiting LOX-1 expression and cardiomyocyte apoptosis. Acta biochimica et biophysica Sinica. vol 47. issue 3. 2015-11-27. PMID:25630653. |
the akt inhibitor, ly294002, inhibited the effect of atorvastatin on inducing akt phosphorylation and on suppressing h2o2-mediated caspase up-regulation and cell apoptosis. |
2015-11-27 |
2023-08-13 |
Not clear |
| Lei Zhang, Linfang Cheng, Qiqi Wang, Dongchen Zhou, Zhigang Wu, Ling Shen, Li Zhang, Jianhua Zh. Atorvastatin protects cardiomyocytes from oxidative stress by inhibiting LOX-1 expression and cardiomyocyte apoptosis. Acta biochimica et biophysica Sinica. vol 47. issue 3. 2015-11-27. PMID:25630653. |
these findings indicate that atorvastatin protects cardiomyocyte from oxidative stress via inhibition of lox-1 expression and apoptosis, and that activation of h2o2-inhibited phosphorylation of akt may play an important role in the protective function of atorvastatin. |
2015-11-27 |
2023-08-13 |
Not clear |
| Antonella Cusimano, Roberto Puleio, Natale D'Alessandro, Guido R Loria, James A McCubrey, Giuseppe Montalto, Melchiorre Cervell. Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells. Oncotarget. vol 6. issue 3. 2015-11-25. PMID:25596737. |
here, we report that sc66, a novel akt inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited colony formation and induced apoptosis in hcc cells. |
2015-11-25 |
2023-08-13 |
Not clear |
| Jun Zhou, Jiang Cao, Fan-Jing Meng, Hao Feng, Kai-Lin X. [Inducing Effect of Akt Kinase Inhibitor MK2206 on Apoptosis in U937 Cells and RS4;11 Cells, and Its Mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 23. issue 3. 2015-11-24. PMID:26117006. |
[inducing effect of akt kinase inhibitor mk2206 on apoptosis in u937 cells and rs4;11 cells, and its mechanism]. |
2015-11-24 |
2023-08-13 |
Not clear |
| Jun Zhou, Jiang Cao, Fan-Jing Meng, Hao Feng, Kai-Lin X. [Inducing Effect of Akt Kinase Inhibitor MK2206 on Apoptosis in U937 Cells and RS4;11 Cells, and Its Mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 23. issue 3. 2015-11-24. PMID:26117006. |
this study was purposed to investigate the effect of akt kinase inhibitor mk2206 on proliferation and apoptosis of u937 cells and rs4;11 cells, and to explore its possible mechanism. |
2015-11-24 |
2023-08-13 |
Not clear |
| Bo Zhu, Yi-Qun Huan. [Effects of Silencing AKT Gene by shRNA on Proliferation, Apoptosis and Notch1 Signal Pathway in Jeko-1 Cells]. Zhongguo shi yan xue ye xue za zhi. vol 23. issue 3. 2015-11-24. PMID:26117016. |
[effects of silencing akt gene by shrna on proliferation, apoptosis and notch1 signal pathway in jeko-1 cells]. |
2015-11-24 |
2023-08-13 |
Not clear |